Search Results - "NEWTON, DARREN J."

Early Emergence of CD19-Negative Human Antibody-Secreting Cells at the Plasmablast to Plasma Cell Transition by Arumugakani, Gururaj, Stephenson, Sophie J, Newton, Darren J, Rawstron, Andy, Emery, Paul, Doody, Gina M, McGonagle, Dennis, Tooze, Reuben M

“…Long-lived human plasma cells (PCs) play central roles in immunity and autoimmunity and are enriched among the subpopulation of CD19 human PCs. However,…”
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Intestinal intraepithelial lymphocyte-enterocyte crosstalk regulates production of bactericidal angiogenin 4 by Paneth cells upon microbial challenge by Walker, Catherine R, Hautefort, Isabelle, Dalton, Jane E, Overweg, Karin, Egan, Charlotte E, Bongaerts, Roy J, Newton, Darren J, Cruickshank, Sheena M, Andrew, Elizabeth M, Carding, Simon R

“…Antimicrobial proteins influence intestinal microbial ecology and limit proliferation of pathogens, yet the regulation of their expression has only been…”
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The prothrombotic state in paroxysmal nocturnal hemoglobinuria: a multifaceted source by Peacock-Young, Barnaby, Macrae, Fraser L, Newton, Darren J, Hill, Anita, Ariëns, Robert A S

“…Paroxysmal nocturnal hemoglobinuria is a rare acquired hematologic disorder, the most serious complication of which is thrombosis. The increased incidence of…”
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subset of IL-10-producing γδ T cells protect the liver from Listeria-elicited, CD8⁺ T cell-mediated injury by Rhodes, Katherine A, Andrew, Elizabeth M, Newton, Darren J, Tramonti, Daniela, Carding, Simon R

“…Although γδ T cells play a role in protecting tissues from pathogen-elicited damage to bacterial, viral and parasitic pathogens, the mechanisms involved in the…”
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The second to fourth digit ratio and variation in the androgen receptor gene by Manning, John T., Bundred, Peter E., Newton, Darren J., Flanagan, Brian F.

“…The second to fourth digit ratio (2D:4D) is sexually dimorphic, with lower mean values in males compared to females. It has been suggested that the sex…”
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Evidence for the involvement of lung‐specific γδ T cell subsets in local responses to Streptococcus pneumoniae infection by Kirby, Alun C., Newton, Darren J., Carding, Simon R., Kaye, Paul M.

“…Although γδ T cells are involved in the response to many pathogens, the dynamics and heterogeneity of the local γδ T cell response remains poorly defined. We…”
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Minimal residual disease is an independent predictor for 10-year survival in CLL by Kwok, Marwan, Rawstron, Andy C., Varghese, Abraham, Evans, Paul A.S., O'Connor, Sheila J.M., Doughty, Chi, Newton, Darren J., Moreton, Paul, Hillmen, Peter

“…Minimal residual disease (MRD) negativity, defined as <1 chronic lymphocytic leukemia (CLL) cell detectable per 10 000 leukocytes, has been shown to…”
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Exploratory Study of MYD88 L265P, Rare NLRP3 Variants, and Clonal Hematopoiesis Prevalence in Patients With Schnitzler Syndrome by Pathak, Shelly, Rowczenio, Dorota M., Owen, Roger G., Doody, Gina M., Newton, Darren J., Taylor, Claire, Taylor, Jan, Cargo, Catherine, Hawkins, Philip N., Krause, Karoline, Lachmann, Helen J., Savic, Sinisa

“…Objective To assess the prevalence of the MYD88 L265P mutation and variants within NLRP3 and evaluate the status of oligoclonal hematopoiesis in 30 patients…”
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Immunophenotypic assessment of PNH clones in major and minor cell lineages in the peripheral blood of patients with paroxysmal nocturnal hemoglobinuria by Richards, Stephen J., Dickinson, Anita J., Newton, Darren J., Hillmen, Peter

“…Background Flow cytometric immunophenotyping is essential for the diagnosis of paroxysmal nocturnal hemoglobinuria (PNH). Most cases have easy to interpret…”
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The incidence and prevalence of patients with paroxysmal nocturnal haemoglobinuria and aplastic anaemia PNH syndrome: A retrospective analysis of the UK’s population‐based haematological malignancy research network 2004‐2018 by Richards, Stephen J., Painter, Daniel, Dickinson, Anita J., Griffin, Morag, Munir, Talha, Arnold, Louise, Payne, Daniel, Pike, Alexandra, Muus, Petra, Hill, Anita, Newton, Darren J., McKinley, Claire, Jones, Rachael, Kelly, Richard, Smith, Alex, Roman, Eve, Hillmen, Peter

“…Objectives A retrospective population‐based study to determine the incidence and prevalence of patients with the rare blood disease paroxysmal nocturnal…”
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Presentation clinical, haematological and immunophenotypic features of 1081 patients with GPI‐deficient (paroxysmal nocturnal haemoglobinuria) cells detected by flow cytometry by Richards, Stephen J., Dickinson, Anita J., Cullen, Matthew J., Griffin, Morag, Munir, Tahla, McKinley, Claire, Mitchell, Lindsay D., Newton, Darren J., Arnold, Louise, Hill, Anita, Hillmen, Peter

“…Summary A retrospective analysis of presentation clinical, laboratory and immunophenotypic features of 1 081 patients with paroxysmal nocturnal haemoglobinuria…”
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Identification of Novel γδ T-Cell Subsets following Bacterial Infection in the Absence of Vγ1+ T Cells: Homeostatic Control of γδ T-Cell Responses to Pathogen Infection by Vγ1+ T Cells by NEWTON, Darren J, ANDREW, Elizabeth M, DALTON, Jane E, MEARS, Rainy, CARDING, Simon R

“…AUTHOR'S CORRECTION ( vol. 76 , p. 863 ) Classifications Services IAI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike…”
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Neoadjuvant Intravenous Oncolytic Vaccinia Virus Therapy Promotes Anticancer Immunity in Patients by Samson, Adel, West, Emma J, Carmichael, Jonathan, Scott, Karen J, Turnbull, Samantha, Kuszlewicz, Bethany, Dave, Rajiv V, Peckham-Cooper, Adam, Tidswell, Emma, Kingston, Jennifer, Johnpulle, Michelle, da Silva, Barbara, Jennings, Victoria A, Bendjama, Kaidre, Stojkowitz, Nicolas, Lusky, Monika, Prasad, K R, Toogood, Giles J, Auer, Rebecca, Bell, John, Twelves, Chris J, Harrington, Kevin J, Vile, Richard G, Pandha, Hardev, Errington-Mais, Fiona, Ralph, Christy, Newton, Darren J, Anthoney, Alan, Melcher, Alan A, Collinson, Fiona

“…Improving the chances of curing patients with cancer who have had surgery to remove metastatic sites of disease is a priority area for cancer research…”
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Patients with paroxysmal nocturnal hemoglobinuria demonstrate a prothrombotic clotting phenotype which is improved by complement inhibition with eculizumab by Macrae, Fraser L., Peacock‐Young, Barnaby, Bowman, Polly, Baker, Stephen R., Quested, Sam, Linton, Emma, Hillmen, Peter, Griffin, Morag, Munir, Talha, Payne, Daniel, McKinley, Claire, Clarke, Deborah, Newton, Darren J, Hill, Anita, Ariëns, Robert A. S.

“…Paroxysmal nocturnal hemoglobinuria (PNH) is a rare hematological disorder, characterized by complement‐mediated intravascular hemolysis and thrombosis. The…”
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Intraepithelial γδ + Lymphocytes Maintain the Integrity of Intestinal Epithelial Tight Junctions in Response to Infection by Dalton, Jane E., Cruickshank, Sheena M., Egan, Charlotte E., Mears, Rainy, Newton, Darren J., Andrew, Elizabeth M., Lawrence, Beth, Howell, Gareth, Else, Kathryn J., Gubbels, Marc–Jan, Striepen, Boris, Smith, Judith E., White, Stanley J., Carding, Simon R.

“…Background & Aims: Intestinal epithelial integrity and permeability is dependent on intercellular tight junction (TJ) complexes. How TJ integrity is regulated…”
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Evidence for the opposing roles of different γδ T cell subsets in macrophage homeostasis by Tramonti, Daniela, Andrew, Elizabeth M., Rhodes, Kate, Newton, Darren J., Carding, Simon R.

“…To ensure invading pathogens are eliminated with minimal damage to host tissues it is essential that macrophage activation be tightly regulated. Previously we…”
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Evidence for the opposing roles of different gamma delta T cell subsets in macrophage homeostasis by Tramonti, Daniela, Andrew, Elizabeth M, Rhodes, Kate, Newton, Darren J, Carding, Simon R

“…To ensure invading pathogens are eliminated with minimal damage to host tissues it is essential that macrophage activation be tightly regulated. Previously we…”
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MCP-1 but not CINC synthesis is increased in rat pancreatic acini in response to cerulein hyperstimulation by Bhatia, Madhav, Brady, Mark, Kang, Yun Kyung, Costello, Eithne, Newton, Darren J, Christmas, Stephen E, Neoptolemos, John P, Slavin, John

“…Inflammatory mediators including chemokines play a critical role in acute pancreatitis. The precise nature of early inflammatory signals within the pancreas…”
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Natural Killer Cell Receptor Expression by Human First Trimester Decidual Granular Leukocytes and T-Lymphocytes by LEWIS, BARRY J., CROKER, SIMON, NEWTON, DARREN J., LENNON, GREIG P., JOHNSON, PETER M., CHRISTMAS, STEPHEN E.

“…PROBLEM: Detailed analysis of the expression of natural killer (NK) cell activatory and inhibitory receptors by human decidual leukocyte subpopulations has not…”
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Exploratory Study of MYD 88 L265P, Rare NLRP 3 Variants, and Clonal Hematopoiesis Prevalence in Patients With Schnitzler Syndrome by Pathak, Shelly, Rowczenio, Dorota M., Owen, Roger G., Doody, Gina M., Newton, Darren J., Taylor, Claire, Taylor, Jan, Cargo, Catherine, Hawkins, Philip N., Krause, Karoline, Lachmann, Helen J., Savic, Sinisa

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