Search Results - "NIEHRS, Christof"

Regulatory R-loops as facilitators of gene expression and genome stability by Niehrs, Christof, Luke, Brian

“…R-loops are three-stranded structures that harbour an RNA–DNA hybrid and frequently form during transcription. R-loop misregulation is associated with DNA…”
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On growth and form: a Cartesian coordinate system of Wnt and BMP signaling specifies bilaterian body axes by Niehrs, Christof

“…The regulation of body axis specification in the common ancestor of bilaterians remains controversial. BMP signaling appears to be an ancient program for…”
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R-spondins are BMP receptor antagonists in Xenopus early embryonic development by Lee, Hyeyoon, Seidl, Carina, Sun, Rui, Glinka, Andrey, Niehrs, Christof

“…BMP signaling plays key roles in development, stem cells, adult tissue homeostasis, and disease. How BMP receptors are extracellularly modulated and in which…”
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GADD45A binds R-loops and recruits TET1 to CpG island promoters by Arab, Khelifa, Karaulanov, Emil, Musheev, Michael, Trnka, Philipp, Schäfer, Andrea, Grummt, Ingrid, Niehrs, Christof

“…R-loops are DNA–RNA hybrids enriched at CpG islands (CGIs) that can regulate chromatin states 1 – 8 . How R-loops are recognized and interpreted by specific…”
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Post-transcriptional Wnt Signaling Governs Epididymal Sperm Maturation by Koch, Stefan, Acebron, Sergio P., Herbst, Jessica, Hatiboglu, Gencay, Niehrs, Christof

“…The canonical Wnt signaling pathway is of paramount importance in development and disease. An emergent question is whether the upstream cascade of the…”
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Rspo3 Binds Syndecan 4 and Induces Wnt/PCP Signaling via Clathrin-Mediated Endocytosis to Promote Morphogenesis by Ohkawara, Bisei, Glinka, Andrei, Niehrs, Christof

“…The R-Spondin ( Rspo) family of secreted Wnt modulators is involved in development and disease and holds therapeutic promise as stem cell growth factors…”
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R-Spondin 2 governs Xenopus left-right body axis formation by establishing an FGF signaling gradient by Lee, Hyeyoon, Camuto, Celine Marie, Niehrs, Christof

“…Establishment of the left-right (LR, sinistral, dextral) body axis in many vertebrate embryos relies on cilia-driven leftward fluid flow within an LR organizer…”
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Regionally specific induction by the Spemann-Mangold organizer by Niehrs, Christof

“…Eighty years ago, Spemann and Mangold discovered the extraordinary inductive potency of the dorsal blastopore lip in amphibian embryos. Many inducers released…”
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Fgf and Wnt signaling interaction in the mesenchymal niche regulates the murine hair cycle clock by Harshuk-Shabso, Sarina, Dressler, Hila, Niehrs, Christof, Aamar, Emil, Enshell-Seijffers, David

“…Tissue growth in the adult is an orchestrated process that often requires biological clocks to time stem cell and progenitor activity. Here, we employed the…”
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RNA fate determination through cotranscriptional adenosine methylation and microprocessor binding by Knuckles, Philip, Carl, Sarah H, Musheev, Michael, Niehrs, Christof, Wenger, Alice, Bühler, Marc

“…Microprocessor components Dgcr8 and Drosha associate with transcriptionally active coding and noncoding genes in a Mettl3-dependent manner and, upon…”
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A MET-PTPRK kinase-phosphatase rheostat controls ZNRF3 and Wnt signaling by Kim, Minseong, Reinhard, Carmen, Niehrs, Christof

“…Zinc and ring finger 3 (ZNRF3) is a transmembrane E3 ubiquitin ligase that targets Wnt receptors for ubiquitination and lysosomal degradation. Previously, we…”
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Mitotic Wnt Signaling Promotes Protein Stabilization and Regulates Cell Size by Acebron, Sergio P., Karaulanov, Emil, Berger, Birgit S., Huang, Ya-Lin, Niehrs, Christof

“…Canonical Wnt signaling is thought to regulate cell behavior mainly by inducing β-catenin-dependent transcription of target genes. In proliferating cells Wnt…”
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The tumor suppressor PTPRK promotes ZNRF3 internalization and is required for Wnt inhibition in the Spemann organizer by Chang, Ling-Shih, Kim, Minseong, Glinka, Andrey, Reinhard, Carmen, Niehrs, Christof

“…A hallmark of Spemann organizer function is its expression of Wnt antagonists that regulate axial embryonic patterning. Here we identify the tumor suppressor…”
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Gemcitabine functions epigenetically by inhibiting repair mediated DNA demethylation by Schäfer, Andrea, Schomacher, Lars, Barreto, Guillermo, Döderlein, Gabi, Niehrs, Christof

“…Gemcitabine is a cytotoxic cytidine analog, which is widely used in anti-cancer therapy. One mechanism by which gemcitabine acts is by inhibiting nucleotide…”
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Long Noncoding RNA TARID Directs Demethylation and Activation of the Tumor Suppressor TCF21 via GADD45A by Arab, Khelifa, Park, Yoon Jung, Lindroth, Anders M., Schäfer, Andrea, Oakes, Christopher, Weichenhan, Dieter, Lukanova, Annekatrin, Lundin, Eva, Risch, Angela, Meister, Michael, Dienemann, Hendrik, Dyckhoff, Gerhard, Herold-Mende, Christel, Grummt, Ingrid, Niehrs, Christof, Plass, Christoph

“…DNA methylation is a dynamic and reversible process that governs gene expression during development and disease. Several examples of active DNA demethylation…”
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Mammalian N1-adenosine PARylation is a reversible DNA modification by Musheev, Michael U., Schomacher, Lars, Basu, Amitava, Han, Dandan, Krebs, Laura, Scholz, Carola, Niehrs, Christof

“…Poly-ADP-ribosylation (PARylation) is regarded as a protein-specific modification. However, some PARPs were recently shown to modify DNA termini in vitro…”
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Mucociliary Wnt signaling promotes cilia biogenesis and beating by Seidl, Carina, Da Silva, Fabio, Zhang, Kaiqing, Wohlgemuth, Kai, Omran, Heymut, Niehrs, Christof

“…It is widely thought that Wnt/Lrp6 signaling proceeds through the cytoplasm and that motile cilia are signaling-inert nanomotors. Contrasting both views, we…”
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Sticking Around: Short-Range Activity of Wnt Ligands by Boutros, Michael, Niehrs, Christof

“…Wnt ligands are secreted lipid-modified proteins that are essential for development and homeostasis. Published recently in Nature, Farin et al. (2016) report…”
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Requirement of Prorenin Receptor and Vacuolar H⁺ -ATPase-Mediated Acidification for Wnt Signaling by Cruciat, Cristina-Maria, Ohkawara, Bisei, Acebron, Sergio P., Karaulanov, Emil, Reinhard, Carmen, Ingelfinger, Dierk, Boutros, Michael, Niehrs, Christof

“…Wnt/ß-catenin signaling is important in stem cell biology, embryonic development, and disease, including cancer. However, the mechanism of Wnt signal…”
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An ATF2‐based luciferase reporter to monitor non‐canonical Wnt signaling in xenopus embryos by Ohkawara, Bisei, Niehrs, Christof

“…Non‐canonical/planar cell polarity (PCP) Wnt signaling plays important roles in embryonic development and tissue homeostasis, and is implicated in human…”
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