Search Results - "NICOLLS, Mark R"

Inflammation and Immunity in the Pathogenesis of Pulmonary Arterial Hypertension by Rabinovitch, Marlene, Guignabert, Christophe, Humbert, Marc, Nicolls, Mark R

“…This review summarizes an expanding body of knowledge indicating that failure to resolve inflammation and altered immune processes underlie the development of…”
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Temporal Response of the Human Virome to Immunosuppression and Antiviral Therapy by De Vlaminck, Iwijn, Khush, Kiran K., Strehl, Calvin, Kohli, Bitika, Luikart, Helen, Neff, Norma F., Okamoto, Jennifer, Snyder, Thomas M., Cornfield, David N., Nicolls, Mark R., Weill, David, Bernstein, Daniel, Valantine, Hannah A., Quake, Stephen R.

“…There are few substantive methods to measure the health of the immune system, and the connection between immune strength and the viral component of the…”
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Pathology and pathobiology of pulmonary hypertension: state of the art and research perspectives by Humbert, Marc, Guignabert, Christophe, Bonnet, Sébastien, Dorfmüller, Peter, Klinger, James R, Nicolls, Mark R, Olschewski, Andrea J, Pullamsetti, Soni S, Schermuly, Ralph T, Stenmark, Kurt R, Rabinovitch, Marlene

“…Clinical and translational research has played a major role in advancing our understanding of pulmonary hypertension (PH), including pulmonary arterial…”
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Lymphatic Dysfunction, Leukotrienes, and Lymphedema by Jiang, Xinguo, Nicolls, Mark R, Tian, Wen, Rockson, Stanley G

“…The lymphatic system is essential for the maintenance of tissue fluid homeostasis, gastrointestinal lipid absorption, and immune trafficking. Whereas lymphatic…”
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Pathobiology of pulmonary arterial hypertension and right ventricular failure by VOELKEL, Norbert F, GOMEZ-ARROYO, Jose, ABBATE, Antonio, BOGAARD, Harm J, NICOLLS, Mark R

“…Pulmonary arterial hypertension (PAH) is no longer an orphan disease. There are three different classes of drugs for the treatment of PAH that are currently…”
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Noninvasive monitoring of infection and rejection after lung transplantation by De Vlaminck, Iwijn, Martin, Lance, Kertesz, Michael, Patel, Kapil, Kowarsky, Mark, Strehl, Calvin, Cohen, Garrett, Luikart, Helen, Neff, Norma F., Okamoto, Jennifer, Nicolls, Mark R., Cornfield, David, Weill, David, Valantine, Hannah, Khush, Kiran K., Quake, Stephen R.

“…The survival rate following lung transplantation is among the lowest of all solid-organ transplants, and current diagnostic tests often fail to distinguish…”
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Discovery of Distinct Immune Phenotypes Using Machine Learning in Pulmonary Arterial Hypertension by Sweatt, Andrew J, Hedlin, Haley K, Balasubramanian, Vidhya, Hsi, Andrew, Blum, Lisa K, Robinson, William H, Haddad, Francois, Hickey, Peter M, Condliffe, Robin, Lawrie, Allan, Nicolls, Mark R, Rabinovitch, Marlene, Khatri, Purvesh, Zamanian, Roham T

“…RATIONALE:Accumulating evidence implicates inflammation in pulmonary arterial hypertension (PAH) and therapies targeting immunity are under investigation,…”
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The Lymphatic System in Obesity, Insulin Resistance, and Cardiovascular Diseases by Jiang, Xinguo, Tian, Wen, Nicolls, Mark R, Rockson, Stanley G

“…Obesity, insulin resistance, dyslipidemia, and hypertension are fundamental clinical manifestations of the metabolic syndrome. Studies over the last few…”
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Colorectal Cancer-Associated Microbiome Patterns and Signatures by Zhao, Lan, Cho, William C, Nicolls, Mark R

“…The gut microbiome is dynamic and shaped by diet, age, geography, and environment. The disruption of normal gut microbiota (dysbiosis) is closely related to…”
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Leukotrienes in Tumor-Associated Inflammation by Tian, Wen, Jiang, Xinguo, Kim, Dongeon, Guan, Torrey, Nicolls, Mark R, Rockson, Stanley G

“…Leukotrienes are biologically active eicosanoid lipid mediators that originate from oxidative metabolism of arachidonic acid. Biosynthesis of leukotrienes…”
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Phenotypically Silent Bone Morphogenetic Protein Receptor 2 Mutations Predispose Rats to Inflammation-Induced Pulmonary Arterial Hypertension by Enhancing the Risk for Neointimal Transformation by Tian, Wen, Jiang, Xinguo, Sung, Yon K, Shuffle, Eric, Wu, Ting-Hsuan, Kao, Peter N, Tu, Allen B, Dorfmüller, Peter, Cao, Aiqin, Wang, Lingli, Peng, Gongyong, Kim, Yesl, Zhang, Patrick, Chappell, James, Pasupneti, Shravani, Dahms, Petra, Maguire, Peter, Chaib, Hassan, Zamanian, Roham, Peters-Golden, Marc, Snyder, Michael P, Voelkel, Norbert F, Humbert, Marc, Rabinovitch, Marlene, Nicolls, Mark R

“…BACKGROUND:Bmpr2 (bone morphogenetic protein receptor 2) mutations are critical risk factors for hereditary pulmonary arterial hypertension (PAH) with…”
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Machine Learning Algorithms to Differentiate Among Pulmonary Complications After Hematopoietic Cell Transplant by Sharifi, Husham, Lai, Yu Kuang, Guo, Henry, Hoppenfeld, Mita, Guenther, Zachary D., Johnston, Laura, Brondstetter, Theresa, Chhatwani, Laveena, Nicolls, Mark R., Hsu, Joe L.

“…Pulmonary complications, including infections, are highly prevalent in patients after hematopoietic cell transplantation with chronic graft-vs-host disease…”
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Unique Predictors of Mortality in Patients With Pulmonary Arterial Hypertension Associated With Systemic Sclerosis in the REVEAL Registry by Chung, Lorinda, MD, Farber, Harrison W., MD, FCCP, Benza, Raymond, MD, Miller, Dave P., MS, Parsons, Lori, BS, Hassoun, Paul M., MD, FCCP, McGoon, Michael, MD, FCCP, Nicolls, Mark R., MD, Zamanian, Roham T., MD

“…Abstract BACKGROUND: Patients with pulmonary arterial hypertension (PAH) associated with systemic sclerosis (SSc-APAH) experience higher mortality rates than…”
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The Role of Regulatory T Cells in Pulmonary Arterial Hypertension by Tian, Wen, Jiang, Shirley Y, Jiang, Xinguo, Tamosiuniene, Rasa, Kim, Dongeon, Guan, Torrey, Arsalane, Siham, Pasupneti, Shravani, Voelkel, Norbert F, Tang, Qizhi, Nicolls, Mark R

“…Pulmonary arterial hypertension (PAH) is a chronic, incurable condition characterized by pulmonary vascular remodeling, perivascular inflammation, and right…”
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The inflammatory role of dysregulated IRS2 in pulmonary vascular remodeling under hypoxic conditions by Nakahara, Mayumi, Ito, Homare, Skinner, John T, Lin, Qing, Tamosiuniene, Rasa, Nicolls, Mark R, Keegan, Achsah D, Johns, Roger A, Yamaji-Kegan, Kazuyo

“…Pulmonary hypertension (PH) is a devastating disease characterized by progressive elevation of pulmonary vascular resistance, right ventricular failure, and…”
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A brief overview of mouse models of pulmonary arterial hypertension: problems and prospects by Gomez-Arroyo, Jose, Saleem, Sheinei J, Mizuno, Shiro, Syed, Aamer A, Bogaard, Harm J, Abbate, Antonio, Taraseviciene-Stewart, Laimute, Sung, Yon, Kraskauskas, Donatas, Farkas, Daniela, Conrad, Daniel H, Nicolls, Mark R, Voelkel, Norbert F

“…Many chronic pulmonary diseases are associated with pulmonary hypertension (PH) and pulmonary vascular remodeling, which is a term that continues to be used to…”
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Pilot studies demonstrate the potential benefits of antiinflammatory therapy in human lymphedema by Rockson, Stanley G, Tian, Wen, Jiang, Xinguo, Kuznetsova, Tatiana, Haddad, Francois, Zampell, Jamie, Mehrara, Babak, Sampson, Joshua P, Roche, Leslie, Kim, Jinah, Nicolls, Mark R

“…Lymphedema is a common condition affecting millions around the world that still lacks approved medical therapy. Because ketoprofen, an NSAID, has been…”
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The Kinetics of Lymphatic Dysfunction and Leukocyte Expansion in the Draining Lymph Node during LTB4 Antagonism in a Mouse Model of Lymphedema by Cribb, Matthew T., Sestito, Lauren F., Rockson, Stanley G., Nicolls, Mark R., Thomas, Susan N., Dixon, J. Brandon

“…The mechanisms of lymphedema development are not well understood, but emerging evidence highlights the crucial role the immune system plays in driving its…”
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Inducible expression of immediate early genes is regulated through dynamic chromatin association by NF45/ILF2 and NF90/NF110/ILF3 by Wu, Ting-Hsuan, Shi, Lingfang, Lowe, Anson W, Nicolls, Mark R, Kao, Peter N

“…Immediate early gene (IEG) transcription is rapidly activated by diverse stimuli. This transcriptional regulation is assumed to involve constitutively…”
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Donor-derived, cell-free DNA levels by next-generation targeted sequencing are elevated in allograft rejection after lung transplantation by Khush, Kiran K, De Vlaminck, Iwijn, Luikart, Helen, Ross, David J, Nicolls, Mark R

“…Surveillance after lung transplantation is critical to the detection of acute cellular rejection (ACR) and prevention of chronic lung allograft dysfunction…”
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