Search Results - "NICKEL, Joachim"

Promiscuity and specificity in BMP receptor activation by Mueller, Thomas D., Nickel, Joachim

“…Bone Morphogenetic Proteins (BMPs), together with Transforming Growth Factor (TGF)-β and Activins/Inhibins constitute the TGF-β superfamily of ligands. This…”
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Specification of BMP Signaling by Nickel, Joachim, Mueller, Thomas D

“…Bone Morphogenetic Proteins (BMPs) together with the Growth and Differentiation Factors (GDFs) form the largest subgroup of the Transforming Growth Factor…”
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Unraveling the Connection between Fibroblast Growth Factor and Bone Morphogenetic Protein Signaling by Schliermann, Anna, Nickel, Joachim

“…Ontogeny of higher organisms as well the regulation of tissue homeostasis in adult individuals requires a fine-balanced interplay of regulating factors that…”
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Release and bioactivity of bone morphogenetic protein-2 are affected by scaffold binding techniques in vitro and in vivo by Suliman, Salwa, Xing, Zhe, Wu, Xujun, Xue, Ying, Pedersen, Torbjorn O, Sun, Yang, Døskeland, Anne P, Nickel, Joachim, Waag, Thilo, Lygre, Henning, Finne-Wistrand, Anna, Steinmüller-Nethl, Doris, Krueger, Anke, Mustafa, Kamal

“…A low dose of 1μg rhBMP-2 was immobilised by four different functionalising techniques on recently developed poly(l-lactide)-co-(ε-caprolactone)…”
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Enhanced reconstruction of long bone architecture by a growth factor mutant combining positive features of GDF-5 and BMP-2 by Kleinschmidt, Kerstin, Ploeger, Frank, Nickel, Joachim, Glockenmeier, Julia, Kunz, Pierre, Richter, Wiltrud

“…Abstract Non healing bone defects remain a worldwide health problem and still only few osteoinductive growth factors are available for clinical use in bone…”
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Site-Directed Immobilization of an Engineered Bone Morphogenetic Protein 2 (BMP2) Variant to Collagen-Based Microspheres Induces Bone Formation In Vivo by Siverino, Claudia, Fahmy-Garcia, Shorouk, Mumcuoglu, Didem, Oberwinkler, Heike, Muehlemann, Markus, Mueller, Thomas, Farrell, Eric, van Osch, Gerjo J V M, Nickel, Joachim

“…For the treatment of large bone defects, the commonly used technique of autologous bone grafting presents several drawbacks and limitations. With the discovery…”
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Receptor oligomerization and beyond: a case study in bone morphogenetic proteins by Heinecke, Kai, Seher, Axel, Schmitz, Werner, Mueller, Thomas D, Sebald, Walter, Nickel, Joachim

“…Transforming growth factor (TGF)beta superfamily members transduce signals by oligomerizing two classes of serine/threonine kinase receptors, termed type I and…”
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Growth on Metallo-Supramolecular Coordination Polyelectrolyte (MEPE) Stimulates Osteogenic Differentiation of Human Osteosarcoma Cells (MG63) and Human Bone Marrow Derived Mesenchymal Stem Cells by Belka, Janina, Nickel, Joachim, Kurth, Dirk G

“…Culturing of cells is typically performed on standard tissue culture plates generating growth conditions, which in general do not reflect the native…”
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GDF-5 can act as a context-dependent BMP-2 antagonist by Klammert, Uwe, Mueller, Thomas D, Hellmann, Tina V, Wuerzler, Kristian K, Kotzsch, Alexander, Schliermann, Anna, Schmitz, Werner, Kuebler, Alexander C, Sebald, Walter, Nickel, Joachim

“…Bone morphogenetic protein (BMP)-2 and growth and differentiation factor (GDF)-5 are two related transforming growth factor (TGF)-β family members with…”
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Crystal structure analysis reveals a spring-loaded latch as molecular mechanism for GDF-5-type I receptor specificity by Kotzsch, Alexander, Nickel, Joachim, Seher, Axel, Sebald, Walter, Müller, Thomas D

“…Dysregulation of growth and differentiation factor 5 (GDF‐5) signalling, a member of the TGF‐β superfamily, is strongly linked to skeletal malformation…”
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The anti-myeloma activity of bone morphogenetic protein 2 predominantly relies on the induction of growth arrest and is apoptosis-independent by Lagler, Charlotte, El-Mesery, Mohamed, Kübler, Alexander Christian, Müller-Richter, Urs Dietmar Achim, Stühmer, Thorsten, Nickel, Joachim, Müller, Thomas Dieter, Wajant, Harald, Seher, Axel

“…Multiple myeloma (MM), a malignancy of the bone marrow, is characterized by a pathological increase in antibody-producing plasma cells and an increase in…”
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Comparative in vitro treatment of mesenchymal stromal cells with GDF-5 and R57A induces chondrogenic differentiation while limiting chondrogenic hypertrophy by Weißenberger, Manuel, Wagenbrenner, Mike, Nickel, Joachim, Ahlbrecht, Rasmus, Blunk, Torsten, Steinert, Andre F., Gilbert, Fabian

“…Purpose Hypertrophic cartilage is an important characteristic of osteoarthritis and can often be found in patients suffering from osteoarthritis. Although the…”
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Anisotropic Cryostructured Collagen Scaffolds for Efficient Delivery of RhBMP–2 and Enhanced Bone Regeneration by Stuckensen, Kai, Lamo-Espinosa, José M., Muiños-López, Emma, Ripalda-Cemboráin, Purificación, López-Martínez, Tania, Iglesias, Elena, Abizanda, Gloria, Andreu, Ion, Flandes-Iparraguirre, María, Pons-Villanueva, Juan, Elizalde, Reyes, Nickel, Joachim, Ewald, Andrea, Gbureck, Uwe, Prósper, Felipe, Groll, Jürgen, Granero-Moltó, Froilán

“…In the treatment of bone non-unions, an alternative to bone autografts is the use of bone morphogenetic proteins (BMPs), e.g., BMP–2, BMP–7, with powerful…”
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Addition of heparin binding sites strongly increases the bone forming capabilities of BMP9 in vivo by Siverino, Claudia, Fahmy-Garcia, Shorouk, Niklaus, Viktoria, Kops, Nicole, Dolcini, Laura, Misciagna, Massimiliano Maraglino, Ridwan, Yanto, Farrell, Eric, van Osch, Gerjo J.V.M., Nickel, Joachim

“…Bone Morphogenetic proteins (BMPs) like BMP2 and BMP7 have shown great potential in the treatment of severe bone defects. In recent in vitro studies, BMP9…”
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Utilizing BMP-2 muteins for treatment of multiple myeloma by Seher, Axel, Lagler, Charlotte, Stühmer, Thorsten, Müller-Richter, Urs Dietmar Achim, Kübler, Alexander Christian, Sebald, Walter, Müller, Thomas Dieter, Nickel, Joachim

“…Multiple myeloma (MM) represents a haematological cancer characterized by the pathological hyper proliferation of antibody-producing B-lymphocytes. Patients…”
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von Willebrand Factor Type C Domain-containing Proteins Regulate Bone Morphogenetic Protein Signaling through Different Recognition Mechanisms by Zhang, Jin-Li, Huang, Yi, Qiu, Li-Yan, Nickel, Joachim, Sebald, Walter

“…Bone morphogenetic protein (BMP) function is regulated in the extracellular space by many modulator proteins, including those containing a von Willebrand…”
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Type I receptor binding of bone morphogenetic protein 6 is dependent on N-glycosylation of the ligand by Saremba, Stefan, Nickel, Joachim, Seher, Axel, Kotzsch, Alexander, Sebald, Walter, Mueller, Thomas D

“…Bone morphogenetic proteins (BMPs), together with transforming growth factor (TGF)-β and activins/inhibins, constitute the TGF-β superfamily of ligands. This…”
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Identification of a Novel TGF-β-Binding Site in the Zona Pellucida C-terminal (ZP-C) Domain of TGF-β-Receptor-3 (TGFR-3) by Diestel, Uschi, Resch, Marcus, Meinhardt, Kathrin, Weiler, Sigrid, Hellmann, Tina V, Mueller, Thomas D, Nickel, Joachim, Eichler, Jutta, Muller, Yves A

“…The zona pellucida (ZP) domain is present in extracellular proteins such as the zona pellucida proteins and tectorins and participates in the formation of…”
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Functional Antibodies Targeting IsaA of Staphylococcus aureus Augment Host Immune Response and Open New Perspectives for Antibacterial Therapy by LORENZ, Udo, LORENZ, Birgit, SCHMITTER, Tim, STREKER, Karin, ERCK, Christian, WEHLAND, Jürgen, NICKEL, Joachim, ZIMMERMANN, Bastian, OHLSEN, Knut

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Effectiveness of BMP-2 and PDGF-BB Adsorption onto a Collagen/Collagen-Magnesium-Hydroxyapatite Scaffold in Weight-Bearing and Non-Weight-Bearing Osteochondral Defect Bone Repair: In Vitro, Ex Vivo and In Vivo Evaluation by Xu, Jietao, Fahmy-Garcia, Shorouk, Wesdorp, Marinus A, Kops, Nicole, Forte, Lucia, De Luca, Claudio, Misciagna, Massimiliano Maraglino, Dolcini, Laura, Filardo, Giuseppe, Labberté, Margot, Vancíková, Karin, Kok, Joeri, van Rietbergen, Bert, Nickel, Joachim, Farrell, Eric, Brama, Pieter A J, van Osch, Gerjo J V M

“…Despite promising clinical results in osteochondral defect repair, a recently developed bi-layered collagen/collagen-magnesium-hydroxyapatite scaffold has…”
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