Search Results - "NICHOL, J. L."

Platelets Generated In Vitro From Proplatelet-Displaying Human Megakaryocytes Are Functional by Choi, Esther S., Nichol, Janet L., Hokom, Martha M., Hornkohl, Alex C., Hunt, Pamela

“…An in vitro culture system demonstrating the transitions from megakaryocyte progenitors to functional platelets is described. CD34-selected cells from normal…”
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Evaluation of bleeding and thrombotic events during long‐term use of romiplostim in patients with chronic immune thrombocytopenia (ITP) by GERNSHEIMER, T. B., GEORGE, J. N., ALEDORT, L. M., TARANTINO, M. D., SUNKARA, U., MATTHEW GUO, D., NICHOL, J. L.

“…Background: Romiplostim is a peptibody protein that raises platelet counts during long‐term treatment of patients with chronic immune thrombocytopenia (ITP)…”
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Serum thrombopoietin levels in patients with aplastic anaemia by Marsh, J C, Gibson, F M, Prue, R L, Bowen, A, Dunn, V T, Hornkohl, A C, Nichol, J L, Gordon-Smith, E C

“…Endogenous serum thrombopoietin (TPO) levels were measured in 31 patients with aplastic anaemia (AA) using an enzyme immunoassay with a sensitivity of 20 pg/…”
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Pegylated Megakaryocyte Growth and Development Factor Abrogates the Lethal Thrombocytopenia Associated With Carboplatin and Irradiation in Mice by Hokom, Martha M., Lacey, David, Kinstler, Olaf B., Choi, Esther, Kaufman, Steve, Faust, Judy, Rowan, Chris, Dwyer, Erik, Nichol, Janet L., Grasel, Timothy, Wilson, John, Steinbrink, Randy, Hecht, Randy, Winters, Dwight, Boone, Thomas, Hunt, Pamela

“…Megakaryocyte growth and development factor (MGDF) is a potent inducer of megakaryopoiesis in vitro and thrombopoiesis in vivo. The effects of MGDF appear to…”
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High levels of thrombopoietin in sera of patients with essential thrombocythemia : Cause or consequence of abnormal platelet production? by GRIESSHAMMER, M, HORNKOHL, A, NICHOL, J. L, HECHT, T, RAGHAVACHAR, A, HEIMPEL, H, SCHREZENMEIER, H

“…Thrombopoietin (TPO) is the most important regulator of megakaryocyte development and platelet production. Platelet production is thought to be regulated by a…”
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Thrombopoietin serum levels in patients with aplastic anaemia: correlation with platelet count and persistent elevation in remission by Schrezenmeier, Hubert, Griesshammer, Martin, Hornkohl, Alex, Nichol, Janet L., Hecht, Thomas, Heimpel, Herrmann, Kubanek, Bernhard, Raghavachar, Aruna

“…In an attempt to evaluate the role of thrombopoietin (TPO) in the pathobiology of aplastic anaemia (AA), we have examined TPO levels in sera from 54 AA…”
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Thrombopoietin levels in HIV-associated thrombocytopenia in children by Young, Guy, Loechelt, Brett J., Rakusan, Tamara A., Nichol, Janet L., Luban, Naomi L.C.

“…Objectives: To determine the mechanism of human immunodeficiency virus (HIV)–associated thrombocytopenia by using thrombopoietin (TPO) levels. Study design:…”
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Serum thrombopoietin levels and anti-thrombopoietin antibodies in systemic lupus erythematosus by Füreder, W, Firbas, U, Nichol, J L, Pistillo, J, Winkler, S, Hiesberger, H, Sperr, W R, Smolen, J, Schett, G

“…Thrombocytopenia is a common phenomenon in patients suffering from systemic lupus erythematosus (SLE). The cause of thrombocytopenia in SLE, however, is poorly…”
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Purification and Biologic Characterization of Plasma-Derived Megakaryocyte Growth and Development Factor by Hunt, Pamela, Li, Yue-Sheng, Nichol, Janet L., Hokom, Martha M., Bogenberger, Jakob M., Swift, Susan E., Skrine, James D., Hornkohl, Alex C., Lu, Hsieng, Clogston, Chris, Merewether, Lee Anne, Johnson, Merrie Jo, Parker, Vann, Knudten, Andrew, Farese, Ann, Hsu, Rou Yin, Garcia, Andrew, Stead, Richard, Bosselman, Robert A., Bartley, Timothy D.

“…The isolation and cloning of the ligand for the cytokine receptor, Mpl, have been recently described. In this report we present details of the purification of…”
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Indirect study of thrombopoiesis(TPO, reticulated platelets, glycocalicin)in patients with hereditary macrothrombocytopenia by Fabris, F., Cordiano, I., Steffana, A., Ramon, R., Scandellari, R., Nichol, J. L., Girolami, A.

“…: Chronic isolated hereditary macrothrombocytopenia (CHMT) is a congenital form of macrothrombocytopenia that seems to be due to defective production secondary…”
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Haematological abnormalities in early abstinent alcoholics are closely associated with alterations in thrombopoietin and erythropoietin serum profiles by Schmitt, M, Gleiter, C H, Nichol, J L, Pralle, L, Hasselblatt, M, Poser, W, Ehrenreich, H

“…Numerous reports exist on haematological pathology in alcoholism. However, no data are available regarding a potential involvement of haematopoietic growth…”
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Chronic Thrombocytopenia Is Induced in Dogs by Development of Cross-Reacting Antibodies to the MpL Ligand by Dale, David C., Nichol, Janet L., Rich, Douglas A., Best, Dawn M., Slichter, Sherrill J., Sheridan, William, Hunt, Pam

“…The MpL ligand (ML) is a potent stimulus for thrombocytopoiesis. To create an in vivo model of ML deficiency, we injected dogs with a recombinant human ML…”
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Endogenous TPO (eTPO) levels in health and disease: Possible clues for therapeutic intervention by Nichol, Janet Lee

“…The factor which is the primary regulator of megakaryocyte and platelet production has recently been identified as the ligand for the receptor Mpl. This…”
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Identification and cloning of a megakaryocyte growth and development factor that is a ligand for the cytokine receptor Mpl by Bartley, T D, Bogenberger, J, Hunt, P, Li, Y S, Lu, H S, Martin, F, Chang, M S, Samal, B, Nichol, J L, Swift, S

“…A novel megakaryocyte growth and development factor (MGDF) has been identified in aplastic canine plasma, and its cDNAs have been cloned from canine, murine,…”
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Ineffective platelet production in thrombocytopenic human immunodeficiency virus-infected patients by COLE, J. L, MARZEC, U. M, GUNTHEL, C. J, KARPATKIN, S, WORFORD, L, SUNDELL, I. B, LENNOX, J. L, NICHOL, J. L, HARKER, L. A

“…Thrombocytopenia has been characterized in six patients infected with human immunodeficiency virus (HIV) with respect to the delivery of viable platelets into…”
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Serum thrombopoietin levels following orthotopic liver transplantation by Richards, E M, Alexander, G J, Nichol, J L, Baglin, T P

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Megakaryocyte growth and development factor. Analyses of in vitro effects on human megakaryopoiesis and endogenous serum levels during chemotherapy-induced thrombocytopenia by Nichol, J L, Hokom, M M, Hornkohl, A, Sheridan, W P, Ohashi, H, Kato, T, Li, Y S, Bartley, T D, Choi, E, Bogenberger, J

“…The present study shows that recombinant human megakaryocyte growth and development factor (r-HuMGDF) behaves both as a megakaryocyte colony stimulating factor…”
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Cyclic immune thrombocytopenia responsive to thrombopoietic growth factor therapy by Rice, Lawrence, Nichol, Janet L., McMillan, Robert, Roskos, Lorin K., Bacile, Margaret

“…We report a patient with cyclic thrombocytopenia and antiplatelet antibodies, a variant of chronic immune thrombocytopenic purpura (ITP), with a several year…”
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Ex Vivo Cultured Megakaryocytes Express Functional Glycoprotein IIb-IIIa Receptors and Are Capable of Adenovirus-Mediated Transgene Expression by Faraday, Nauder, Rade, Jeffrey J., Johns, David C., Khetawat, Gopal, Noga, Stephen J., DiPersio, John F., Jin, Ying, Nichol, Janet L., Haug, Jeff S., Bray, Paul F.

“…Investigation of the molecular basis of megakaryocyte (MK) and platelet biology has been limited by an inadequate source of genetically manipulable cells…”
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The Mpl ligand and platelet homeostasis by Nichol, JL

“…The classification of Mpl as a cytokine receptor present on cells of the platelet lineage has led to the identification and cloning of its ligand. This has…”
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