Search Results - "NEWMAN, JOHN W"

Perinatal exposure of mice to the pesticide DDT impairs energy expenditure and metabolism in adult female offspring by La Merrill, Michele, Karey, Emma, Moshier, Erin, Lindtner, Claudia, La Frano, Michael R, Newman, John W, Buettner, Christoph

“…Dichlorodiphenyltrichloroethane (DDT) has been used extensively to control malaria, typhus, body lice and bubonic plague worldwide, until countries began…”
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Plasma Metabolomic Profiles Reflective of Glucose Homeostasis in Non-Diabetic and Type 2 Diabetic Obese African-American Women by Fiehn, Oliver, Garvey, W. Timothy, Newman, John W, Lok, Kerry H, Hoppel, Charles L, Adams, Sean H, Gimble, Jeffrey M

“…Insulin resistance progressing to type 2 diabetes mellitus (T2DM) is marked by a broad perturbation of macronutrient intermediary metabolism. Understanding the…”
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Saturated fatty acids activate TLR-mediated proinflammatory signaling pathways[S] by Huang, Shurong, Rutkowsky, Jennifer M., Snodgrass, Ryan G., Ono-Moore, Kikumi D., Schneider, Dina A., Newman, John W., Adams, Sean H., Hwang, Daniel H.

“…Toll-like receptor 4 (TLR4) and TLR2 were shown to be activated by saturated fatty acids (SFAs) but inhibited by docosahexaenoic acid (DHA). However, one…”
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Human Serum Metabolome by Psychogios, Nikolaos, Hau, David D, Peng, Jun, Guo, An Chi, Mandal, Rupasri, Bouatra, Souhaila, Sinelnikov, Igor, Krishnamurthy, Ramanarayan, Eisner, Roman, Gautam, Bijaya, Young, Nelson, Xia, Jianguo, Knox, Craig, Dong, Edison, Huang, Paul, Hollander, Zsuzsanna, Pedersen, Theresa L, Smith, Steven R, Bamforth, Fiona, Greiner, Russ, McManus, Bruce, Newman, John W, Goodfriend, Theodore, Wishart, David S, Flower, Darren

“…Continuing improvements in analytical technology along with an increased interest in performing comprehensive, quantitative metabolic profiling, is leading to…”
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Resistant Starch Type 2 from Wheat Reduces Postprandial Glycemic Response with Concurrent Alterations in Gut Microbiota Composition by Hughes, Riley L, Horn, William H, Finnegan, Peter, Newman, John W, Marco, Maria L, Keim, Nancy L, Kable, Mary E

“…The majority of research on the physiological effects of dietary resistant starch type 2 (RS2) has focused on sources derived from high-amylose maize. In this…”
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Lipid profiling following intake of the omega 3 fatty acid DHA identifies the peroxidized metabolites F4-neuroprostanes as the best predictors of atherosclerosis prevention by Gladine, Cécile, Newman, John W, Durand, Thierry, Pedersen, Theresa L, Galano, Jean-Marie, Demougeot, Céline, Berdeaux, Olivier, Pujos-Guillot, Estelle, Mazur, Andrzej, Comte, Blandine

“…The anti-atherogenic effects of omega 3 fatty acids, namely eicosapentaenoic (EPA) and docosahexaenoic acids (DHA) are well recognized but the impact of…”
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Aberrant fatty acid metabolism in skeletal muscle contributes to insulin resistance in zinc transporter 7 (znt7)-knockout mice by Huang, Liping, Tepaamorndech, Surapun, Kirschke, Catherine P., Newman, John W., Keyes, William R., Pedersen, Theresa L., Dumnil, Jureeporn

“…ZnT7 (Slc30a7) is a widely expressed zinc transporter involved in sequestration of zinc into the Golgi apparatus and vesicular compartments. znt7-knockout (KO)…”
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Harmonized procedures lead to comparable quantification of total oxylipins across laboratories by Mainka, Malwina, Dalle, Céline, Pétéra, Mélanie, Dalloux-Chioccioli, Jessica, Kampschulte, Nadja, Ostermann, Annika I., Rothe, Michael, Bertrand-Michel, Justine, Newman, John W., Gladine, Cécile, Schebb, Nils Helge

“…Oxylipins are potent lipid mediators involved in a variety of physiological processes. Their profiling has the potential to provide a wealth of information…”
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Unveiling the "hidden quality" of the walnut pellicle: a precious source of bioactive lipids by Abbattista, Ramona, Feinberg, Noah G, Snodgrass, Isabel F, Newman, John W, Dandekar, Abhaya M

“…Tree nut consumption has been widely associated with various health benefits, with walnuts, in particular, being linked with improved cardiovascular and…”
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Type 2 Diabetes Associated Changes in the Plasma Non-Esterified Fatty Acids, Oxylipins and Endocannabinoids by Grapov, Dmitry, Adams, Sean H, Pedersen, Theresa L, Garvey, W. Timothy, Newman, John W, Schunck, Wolf-Hagen

“…Type 2 diabetes has profound effects on metabolism that can be detected in plasma. While increases in circulating non-esterified fatty acids (NEFA) are…”
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Quantitative profiling of oxylipins through comprehensive LC-MS/MS analysis: application in cardiac surgery by Strassburg, Katrin, Huijbrechts, Annemarie M. L., Kortekaas, Kirsten A., Lindeman, Jan H., Pedersen, Theresa L., Dane, Adrie, Berger, Ruud, Brenkman, Arjan, Hankemeier, Thomas, van Duynhoven, John, Kalkhoven, Eric, Newman, John W., Vreeken, Rob J.

“…Oxylipins, including eicosanoids, affect a broad range of biological processes, such as the initiation and resolution of inflammation. These compounds, also…”
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Triglyceride-rich lipoprotein lipolysis releases neutral and oxidized FFAs that induce endothelial cell inflammation by Wang, Limin, Gill, Rajan, Pedersen, Theresa L., Higgins, Laura J., Newman, John W., Rutledge, John C.

“…Triglyceride-rich lipoprotein (TGRL) lipolysis products provide a pro-inflammatory stimulus that can alter endothelial barrier function. To probe the mechanism…”
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Mid-gestation serum lipidomic profile associations with spontaneous preterm birth are influenced by body mass index by Borkowski, Kamil, Newman, John W, Aghaeepour, Nima, Mayo, Jonathan A, Blazenović, Ivana, Fiehn, Oliver, Stevenson, David K, Shaw, Gary M, Carmichael, Suzan L

“…Spontaneous preterm birth (sPTB) is a major cause of infant morbidity and mortality. While metabolic changes leading to preterm birth are unknown, several…”
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Serum metabolomic biomarkers of perceptual speed in cognitively normal and mildly impaired subjects with fasting state stratification by Borkowski, Kamil, Taha, Ameer Y., Pedersen, Theresa L., De Jager, Philip L., Bennett, David A., Arnold, Matthias, Kaddurah-Daouk, Rima, Newman, John W.

“…Cognitive decline is associated with both normal aging and early pathologies leading to dementia. Here we used quantitative profiling of metabolites involved…”
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Sweat lipid mediator profiling: a noninvasive approach for cutaneous research by Agrawal, Karan, Hassoun, Lauren A., Foolad, Negar, Pedersen, Theresa L., Sivamani, Raja K., Newman, John W.

“…Recent advances in analytical and sweat collection techniques provide new opportunities to identify noninvasive biomarkers for the study of skin inflammation…”
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Phospholipase A2 reduction ameliorates cognitive deficits in a mouse model of Alzheimer's disease by Sanchez-Mejia, Rene O, Newman, John W, Toh, Sandy, Yu, Gui-Qiu, Zhou, Yungui, Halabisky, Brian, Cissé, Moustapha, Scearce-Levie, Kimberly, Cheng, Irene H, Gan, Li, Palop, Jorge J, Bonventre, Joseph V, Mucke, Lennart

“…The contribution of fatty acids to Alzheimer's disease pathogenesis is unclear. The authors identify an increase in arachadonic acid and its metabolites in a…”
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Dietary Docosahexaenoic Acid and Glucose Systemic Metabolic Changes in the Mouse by Watkins, Bruce A, Newman, John W, Kuchel, George A, Fiehn, Oliver, Kim, Jeffrey

“…The endocannabinoid system (ECS) participates in regulating whole body energy balance. Overactivation of the ECS has been associated with the negative…”
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Integration of plasma and CSF metabolomics with CSF proteomic reveals novel associations between lipid mediators and central nervous system vascular and energy metabolism by Borkowski, Kamil, Seyfried, Nicholas T., Arnold, Matthias, Lah, James J., Levey, Allan I., Hales, Chadwick M., Dammer, Eric B., Blach, Colette, Louie, Gregory, Kaddurah-Daouk, Rima, Newman, John W.

“…Integration of the omics data, including metabolomics and proteomics, provides a unique opportunity to search for new associations within metabolic disorders,…”
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Associations of microbial and indoleamine-2,3-dioxygenase-derived tryptophan metabolites with immune activation in healthy adults by Riazati, Niknaz, Kable, Mary E, Newman, John W, Adkins, Yuriko, Freytag, Tammy, Jiang, Xiaowen, Stephensen, Charles B

“…Tryptophan (Trp) metabolites from intestinal bacteria (indole, indole acetic acid [IAA] and indole propionic acid [IPA]), and the Trp metabolite kynurenine…”
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Detection of omega-3 oxylipins in human plasma and response to treatment with omega-3 acid ethyl esters by Shearer, Gregory C, Harris, William S, Pedersen, Theresa L, Newman, John W

“…The long-chain omega-3 fatty acids (n-3 FA) eicosapentaenoic acid (EPA) and docosahexaenoic acids (DHA) have beneficial health effects, but the molecular…”
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