Search Results - "NIGGLI, Felix K"

Induction of autophagy-dependent necroptosis is required for childhood acute lymphoblastic leukemia cells to overcome glucocorticoid resistance by Bonapace, Laura, Bornhauser, Beat C, Schmitz, Maike, Cario, Gunnar, Ziegler, Urs, Niggli, Felix K, Schäfer, Beat W, Schrappe, Martin, Stanulla, Martin, Bourquin, Jean-Pierre

“…In vivo resistance to first-line chemotherapy, including to glucocorticoids, is a strong predictor of poor outcome in children with acute lymphoblastic…”
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Phenotypic profiling with a living biobank of primary rhabdomyosarcoma unravels disease heterogeneity and AKT sensitivity by Manzella, Gabriele, Schreck, Leonie D., Breunis, Willemijn B., Molenaar, Jan, Merks, Hans, Barr, Frederic G., Sun, Wenyue, Römmele, Michaela, Zhang, Luduo, Tchinda, Joelle, Ngo, Quy A., Bode, Peter, Delattre, Olivier, Surdez, Didier, Rekhi, Bharat, Niggli, Felix K., Schäfer, Beat W., Wachtel, Marco

“…Cancer therapy is currently shifting from broadly used cytotoxic drugs to patient-specific precision therapies. Druggable driver oncogenes, identified by…”
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USP19 deubiquitinates EWS-FLI1 to regulate Ewing sarcoma growth by Gierisch, Maria E., Pedot, Gloria, Walser, Franziska, Lopez-Garcia, Laura A., Jaaks, Patricia, Niggli, Felix K., Schäfer, Beat W.

“…Ewing sarcoma is the second most common pediatric bone and soft tissue tumor presenting with an aggressive behavior and prevalence to metastasize. The…”
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Inhibition of HDACs reduces Ewing sarcoma tumor growth through EWS-FLI1 protein destabilization by Pedot, Gloria, Marques, Joana Graça, Ambühl, Philip P, Wachtel, Marco, Kasper, Stephanie, Ngo, Quy A, Niggli, Felix K, Schäfer, Beat W

“…Oncogenic transcription factors lacking enzymatic activity or targetable binding pockets are typically considered "undruggable". An example is provided by the…”
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CRISPR activation screen identifies TGFβ-associated PEG10 as a crucial tumor suppressor in Ewing sarcoma by Saratov, Vadim, Ngo, Quy A., Pedot, Gloria, Sidorov, Semjon, Wachtel, Marco, Niggli, Felix K., Schäfer, Beat W.

“…As the second most common pediatric bone and soft tissue tumor, Ewing sarcoma (ES) is an aggressive disease with a pathognomonic chromosomal translocation…”
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Corrigendum to "Inhibition of HDACs reduces Ewing sarcoma tumor growth through EWS-FLI1 protein destabilization" [Neoplasia volume 27 (2022) pp. 100784/Number C] by Pedot, Gloria, Marques, Joana Graça, Ambühl, Philip P, Wachtel, Marco, Kasper, Stephanie, Ngo, Quy A, Niggli, Felix K, Schäfer, Beat W

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Author Correction: CRISPR activation screen identifies TGFβ-associated PEG10 as a crucial tumor suppressor in Ewing sarcoma by Saratov, Vadim, Ngo, Quy A., Pedot, Gloria, Sidorov, Semjon, Wachtel, Marco, Niggli, Felix K., Schäfer, Beat W.

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Predicting Adverse Events in Children With Fever and Chemotherapy-Induced Neutropenia: The Prospective Multicenter SPOG 2003 FN Study by Ammann, Roland A, Bodmer, Nicole, Hirt, Andreas, Niggli, Felix K, Nadal, David, Simon, Arne, Ozsahin, Hulya, Kontny, Udo, Kühne, Thomas, Popovic, Maja Beck, Lüthy, Annette Ridolfi, Aebi, Christoph

“…PURPOSE To develop a score predicting the risk of adverse events (AEs) in pediatric patients with cancer who experience fever and neutropenia (FN) and to…”
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Proteasomal Degradation of the EWS-FLI1 Fusion Protein Is Regulated by a Single Lysine Residue by Gierisch, Maria E., Pfistner, Franziska, Lopez-Garcia, Laura A., Harder, Lena, Schäfer, Beat W., Niggli, Felix K.

“…E-26 transformation-specific (ETS) proteins are transcription factors directing gene expression through their conserved DNA binding domain. They are implicated…”
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Targeting the EWS-ETS transcriptional program by BET bromodomain inhibition in Ewing sarcoma by Hensel, Tim, Giorgi, Chiara, Schmidt, Oxana, Calzada-Wack, Julia, Neff, Frauke, Buch, Thorsten, Niggli, Felix K, Schäfer, Beat W, Burdach, Stefan, Richter, Günther H S

“…Ewing sarcomas (ES) are highly malignant bone or soft tissue tumors. Genetically, ES are defined by balanced chromosomal EWS/ETS translocations, which give…”
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Pencil Beam Scanning Proton Therapy for Pediatric Parameningeal Rhabdomyosarcomas: Clinical Outcome of Patients Treated at the Paul Scherrer Institute by Weber, Damien C., Ares, Carmen, Albertini, Francesca, Frei-Welte, Martina, Niggli, Felix K., Schneider, Ralf, Lomax, Antony J

“…Background Parameningeal rhabdomyosarcomas (PM‐RMSs) represent approximately 25% of all rhabdomyosarcoma (RMS) cases. These tumors are associated with early…”
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Exploring the association of hemoglobin level and adverse events in children with cancer presenting with fever in neutropenia by Ammann, Roland A, Niggli, Felix K, Leibundgut, Kurt, Teuffel, Oliver, Bodmer, Nicole

“…In children and adolescents with fever in neutropenia (FN) during chemotherapy for cancer, hemoglobin ≥90 g/L at presentation with FN had been associated with…”
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PI3K/AKT signaling modulates transcriptional expression of EWS/FLI1 through specificity protein 1 by Giorgi, Chiara, Boro, Aleksandar, Rechfeld, Florian, Lopez-Garcia, Laura A, Gierisch, Maria E, Schäfer, Beat W, Niggli, Felix K

“…Ewing sarcoma (ES) is the second most frequent bone cancer in childhood and is characterized by the presence of the balanced translocation t(11;22)(q24;q12) in…”
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Health-related quality of life in long-term survivors of relapsed childhood acute lymphoblastic leukemia by Essig, Stefan, von der Weid, Nicolas X, Strippoli, Marie-Pierre F, Rebholz, Cornelia E, Michel, Gisela, Rueegg, Corina S, Niggli, Felix K, Kuehni, Claudia E

“…Relapses occur in about 20% of children with acute lymphoblastic leukemia (ALL). Approximately one-third of these children can be cured. Their risk for late…”
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Real-Time Quantitative Broad-Range PCR Assay for Detection of the 16S rRNA Gene Followed by Sequencing for Species Identification by ZUCOL, Franziska, AMMANN, Roland A, BERGER, Christoph, AEBI, Christoph, ALTWEGG, Martin, NIGGLI, Felix K, NADAL, David

“…Article Usage Stats Services JCM Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Furin targeted drug delivery for treatment of rhabdomyosarcoma in a mouse model by Hajdin, Katarina, D'Alessandro, Valentina, Niggli, Felix K, Schäfer, Beat W, Bernasconi, Michele

“…Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma in children. Improvement of treatment efficacy and decreased side effects through tumor-targeted…”
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Subtype and Prognostic Classification of Rhabdomyosarcoma by Immunohistochemistry by WACHTEL, Marco, RUNGE, Tina, LEUSCHNER, Ivo, STEGMAIER, Sabine, KOSCIELNIAK, Ewa, TREUNER, Jörn, ODERMATT, Bernhard, BEHNKE, Silvia, NIGGLI, Felix K, SCHÄFER, Beat W

“…Rhabdomyosarcoma (RMS) is classified into two main subgroups: the embryonal (ERMS) and the alveolar (ARMS) form. The majority of the ARMSs are associated with…”
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Health-related quality of life in children with newly diagnosed cancer: a one year follow-up study by Landolt, Markus A, Vollrath, Margarete, Niggli, Felix K, Gnehm, Hanspeter E, Sennhauser, Felix H

“…Most studies on health-related quality of life (HRQOL) in children with cancer focussed on survivors. Only few studies have evaluated patients during ongoing…”
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Low-dose arsenic trioxide sensitizes glucocorticoid-resistant acute lymphoblastic leukemia cells to dexamethasone via an Akt-dependent pathway by Bornhauser, Beat C., Bonapace, Laura, Lindholm, Dan, Martinez, Rodrigo, Cario, Gunnar, Schrappe, Martin, Niggli, Felix K., Schäfer, Beat W., Bourquin, Jean-Pierre

“…Incorporation of apoptosis-inducing agents into current therapeutic regimens is an attractive strategy to improve treatment for drug-resistant leukemia. We…”
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CD133 positive embryonal rhabdomyosarcoma stem-like cell population is enriched in rhabdospheres by Walter, Dagmar, Satheesha, Sampoorna, Albrecht, Patrick, Bornhauser, Beat C, D'Alessandro, Valentina, Oesch, Susanne M, Rehrauer, Hubert, Leuschner, Ivo, Koscielniak, Ewa, Gengler, Carole, Moch, Holger, Bernasconi, Michele, Niggli, Felix K, Schäfer, Beat W

“…Cancer stem cells (CSCs) have been identified in a number of solid tumors, but not yet in rhabdomyosarcoma (RMS), the most frequently occurring soft tissue…”
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