Search Results - "NEYSES, Ludwig"

The role of metabolites and metabolomics in clinically applicable biomarkers of disease by Mamas, Mamas, Dunn, Warwick B., Neyses, Ludwig, Goodacre, Royston

“…Metabolomics allows the simultaneous and relative quantification of thousands of different metabolites within a given sample using sensitive and specific…”
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Automated workflows for accurate mass-based putative metabolite identification in LC/MS-derived metabolomic datasets by BROWN, Marie, WEDGE, David C, GOODACRE, Royston, KELL, Douglas B, BAKER, Philip N, KENNY, Louise C, MAMAS, Mamas A, NEYSES, Ludwig, DUNN, Warwick B

“…The study of metabolites (metabolomics) is increasingly being applied to investigate microbial, plant, environmental and mammalian systems. One of the limiting…”
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Role of advanced glycation end products in cardiovascular disease by Hegab, Zeinab, Gibbons, Stephen, Neyses, Ludwig, Mamas, Mamas A

“…Advanced glycation end products(AGEs) are produced through the non enzymatic glycation and oxidation of proteins,lipids and nucleic acids.Enhanced formation of…”
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A meta-analysis of the prognostic significance of atrial fibrillation in chronic heart failure by Mamas, Mamas A., Caldwell, Jane C., Chacko, Sanoj, Garratt, Clifford J., Fath-Ordoubadi, Farzin, Neyses, Ludwig

“…Aims Atrial fibrillation (AF) is one of the commonest sustained arrhythmias in chronic heart failure (CHF), although the prognostic implications of the…”
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The plasma membrane calcium ATPase 4 signalling in cardiac fibroblasts mediates cardiomyocyte hypertrophy by Mohamed, Tamer M. A., Abou-Leisa, Riham, Stafford, Nicholas, Maqsood, Arfa, Zi, Min, Prehar, Sukhpal, Baudoin-Stanley, Florence, Wang, Xin, Neyses, Ludwig, Cartwright, Elizabeth J., Oceandy, Delvac

“…The heart responds to pathological overload through myocyte hypertrophy. Here we show that this response is regulated by cardiac fibroblasts via a paracrine…”
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The effects of the cardiac myosin activator, omecamtiv mecarbil, on cardiac function in systolic heart failure: a double-blind, placebo-controlled, crossover, dose-ranging phase 2 trial by Cleland, John GF, Prof, Teerlink, John R, Prof, Senior, Roxy, Prof, Nifontov, Evgeny M, Prof, Mc Murray, John JV, Prof, Lang, Chim C, Prof, Tsyrlin, Vitaly A, Prof, Greenberg, Barry H, Prof, Mayet, Jamil, MD, Francis, Darrel P, MD, Shaburishvili, Tamaz, MD, Monaghan, Mark, PhD, Saltzberg, Mitchell, MD, Neyses, Ludwig, Prof, Wasserman, Scott M, MD, Lee, Jacqueline H, Saikali, Khalil G, PhD, Clarke, Cyril P, MBBS, Goldman, Jonathan H, MD, Wolff, Andrew A, MD, Malik, Fady I, MD

“…Summary Background Many patients with heart failure remain symptomatic and have a poor prognosis despite existing treatments. Decreases in myocardial…”
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PMCA4 inhibition does not affect cardiac remodelling following myocardial infarction, but may reduce susceptibility to arrhythmia by Stafford, Nicholas, Zi, Min, Baudoin, Florence, Mohamed, Tamer M. A., Prehar, Sukhpal, De Giorgio, Daria, Cartwright, Elizabeth J., Latini, Roberto, Neyses, Ludwig, Oceandy, Delvac

“…Ischaemic heart disease is the world’s leading cause of mortality. Survival rates from acute myocardial infarction (MI) have improved in recent years; however,…”
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Perturbations in cardiac metabolism in a human model of acute myocardial ischaemia by Chacko, Sanoj, Mamas, Mamas A., El-Omar, Magdi, Simon, David, Haseeb, Sohaib, Fath-ordoubadi, Farzin, Clarke, Bernard, Neyses, Ludwig, Dunn, Warwick B.

“…Introduction Acute myocardial ischaemia and the transition from reversible to irreversible myocardial injury are associated with abnormal metabolic patterns…”
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Pak1 as a novel therapeutic target for antihypertrophic treatment in the heart by Liu, Wei, Zi, Min, Naumann, Ronald, Ulm, Susanne, Jin, Jiawei, Taglieri, Domenico M, Prehar, Sukhpal, Gui, Junhong, Tsui, Hoyee, Xiao, Rui-Ping, Neyses, Ludwig, Solaro, R John, Ke, Yunbo, Cartwright, Elizabeth J, Lei, Ming, Wang, Xin

“…Stress-induced hypertrophic remodeling is a critical pathogenetic process leading to heart failure. Although many signal transduction cascades are demonstrated…”
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Targeted Deletion of the Extracellular Signal-Regulated Protein Kinase 5 Attenuates Hypertrophic Response and Promotes Pressure Overload–Induced Apoptosis in the Heart by Kimura, Tomomi E, Jin, Jiawei, Zi, Min, Prehar, Sukhpal, Liu, Wei, Oceandy, Delvac, Abe, Jun-ichi, Neyses, Ludwig, Weston, Arthur H, Cartwright, Elizabeth J, Wang, Xin

“…RATIONALE:Mitogen-activated protein kinase (MAPK) pathways provide a critical connection between extrinsic and intrinsic signals to cardiac hypertrophy…”
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Absence of α7 integrin in dystrophin-deficient mice causes a myopathy similar to Duchenne muscular dystrophy by Guo, Chun, Willem, Michael, Werner, Alexander, Raivich, Gennadij, Emerson, Michael, Neyses, Ludwig, Mayer, Ulrike

“…Both the dystrophin–glycoprotein complex and α7β1 integrin have critical roles in the maintenance of muscle integrity via the provision of mechanical links…”
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A novel immunomodulator, FTY-720 reverses existing cardiac hypertrophy and fibrosis from pressure overload by targeting NFAT (nuclear factor of activated T-cells) signaling and periostin by Liu, Wei, Zi, Min, Tsui, Hoyee, Chowdhury, Sanjoy K, Zeef, Leo, Meng, Qing-Jun, Travis, Mark, Prehar, Sukhpal, Berry, Andrew, Hanley, Neil A, Neyses, Ludwig, Xiao, Rui-Ping, Oceandy, Delvac, Ke, Yunbo, Solaro, R John, Cartwright, Elizabeth J, Lei, Ming, Wang, Xin

“…Hypertension or aortic stenosis causes pressure overload, which evokes hypertrophic myocardial growth. Sustained cardiac hypertrophy eventually progresses to…”
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Plasma Membrane Ca2+ ATPase 4 Is Required for Sperm Motility and Male Fertility by Schuh, Kai, Cartwright, Elizabeth J, Jankevics, Eriks, Bundschu, Karin, Liebermann, Jürgen, Williams, Judith C, Armesilla, Angel L, Emerson, Michael, Oceandy, Delvac, Knobeloch, Klaus-Peter, Neyses, Ludwig

“…Calcium and Ca 2+ -dependent signals play a crucial role in sperm motility and mammalian fertilization, but the molecules and mechanisms underlying these Ca 2+…”
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Cardiac hypertrophy or failure? - A systematic evaluation of the transverse aortic constriction model in C57BL/6NTac and C57BL/6J substrains by Zi, Min, Stafford, Nicholas, Prehar, Sukhpal, Baudoin, Florence, Oceandy, Delvac, Wang, Xin, Bui, Thuy, Shaheen, Mohamed, Neyses, Ludwig, Cartwright, Elizabeth J.

“…The mouse model of transverse aortic constriction (TAC) has been widely used as a cardiac stress in the investigation of the molecular mechanisms of cardiac…”
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Development and characterization of a novel fluorescent indicator protein PMCA4-GCaMP2 in cardiomyocytes by Mohamed, Tamer M.A, Abou-Leisa, Riham, Baudoin, Florence, Stafford, Nicholas, Neyses, Ludwig, Cartwright, Elizabeth J, Oceandy, Delvac

“…Abstract Isoform 4 of the plasma membrane calcium/calmodulin dependent ATPase (PMCA4) has recently emerged as an important regulator of several key…”
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Endothelial nitric oxide synthase activity is inhibited by the plasma membrane calcium ATPase in human endothelial cells by Holton, MaryLouisa, Mohamed, Tamer M.A., Oceandy, Delvac, Wang, Weiguang, Lamas, Santiago, Emerson, Michael, Neyses, Ludwig, Armesilla, Angel L.

“…Aims Nitric oxide (NO) plays a pivotal role in the regulation of cardiovascular physiology. Endothelial NO is mainly produced by the endothelial nitric oxide…”
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Outcomes in patients with acute and stable coronary syndromes; insights from the prospective NOBORI-2 study by Fath-Ordoubadi, Farzin, Spaepen, Erik, El-Omar, Magdi, Fraser, Douglas G, Khan, Muhammad A, Neyses, Ludwig, Danzi, Gian B, Roguin, Ariel, Paunovic, Dragica, Mamas, Mamas A

“…Contemporary data remains limited regarding mortality and major adverse cardiac events (MACE) outcomes in patients undergoing PCI for different manifestations…”
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Conditional Neuronal Nitric Oxide Synthase Overexpression Impairs Myocardial Contractility by Burkard, Natalie, Rokita, Adam G, Kaufmann, Susann G, Hallhuber, Matthias, Wu, Rongxue, Hu, Kai, Hofmann, Ulrich, Bonz, Andreas, Frantz, Stefan, Cartwright, Elizabeth J, Neyses, Ludwig, Maier, Lars S, Maier, Sebastian K.G, Renné, Thomas, Schuh, Kai, Ritter, Oliver

“…The role of the neuronal NO synthase (nNOS or NOS1) enzyme in the control of cardiac function still remains unclear. Results from nNOS mice or from…”
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The molecular basis of myocardial hypertrophy and heart failure by Ritter, Oliver, Neyses, Ludwig

“…Heart failure (HF) is the inability of the heart to cope with the metabolic demands of the periphery. It is the common end-stage of many frequent cardiac…”
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Pacing-induced cardiomyopathy: pathophysiological insights through matrix metalloproteinases by Ahmed, Fozia Z., Khattar, Rajdeep S., Zaidi, Amir M., Neyses, Ludwig, Oceandy, Delvac, Mamas, Mamas

“…Pacing-induced ventricular dysfunction and pacing-induced cardiomyopathy (PiCMP) are recognized complications of chronic right ventricular pacing. Alterations…”
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