Search Results - "NEWBOLD, R. R"

In vivo effects of bisphenol A in laboratory rodent studies by Richter, Catherine A., Birnbaum, Linda S., Farabollini, Francesca, Newbold, Retha R., Rubin, Beverly S., Talsness, Chris E., Vandenbergh, John G., Walser-Kuntz, Debby R., vom Saal, Frederick S.

“…Concern is mounting regarding the human health and environmental effects of bisphenol A (BPA), a high-production-volume chemical used in synthesis of plastics…”
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Prenatal Exposure to Bisphenol A at Environmentally Relevant Doses Adversely Affects the Murine Female Reproductive Tract Later in Life by Newbold, Retha R., Jefferson, Wendy N., Padilla-Banks, Elizabeth

“…Background: Exposure to endocrine-disrupting chemicals during critical developmental periods causes adverse consequences later in life; an example is prenatal…”
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Adverse Effects of the Model Environmental Estrogen Diethylstilbestrol Are Transmitted to Subsequent Generations by Newbold, Retha R, Padilla-Banks, Elizabeth, Jefferson, Wendy N

“…The synthetic estrogen diethylstilbestrol (DES) is a potent perinatal endocrine disruptor. In humans and experimental animals, exposure to DES during critical…”
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Long-term adverse effects of neonatal exposure to bisphenol A on the murine female reproductive tract by Newbold, Retha R., Jefferson, Wendy N., Padilla-Banks, Elizabeth

“…The developing fetus is uniquely sensitive to perturbation by chemicals with hormone-like activity. The adverse effects of prenatal diethylstilbestrol (DES)…”
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Neonatal Bisphenol-A Exposure Alters Rat Reproductive Development and Ovarian Morphology Without Impairing Activation of Gonadotropin-Releasing Hormone Neurons by Adewale, Heather B, Jefferson, Wendy N, Newbold, Retha R, Patisaul, Heather B

“…Developmental exposure to endocrine-disrupting compounds is hypothesized to adversely affect female reproductive physiology by interfering with the…”
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Prenatal exposure to diethylstilbestrol (DES) by Newbold, Retha R., M.S

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Perinatal Environmental Exposures Affect Mammary Development, Function, and Cancer Risk in Adulthood by FENTON, Suzanne E, REED, Casey, NEWBOLD, Retha R

“…Puberty is an important transition that enables reproduction of mammalian species. Precocious puberty, specifically early thelarche (the appearance of breast…”
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Estradiol, Progesterone, and Genistein Inhibit Oocyte Nest Breakdown and Primordial Follicle Assembly in the Neonatal Mouse Ovary in Vitro and in Vivo by Chen, Ying, Jefferson, Wendy N, Newbold, Retha R, Padilla-Banks, Elizabeth, Pepling, Melissa E

“…In developing mouse ovaries, oocytes develop as clusters of cells called nests or germ cell cysts. Shortly after birth, oocyte nests dissociate and granulosa…”
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Disruption of the female reproductive system by the phytoestrogen genistein by Jefferson, Wendy N., Padilla-Banks, Elizabeth, Newbold, Retha R.

“…Studies in our laboratory have shown that developmental exposure to genistein causes deleterious effects on the reproductive system. Oral exposure to genistin…”
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Developmental exposure to endocrine disruptors and the obesity epidemic by Newbold, Retha R., Padilla-Banks, Elizabeth, Snyder, Ryan J., Phillips, Terry M., Jefferson, Wendy N.

“…Xenobiotic and dietary compounds with hormone-like activity can disrupt endocrine signaling pathways that play important roles during perinatal differentiation…”
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Evidence for a Tumour Suppressor Function of SETD2 in Human Breast Cancer: A New Hypothesis by NEWBOLD, R. F, MOKBEL, K

“…SET domain containing protein 2 (SETD2) is a histone methyltransferase that is involved in transcriptional elongation. We previously demonstrated SETD2 to be a…”
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Nitrate and sulfate: Effective alternative hydrogen sinks for mitigation of ruminal methane production in sheep by van Zijderveld, S M, Gerrits, W J J, Apajalahti, J A, Newbold, J R, Dijkstra, J, Leng, R A, Perdok, H B

“…Twenty male crossbred Texel lambs were used in a 2 × 2 factorial design experiment to assess the effect of dietary addition of nitrate (2.6% of dry matter) and…”
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Persistency of methane mitigation by dietary nitrate supplementation in dairy cows by van Zijderveld, S M, Gerrits, W J J, Dijkstra, J, Newbold, J R, Hulshof, R B A, Perdok, H B

“…Feeding nitrate to dairy cows may lower ruminal methane production by competing for reducing equivalents with methanogenesis. Twenty lactating…”
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The mRNA expression of SETD2 in human breast cancer: correlation with clinico-pathological parameters by Al Sarakbi, W, Sasi, W, Jiang, W G, Roberts, T, Newbold, R F, Mokbel, K

“…SET domain containing protein 2 (SETD2) is a histone methyltransferase that is involved in transcriptional elongation. There is evidence that SETD2 interacts…”
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Adverse Effects on Female Development and Reproduction in CD-1 Mice Following Neonatal Exposure to the Phytoestrogen Genistein at Environmentally Relevant Doses by Jefferson, Wendy N, Padilla-Banks, Elizabeth, Newbold, Retha R

“…Outbred female CD-1 mice were treated with genistein (Gen), the primary phytoestrogen in soy, by s.c. injections on Neonatal Days 1–5 at doses of 0.5, 5, or 50…”
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Induction of uterine adenocarcinoma in CD-1 mice by catechol estrogens by NEWBOLD, R. R, LIEHR, J. G

“…Catechol estrogens may mediate estrogen-induced carcinogenesis because 4-hydroxyestradiol induces DNA damage and renal tumors in hamsters, and this metabolite…”
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Mass spectrometric determination of Genistein tissue distribution in diet-exposed Sprague-Dawley rats by Chang, H C, Churchwell, M I, Delclos, K B, Newbold, R R, Doerge, D R

“…Genistein, the principal soy isoflavone, was administered in the diet to male and female Sprague-Dawley rats as part of a multigeneration study of potential…”
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Carcinogen-specific mutational and epigenetic alterations in INK4A, INK4B and p53 tumour-suppressor genes drive induced senescence bypass in normal diploid mammalian cells by Yasaei, H, Gilham, E, Pickles, J C, Roberts, T P, O'Donovan, M, Newbold, R F

“…Immortalization (senescence bypass) is a critical rate-limiting step in the malignant transformation of mammalian somatic cells. Human cells must breach at…”
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A round robin approach to the analysis of bisphenol A (BPA) in human blood samples by Vandenberg, Laura N, Gerona, Roy R, Kannan, Kurunthachalam, Taylor, Julia A, van Breemen, Richard B, Dickenson, Carrie A, Liao, Chunyang, Yuan, Yang, Newbold, Retha R, Padmanabhan, Vasantha, Vom Saal, Frederick S, Woodruff, Tracey J

“…Human exposure to bisphenol A (BPA) is ubiquitous, yet there are concerns about whether BPA can be measured in human blood. This Round Robin was designed to…”
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Lessons learned from perinatal exposure to diethylstilbestrol by Newbold, Retha R

“…The synthetic estrogen diethylstilbestrol (DES) is well documented to be a perinatal carcinogen in both humans and experimental animals. Exposure to DES during…”
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