Search Results - "NIERHAUS, Axel"

Cytokine Storm—Definition, Causes, and Implications by Jarczak, Dominik, Nierhaus, Axel

“…The human innate and adaptive immune systems consist of effector cells producing cytokines (interleukins, interferons, chemokines, and numerous other…”
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Sepsis—Pathophysiology and Therapeutic Concepts by Jarczak, Dominik, Kluge, Stefan, Nierhaus, Axel

“…Sepsis is a life-threatening condition and a global disease burden. Today, the heterogeneous syndrome is defined as severe organ dysfunction caused by a…”
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Use of Intravenous Immunoglobulins in Sepsis Therapy-A Clinical View by Jarczak, Dominik, Kluge, Stefan, Nierhaus, Axel

“…Sepsis is a life-threatening organ dysfunction, defined by a dysregulated host immune response to infection. During sepsis, the finely tuned system of…”
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Septic Hyperinflammation-Is There a Role for Extracorporeal Blood Purification Techniques? by Jarczak, Dominik, Kluge, Stefan, Nierhaus, Axel

“…This manuscript investigates the role of extracorporeal blood purification techniques in managing septic hyperinflammation, a critical aspect of sepsis…”
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Comparison of clinical characteristics and disease outcome of COVID-19 and seasonal influenza by Brehm, Thomas Theo, van der Meirschen, Marc, Hennigs, Annette, Roedl, Kevin, Jarczak, Dominik, Wichmann, Dominic, Frings, Daniel, Nierhaus, Axel, Oqueka, Tim, Fiedler, Walter, Christopeit, Maximilian, Kraef, Christian, Schultze, Alexander, Lütgehetmann, Marc, Addo, Marylyn M, Schmiedel, Stefan, Kluge, Stefan, Schulze zur Wiesch, Julian

“…While several studies have described the clinical course of patients with coronavirus disease 2019 (COVID-19), direct comparisons with patients with seasonal…”
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Effect of therapeutic drug monitoring-based dose optimization of piperacillin/tazobactam on sepsis-related organ dysfunction in patients with sepsis: a randomized controlled trial by Hagel, Stefan, Bach, Friedhelm, Brenner, Thorsten, Bracht, Hendrik, Brinkmann, Alexander, Annecke, Thorsten, Hohn, Andreas, Weigand, Markus, Michels, Guido, Kluge, Stefan, Nierhaus, Axel, Jarczak, Dominik, König, Christina, Weismann, Dirk, Frey, Otto, Witzke, Dominic, Müller, Carsten, Bauer, Michael, Kiehntopf, Michael, Neugebauer, Sophie, Lehmann, Thomas, Roberts, Jason A., Pletz, Mathias W.

“…Purpose Insufficient antimicrobial exposure is associated with worse outcomes in sepsis. We evaluated whether therapeutic drug monitoring (TDM)-guided…”
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Human leucocyte antigen (HLA-DR) gene expression is reduced in sepsis and correlates with impaired TNFα response: A diagnostic tool for immunosuppression? by Winkler, Martin Sebastian, Rissiek, Anne, Priefler, Marion, Schwedhelm, Edzard, Robbe, Linda, Bauer, Antonia, Zahrte, Corinne, Zoellner, Christian, Kluge, Stefan, Nierhaus, Axel

“…Sepsis is defined as a dysregulated immune response to infection. Impaired immune response in sepsis, often described as endotoxin tolerance, is characterized…”
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The use of mid-regional proadrenomedullin to identify disease severity and treatment response to sepsis - a secondary analysis of a large randomised controlled trial by Elke, Gunnar, Bloos, Frank, Wilson, Darius Cameron, Brunkhorst, Frank Martin, Briegel, Josef, Reinhart, Konrad, Loeffler, Markus, Kluge, Stefan, Nierhaus, Axel, Jaschinski, Ulrich, Moerer, Onnen, Weyland, Andreas, Meybohm, Patrick

“…This study assessed the ability of mid-regional proadrenomedullin (MR-proADM) in comparison to conventional biomarkers (procalcitonin (PCT), lactate,…”
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Extracorporeal cytokine elimination as rescue therapy in refractory septic shock: a prospective single-center study by Friesecke, Sigrun, Stecher, Stephanie-Susanne, Gross, Stefan, Felix, Stephan B., Nierhaus, Axel

“…Sepsis is the most common cause of death in medical intensive care units (ICU). If sepsis progresses to refractory septic shock, mortality may reach 90–100%…”
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Replication of SARS-CoV-2 in adipose tissue determines organ and systemic lipid metabolism in hamsters and humans by Zickler, Martin, Stanelle-Bertram, Stephanie, Ehret, Sandra, Heinrich, Fabian, Lange, Philine, Schaumburg, Berfin, Kouassi, Nancy Mounogou, Beck, Sebastian, Jaeckstein, Michelle Y., Mann, Oliver, Krasemann, Susanne, Schroeder, Maria, Jarczak, Dominik, Nierhaus, Axel, Kluge, Stefan, Peschka, Manuela, Schlüter, Hartmut, Renné, Thomas, Pueschel, Klaus, Kloetgen, Andreas, Scheja, Ludger, Ondruschka, Benjamin, Heeren, Joerg, Gabriel, Guelsah

“…Zickler et al. describe SARS-CoV-2 RNA in post-mortem samples of human adipose tissue. In the hamster model, SARS-CoV-2 propagation in adipose tissue leads to…”
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Decreased serum concentrations of sphingosine-1-phosphate in sepsis by Winkler, Martin Sebastian, Nierhaus, Axel, Holzmann, Maximilian, Mudersbach, Eileen, Bauer, Antonia, Robbe, Linda, Zahrte, Corinne, Geffken, Maria, Peine, Sven, Schwedhelm, Edzard, Daum, Guenter, Kluge, Stefan, Zoellner, Christian

“…Sphingosine-1-phosphate (S1P) is a signaling lipid that regulates pathophysiological processes involved in sepsis progression, including endothelial…”
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Use of polyclonal immunoglobulins as adjunctive therapy for sepsis or septic shock by Kreymann, K Georg, de Heer, Geraldine, Nierhaus, Axel, Kluge, Stefan

“…OBJECTIVE:There is ongoing debate about the efficacy of polyvalent immunoglobulins as adjunctive therapy for sepsis or septic shock. Two meta-analyses by the…”
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Best-practice IgM- and IgA-enriched immunoglobulin use in patients with sepsis by Nierhaus, Axel, Berlot, Giorgio, Kindgen-Milles, Detlef, Müller, Eckhard, Girardis, Massimo

“…Background Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection. Despite treatment being in line with current…”
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Severe liver dysfunction complicating course of COVID-19 in the critically ill: multifactorial cause or direct viral effect? by Roedl, Kevin, Jarczak, Dominik, Drolz, Andreas, Wichmann, Dominic, Boenisch, Olaf, de Heer, Geraldine, Burdelski, Christoph, Frings, Daniel, Sensen, Barbara, Nierhaus, Axel, Lütgehetmann, Marc, Kluge, Stefan, Fuhrmann, Valentin

“…Background SARS-CoV-2 caused a pandemic and global threat for human health. Presence of liver injury was commonly reported in patients with coronavirus disease…”
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Markers of nitric oxide are associated with sepsis severity: an observational study by Winkler, Martin Sebastian, Kluge, Stefan, Holzmann, Maximilian, Moritz, Eileen, Robbe, Linda, Bauer, Antonia, Zahrte, Corinne, Priefler, Marion, Schwedhelm, Edzard, Böger, Rainer H, Goetz, Alwin E, Nierhaus, Axel, Zoellner, Christian

“…Nitric oxide (NO) regulates processes involved in sepsis progression, including vascular function and pathogen defense. Direct NO measurement in patients is…”
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Pharmacokinetics of meropenem in septic patients on sustained low-efficiency dialysis: a population pharmacokinetic study by Braune, Stephan, König, Christina, Roberts, Jason A, Nierhaus, Axel, Steinmetz, Oliver, Baehr, Michael, Kluge, Stefan, Langebrake, Claudia

“…The aim of the study was to describe the population pharmacokinetics (PK) of meropenem in critically ill patients receiving sustained low-efficiency dialysis…”
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Symmetrical (SDMA) and asymmetrical dimethylarginine (ADMA) in sepsis: high plasma levels as combined risk markers for sepsis survival by Winkler, Martin Sebastian, Nierhaus, Axel, Rösler, Gilbert, Lezius, Susanne, Harlandt, Olaf, Schwedhelm, Edzard, Böger, Rainer H, Kluge, Stefan

“…Nitric oxide (NO) regulates processes involved in sepsis progression, including vascular and immune function. NO is generated by nitric oxide synthases (NOS)…”
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High estradiol and low testosterone levels are associated with critical illness in male but not in female COVID-19 patients: a retrospective cohort study by Schroeder, Maria, Schaumburg, Berfin, Mueller, Zacharias, Parplys, Ann, Jarczak, Dominik, Roedl, Kevin, Nierhaus, Axel, de Heer, Geraldine, Grensemann, Joern, Schneider, Bettina, Stoll, Fabian, Bai, Tian, Jacobsen, Henning, Zickler, Martin, Stanelle-Bertram, Stephanie, Klaetschke, Kristin, Renné, Thomas, Meinhardt, Andreas, Aberle, Jens, Hiller, Jens, Peine, Sven, Kreienbrock, Lothar, Klingel, Karin, Kluge, Stefan, Gabriel, Guelsah

“…Male sex was repeatedly identified as a risk factor for death and intensive care admission. However, it is yet unclear whether sex hormones are associated with…”
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Cerebrovascular autoregulation and arterial carbon dioxide in patients with acute respiratory distress syndrome: a prospective observational cohort study by Kahl, Ursula, Yu, Yuanyuan, Nierhaus, Axel, Frings, Daniel, Sensen, Barbara, Daubmann, Anne, Kluge, Stefan, Fischer, Marlene

“…Background Early hypercapnia is common in patients with acute respiratory distress syndrome (ARDS) and is associated with increased mortality. Fluctuations of…”
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Loss of sphingosine 1-phosphate (S1P) in septic shock is predominantly caused by decreased levels of high-density lipoproteins (HDL) by Winkler, Martin Sebastian, Märtz, Konstantin B, Nierhaus, Axel, Daum, Günter, Schwedhelm, Edzard, Kluge, Stefan, Gräler, Markus H

“…Sphingosine 1-phosphate (S1P) is a signaling lipid essential in regulating processes involved in sepsis pathophysiology, including endothelial permeability and…”
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