Search Results - "NIEMAND, Jandeli"

Hierarchical transcriptional control regulates Plasmodium falciparum sexual differentiation by van Biljon, Riëtte, van Wyk, Roelof, Painter, Heather J, Orchard, Lindsey, Reader, Janette, Niemand, Jandeli, Llinás, Manuel, Birkholtz, Lyn-Marie

“…Malaria pathogenesis relies on sexual gametocyte forms of the malaria parasite to be transmitted between the infected human and the mosquito host but the…”
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Eliminating malaria transmission requires targeting immature and mature gametocytes through lipoidal uptake of antimalarials by Naude, Mariska, van Heerden, Ashleigh, Reader, Janette, van der Watt, Mariëtte, Niemand, Jandeli, Joubert, Dorè, Siciliano, Giulia, Alano, Pietro, Njoroge, Mathew, Chibale, Kelly, Herreros, Esperanza, Leroy, Didier, Birkholtz, Lyn-Marié

“…Novel antimalarial compounds targeting both the pathogenic and transmissible stages of the human malaria parasite, Plasmodium falciparum , would greatly…”
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Bioassay-guided isolation and identification of gametocytocidal compounds from Artemisia afra (Asteraceae) by Moyo, Phanankosi, Kunyane, Phaladi, Selepe, Mamoalosi A, Eloff, Jacobus N, Niemand, Jandeli, Louw, Abraham I, Maharaj, Vinesh J, Birkholtz, Lyn-Marie

“…Optimal adoption of the malaria transmission-blocking strategy is currently limited by lack of safe and efficacious drugs. This has sparked the exploration of…”
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Understanding human genetic factors influencing primaquine safety and efficacy to guide primaquine roll-out in a pre-elimination setting in southern Africa by Awandu, Shehu S, Raman, Jaishree, Makhanthisa, Takalani I, Kruger, Philip, Frean, John, Bousema, Teun, Niemand, Jandeli, Birkholtz, Lyn-Marie

“…Primaquine (PQ) is recommended as an addition to standard malaria treatments in pre-elimination settings due to its pronounced activity against mature…”
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Human Aurora kinase inhibitor Hesperadin reveals epistatic interaction between Plasmodium falciparum PfArk1 and PfNek1 kinases by Morahan, Belinda J., Abrie, Clarissa, Al-Hasani, Keith, Batty, Mitchell B., Corey, Victoria, Cowell, Anne N., Niemand, Jandeli, Winzeler, Elizabeth A., Birkholtz, Lyn-Marie, Doerig, Christian, Garcia-Bustos, Jose F.

“…Mitosis has been validated by numerous anti-cancer drugs as being a druggable process, and selective inhibition of parasite proliferation provides an obvious…”
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Morphological and Molecular Descriptors of the Developmental Cycle of Babesia divergens Parasites in Human Erythrocytes by Rossouw, Ingrid, Maritz-Olivier, Christine, Niemand, Jandeli, van Biljon, Riette, Smit, Annel, Olivier, Nicholas A, Birkholtz, Lyn-Marie

“…Human babesiosis, especially caused by the cattle derived Babesia divergens parasite, is on the increase, resulting in renewed attentiveness to this…”
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Anthracene-Polyamine Conjugates Inhibit In Vitro Proliferation of Intraerythrocytic Plasmodium falciparum Parasites by NIEMAND, Jandeli, BURGER, Pieter, VERLINDEN, Bianca K, READER, Janette, JOUBERT, Annie M, KAISER, Annette, LOUW, Abraham I, KIRK, Kiaran, PHANSTIEL, Otto, BIRKHOLTZ, Lyn-Marie

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Genetic complexity alters drug susceptibility of asexual and gametocyte stages of Plasmodium falciparum to antimalarial candidates by Greyling, Nicola, van der Watt, Mariëtte, Gwarinda, Hazel, van Heerden, Ashleigh, Greenhouse, Bryan, Leroy, Didier, Niemand, Jandeli, Birkholtz, Lyn-Marié

“…Malaria elimination requires interventions able to target both the asexual blood stage (ABS) parasites and transmissible gametocyte stages of . Lead…”
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Polyamine homoeostasis as a drug target in pathogenic protozoa: peculiarities and possibilities by Birkholtz, Lyn-Marie, Williams, Marni, Niemand, Jandeli, Louw, Abraham I, Persson, Lo, Heby, Olle

“…New drugs are urgently needed for the treatment of tropical and subtropical parasitic diseases, such as African sleeping sickness, Chagas' disease,…”
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Inducing controlled cell cycle arrest and re-entry during asexual proliferation of Plasmodium falciparum malaria parasites by van Biljon, Riëtte, Niemand, Jandeli, van Wyk, Roelof, Clark, Katherine, Verlinden, Bianca, Abrie, Clarissa, von Grüning, Hilde, Smidt, Werner, Smit, Annél, Reader, Janette, Painter, Heather, Llinás, Manuel, Doerig, Christian, Birkholtz, Lyn-Marié

“…The life cycle of the malaria parasite Plasmodium falciparum is tightly regulated, oscillating between stages of intense proliferation and quiescence. Cyclic…”
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Discovery of Novel Alkylated (bis)Urea and (bis)Thiourea Polyamine Analogues with Potent Antimalarial Activities by Verlinden, Bianca K, Niemand, Jandeli, Snyman, Janette, Sharma, Shiv K, Beattie, Ross J, Woster, Patrick M, Birkholtz, Lyn-Marie

“…A series of alkylated (bis)urea and (bis)thiourea polyamine analogues were synthesized and screened for antimalarial activity against chloroquine-sensitive and…”
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Potent Plasmodium falciparum gametocytocidal compounds identified by exploring the kinase inhibitor chemical space for dual active antimalarials by van der Watt, Mariëtte E, Reader, Janette, Churchyard, Alisje, Nondaba, Sindisiwe H, Lauterbach, Sonja B, Niemand, Jandeli, Abayomi, Sijuade, van Biljon, Riëtte A, Connacher, Jessica I, van Wyk, Roelof D J, Le Manach, Claire, Paquet, Tanya, González Cabrera, Diego, Brunschwig, Christel, Theron, Anjo, Lozano-Arias, Sonia, Rodrigues, Janneth F I, Herreros, Esperanza, Leroy, Didier, Duffy, James, Street, Leslie J, Chibale, Kelly, Mancama, Dalu, Coetzer, Theresa L, Birkholtz, Lyn-Marie

“…Novel chemical tools to eliminate malaria should ideally target both the asexual parasites and transmissible gametocytes. Several imidazopyridazines (IMPs) and…”
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Interrogating alkyl and arylalkylpolyamino (bis)urea and (bis)thiourea isosteres as potent antimalarial chemotypes against multiple lifecycle forms of Plasmodium falciparum parasites by Verlinden, Bianca K., de Beer, Marna, Pachaiyappan, Boobalan, Besaans, Ethan, Andayi, Warren A., Reader, Janette, Niemand, Jandeli, van Biljon, Riette, Guy, Kiplin, Egan, Timothy, Woster, Patrick M., Birkholtz, Lyn-Marie

“…[Display omitted] A new series of potent potent aryl/alkylated (bis)urea- and (bis)thiourea polyamine analogues were synthesized and evaluated in vitro for…”
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Morphological and Molecular Descriptors of the Developmental Cycle of Babesia divergens Parasites in Human Erythrocytes: e0003711 by Rossouw, Ingrid, Maritz-Olivier, Christine, Niemand, Jandeli, Biljon, Riette van, Smit, Annel, Olivier, Nicholas A, Birkholtz, Lyn-Marie

“…Human babesiosis, especially caused by the cattle derived Babesia divergens parasite, is on the increase, resulting in renewed attentiveness to this…”
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Chemogenomic Fingerprints Associated with Stage-Specific Gametocytocidal Compound Action against Human Malaria Parasites by Niemand, Jandeli, van Biljon, Riëtte, van der Watt, Mariëtte, van Heerden, Ashleigh, Reader, Janette, van Wyk, Roelof, Orchard, Lindsey, Chibale, Kelly, Llinás, Manuel, Birkholtz, Lyn-Marié

“…Kinase-focused inhibitors previously revealed compounds with differential activity against different stages of Plasmodium falciparum gametocytes. MMV666810, a…”
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Novel S-adenosyl-L-methionine decarboxylase inhibitors as potent antiproliferative agents against intraerythrocytic Plasmodium falciparum parasites by le Roux, Dina, Burger, Pieter B., Niemand, Jandeli, Grobler, Anne, Urbán, Patricia, Fernàndez-Busquets, Xavier, Barker, Robert H., Serrano, Adelfa E., I. Louw, Abraham, Birkholtz, Lyn-Marie

“…[Display omitted] •A highly specific inhibitor, Genz-644131, was identified for P. falciparum AdoMetDC.•Increased specificity for bifunctional over…”
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A Phage Display Study of Interacting Peptide Binding Partners of Malarial S-Adenosylmethionine Decarboxylase/Ornithine Decarboxylase by Niemand, Jandeli

“…Due to the increasing resistance against the currently used antimalarial drugs, novel chemotherapeutic agents that target new metabolic pathways for the…”
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