Search Results - "NICHOLS, G"

The relationship between the gut microbiome and host gene expression: a review by Nichols, Robert G., Davenport, Emily R.

“…Despite the growing knowledge surrounding host–microbiome interactions, we are just beginning to understand how the gut microbiome influences—and is influenced…”
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A topic model approach to measuring interdisciplinarity at the National Science Foundation by Nichols, Leah G.

“…As the National Science Foundation (NSF) implements new cross-cutting initiatives and programs, interest in assessing the success of these experiments in…”
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Coronavirus seasonality, respiratory infections and weather by Nichols, G L, Gillingham, E L, Macintyre, H L, Vardoulakis, S, Hajat, S, Sarran, C E, Amankwaah, D, Phalkey, R

“…The survival of coronaviruses are influenced by weather conditions and seasonal coronaviruses are more common in winter months. We examine the seasonality of…”
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Intestine farnesoid X receptor agonist and the gut microbiota activate G‐protein bile acid receptor‐1 signaling to improve metabolism by Pathak, Preeti, Xie, Cen, Nichols, Robert G., Ferrell, Jessica M., Boehme, Shannon, Krausz, Kristopher W., Patterson, Andrew D., Gonzalez, Frank J., Chiang, John Y.L.

“…Bile acids activate farnesoid X receptor (FXR) and G protein–coupled bile acid receptor‐1 (aka Takeda G protein–coupled receptor‐5 [TGR5]) to regulate bile…”
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Gut microbiota and intestinal FXR mediate the clinical benefits of metformin by Sun, Lulu, Xie, Cen, Wang, Guang, Wu, Yue, Wu, Qing, Wang, Xuemei, Liu, Jia, Deng, Yangyang, Xia, Jialin, Chen, Bo, Zhang, Songyang, Yun, Chuyu, Lian, Guan, Zhang, Xiujuan, Zhang, Heng, Bisson, William H., Shi, Jingmin, Gao, Xiaoxia, Ge, Pupu, Liu, Cuihua, Krausz, Kristopher W., Nichols, Robert G., Cai, Jingwei, Rimal, Bipin, Patterson, Andrew D., Wang, Xian, Gonzalez, Frank J., Jiang, Changtao

“…The anti-hyperglycemic effect of metformin is believed to be caused by its direct action on signaling processes in hepatocytes, leading to lower hepatic…”
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Intermittent Fasting Promotes White Adipose Browning and Decreases Obesity by Shaping the Gut Microbiota by Li, Guolin, Xie, Cen, Lu, Siyu, Nichols, Robert G., Tian, Yuan, Li, Licen, Patel, Daxeshkumar, Ma, Yinyan, Brocker, Chad N., Yan, Tingting, Krausz, Kristopher W., Xiang, Rong, Gavrilova, Oksana, Patterson, Andrew D., Gonzalez, Frank J.

“…While activation of beige thermogenesis is a promising approach for treatment of obesity-associated diseases, there are currently no known pharmacological…”
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Distinct macrophage lineages contribute to disparate patterns of cardiac recovery and remodeling in the neonatal and adult heart by Lavine, Kory J., Epelman, Slava, Uchida, Keita, Weber, Kassandra J., Nichols, Colin G., Schilling, Joel D., Ornitz, David M., Randolph, Gwendalyn J., Mann, Douglas L.

“…Significance This study addresses a fundamentally important and widely debated issue in the field of inflammation, which is why inflammation can be…”
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Pancreatic β Cell Dedifferentiation in Diabetes and Redifferentiation following Insulin Therapy by Wang, Zhiyu, York, Nathaniel W., Nichols, Colin G., Remedi, Maria S.

“…Diabetes is characterized by “glucotoxic” loss of pancreatic β cell function and insulin content, but underlying mechanisms remain unclear. A mouse model of…”
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Pore-forming transmembrane domains control ion selectivity and selectivity filter conformation in the KirBac1.1 potassium channel by Matamoros, Marcos, Nichols, Colin G

“…Potassium (K+) channels are membrane proteins with the remarkable ability to very selectively conduct K+ ions across the membrane. High-resolution structures…”
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Seeing spermine blocking of K+ ion movement through inward rectifier Kir2.2 channels by Lee, Sun-Joo, Nichols, Colin G

“…Inwardly rectifier potassium (Kir) channels are a major potassium channel sub-class whose function is regulated by ligand-dependent gating and highly…”
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Coronavirus Proteins as Ion Channels: Current and Potential Research by McClenaghan, Conor, Hanson, Alex, Lee, Sun-Joo, Nichols, Colin G

“…Coronavirus (CoV) outbreaks have recently emerged as a global public health threat due to their exceptional zoonotic potential - a feature arising from their…”
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The microbiome modulating activity of bile acids by Tian, Yuan, Gui, Wei, Koo, Imhoi, Smith, Philip B., Allman, Erik L., Nichols, Robert G., Rimal, Bipin, Cai, Jingwei, Liu, Qing, Patterson, Andrew D.

“…Bile acids are potent antibacterial compounds and play an important role in shaping the microbial ecology of the gut. Here, we combined flow cytometry, growth…”
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The Glucose Transporter Glut1 Is Selectively Essential for CD4 T Cell Activation and Effector Function by Macintyre, Andrew N., Gerriets, Valerie A., Nichols, Amanda G., Michalek, Ryan D., Rudolph, Michael C., Deoliveira, Divino, Anderson, Steven M., Abel, E. Dale, Chen, Benny J., Hale, Laura P., Rathmell, Jeffrey C.

“…CD4 T cell activation leads to proliferation and differentiation into effector (Teff) or regulatory (Treg) cells that mediate or control immunity. While each…”
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ATP-Sensitive Potassium Channels in Hyperinsulinism and Type 2 Diabetes: Inconvenient Paradox or New Paradigm? by Nichols, Colin G, York, Nathaniel W, Remedi, Maria S

“…Secretion of insulin from pancreatic β-cells is complex, but physiological glucose-dependent secretion is dominated by electrical activity, in turn controlled…”
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Persistent Organic Pollutants Modify Gut Microbiota-Host Metabolic Homeostasis in Mice Through Aryl Hydrocarbon Receptor Activation by Zhang, Limin, Nichols, Robert G, Correll, Jared, Murray, Iain A, Tanaka, Naoki, Smith, Philip B, Hubbard, Troy D, Sebastian, Aswathy, Albert, Istvan, Hatzakis, Emmanuel, Gonzalez, Frank J, Perdew, Gary H, Patterson, Andrew D

“…Alteration of the gut microbiota through diet and environmental contaminants may disturb physiological homeostasis, leading to various diseases including…”
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Structure of a bacterial voltage-gated sodium channel pore reveals mechanisms of opening and closing by McCusker, Emily C., Bagnéris, Claire, Naylor, Claire E., Cole, Ambrose R., D'Avanzo, Nazzareno, Nichols, Colin G., Wallace, B.A.

“…Sodium-gated ion channels open and close in response to the flow of ions. Here, McCusker et al. report the open structure of a sodium-gated ion channel pore…”
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Effects of T cell leptin signaling on systemic glucose tolerance and T cell responses in obesity by Kiernan, Kaitlin, Nichols, Amanda G, Alwarawrah, Yazan, MacIver, Nancie J

“…Leptin is an adipokine secreted in proportion to adipocyte mass and is therefore increased in obesity. Leptin signaling has been shown to directly promote…”
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Preferential Gq signaling in diabetes: an electrical switch in incretin action and in diabetes progression? by Nichols, Colin G, York, Nathaniel W, Remedi, Maria S

“…Patients with type 2 diabetes (T2D) fail to secrete insulin in response to increased glucose levels that occur with eating. Glucagon-like peptide-1 (GLP-1) and…”
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Life-cycle energy implications of different residential settings: Recognizing buildings, travel, and public infrastructure by Nichols, Brice G., Kockelman, Kara M.

“…The built environment can be used to influence travel demand, but very few studies consider the relative energy savings of such policies in context of a…”
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Structural dynamics of potassium-channel gating revealed by single-molecule FRET by Wang, Shizhen, Vafabakhsh, Reza, Borschel, William F, Ha, Taekjip, Nichols, Colin G

“…Single-molecule FRET provides insight into the structural dynamics of the KirBac1.1 potassium channel and reveals that channel gating is controlled by the…”
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