Search Results - "NEWELL, D. R"

Editorial Expression of Concern: Pre-clinical evaluation of cyclin-dependent kinase 2 and 1 inhibition in anti-estrogen-sensitive and resistant breast cancer cells by Johnson, N., Bentley, J., Wang, L-Z, Newell, D. R., Robson, C. N., Shapiro, G. I., Curtin, N. J.

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The synergistic interaction of MEK and PI3K inhibitors is modulated by mTOR inhibition by Haagensen, E J, Kyle, S, Beale, G S, Maxwell, R J, Newell, D R

“…Background: Combined targeting of MAPK and PI3K signalling pathways may be necessary for optimal therapeutic activity in cancer. This study evaluated the MEK…”
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Structurally diverse MDM2–p53 antagonists act as modulators of MDR-1 function in neuroblastoma by Chen, L, Zhao, Y, Halliday, G C, Berry, P, Rousseau, R F, Middleton, S A, Nichols, G L, Del Bello, F, Piergentili, A, Newell, D R, Lunec, J, Tweddle, D A

“…Background: A frequent mechanism of acquired multidrug resistance in human cancers is overexpression of ATP-binding cassette transporters such as the…”
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Thiothymidine combined with UVA as a potential novel therapy for bladder cancer by Pridgeon, S W, Heer, R, Taylor, G A, Newell, D R, O'Toole, K, Robinson, M, Xu, Y-Z, Karran, P, Boddy, A V

“…Background: Thiothymidine (S 4 TdR) can be incorporated into DNA and sensitise cells to DNA damage and cell death following exposure to UVA light. Studies were…”
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Differential effects of the poly (ADP-ribose) polymerase (PARP) inhibitor NU1025 on topoisomerase I and II inhibitor cytotoxicity in L1210 cells in vitro by BOWMAN, K. J, NEWELL, D. R, CALVERT, A. H, CURTIN, N. J

“…The potent novel poly(ADP-ribose) polymerase (PARP) inhibitor, NU1025, enhances the cytotoxicity of DNA-methylating agents and ionizing radiation by inhibiting…”
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Resistance-Modifying Agents. 9. Synthesis and Biological Properties of Benzimidazole Inhibitors of the DNA Repair Enzyme Poly(ADP-ribose) Polymerase by White, Alex W, Almassy, Robert, Calvert, A. Hilary, Curtin, Nicola J, Griffin, Roger J, Hostomsky, Zdenek, Maegley, Karen, Newell, David R, Srinivasan, Sheila, Golding, Bernard T

“…The nuclear enzyme poly(ADP-ribose) polymerase (PARP) facilitates the repair of DNA strand breaks and is implicated in the resistance of cancer cells to…”
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Carboplatin dosage: prospective evaluation of a simple formula based on renal function by Calvert, A H, Newell, D R, Gumbrell, L A, O'Reilly, S, Burnell, M, Boxall, F E, Siddik, Z H, Judson, I R, Gore, M E, Wiltshaw, E

“…A dosage formula has been derived from a retrospective analysis of carboplatin pharmacokinetics in 18 patients with pretreatment glomerular filtration rates…”
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Inhibition of telomerase activity by cisplatin in human testicular cancer cells by Burger, A.M., Double, J.A., Newell, D.R.

“…Telomerase, a ribonucleoprotein, elongates and/or maintains telomeres by adding TTAGGG tandem repeat sequences using the RNA component of the enzyme as a…”
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Potentiation of Temozolomide and Topotecan Growth Inhibition and Cytotoxicity by Novel Poly(adenosine Diphosphoribose) Polymerase Inhibitors in a Panel of Human Tumor Cell Lines by DELANEY, C. A, WANG, L.-Z, KYLE, S, WHITE, A. W, CALVERT, A. H, CURTIN, N. J, DURKACZ, B. W, HOSTOMSKY, Z, NEWELL, D. R

“…Potent poly(ADP-ribose) polymerase (PARP) inhibitors have been developed that potentiate the cytotoxicity of ionizing radiation and anticancer drugs. The…”
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Carboplatin dosage: prospective evaluation of a simple formula based on renal function by Calvert, A H, Newell, D R, Gumbrell, L A, O'Reilly, S, Burnell, M, Boxall, F E, Siddik, Z H, Judson, I R, Gore, M E, Wiltshaw, E

“…A dosage formula has been derived from a retrospective analysis of carboplatin pharmacokinetics in 18 patients with pretreatment glomerular filtration rates…”
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Identification of Novel Purine and Pyrimidine Cyclin-Dependent Kinase Inhibitors with Distinct Molecular Interactions and Tumor Cell Growth Inhibition Profiles by Arris, Christine E, Boyle, F. Thomas, Calvert, A. Hilary, Curtin, Nicola J, Endicott, Jane A, Garman, Elspeth F, Gibson, Ashleigh E, Golding, Bernard T, Grant, Sharon, Griffin, Roger J, Jewsbury, Philip, Johnson, Louise N, Lawrie, Alison M, Newell, David R, Noble, Martin E. M, Sausville, Edward A, Schultz, Robert, Yu, Wyatt

“…Substituted guanines and pyrimidines were tested as inhibitors of cyclin B1/CDK1 and cyclin A3/CDK2 and soaked into crystals of monomeric CDK2. O…”
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Flasks, fibres and flanks - pre-clinical tumour models for predicting clinical antitumour activity by Newell, D R

“…Abstract only…”
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Evaluation of rodent-only toxicology for early clinical trials with novel cancer therapeutics by NEWELL, D. R, BURTLES, S. S, FOX, B. W, JODRELL, D. I, CONNORS, T. A

“…Preclinical toxicology studies are performed prior to phase I trials with novel cancer therapeutics to identify a safe clinical starting dose and potential…”
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Dipyridamole potentiates the in vitro activity of MTA (LY231514) by inhibition of thymidine transport by SMITH, P. G, MARSHMAN, E, NEWELL, D. R, CURTIN, N. J

“…The novel pyrrolopyrimidine-based antifolate LY231514 (MTA), inhibits multiple folate-requiring enzymes including thymidylate synthase, glycinamide…”
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Professor Tom Connors and the development of novel cancer therapies by the Phase I II Clinical Trials Committee of Cancer Research UK by NEWELL, D. R, SEARLE, K. M, WESTWOOD, N. B, BURTLES, S. S

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Pre-clinical evaluation of cyclin-dependent kinase 2 and 1 inhibition in anti-estrogen-sensitive and resistant breast cancer cells by Johnson, N, Bentley, J, Wang, L-Z, Newell, D R, Robson, C N, Shapiro, G I, Curtin, N J

“…Background: Cellular proliferation, driven by cyclin-dependent kinases (CDKs) and their cyclin partners, is deregulated in cancer. Anti-estrogens, such as…”
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The Impact of p53 Status on Cellular Sensitivity to Antifolate Drugs by XIAOHONG LU, ERRINGTON, Julie, CURTIN, Nicola J, LUNEC, John, NEWELL, David R

“…The impact of p53 status on cellular sensitivity to antifolate drugs has been examined in seven human cell lines (A549, MCF7, T-47D, CCRF-CEM, COR-L23, A2780,…”
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Decreased telomerase activity is not a reliable indicator of chemosensitivity in testicular cancer cell lines by Cressey, T.R, Tilby, M.J, Newell, D.R

“…Telomere stabilisation is a critical step in tumorigenesis and telomerase, an enzyme which counteracts telomeric DNA loss, is active in most tumours…”
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Resistance-Modifying Agents. 5. Synthesis and Biological Properties of Quinazolinone Inhibitors of the DNA Repair Enzyme Poly(ADP-ribose) Polymerase (PARP) by Griffin, Roger J, Srinivasan, Sheila, Bowman, Karen, Calvert, A. Hilary, Curtin, Nicola J, Newell, David R, Pemberton, Louise C, Golding, Bernard T

“…Clinical studies concerning the role of poly(ADP-ribose) polymerase (PARP) in the repair of drug- and radiation-induced DNA damage have been impeded by the…”
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Phase I study of temozolomide in paediatric patients with advanced cancer by ESTLIN, E. J, LASHFORD, L, STEVENS, M. C. G, MOTT, M, STEVENS, R, NEWELL, D. R, WALKER, D, DICKS-MIREAUX, C, MCDOWELL, H, REIDENBERG, P, STATKEVICH, P, MARCO, A, ABLETT, S, BATRA, V, DUGAN, M, PEARSON, A. D. J, PRICE, L, GOWING, R, GHOLKAR, A, KOHLER, J, LEWIS, I. J, MORLAND, B, PINKERTON, C. R

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