Search Results - "NGUYEN, Tri Q"

Connective tissue growth factor (CTGF) from basics to clinics by Ramazani, Yasaman, Knops, Noël, Elmonem, Mohamed A., Nguyen, Tri Q., Arcolino, Fanny Oliveira, van den Heuvel, Lambert, Levtchenko, Elena, Kuypers, Dirk, Goldschmeding, Roel

“…Connective tissue growth factor, also known as CCN2, is a cysteine-rich matricellular protein involved in the control of biological processes, such as cell…”
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Diverse origins of the myofibroblast—implications for kidney fibrosis by Falke, Lucas L., Gholizadeh, Shima, Goldschmeding, Roel, Kok, Robbert J., Nguyen, Tri Q.

“…Key Points Myofibroblasts involved in kidney fibrosis might originate from diverse origins, including bone marrow-derived fibroblasts, tubular epithelial…”
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Targeting CTGF, EGF and PDGF pathways to prevent progression of kidney disease by Kok, Helena M., Falke, Lucas L., Goldschmeding, Roel, Nguyen, Tri Q.

“…Key Points During progression of chronic kidney disease, the sustained release of proinflammatory and profibrotic cytokines and growth factors leads to an…”
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Connective tissue growth factor regulates fibrosis-associated renal lymphangiogenesis by Kinashi, Hiroshi, Falke, Lucas L, Nguyen, Tri Q, Bovenschen, Niels, Aten, Jan, Leask, Andrew, Ito, Yasuhiko, Goldschmeding, Roel

“…Lymphangiogenesis is correlated with the degree of renal interstitial fibrosis. Pro-fibrotic transforming growth factor β induces VEGF-C production, the main…”
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Reversibility of Structural and Functional Damage in a Model of Advanced Diabetic Nephropathy by PICHAIWONG, Warangkana, HUDKINS, Kelly L, SHANKLAND, Stuart J, ALPERS, Charles E, WIETECHA, Tomasz, NGUYEN, Tri Q, TACHAUDOMDACH, Chiraporn, WEI LI, ASKARI, Bardia, KOBAYASHI, Takahisa, O'BRIEN, Kevin D, PIPPIN, Jeffrey W

“…The reversibility of diabetic nephropathy remains controversial. Here, we tested whether replacing leptin could reverse the advanced diabetic nephropathy…”
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Cellular Senescence and the Kidney: Potential Therapeutic Targets and Tools by Knoppert, Sebastian N, Valentijn, Floris A, Nguyen, Tri Q, Goldschmeding, Roel, Falke, Lucas L

“…Chronic kidney disease (CKD) is an increasing health burden (affecting approximately 13.4% of the population). Currently, no curative treatment options are…”
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The phenotypes of podocytes and parietal epithelial cells may overlap in diabetic nephropathy by Andeen, Nicole K, Nguyen, Tri Q, Steegh, Floor, Hudkins, Kelly L, Najafian, Behzad, Alpers, Charles E

“…Reversal of diabetic nephropathy (DN) has been achieved in humans and mice, but only rarely and under special circumstances. As progression of DN is related to…”
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Bone Morphogenetic Protein-7 and Connective Tissue Growth Factor: Novel Targets for Treatment of Renal Fibrosis? by Nguyen, Tri Q., Goldschmeding, Roel

“…Renal fibrosis is the major determinant in progression of kidney disease and results from an inappropriate response to acute and chronic kidney injury…”
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Connective tissue growth factor is correlated with peritoneal lymphangiogenesis by Kinashi, Hiroshi, Toda, Naohiro, Sun, Ting, Nguyen, Tri Q., Suzuki, Yasuhiro, Katsuno, Takayuki, Yokoi, Hideki, Aten, Jan, Mizuno, Masashi, Maruyama, Shoichi, Yanagita, Motoko, Goldschmeding, Roel, Ito, Yasuhiko

“…Lymphatic absorption in the peritoneal cavity may contribute to ultrafiltration failure in peritoneal dialysis (PD). Lymphatic vessels develop during…”
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A Human Conditionally Immortalized Proximal Tubule Epithelial Cell Line as a Novel Model for Studying Senescence and Response to Senolytics by Yang, Yi, Mihajlovic, Milos, Valentijn, Floris, Nguyen, Tri Q, Goldschmeding, Roel, Masereeuw, Rosalinde

“…Accumulating evidence suggests that senescence of kidney tubule epithelial cells leads to fibrosis. These cells secrete senescence-associated secretory…”
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Ccn2 Deletion Reduces Cardiac Dysfunction, Oxidative Markers, and Fibrosis Induced by Doxorubicin Administration in Mice by Tejera-Muñoz, Antonio, Cortés, Marcelino, Rodriguez-Rodriguez, Alianet, Tejedor-Santamaria, Lucia, Marchant, Vanessa, Rayego-Mateos, Sandra, Gimeno-Longas, Maria José, Leask, Andrew, Nguyen, Tri Q, Martín, María, Tuñón, Jose, Rodríguez, Isabel, Ruiz-Ortega, Marta, Rodrigues-Díez, Raul R

“…Cellular Communication Network Factor 2 (CCN2) is a matricellular protein implicated in cell communication and microenvironmental signaling. Overexpression of…”
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Nephronophthisis-associated CEP164 regulates cell cycle progression, apoptosis and epithelial-to-mesenchymal transition by Slaats, Gisela G, Ghosh, Amiya K, Falke, Lucas L, Le Corre, Stéphanie, Shaltiel, Indra A, van de Hoek, Glenn, Klasson, Timothy D, Stokman, Marijn F, Logister, Ive, Verhaar, Marianne C, Goldschmeding, Roel, Nguyen, Tri Q, Drummond, Iain A, Hildebrandt, Friedhelm, Giles, Rachel H

“…We recently reported that centrosomal protein 164 (CEP164) regulates both cilia and the DNA damage response in the autosomal recessive polycystic kidney…”
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Deep learning-based classification of kidney transplant pathology: a retrospective, multicentre, proof-of-concept study by Kers, Jesper, Bülow, Roman D, Klinkhammer, Barbara M, Breimer, Gerben E, Fontana, Francesco, Abiola, Adeyemi Adefidipe, Hofstraat, Rianne, Corthals, Garry L, Peters-Sengers, Hessel, Djudjaj, Sonja, von Stillfried, Saskia, Hölscher, David L, Pieters, Tobias T, van Zuilen, Arjan D, Bemelman, Frederike J, Nurmohamed, Azam S, Naesens, Maarten, Roelofs, Joris J T H, Florquin, Sandrine, Floege, Jürgen, Nguyen, Tri Q, Kather, Jakob N, Boor, Peter

“…Histopathological assessment of transplant biopsies is currently the standard method to diagnose allograft rejection and can help guide patient management, but…”
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A panel of novel biomarkers representing different disease pathways improves prediction of renal function decline in type 2 diabetes by Pena, Michelle J, Heinzel, Andreas, Heinze, Georg, Alkhalaf, Alaa, Bakker, Stephan J L, Nguyen, Tri Q, Goldschmeding, Roel, Bilo, Henk J G, Perco, Paul, Mayer, Bernd, de Zeeuw, Dick, Lambers Heerspink, Hiddo J

“…We aimed to identify a novel panel of biomarkers predicting renal function decline in type 2 diabetes, using biomarkers representing different disease pathways…”
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CONFIDENT-trial protocol: a pragmatic template for clinical implementation of artificial intelligence assistance in pathology by Flach, Rachel N, Stathonikos, Nikolas, Nguyen, Tri Q, Ter Hoeve, Natalie D, van Diest, Paul J, van Dooijeweert, Carmen

“…IntroductionArtificial intelligence (AI) has been on the rise in the field of pathology. Despite promising results in retrospective studies, and several CE-IVD…”
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CTGF Inhibits BMP-7 Signaling in Diabetic Nephropathy by NGUYEN, Tri Q, ROESTENBERG, Peggy, BRANDAN, Enrique, LYONS, Karen M, GOLDSCHMEDING, Roel, VAN NIEUWENHOVEN, Frans A, BOVENSCHEN, Niels, ZEKE LI, XU, Leon, OLIVER, Noelynn, ATEN, Jan, JOLES, Jaap A, VIAL, Cecilia

“…In diabetic nephropathy, connective tissue growth factor (CTGF) is upregulated and bone morphogenetic protein 7 (BMP-7) is downregulated. CTGF is known to…”
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Age-dependent shifts in renal response to injury relate to altered BMP6/CTGF expression and signaling by Falke, Lucas L, Kinashi, Hiroshi, Dendooven, Amelie, Broekhuizen, Roel, Stoop, Reinout, Joles, Jaap A, Nguyen, Tri Q, Goldschmeding, Roel

“…Age is associated with an increased prevalence of chronic kidney disease (CKD), which, through progressive tissue damage and fibrosis, ultimately leads to loss…”
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Deep learning supported mitoses counting on whole slide images: A pilot study for validating breast cancer grading in the clinical workflow by van Bergeijk, Stijn A., Stathonikos, Nikolas, ter Hoeve, Natalie D., Lafarge, Maxime W., Nguyen, Tri Q., van Diest, Paul J., Veta, Mitko

“…Breast cancer (BC) prognosis is largely influenced by histopathological grade, assessed according to the Nottingham modification of Bloom-Richardson (BR)…”
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CCN2 Aggravates the Immediate Oxidative Stress-DNA Damage Response following Renal Ischemia-Reperfusion Injury by Valentijn, Floris A, Knoppert, Sebastiaan N, Pissas, Georgios, Rodrigues-Diez, Raúl R, Marquez-Exposito, Laura, Broekhuizen, Roel, Mokry, Michal, Kester, Lennart A, Falke, Lucas L, Goldschmeding, Roel, Ruiz-Ortega, Marta, Eleftheriadis, Theodoros, Nguyen, Tri Q

“…AKI, due to the fact of altered oxygen supply after kidney transplantation, is characterized by renal ischemia-reperfusion injury (IRI). Recent data suggest…”
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CCN2 Activates RIPK3, NLRP3 Inflammasome, and NRF2/Oxidative Pathways Linked to Kidney Inflammation by Rayego-Mateos, Sandra, Marquez-Exposito, Laura, Basantes, Pamela, Tejedor-Santamaria, Lucia, Sanz, Ana B., Nguyen, Tri Q., Goldschmeding, Roel, Ortiz, Alberto, Ruiz-Ortega, Marta

“…Inflammation is a key characteristic of both acute and chronic kidney diseases. Preclinical data suggest the involvement of the NLRP3/Inflammasome,…”
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