Search Results - "NIBBS, Robert J"

Immune regulation by atypical chemokine receptors by Nibbs, Robert J. B., Graham, Gerard J.

“…Key Points Leukocyte migration is a central component of all physiological and pathological immune and inflammatory responses. Chemokines, functioning through…”
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The small and large intestine contain related mesenchymal subsets that derive from embryonic Gli1+ precursors by Pærregaard, Simone Isling, Wulff, Line, Schussek, Sophie, Niss, Kristoffer, Mörbe, Urs, Jendholm, Johan, Wendland, Kerstin, Andrusaite, Anna T., Brulois, Kevin F., Nibbs, Robert J. B., Sitnik, Katarzyna, Mowat, Allan McI, Butcher, Eugene C., Brunak, Søren, Agace, William W.

“…The intestinal lamina propria contains a diverse network of fibroblasts that provide key support functions to cells within their local environment. Despite…”
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A Novel Computational Model Predicts Key Regulators of Chemokine Gradient Formation in Lymph Nodes and Site-Specific Roles for CCL19 and ACKR4 by Jafarnejad, Mohammad, Zawieja, David C, Brook, Bindi S, Nibbs, Robert J B, Moore, Jr, James E

“…The chemokine receptor CCR7 drives leukocyte migration into and within lymph nodes (LNs). It is activated by chemokines CCL19 and CCL21, which are scavenged by…”
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CXCR2 Inhibition Profoundly Suppresses Metastases and Augments Immunotherapy in Pancreatic Ductal Adenocarcinoma by Steele, Colin W., Karim, Saadia A., Leach, Joshua D.G., Bailey, Peter, Upstill-Goddard, Rosanna, Rishi, Loveena, Foth, Mona, Bryson, Sheila, McDaid, Karen, Wilson, Zena, Eberlein, Catherine, Candido, Juliana B., Clarke, Mairi, Nixon, Colin, Connelly, John, Jamieson, Nigel, Carter, C. Ross, Balkwill, Frances, Chang, David K., Evans, T.R. Jeffry, Strathdee, Douglas, Biankin, Andrew V., Nibbs, Robert J.B., Barry, Simon T., Sansom, Owen J., Morton, Jennifer P.

“…CXCR2 has been suggested to have both tumor-promoting and tumor-suppressive properties. Here we show that CXCR2 signaling is upregulated in human pancreatic…”
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Expression of the Atypical Chemokine Receptor ACKR4 Identifies a Novel Population of Intestinal Submucosal Fibroblasts That Preferentially Expresses Endothelial Cell Regulators by Thomson, Carolyn A, van de Pavert, Serge A, Stakenborg, Michelle, Labeeuw, Evelien, Matteoli, Gianluca, Mowat, Allan McI, Nibbs, Robert J B

“…Atypical chemokine receptors (ACKRs) are expressed by discrete populations of stromal cells at specific anatomical locations where they control leukocyte…”
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The atypical chemokine receptor CCRL1 shapes functional CCL21 gradients in lymph nodes by Ulvmar, Maria H, Werth, Kathrin, Braun, Asolina, Kelay, Poonam, Hub, Elin, Eller, Kathrin, Chan, Li, Lucas, Beth, Novitzky-Basso, Igor, Nakamura, Kyoko, Rülicke, Thomas, Nibbs, Robert J B, Worbs, Tim, Förster, Reinhold, Rot, Antal

“…Antigen-bearing dendritic cells transit through the lymphatics via chemokine receptor CCR7–dependent chemotactic cues. Rot and colleagues show that the…”
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CXCR2 inhibition suppresses acute and chronic pancreatic inflammation by Steele, Colin W, Karim, Saadia A, Foth, Mona, Rishi, Loveena, Leach, Joshua DG, Porter, Ross J, Nixon, Colin, Jeffry Evans, TR, Carter, C Ross, Nibbs, Robert JB, Sansom, Owen J, Morton, Jennifer P

“…Pancreatitis is a significant clinical problem and the lack of effective therapeutic options means that treatment is often palliative rather than curative. A…”
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Maternal Plasma DHA Levels Increase Prior to 29 Days Post-LH Surge in Women Undergoing Frozen Embryo Transfer: A Prospective, Observational Study of Human Pregnancy by Meyer, Barbara J, Onyiaodike, Christopher C, Brown, E. Ann, Jordan, Fiona, Murray, Heather, Nibbs, Robert J. B, Sattar, Naveed, Lyall, Helen, Nelson, Scott M, Freeman, Dilys J

“…Maternal plasma fatty acid changes were measured in early pregnancy and an increase in maternal plasma DHA concentration is initiated in human pregnancy prior…”
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Universal expression and dual function of the atypical chemokine receptor D6 on innate-like B cells in mice by Hansell, Chris A.H., Schiering, Chris, Kinstrie, Ross, Ford, Laura, Bordon, Yvonne, McInnes, Iain B., Goodyear, Carl S., Nibbs, Robert J.B.

“…Mouse innate-like B cells are a heterogeneous collection of multifunctional cells that control infection, play housekeeping roles, contribute to adaptive…”
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The chemokine receptors ACKR2 and CCR2 reciprocally regulate lymphatic vessel density by Lee, Kit M, Danuser, Renzo, Stein, Jens V, Graham, Delyth, Nibbs, Robert JB, Graham, Gerard J

“…Macrophages regulate lymphatic vasculature development; however, the molecular mechanisms regulating their recruitment to developing, and adult, lymphatic…”
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The atypical chemokine receptor CCX-CKR scavenges homeostatic chemokines in circulation and tissues and suppresses Th17 responses by Comerford, Iain, Nibbs, Robert J.B., Litchfield, Wendel, Bunting, Mark, Harata-Lee, Yuka, Haylock-Jacobs, Sarah, Forrow, Steve, Korner, Heinrich, McColl, Shaun R.

“…Our previous in vitro studies led to proposals that the atypical chemokine receptor CCX-CKR is a scavenger of CCR7 ligand homeostatic chemokines. In the…”
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A guide to chemokines and their receptors by Hughes, Catherine E., Nibbs, Robert J. B.

“…The chemokines (or chemotactic cytokines) are a large family of small, secreted proteins that signal through cell surface G protein‐coupled heptahelical…”
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CCX-CKR deficiency alters thymic stroma impairing thymocyte development and promoting autoimmunity by Bunting, Mark D., Comerford, Iain, Seach, Natalie, Hammett, Maree V., Asquith, Darren L., Körner, Heinrich, Boyd, Richard L., Nibbs, Robert J.B., McColl, Shaun R.

“…The atypical chemokine receptor CCX-CKR regulates bioavailability of CCL19, CCL21, and CCL25, homeostatic chemokines that play crucial roles in thymic…”
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D6 facilitates cellular migration and fluid flow to lymph nodes by suppressing lymphatic congestion by Lee, Kit Ming, McKimmie, Clive S., Gilchrist, Derek S., Pallas, Kenneth J., Nibbs, Robert J., Garside, Paul, McDonald, Victoria, Jenkins, Christopher, Ransohoff, Richard, Liu, LiPing, Milling, Simon, Cerovic, Vuk, Graham, Gerard J.

“…Lymphatic endothelial cells are important for efficient flow of antigen-bearing fluid and antigen-presenting cells (APCs) from peripheral sites to lymph nodes…”
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Atypical chemokine receptor ACKR2 mediates chemokine scavenging by primary human trophoblasts and can regulate fetal growth, placental structure, and neonatal mortality in mice by Teoh, Pek Joo, Menzies, Fiona M, Hansell, Chris A H, Clarke, Mairi, Waddell, Carolann, Burton, Graham J, Nelson, Scott M, Nibbs, Robert J B

“…Inflammatory chemokines produced in the placenta can direct the migration of placental leukocytes using chemokine receptors that decorate the surface of these…”
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Co-inhibition of TGF-β and PD-L1 pathways in a metastatic colorectal cancer mouse model triggers interferon responses, innate cells and T cells, alongside metabolic changes and tumor resistance by Nair, Reshmi, Lannagan, Tamsin R M, Jackstadt, Rene, Andrusaite, Anna, Cole, John, Boyne, Caitlin, Nibbs, Robert J B, Sansom, Owen J, Milling, Simon

“…Colorectal cancer (CRC) is the third most prevalent cancer worldwide with a high mortality rate (20-30%), especially due to metastasis to adjacent organs…”
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CCL19 is a specific ligand of the constitutively recycling atypical human chemokine receptor CRAM-B by Leick, Marion, Catusse, Julie, Follo, Marie, Nibbs, Robert J, Hartmann, Tanja N, Veelken, Hendrik, Burger, Meike

“…The human chemokine receptor CRAM (chemokine receptor on activated macrophages), encoded by the gene CCRL2, is a new candidate for the atypical chemokine…”
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Chemokine Scavenger D6 Is Expressed by Trophoblasts and Aids the Survival of Mouse Embryos Transferred into Allogeneic Recipients by Madigan, Judith, Freeman, Dilys J, Menzies, Fiona, Forrow, Steve, Nelson, Scott M, Young, Anne, Sharkey, Andrew, Moffett, Ashley, Graham, Gerard J, Greer, Ian A, Rot, Antal, Nibbs, Robert J. B

“…Proinflammatory CC chemokines are thought to drive recruitment of maternal leukocytes into gestational tissues and regulate extravillous trophoblast migration…”
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The Atypical Chemokine Receptor D6 Contributes to the Development of Experimental Colitis by Bordon, Yvonne, Hansell, Chris A. H, Sester, David P, Clarke, Mairi, Mowat, Allan McI, Nibbs, Robert J. B

“…Proinflammatory CC chemokines control leukocyte recruitment and function during inflammation by engaging chemokine receptors expressed on circulating…”
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Mass spectrometry imaging identifies palmitoylcarnitine as an immunological mediator during Salmonella Typhimurium infection by Hulme, Heather E., Meikle, Lynsey M., Wessel, Hannah, Strittmatter, Nicole, Swales, John, Thomson, Carolyn, Nilsson, Anna, Nibbs, Robert J. B., Milling, Simon, Andren, Per E., Mackay, C. Logan, Dexter, Alex, Bunch, Josephine, Goodwin, Richard J. A., Burchmore, Richard, Wall, Daniel M.

“…Salmonella Typhimurium causes a self-limiting gastroenteritis that may lead to systemic disease. Bacteria invade the small intestine, crossing the intestinal…”
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