Search Results - "NICOLAES, Gerry A. F"

Evolution of NETosis markers and DAMPs have prognostic value in critically ill COVID-19 patients by Huckriede, Joram, Anderberg, Sara Bülow, Morales, Albert, de Vries, Femke, Hultström, Michael, Bergqvist, Anders, Ortiz-Pérez, José T., Sels, Jan Willem, Wichapong, Kanin, Lipcsey, Miklos, van de Poll, Marcel, Larsson, Anders, Luther, Tomas, Reutelingsperger, Chris, de Frutos, Pablo Garcia, Frithiof, Robert, Nicolaes, Gerry A. F.

“…Coronavirus disease 19 (COVID-19) presents with disease severities of varying degree. In its most severe form, infection may lead to respiratory failure and…”
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M6229 Protects against Extracellular-Histone-Induced Liver Injury, Kidney Dysfunction, and Mortality in a Rat Model of Acute Hyperinflammation by Reutelingsperger, Chris P M, Gijbels, Marion J, Spronk, Henri, Van Oerle, Rene, Schrijver, Roy, Ekhart, Peter, de Kimpe, Sjef, Nicolaes, Gerry A F

“…Extracellular histones have been shown to act as DAMPs in a variety of inflammatory diseases. Moreover, they have the ability to induce cell death. In this…”
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Discovery of Small Molecule CD40–TRAF6 Inhibitors by Zarzycka, Barbara, Seijkens, Tom, Nabuurs, Sander B, Ritschel, Tina, Grommes, Jochen, Soehnlein, Oliver, Schrijver, Roy, van Tiel, Claudia M, Hackeng, Tilman M, Weber, Christian, Giehler, Fabian, Kieser, Arnd, Lutgens, Esther, Vriend, Gert, Nicolaes, Gerry A. F

“…The CD154–CD40 receptor complex plays a pivotal role in several inflammatory pathways. Attempts to inhibit the formation of this complex have resulted in…”
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Extracellular histone release by renal cells after warm and cold ischemic kidney injury: Studies in an ex-vivo porcine kidney perfusion model by van Smaalen, Tim C, Beurskens, Danielle M H, Kox, Jasper J H F M, Polonia, Rasheendra, Vos, Rein, Duimel, Hans, van de Wetering, Willine J, López-Iglesias, Carmen, Reutelingsperger, Chris P, Ernest van Heurn, L W, Peutz-Kootstra, Carine J, Nicolaes, Gerry A F

“…Extracellular histones are cytotoxic molecules involved in experimental acute kidney injury. In patients receiving a renal transplant from donors after…”
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Association of corticosteroid therapy with reduced acute kidney injury and lower NET markers in severe COVID-19: an observational study by Bülow Anderberg, Sara, Huckriede, Joram, Hultström, Michael, Larsson, Anders, de Vries, Femke, Lipcsey, Miklos, Nicolaes, Gerry A. F., Frithiof, Robert

“…Background Acute kidney injury (AKI) is common in critical cases of coronavirus disease 2019 (COVID-19) and associated with worse outcome. Dysregulated…”
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Riboflavin-responsive oxidative phosphorylation complex I deficiency caused by defective ACAD9: new function for an old gene by GERARDS, Mike, VAN DEN BOSCH, Bianca J. C, PROKISCH, Holger, RÖTIG, Agnès, DE COO, Irenaeus F. M, SMELTS, Hubert J. M, DANHAUSER, Katharina, SERRE, Valérie, VAN WEEGHEL, Michel, WANDERS, Ronald J. A, NICOLAES, Gerry A. F, SLUITER, Wim, SCHOONDERWOERD, Kees, SCHOLTE, Hans R

“…Mitochondrial complex I deficiency is the most common oxidative phosphorylation defect. Mutations have been detected in mitochondrial and nuclear genes, but…”
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Effects of exogenous recombinant APC in mouse models of ischemia reperfusion injury and of atherosclerosis by Wildhagen, Karin C A A, Schrijver, Roy, Beckers, Linda, ten Cate, Hugo, Reutelingsperger, Chris P M, Lutgens, Esther, Nicolaes, Gerry A F

“…Activated protein C (APC) is a serine protease that has both anticoagulant and cytoprotective properties. The cytoprotective effects are protease activated…”
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Decreased endothelial glycocalyx thickness is an early predictor of mortality in sepsis by Beurskens, Daniëlle MH, Bol, Martine E, Delhaas, Tammo, van de Poll, Marcel CG, Reutelingsperger, Chris PM, Nicolaes, Gerry AF, Sels, Jan-Willem EM

“…Microcirculatory alterations play an important role in the early phase of sepsis. Shedding of the endothelial glycocalyx is regarded as a central…”
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Nonanticoagulant heparin prevents histone-mediated cytotoxicity in vitro and improves survival in sepsis by Wildhagen, Karin C.A.A., García de Frutos, Pablo, Reutelingsperger, Chris P., Schrijver, Roy, Aresté, Cristina, Ortega-Gómez, Almudena, Deckers, Niko M., Hemker, H. Coenraad, Soehnlein, Oliver, Nicolaes, Gerry A.F.

“…Extracellular histones are considered to be major mediators of death in sepsis. Although sepsis is a condition that may benefit from low-dose heparin…”
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Inhibiting Inflammation with Myeloid Cell-Specific Nanobiologics Promotes Organ Transplant Acceptance by Braza, Mounia S., van Leent, Mandy M.T., Lameijer, Marnix, Sanchez-Gaytan, Brenda L., Arts, Rob J.W., Pérez-Medina, Carlos, Conde, Patricia, Garcia, Mercedes R., Gonzalez-Perez, Maria, Brahmachary, Manisha, Fay, Francois, Kluza, Ewelina, Kossatz, Susanne, Dress, Regine J., Salem, Fadi, Rialdi, Alexander, Reiner, Thomas, Boros, Peter, Strijkers, Gustav J., Calcagno, Claudia C., Ginhoux, Florent, Marazzi, Ivan, Lutgens, Esther, Nicolaes, Gerry A.F., Weber, Christian, Swirski, Filip K., Nahrendorf, Matthias, Fisher, Edward A., Duivenvoorden, Raphaël, Fayad, Zahi A., Netea, Mihai G., Mulder, Willem J.M., Ochando, Jordi

“…Inducing graft acceptance without chronic immunosuppression remains an elusive goal in organ transplantation. Using an experimental transplantation mouse…”
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Histone H3 Cleavage in Severe COVID-19 ICU Patients by Huckriede, Joram, de Vries, Femke, Hultström, Michael, Wichapong, Kanin, Reutelingsperger, Chris, Lipcsey, Miklos, Garcia de Frutos, Pablo, Frithiof, Robert, Nicolaes, Gerry A. F.

“…The severity of coronavirus disease 19 (COVID-19) is associated with neutrophil extracellular trap (NET) formation. During NET formation, cytotoxic…”
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Inhibition of Neutral Sphingomyelinase 2 by Novel Small Molecule Inhibitors Results in Decreased Release of Extracellular Vesicles by Vascular Smooth Muscle Cells and Attenuated Calcification by Pavlic, Angelina, Poelman, Hessel, Wasilewski, Grzegorz, Wichapong, Kanin, Lux, Petra, Maassen, Cecile, Lutgens, Esther, Schurgers, Leon J, Reutelingsperger, Chris P, Nicolaes, Gerry A F

“…Vascular calcification (VC) is an important contributor and prognostic factor in the pathogenesis of cardiovascular diseases. VC is an active process mediated…”
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Structure-Based Design of Peptidic Inhibitors of the Interaction between CC Chemokine Ligand 5 (CCL5) and Human Neutrophil Peptides 1 (HNP1) by Wichapong, Kanin, Alard, Jean-Eric, Ortega-Gomez, Almudena, Weber, Christian, Hackeng, Tilman M, Soehnlein, Oliver, Nicolaes, Gerry A. F

“…Protein–protein interactions (PPIs) are receiving increasing interest, much sparked by the realization that they represent druggable targets. Recently, we…”
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Design of Protein-Membrane Interaction Inhibitors by Virtual Ligand Screening, Proof of Concept with the C2 Domain of Factor V by Segers, Kenneth, Sperandio, Olivier, Sack, Markus, Fischer, Rainer, Miteva, Maria A., Rosing, Jan, Nicolaes, Gerry A. F., Villoutreix, Bruno O.

“…Most orally bioavailable drugs on the market are competitive inhibitors of catalytic sites, but a significant number of targets remain undrugged, because their…”
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N-glycan–mediated shielding of ADAMTS13 prevents binding of pathogenic autoantibodies in immune-mediated TTP by Ercig, Bogac, Graça, Nuno A.G., Kangro, Kadri, Arfman, Tom, Wichapong, Kanin, Hrdinová, Johana, Kaijen, Paul, van Alphen, Floris P.J., van den Biggelaar, Maartje, Vanhoorelbeke, Karen, Veyradier, Agnès, Coppo, Paul, Reutelingsperger, Chris, Nicolaes, Gerry A.F., Männik, Andres, Voorberg, Jan

“…Immune-mediated thrombotic thrombocytopenic purpura (iTTP) is an autoimmune disorder caused by the development of autoantibodies targeting different domains of…”
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Factor Xa Activation of Factor V Is of Paramount Importance in Initiating the Coagulation System: Lessons From a Tick Salivary Protein by Schuijt, Tim J, Bakhtiari, Kamran, Daffre, Sirlei, DePonte, Kathleen, Wielders, Simone J.H, Marquart, J Arnoud, Hovius, Joppe W, van der Poll, Tom, Fikrig, Erol, Bunce, Matthew W, Camire, Rodney M, Nicolaes, Gerry A.F, Meijers, Joost C.M, van ‘t Veer, Cornelis

“…BACKGROUND—Generation of active procoagulant cofactor factor Va (FVa) and its subsequent association with the enzyme activated factor X (FXa) to form the…”
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Acetaminophen Overdose as a Potential Risk Factor for Parkinson's Disease by Bohler, Sacha, Liu, Xiaosong, Krauskopf, Julian, Caiment, Florian, Aubrecht, Jiri, Nicolaes, Gerry A. F., Kleinjans, Jos C. S., Briedé, Jacco J.

“…Four complementary approaches were used to investigate acetaminophen overdose as a risk factor for Parkinson's disease (PD). Circulating microRNAs (miRNAs)…”
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Structure-Based Cyclic Glycoprotein Ibα-Derived Peptides Interfering with von Willebrand Factor-Binding, Affecting Platelet Aggregation under Shear by Hrdinova, Johana, Fernández, Delia I, Ercig, Bogac, Tullemans, Bibian M E, Suylen, Dennis P L, Agten, Stijn M, Jurk, Kerstin, Hackeng, Tilman M, Vanhoorelbeke, Karen, Voorberg, Jan, Reutelingsperger, Chris P M, Wichapong, Kanin, Heemskerk, Johan W M, Nicolaes, Gerry A F

“…The plasmatic von Willebrand factor (VWF) circulates in a compact form unable to bind platelets. Upon shear stress, the VWF A1 domain is exposed, allowing…”
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CCL18 aggravates atherosclerosis by inducing CCR6-dependent T-cell influx and polarization by Singh, Anjana, Kraaijeveld, Adriaan O, Curaj, Adelina, Wichapong, Kanin, Hammerich, Linda, de Jager, Saskia C A, Bot, Ilze, Atamas, Sergei P, van Berkel, Theo J C, Jukema, J Wouter, Comerford, Iain, McColl, Shaun R, Mees, Barend, Heemskerk, Johan W M, Nicolaes, Gerry A F, Hackeng, Tilman, Liehn, Elisa Anamaria, Tacke, Frank, Biessen, Erik A L

“…The CC chemokine ligand 18 (CCL18) is a chemokine highly expressed in chronic inflammation in humans. Recent observations of elevated CCL18 plasma levels in…”
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Role of Vitamin K-Dependent Factors Protein S and GAS6 and TAM Receptors in SARS-CoV-2 Infection and COVID-19-Associated Immunothrombosis by Tutusaus, Anna, Marí, Montserrat, Ortiz-Pérez, José T, Nicolaes, Gerry A F, Morales, Albert, García de Frutos, Pablo

“…The vitamin K-dependent factors protein S (PROS1) and growth-arrest-specific gene 6 (GAS6) and their tyrosine kinase receptors TYRO3, AXL, and MERTK, the TAM…”
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