Search Results - "NEVEN, Ellen"

Sclerostin Protects Against Vascular Calcification Development in Mice by De Maré, Annelies, Opdebeeck, Britt, Neven, Ellen, D’Haese, Patrick C., Verhulst, Anja

“…ABSTRACT Sclerostin is a negative regulator of the Wnt/β‐catenin signaling and is, therefore, an important inhibitor of bone formation and turnover. Because…”
Get full text

The Influence of CKD on Colonic Microbial Metabolism by Poesen, Ruben, Windey, Karen, Neven, Ellen, Kuypers, Dirk, De Preter, Vicky, Augustijns, Patrick, D'Haese, Patrick, Evenepoel, Pieter, Verbeke, Kristin, Meijers, Björn

“…There is increasing interest in the colonic microbiota as a relevant source of uremic retention solutes accumulating in CKD. Renal disease can also profoundly…”
Get full text

Remote sensing and signaling in kidney proximal tubules stimulates gut microbiome-derived organic anion secretion by Jansen, Jitske, Jansen, Katja, Neven, Ellen, Poesen, Ruben, Othman, Amr, van Mil, Alain, Sluijter, Joost, Torano, Javier Sastre, Zaal, Esther A., Berkers, Celia R., Esser, Diederik, Wichers, Harry J., van Ede, Karin, van Duursen, Majorie, Burtey, Stéphane, Verhaar, Marianne C., Meijers, Björn, Masereeuw, Rosalinde

“…Membrane transporters and receptors are responsible for balancing nutrient and metabolite levels to aid body homeostasis. Here, we report that proximal tubule…”
Get full text

Metformin: A Candidate Drug for Renal Diseases by Corremans, Raphaëlle, Vervaet, Benjamin A, D'Haese, Patrick C, Neven, Ellen, Verhulst, Anja

“…Over the past decades metformin has been the optimal first-line treatment for type 2 diabetes mellitus (T2DM). Only in the last few years, it has become…”
Get full text

Sclerostin as Regulatory Molecule in Vascular Media Calcification and the Bone-Vascular Axis by De Maré, Annelies, Maudsley, Stuart, Azmi, Abdelkrim, Hendrickx, Jhana O, Opdebeeck, Britt, Neven, Ellen, D'Haese, Patrick C, Verhulst, Anja

“…Sclerostin is a well-known inhibitor of bone formation that acts on Wnt/β-catenin signaling. This manuscript considers the possible role of sclerostin in…”
Get full text

Extracellular Nucleotides Regulate Arterial Calcification by Activating Both Independent and Dependent Purinergic Receptor Signaling Pathways by Opdebeeck, Britt, Orriss, Isabel R, Neven, Ellen, D'Haese, Patrick C, Verhulst, Anja

“…Arterial calcification, the deposition of calcium-phosphate crystals in the extracellular matrix, resembles physiological bone mineralization. It is well-known…”
Get full text

A Proteomic Screen to Unravel the Molecular Pathways Associated with Warfarin-Induced or TNAP-Inhibited Arterial Calcification in Rats by Opdebeeck, Britt, Neven, Ellen, Maudsley, Stuart, Leysen, Hanne, Walter, Deborah, Geryl, Hilde, D'Haese, Patrick C, Verhulst, Anja

“…Arterial media calcification refers to the pathological deposition of calcium phosphate crystals in the arterial wall. This pathology is a common and…”
Get full text

Characterization of SNF472 pharmacokinetics and efficacy in uremic and non-uremic rats models of cardiovascular calcification by Ferrer, Miguel D, Ketteler, Markus, Tur, Fernando, Tur, Eva, Isern, Bernat, Salcedo, Carolina, Joubert, Pieter H, Behets, Geert J, Neven, Ellen, D'Haese, Patrick C, Perelló, Joan

“…End-stage renal disease is strongly associated with progressive cardiovascular calcification (CVC) and there is currently no therapy targeted to treat CVC…”
Get full text

Poly(ADP-Ribose) Links the DNA Damage Response and Biomineralization by Müller, Karin H, Hayward, Robert, Rajan, Rakesh, Whitehead, Meredith, Cobb, Andrew M, Ahmad, Sadia, Sun, Mengxi, Goldberga, Ieva, Li, Rui, Bashtanova, Uliana, Puszkarska, Anna M, Reid, David G, Brooks, Roger A, Skepper, Jeremy N, Bordoloi, Jayanta, Chow, Wing Ying, Oschkinat, Hartmut, Groombridge, Alex, Scherman, Oren A, Harrison, James A, Verhulst, Anja, D'Haese, Patrick C, Neven, Ellen, Needham, Lisa-Maria, Lee, Steven F, Shanahan, Catherine M, Duer, Melinda J

“…Biomineralization of the extracellular matrix is an essential, regulated process. Inappropriate mineralization of bone and the vasculature has devastating…”
Get full text

Effect of a magnesium-based phosphate binder on medial calcification in a rat model of uremia by De Schutter, Tineke M, Behets, Geert J, Geryl, Hilde, Peter, Mirjam E, Steppan, Sonja, Gundlach, Kristina, Passlick-Deetjen, Jutta, D'Haese, Patrick C, Neven, Ellen

“…Calcium-based phosphate binders are used to control hyperphosphatemia; however, they promote hypercalcemia and may accelerate aortic calcification. Here we…”
Get more information

Endothelial Contribution to Warfarin-Induced Arterial Media Calcification in Mice by Van den Bergh, Geoffrey, De Moudt, Sofie, Van den Branden, Astrid, Neven, Ellen, Leysen, Hanne, Maudsley, Stuart, De Meyer, Guido R Y, D'Haese, Patrick, Verhulst, Anja

“…Arterial media calcification (AMC) is predominantly regulated by vascular smooth muscle cells (VSMCs), which transdifferentiate into pro-calcifying cells. In…”
Get full text

Cell biological and physicochemical aspects of arterial calcification by Neven, Ellen, De Schutter, Tineke M., De Broe, Marc E., D'Haese, Patrick C.

“…Processes similar to endochondral or intramembranous bone formation occur in the vascular wall. Bone and cartilage tissue as well as osteoblast- and…”
Get full text

Disturbances in Bone Largely Predict Aortic Calcification in an Alternative Rat Model Developed to Study Both Vascular and Bone Pathology in Chronic Kidney Disease by Neven, Ellen, Bashir‐Dar, Rida, Dams, Geert, Behets, Geert J, Verhulst, Anja, Elseviers, Monique, D'Haese, Patrick C

“…ABSTRACT Because current rat models used to study chronic kidney disease (CKD)‐related vascular calcification show consistent but excessive vascular…”
Get full text

A magnesium based phosphate binder reduces vascular calcification without affecting bone in chronic renal failure rats by Neven, Ellen, De Schutter, Tineke M, Dams, Geert, Gundlach, Kristina, Steppan, Sonja, Büchel, Janine, Passlick-Deetjen, Jutta, D'Haese, Patrick C, Behets, Geert J

“…The alternative phosphate binder calcium acetate/magnesium carbonate (CaMg) effectively reduces hyperphosphatemia, the most important inducer of vascular…”
Get full text

Chronic Kidney Disease-Induced Arterial Media Calcification in Rats Prevented by Tissue Non-Specific Alkaline Phosphatase Substrate Supplementation Rather Than Inhibition of the Enzyme by Opdebeeck, Britt, Neven, Ellen, Millán, José Luis, Pinkerton, Anthony B., D’Haese, Patrick C., Verhulst, Anja

“…Patients with chronic kidney disease (CKD) suffer from arterial media calcification and a disturbed bone metabolism. Tissue-nonspecific alkaline phosphatase…”
Get full text

Prevention of vascular calcification with bisphosphonates without affecting bone mineralization: a new challenge? by Neven, Ellen G., De Broe, Marc E., D'Haese, Patrick C.

“…Arterial calcification has been found to coexist with bone loss. Bisphosphonates, used as standard therapy for osteoporosis, inhibit experimentally induced…”
Get full text

Indoxyl Sulfate and p-Cresyl Sulfate Promote Vascular Calcification and Associate with Glucose Intolerance by Opdebeeck, Britt, Maudsley, Stuart, Azmi, Abdelkrim, De Maré, Annelies, De Leger, Wout, Meijers, Bjorn, Verhulst, Anja, Evenepoel, Pieter, D'Haese, Patrick C, Neven, Ellen

“…Protein-bound uremic toxins indoxyl sulfate (IS) and p-cresyl sulfate (PCS) have been associated with cardiovascular morbidity and mortality in patients with…”
Get full text

Human health risk associated with the management of phosphorus in freshwaters using lanthanum and aluminium by D'Haese, Patrick C., Douglas, Grant, Verhulst, Anja, Neven, Ellen, Behets, Geert J., Vervaet, Benjamin A., Finsterle, Karin, Lürling, Miquel, Spears, Bryan

“…The use of geo-engineering materials to manage phosphorus in lakes has increased in recent years with aluminium and lanthanum based materials being most…”
Get full text

Pharmacological TNAP inhibition efficiently inhibits arterial media calcification in a warfarin rat model but deserves careful consideration of potential physiological bone formation/mineralization impairment by Opdebeeck, Britt, Neven, Ellen, Millán, José Luis, Pinkerton, Anthony B., D'Haese, Patrick C., Verhulst, Anja

“…Arterial media calcification is frequently seen in elderly and patients with chronic kidney disease (CKD), diabetes and osteoporosis. Pyrophosphate is a…”
Get full text

Metformin Therapy Is Able to Halt the Progression of Established CKD in Rats: PO0644 by Corremans, Raphaëlle, Neven, Ellen, D’Haese, Patrick, Vervaet, Benjamin A., Verhulst, Anja

Get full text