Search Results - "NICK, HARRY S."

A KCNC3 mutation causes a neurodevelopmental, non-progressive SCA13 subtype associated with dominant negative effects and aberrant EGFR trafficking by Khare, Swati, Nick, Jerelyn A, Zhang, Yalan, Galeano, Kira, Butler, Brittany, Khoshbouei, Habibeh, Rayaprolu, Sruti, Hathorn, Tyisha, Ranum, Laura P W, Smithson, Lisa, Golde, Todd E, Paucar, Martin, Morse, Richard, Raff, Michael, Simon, Julie, Nordenskjöld, Magnus, Wirdefeldt, Karin, Rincon-Limas, Diego E, Lewis, Jada, Kaczmarek, Leonard K, Fernandez-Funez, Pedro, Nick, Harry S, Waters, Michael F

“…The autosomal dominant spinocerebellar ataxias (SCAs) are a diverse group of neurological disorders anchored by the phenotypes of motor incoordination and…”
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Mutation in the kv3.3 voltage-gated potassium channel causing spinocerebellar ataxia 13 disrupts sound-localization mechanisms by Middlebrooks, John C, Nick, Harry S, Subramony, S H, Advincula, Joel, Rosales, Raymond L, Lee, Lillian V, Ashizawa, Tetsuo, Waters, Michael F

“…Normal sound localization requires precise comparisons of sound timing and pressure levels between the two ears. The primary localization cues are interaural…”
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Contribution of Human Manganese Superoxide Dismutase Tyrosine 34 to Structure and Catalysis by Perry, J. Jefferson P, Hearn, Amy S, Cabelli, Diane E, Nick, Harry S, Tainer, John A, Silverman, David N

“…Superoxide dismutase (SOD) enzymes are critical in controlling levels of reactive oxygen species (ROS) that are linked to aging, cancer, and neurodegenerative…”
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Characterization of a mechanism to inhibit ovarian follicle activation by Barilovits, Sarah J., Ph.D, Newsom, Kimberly J., Ph.D, Bickford, Justin S., Ph.D, Beachy, Dawn E., B.F.A, Rhoton-Vlasak, Alice, M.D, Nick, Harry S., Ph.D

“…Objective To demonstrate that a small molecule can induce the transcription factor Foxo3 in the ovary and lead to inhibition of follicle activation. Design…”
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A Map of Human Type 1 Diabetes Progression by Imaging Mass Cytometry by Damond, Nicolas, Engler, Stefanie, Zanotelli, Vito R.T., Schapiro, Denis, Wasserfall, Clive H., Kusmartseva, Irina, Nick, Harry S., Thorel, Fabrizio, Herrera, Pedro L., Atkinson, Mark A., Bodenmiller, Bernd

“…Type 1 diabetes (T1D) results from the autoimmune destruction of insulin-producing β cells. A comprehensive picture of the changes during T1D development is…”
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Heme oxygenase-1 gene ablation or expression modulates cisplatin-induced renal tubular apoptosis by Shiraishi, F, Curtis, L M, Truong, L, Poss, K, Visner, G A, Madsen, K, Nick, H S, Agarwal, A

“…Heme oxygenase-1 (HO-1) is a 32-kDa microsomal enzyme that catalyzes the conversion of heme to biliverdin, releasing iron and carbon monoxide. Induction of…”
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Regulation of human microsomal prostaglandin E synthase-1 by IL-1β requires a distal enhancer element with a unique role for C/EBPβ by Walters, Jewell N, Bickford, Justin S, Newsom, Kimberly J, Beachy, Dawn E, Barilovits, Sarah J, Herlihy, John-David, Nick, Harry S

“…The studies of PGE2 (prostaglandin E2) biosynthesis have focused primarily on the role of cyclo-oxygenases. Efforts have shifted towards the specific PGE2…”
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Induction of group IVC phospholipase A2 in allergic asthma: transcriptional regulation by TNFα in bronchoepithelial cells by Bickford, Justin S, Newsom, Kimberly J, Herlihy, John-David, Mueller, Christian, Keeler, Benjamin, Qiu, Xiaolei, Walters, Jewell N, Su, Nan, Wallet, Shannon M, Flotte, Terence R, Nick, Harry S

“…Airway inflammation in allergen-induced asthma is associated with eicosanoid release. These bioactive lipids exhibit anti- and pro-inflammatory activities with…”
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A distal enhancer controls cytokine-dependent human cPLA2α gene expression[S] by Bickford, Justin S., Beachy, Dawn E., Newsom, Kimberly J., Barilovits, Sarah J., Herlihy, John-David H., Qiu, Xiaolei, Walters, Jewell N., Li, Ning, Nick, Harry S.

“…Specific control of group IVA cytosolic phospholipase A2 (cPLA2α or PLA2G4A) expression modulates arachidonic acid production, thus tightly regulating the…”
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Persistence of Pancreatic Insulin mRNA Expression and Proinsulin Protein in Type 1 Diabetes Pancreata by Wasserfall, Clive, Nick, Harry S., Campbell-Thompson, Martha, Beachy, Dawn, Haataja, Leena, Kusmartseva, Irina, Posgai, Amanda, Beery, Maria, Rhodes, Christopher, Bonifacio, Ezio, Arvan, Peter, Atkinson, Mark

“…The canonical notion that type 1 diabetes (T1D) results following a complete destruction of β cells has recently been questioned as small amounts of C-peptide…”
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KCNC3R420H , a K+ channel mutation causative in spinocerebellar ataxia 13 displays aberrant intracellular trafficking by Gallego-Iradi, Carolina, Bickford, Justin S, Khare, Swati, Hall, Alexis, Nick, Jerelyn A, Salmasinia, Donya, Wawrowsky, Kolja, Bannykh, Serguei, Huynh, Duong P, Rincon-Limas, Diego E, Pulst, Stefan M, Nick, Harry S, Fernandez-Funez, Pedro, Waters, Michael F

“…Abstract Spinocerebellar ataxia 13 (SCA13) is an autosomal dominant disease resulting from mutations in KCNC3 (Kv3.3), a voltage-gated potassium channel. The…”
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An internal enhancer regulates heme- and cadmium-mediated induction of human heme oxygenase-1 by Hill-Kapturczak, Nathalie, Sikorski, Eric, Voakes, Christy, Garcia, Jairo, Nick, Harry S, Agarwal, Anupam

“…Heme oxygenase-1 (HO-1) catalyzes the rate-limiting step in heme degradation, releasing iron, carbon monoxide, and biliverdin. Induction of HO-1 is an adaptive…”
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Metabolic Regulation of Manganese Superoxide Dismutase Expression via Essential Amino Acid Deprivation by Aiken, Kimberly J., Bickford, Justin S., Kilberg, Michael S., Nick, Harry S.

“…Organisms respond to available nutrient levels by rapidly adjusting metabolic flux, in part through changes in gene expression. A consequence of adaptations in…”
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Upstream stimulatory factors, USF1 and USF2, bind to the human haem oxygenase-1 proximal promoter in vivo and regulate its transcription by Hock, Thomas D, Nick, Harry S, Agarwal, Anupam

“…The human HO-1 (haem oxygenase-1) gene encodes a microsomal enzyme responsible for the breakdown of haem, and is also cytoprotective in response to various…”
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Temporal Analysis of Amylase Expression in Control, Autoantibody-Positive, and Type 1 Diabetes Pancreatic Tissues by Kusmartseva, Irina, Beery, Maria, Hiller, Helmut, Padilla, Myriam, Selman, Stephen, Posgai, Amanda, Nick, Harry S, Campbell-Thompson, Martha, Schatz, Desmond A, Haller, Michael J, Wasserfall, Clive H, Atkinson, Mark A

“…Within the human pancreas, exocrine and endocrine cells control secretion of digestive enzymes and production of hormones to maintain metabolic homeostasis,…”
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Structural Mobility in Human Manganese Superoxide Dismutase by Quint, Patrick, Ayala, Idelisa, Busby, Scott A, Chalmers, Michael J, Griffin, Patrick R, Rocca, James, Nick, Harry S, Silverman, David N

“…Human manganese superoxide dismutase (MnSOD) is a homotetramer of 22 kDa subunits, a dimer of dimers containing dimeric and tetrameric interfaces. We have…”
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Altered cellular localisation and expression, together with unconventional protein trafficking, of prion protein, PrPC, in type 1 diabetes by Hiller, Helmut, Yang, Changjun, Beachy, Dawn E., Kusmartseva, Irina, Candelario-Jalil, Eduardo, Posgai, Amanda L., Nick, Harry S., Schatz, Desmond, Atkinson, Mark A., Wasserfall, Clive H.

“…Aims/hypothesis Normal cellular prion protein (PrP C ) is a conserved mammalian glycoprotein found on the outer plasma membrane leaflet through a…”
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Monogenic Diabetes and Integrated Stress Response Genes Display Altered Gene Expression in Type 1 Diabetes by Hiller, Helmut, Beachy, Dawn E, Lebowitz, Joseph J, Engler, Stefanie, Mason, Justin R, Miller, Douglas R, Kusmarteva, Irina, Jacobsen, Laura M, Posgai, Amanda L, Khoshbouei, Habibeh, Oram, Richard A, Schatz, Desmond A, Hattersley, Andrew T, Bodenmiller, Bernd, Atkinson, Mark A, Nick, Harry S, Wasserfall, Clive H

“…Type 1 diabetes (T1D) has a multifactorial autoimmune etiology, involving environmental prompts and polygenic predisposition. We hypothesized that pancreata…”
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Conservation of the PTEN catalytic motif in the bacterial undecaprenyl pyrophosphate phosphatase, BacA/UppP by Bickford, Justin S, Nick, Harry S

“…Isoprenoid lipid carriers are essential in protein glycosylation and bacterial cell envelope biosynthesis. The enzymes involved in their metabolism (synthases,…”
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1637-P: Role of mTORC1 Regulation in the T1D Organ Donor Pancreas by BRUGGEMAN, BRITTANY S., BEACHY, DAWN, JACOBSEN, LAURA M., NICK, HARRY S., ATKINSON, MARK A., SCHATZ, DESMOND, WASSERFALL, CLIVE

“…Current evidence suggests that alteration in cellular metabolism leads to pancreatic β-cell dysfunction and loss in type 1 diabetes (T1D). The mammalian target…”
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