Search Results - "NICHOLS, Ralph C"

AUF1/hnRNP D represses expression of VEGF in macrophages by Fellows, Abigail, Griffin, Mary E, Petrella, Brenda L, Zhong, Lihui, Parvin-Nejad, Fatemeh P, Fava, Roy, Morganelli, Peter, Robey, R Brooks, Nichols, Ralph C

“…Vascular endothelial growth factor (VEGF) is a regulator of vascularization in development and is a key growth factor in tissue repair. In disease, VEGF…”
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WITHDRAWN: AUF1-RGG peptides up-regulate the VEGF antagonist, soluble VEGF receptor-1 (sFlt-1) by Fellows, Abigail, Mierke, Dale, Nichols, Ralph C

“…This article has been withdrawn at the request of the author(s) and/or editor. The Publisher apologizes for any inconvenience this may cause. The full Elsevier…”
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AUF1-RGG peptides up-regulate the VEGF antagonist, soluble VEGF receptor-1 (sFlt-1) by Fellows, Abigail, Mierke, Dale F., Nichols, Ralph C.

“…•The AUF1-RGG peptides are novel reagents that are modeled on the RGG regulatory region of AUF1.•AUF1-RGG peptides decrease expression of VEGF and stimulate…”
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Peptides modeled on the RGG domain of AUF1/hnRNP-D regulate 3′ UTR-dependent gene expression by Fellows, Abigail, Deng, Bin, Mierke, Dale F., Robey, R. Brooks, Nichols, Ralph C.

“…Messenger RNA binding proteins control post-transcriptional gene expression of targeted mRNAs. The RGG (arginine-glycine-glycine) domain of the AUF1/hnRNP-D…”
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Uroporphyrin accumulation in hepatoma cells expressing human or mouse CYP1A2: relation to the role of CYP1A2 in human porphyria cutanea tarda by Nichols, Ralph C., Cooper, Sandra, Trask, Heidi W., Gorman, Nadia, Dalton, Timothy P., Nebert, Daniel W., Sinclair, Jacqueline F., Sinclair, Peter R.

“…In experimental animals, CYP1A2 is absolutely required for the development of uroporphyria induced by treatment with polyhalogenated aromatic compounds or…”
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Arsenic decreases RXRα-dependent transcription of CYP3A and suppresses immune regulators in hepatocytes by Noreault-Conti, Trisha L., Fellows, Abigail, Jacobs, Judith M., Trask, Heidi W., Strom, Stephen C., Evans, Ronald M., Wrighton, Steven A., Sinclair, Peter R., Sinclair, Jacqueline F., Nichols, Ralph C.

“…Arsenite is critical pharmacologically as a treatment for advanced stage blood cancer. However, environmental exposure to arsenic results in multiple diseases…”
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The RGG Domain in hnRNP A2 Affects Subcellular Localization by Nichols, Ralph C., Wang, Xiao Wei, Tang, Jie, Hamilton, B.JoNell, High, Frances A., Herschman, Harvey R., Rigby, William F.C.

“…The heterogeneous nuclear ribonucleoproteins (hnRNP) associate with pre-mRNA in the nucleus and play an important role in RNA processing and splice site…”
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A Flexible Approach to Studying Post-Transcriptional Gene Regulation in Stably Transfected Mammalian Cells by Nichols, Ralph C., Botson, John, Wang, Xiao Wei, Hamilton, B. JoNell, Collins, Jane E., Uribe, Victoria, Brooks, Seth A., Zan, Moe, Rigby, William F. C.

“…The study of post-transcriptional regulation is constrained by the technical limitations associated with both transient and stable transfection of chimeric…”
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Post-transcriptional regulation of glucose transporter-1 by an AU-rich element in the 3 ′UTR and by hnRNP A2 by Griffin, Mary E, Hamilton, B.JoNell, Roy, Kristen M, Du, Min, Willson, Alicia M, Keenan, Benjamin J, Wang, Xiao Wei, Nichols, Ralph C

“…Glucose transporter-1 (GLUT1) mediates uptake of glucose and is up-regulated in some cancers. The amount of this membrane protein is regulated by a…”
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VEGF gene expression is regulated post‐transcriptionally in macrophages by Du, Min, Roy, Kristen M., Zhong, Lihui, Shen, Zheng, Meyers, Hannah E., Nichols, Ralph C.

“…The macrophage is critical to the innate immune response and contributes to human diseases, including inflammatory arthritis and plaque formation in…”
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Arsenite decreases CYP3A4 and RXRα in primary human hepatocytes by NOREAULT, Trisha L, KOSTRUBSKY, Vsevolod E, SINCLAIR, Jacqueline F, WOOD, Sheryl G, NICHOLS, Ralph C, STROM, Stephen C, TRASK, Heidi W, WRIGHTON, Steven A, EVANS, Ronald M, JACOBS, Judith M, SINCLAIR, Peter R

“…Arsenic is a naturally occurring, worldwide contaminant implicated in numerous pathological conditions in humans, including cancer and several forms of liver…”
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hnRNP A2 and hnRNP L Bind the 3′UTR of Glucose Transporter 1 mRNA and Exist as a Complex in Vivo by Hamilton, B.JoNell, Nichols, Ralph C., Tsukamoto, Haruhisa, Boado, Ruben J., Pardridge, William M., Rigby, William F.C.

“…Recent work identified an RNA binding protein whose presence in brain tumors correlated with translational repression of Glut1 expression. RNase T1 mapping…”
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Arsenite decreases CYP3A23 induction in cultured rat hepatocytes by transcriptional and translational mechanisms by Noreault, Trisha L., Jacobs, Judith M., Nichols, Ralph C., Trask, Heidi W., Wrighton, Steven A., Sinclair, Peter R., Evans, Ronald M., Sinclair, Jacqueline F.

“…Arsenic is a naturally occurring, worldwide contaminant implicated in numerous pathological conditions in humans, including cancer and several forms of liver…”
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Effect of proteasome inhibition on toxicity and CYP3A23 induction in cultured rat hepatocytes: Comparison with arsenite by Noreault-Conti, Trisha L., Jacobs, Judith M., Trask, Heidi W., Wrighton, Steven A., Sinclair, Jacqueline F., Nichols, Ralph C.

“…Previous work in our laboratory has shown that acute exposure of primary rat hepatocyte cultures to non-toxic concentrations of arsenite causes major decreases…”
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Mechanism of arsenite-mediated decreases in CYP3A23 in rat hepatocytes by Noreault, Trisha L., Jacobs, Judith M., Nichols, Ralph C., Trask, Heidi W., Wrighton, Steven A., Sinclair, Peter R., Sinclair, Jacqueline F.

“…In primary cultures of rat hepatocytes, exposure to arsenite causes a major decrease in dexamethasone (DEX)-mediated induction of CYP3A23 hemoprotein, with a…”
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Modulation of AUUUA Response Element Binding by Heterogeneous Nuclear Ribonucleoprotein A1 in Human T Lymphocytes by Hamilton, B. JoNell, Burns, Christopher M., Nichols, Ralph C., Rigby, William F.C.

“…The heterogeneous nuclear ribonucleoprotein A1 (hnRNP A1) shuttles between the cytoplasm and nucleus and plays important roles in RNA metabolism. Whereas…”
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hnRNP A2 and hnRNP L bind the 3'UTR of glucose transporter 1 mRNA and exist as a complex in vivo by Hamilton, B J, Nichols, R C, Tsukamoto, H, Boado, R J, Pardridge, W M, Rigby, W F

“…Recent work identified an RNA binding protein whose presence in brain tumors correlated with translational repression of Glut1 expression. RNase T1 mapping…”
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Calcium regulation of the human PMN cytosolic 15-lipoxygenase by Nichols, R C, Vanderhoek, J Y

“…Addition of tracer (pg) amounts of [3H]arachidonic acid to the 120,000 x g cytosolic fraction of human polymorphonuclear leukocytes (PMNs) produced…”
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Modulation of AUUUA response element binding by heterogeneous nuclear ribonucleoprotein A1 in human T lymphocytes. The roles of cytoplasmic location, transcription, and phosphorylation by Hamilton, B J, Burns, C M, Nichols, R C, Rigby, W F

“…The heterogeneous nuclear ribonucleoprotein A1 (hnRNP A1) shuttles between the cytoplasm and nucleus and plays important roles in RNA metabolism. Whereas…”
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A model of mRNA splicing in adult lysosomal storage disease (glycogenosis type II) by Raben, N, Nichols, R C, Martiniuk, F, Plotz, P H

“…Glycogenosis type II is a recessively inherited disorder caused by mutations in the acid maltase (GAA) gene. Clinically, three different phenotypes are…”
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