Search Results - "NIIZUMA, Kuniyasu"

Stem Cell Therapy for Neurological Diseases by Niizuma, Kuniyasu

“…Recently, regenerative medicine, a field of medicine which focuses on the repair or replacement of damaged or lost tissues, has been of great interest…”
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Effects of clazosentan on cerebral vasospasm-related morbidity and all-cause mortality after aneurysmal subarachnoid hemorrhage: two randomized phase 3 trials in Japanese patients by Endo, Hidenori, Hagihara, Yasushi, Kimura, Naoto, Takizawa, Katsumi, Niizuma, Kuniyasu, Togo, Osamu, Tominaga, Teiji

“…Clazosentan has been investigated globally for the prevention of cerebral vasospasm after aneurysmal subarachnoid hemorrhage (aSAH). The authors evaluated its…”
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Oxidative stress and mitochondrial dysfunction as determinants of ischemic neuronal death and survival by Niizuma, Kuniyasu, Endo, Hidenori, Chan, Pak H

“…Mitochondria are the powerhouse of the cell. Their primary physiological function is to generate adenosine triphosphate through oxidative phosphorylation via…”
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What does computational fluid dynamics tell us about intracranial aneurysms? A meta-analysis and critical review by Saqr, Khalid M, Rashad, Sherif, Tupin, Simon, Niizuma, Kuniyasu, Hassan, Tamer, Tominaga, Teiji, Ohta, Makoto

“…Despite the plethora of published studies on intracranial aneurysms (IAs) hemodynamic using computational fluid dynamics (CFD), limited progress has been made…”
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The cell and stress‐specific canonical and noncanonical tRNA cleavage by Rashad, Sherif, Tominaga, Teiji, Niizuma, Kuniyasu

“…Following stress, transfer RNA (tRNA) is cleaved to generate tRNA halves (tiRNAs). These tiRNAs have been shown to repress protein translation. Angiogenin was…”
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RNF213 loss of function reshapes vascular transcriptome and spliceosome leading to disrupted angiogenesis and aggravated vascular inflammatory responses by Zhang, Liyin, Rashad, Sherif, Zhou, Yuan, Niizuma, Kuniyasu, Tominaga, Teiji

“…RNF213 gene mutations are the cause behind Moyamoya disease, a rare cerebrovascular occlusive disease. However, the function of RNF213 in the vascular system…”
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Stress‐induced tRNA cleavage and tiRNA generation in rat neuronal PC12 cells by Elkordy, Alaa, Mishima, Eikan, Niizuma, Kuniyasu, Akiyama, Yasutoshi, Fujimura, Miki, Tominaga, Teiji, Abe, Takaaki

“…Transfer RNA (tRNA) plays a role in stress response programs involved in various pathological conditions including neurological diseases. Under cell stress…”
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Physiologic blood flow is turbulent by Saqr, Khalid M., Tupin, Simon, Rashad, Sherif, Endo, Toshiki, Niizuma, Kuniyasu, Tominaga, Teiji, Ohta, Makoto

“…Contemporary paradigm of peripheral and intracranial vascular hemodynamics considers physiologic blood flow to be laminar. Transition to turbulence is…”
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The stress specific impact of ALKBH1 on tRNA cleavage and tiRNA generation by Rashad, Sherif, Han, Xiaobo, Sato, Kanako, Mishima, Eikan, Abe, Takaaki, Tominaga, Teiji, Niizuma, Kuniyasu

“…tiRNAs are small non-coding RNAs produced when tRNA is cleaved under stress. tRNA methylation modifications has emerged in recent years as important regulators…”
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Human Muse Cells Reconstruct Neuronal Circuitry in Subacute Lacunar Stroke Model by Uchida, Hiroki, Niizuma, Kuniyasu, Kushida, Yoshihiro, Wakao, Shohei, Tominaga, Teiji, Borlongan, Cesario V, Dezawa, Mari

“…BACKGROUND AND PURPOSE—Multilineage-differentiating stress-enduring (muse) cells are endogenous nontumorigenic stem cells with pluripotency harvestable as…”
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Circumferential wall enhancement in evolving intracranial aneurysms on magnetic resonance vessel wall imaging by Omodaka, Shunsuke, Endo, Hidenori, Niizuma, Kuniyasu, Fujimura, Miki, Inoue, Takashi, Endo, Toshiki, Sato, Kenichi, Sugiyama, Shin-Ichiro, Tominaga, Teiji

“…Recent MR vessel wall imaging studies have indicated intracranial aneurysms in the active state could show circumferential enhancement along the aneurysm wall…”
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The hemodynamic complexities underlying transient ischemic attacks in early-stage Moyamoya disease: an exploratory CFD study by Rashad, Sherif, Saqr, Khalid M., Fujimura, Miki, Niizuma, Kuniyasu, Tominaga, Teiji

“…Moyamoya disease (MMD) is a rare cerebro-occlusive disease with unknown etiology that can cause both ischemic and hemorrhagic stroke. MMD is characterized by…”
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Minocycline Prevents Focal Neurological Deterioration Due to Cerebral Hyperperfusion After Extracranial-Intracranial Bypass for Moyamoya Disease by Fujimura, Miki, Niizuma, Kuniyasu, Inoue, Takashi, Sato, Kenichi, Endo, Hidenori, Shimizu, Hiroaki, Tominaga, Teiji

“…Abstract BACKGROUND: Cerebral hyperperfusion (CHP) is a potential complication of superficial temporal artery–middle cerebral artery (STA-MCA) anastomosis for…”
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Early BBB breakdown and subacute inflammasome activation and pyroptosis as a result of cerebral venous thrombosis by Rashad, Sherif, Niizuma, Kuniyasu, Sato-Maeda, Mika, Fujimura, Miki, Mansour, Ahmed, Endo, Hidenori, Ikawa, Shuntaro, Tominaga, Teiji

“…[Display omitted] •Superior sagittal sinus occlusion in rats induces subacute venous infarction.•Cerebral venous thrombosis (CVT) causes MMP9 mediated BBB…”
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A Novel Type of Stem Cells Double-Positive for SSEA-3 and CD45 in Human Peripheral Blood by Sato, Tetsuya, Wakao, Shohei, Kushida, Yoshihiro, Tatsumi, Kazuki, Kitada, Masaaki, Abe, Takatsugu, Niizuma, Kuniyasu, Tominaga, Teiji, Kushimoto, Shigeki, Dezawa, Mari

“…Peripheral blood (PB) contains several types of stem/progenitor cells, including hematopoietic stem and endothelial progenitor cells. We identified a…”
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Intraoperative motor-evoked potential monitoring during coil embolization for anterior choroidal artery aneurysms by Ito, Akira, Sato, Kenichi, Niizuma, Kuniyasu, Endo, Hidenori, Matsumoto, Yasushi, Tominaga, Teiji

“…Purpose Intraoperative motor-evoked potential (MEP) monitoring is widely used in the neck clipping of cerebral aneurysms. Little is known regarding the…”
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Mitochondrial and apoptotic neuronal death signaling pathways in cerebral ischemia by Niizuma, Kuniyasu, Yoshioka, Hideyuki, Chen, Hai, Kim, Gab Seok, Jung, Joo Eun, Katsu, Masataka, Okami, Nobuya, Chan, Pak H.

“…Mitochondria play important roles as the powerhouse of the cell. After cerebral ischemia, mitochondria overproduce reactive oxygen species (ROS), which have…”
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Distinguishing IDH mutation status in gliomas using FTIR-ATR spectra of peripheral blood plasma indicating clear traces of protein amyloid aggregation by Kino, Saiko, Kanamori, Masayuki, Shimoda, Yoshiteru, Niizuma, Kuniyasu, Endo, Hidenori, Matsuura, Yuji

“…Glioma is a primary brain tumor and the assessment of its molecular profile in a minimally invasive manner is important in determining treatment strategies…”
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tRNA cleavage: a new insight by Rashad, Sherif, Niizuma, Kuniyasu, Tominaga, Teiji

“…Over the past decades, tRNA was found to be a rich hub of RNA modifications such as 1-methyladenosine and 5-methycytosine modifications and others, holding…”
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Incidence and Risk Factors of the Watershed Shift Phenomenon after Superficial Temporal Artery-Middle Cerebral Artery Anastomosis for Adult Moyamoya Disease by Tashiro, Ryosuke, Fujimura, Miki, Kameyama, Masayuki, Mugikura, Shunji, Endo, Hidenori, Takeuchi, Yohei, Tomata, Yasutake, Niizuma, Kuniyasu, Tominaga, Teiji

“…Superficial temporal artery-middle cerebral artery (STA-MCA) anastomosis is the standard surgical management for adult moyamoya disease (MMD) patients, but…”
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