Search Results - "NICHOLSON, JEREMY K."

Symbiotic Bacterial Metabolites Regulate Gastrointestinal Barrier Function via the Xenobiotic Sensor PXR and Toll-like Receptor 4 by Venkatesh, Madhukumar, Mukherjee, Subhajit, Wang, Hongwei, Li, Hao, Sun, Katherine, Benechet, Alexandre P., Qiu, Zhijuan, Maher, Leigh, Redinbo, Matthew R., Phillips, Robert S., Fleet, James C., Kortagere, Sandhya, Mukherjee, Paromita, Fasano, Alessio, Le Ven, Jessica, Nicholson, Jeremy K., Dumas, Marc E., Khanna, Kamal M., Mani, Sridhar

“…Intestinal microbial metabolites are conjectured to affect mucosal integrity through an incompletely characterized mechanism. Here we showed that…”
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Gut microbiota modulation of chemotherapy efficacy and toxicity by Alexander, James L., Wilson, Ian D., Teare, Julian, Marchesi, Julian R., Nicholson, Jeremy K., Kinross, James M.

“…Key Points Evidence is increasing that the gut microbiota modulate the actions of chemotherapeutic drugs used in cancer and other diseases We propose the…”
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Gut Microbiota Composition and Activity in Relation to Host Metabolic Phenotype and Disease Risk by Holmes, Elaine, Li, Jia V., Marchesi, Julian R., Nicholson, Jeremy K.

“…The symbiotic gut microbiota modulate health and disease of the host through a series of transgenomic metabolic and immune regulatory axes. We explore…”
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Host-Gut Microbiota Metabolic Interactions by Nicholson, Jeremy K., Holmes, Elaine, Kinross, James, Burcelin, Remy, Gibson, Glenn, Jia, Wei, Pettersson, Sven

“…The composition and activity of the gut microbiota codevelop with the host from birth and is subject to a complex interplay that depends on the host genome,…”
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Impact of the gut microbiota on inflammation, obesity, and metabolic disease by Boulangé, Claire L, Neves, Ana Luisa, Chilloux, Julien, Nicholson, Jeremy K, Dumas, Marc-Emmanuel

“…The human gut harbors more than 100 trillion microbial cells, which have an essential role in human metabolic regulation via their symbiotic interactions with…”
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Quantifying Diet-Induced Metabolic Changes of the Human Gut Microbiome by Shoaie, Saeed, Ghaffari, Pouyan, Kovatcheva-Datchary, Petia, Mardinoglu, Adil, Sen, Partho, Pujos-Guillot, Estelle, de Wouters, Tomas, Juste, Catherine, Rizkalla, Salwa, Chilloux, Julien, Hoyles, Lesley, Nicholson, Jeremy K., Dore, Joel, Dumas, Marc E., Clement, Karine, Bäckhed, Fredrik, Nielsen, Jens

“…The human gut microbiome is known to be associated with various human disorders, but a major challenge is to go beyond association studies and elucidate…”
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Metabolic Phenotyping in Health and Disease by Holmes, Elaine, Wilson, Ian D., Nicholson, Jeremy K.

“…Analyzing metabolites (small molecules <1 kDa) in body fluids such as urine and plasma using various spectroscopic methods provides information on the…”
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Global metabolic profiling of animal and human tissues via UPLC-MS by Want, Elizabeth J, Masson, Perrine, Michopoulos, Filippos, Wilson, Ian D, Theodoridis, Georgios, Plumb, Robert S, Shockcor, John, Loftus, Neil, Holmes, Elaine, Nicholson, Jeremy K

“…Obtaining comprehensive, untargeted metabolic profiles for complex solid samples, e.g., animal tissues, requires sample preparation and access to…”
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Understanding the role of gut microbiome–host metabolic signal disruption in health and disease by Holmes, Elaine, Li, Jia V, Athanasiou, Thanos, Ashrafian, Hutan, Nicholson, Jeremy K

“…There is growing awareness of the importance of the gut microbiome in health and disease, and recognition that the microbe to host metabolic signalling is…”
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Microbiome-host systems interactions: protective effects of propionate upon the blood-brain barrier by Hoyles, Lesley, Snelling, Tom, Umlai, Umm-Kulthum, Nicholson, Jeremy K, Carding, Simon R, Glen, Robert C, McArthur, Simon

“…Gut microbiota composition and function are symbiotically linked with host health and altered in metabolic, inflammatory and neurodegenerative disorders. Three…”
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Global urinary metabolic profiling procedures using gas chromatography–mass spectrometry by Chan, Eric Chun Yong, Pasikanti, Kishore Kumar, Nicholson, Jeremy K

“…The role of urinary metabolic profiling in systems biology research is expanding. This is because of the use of this technology for clinical diagnostic and…”
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Hippurate: The Natural History of a Mammalian–Microbial Cometabolite by Lees, Hannah J, Swann, Jonathan R, Wilson, Ian D, Nicholson, Jeremy K, Holmes, Elaine

“…Hippurate, the glycine conjugate of benzoic acid, is a normal constituent of the endogenous urinary metabolite profile and has long been associated with the…”
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Gut microbiome-host interactions in health and disease by Kinross, James M, Darzi, Ara W, Nicholson, Jeremy K

“…The gut microbiome is the term given to describe the vast collection of symbiotic microorganisms in the human gastrointestinal system and their collective…”
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Metabolic phenotyping in clinical and surgical environments by Nicholson, Jeremy K., Holmes, Elaine, Kinross, James M., Darzi, Ara W., Takats, Zoltan, Lindon, John C.

“…Metabolic phenotyping involves the comprehensive analysis of biological fluids or tissue samples. This analysis allows biochemical classification of a person's…”
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Vaginal dysbiosis increases risk of preterm fetal membrane rupture, neonatal sepsis and is exacerbated by erythromycin by Brown, Richard G, Marchesi, Julian R, Lee, Yun S, Smith, Ann, Lehne, Benjamin, Kindinger, Lindsay M, Terzidou, Vasso, Holmes, Elaine, Nicholson, Jeremy K, Bennett, Phillip R, MacIntyre, David A

“…Preterm prelabour rupture of the fetal membranes (PPROM) precedes 30% of preterm births and is a risk factor for early onset neonatal sepsis. As PPROM is…”
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Global metabolic profiling procedures for urine using UPLC-MS by Want, Elizabeth J, Wilson, Ian D, Gika, Helen, Theodoridis, Georgios, Plumb, Robert S, Shockcor, John, Holmes, Elaine, Nicholson, Jeremy K

“…The production of 'global' metabolite profiles involves measuring low molecular-weight metabolites (<1 kDa) in complex biofluids/tissues to study perturbations…”
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Objective Set of Criteria for Optimization of Sample Preparation Procedures for Ultra-High Throughput Untargeted Blood Plasma Lipid Profiling by Ultra Performance Liquid Chromatography–Mass Spectrometry by Sarafian, Magali H, Gaudin, Mathieu, Lewis, Matthew R, Martin, Francois-Pierre, Holmes, Elaine, Nicholson, Jeremy K, Dumas, Marc-Emmanuel

“…Exploratory or untargeted ultra performance liquid chromatography–mass spectrometry (UPLC–MS) profiling offers an overview of the complex lipid species…”
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Systemic gut microbial modulation of bile acid metabolism in host tissue compartments by Swann, Jonathan R, Want, Elizabeth J, Geier, Florian M, Spagou, Konstantina, Wilson, Ian D, Sidaway, James E, Nicholson, Jeremy K, Holmes, Elaine

“…We elucidate the detailed effects of gut microbial depletion on the bile acid sub-metabolome of multiple body compartments (liver, kidney, heart, and blood…”
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Precision High-Throughput Proton NMR Spectroscopy of Human Urine, Serum, and Plasma for Large-Scale Metabolic Phenotyping by Dona, Anthony C, Jiménez, Beatriz, Schäfer, Hartmut, Humpfer, Eberhard, Spraul, Manfred, Lewis, Matthew R, Pearce, Jake T. M, Holmes, Elaine, Lindon, John C, Nicholson, Jeremy K

“…Proton nuclear magnetic resonance (NMR)-based metabolic phenotyping of urine and blood plasma/serum samples provides important prognostic and diagnostic…”
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Gut microbiota: a potential new territory for drug targeting by Jia, Wei, Li, Houkai, Zhao, Liping, Nicholson, Jeremy K

“…The emerging influence of intestinal microorganisms on human health has led to the prospect of modulating gut microbiota composition as a novel therapeutic…”
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