Search Results - "NEUZIL, JIRÍ"

Mitocans Revisited: Mitochondrial Targeting as Efficient Anti-Cancer Therapy by Dong, Lanfeng, Gopalan, Vinod, Holland, Olivia, Neuzil, Jiri

“…Mitochondria are essential cellular organelles, controlling multiple signalling pathways critical for cell survival and cell death. Increasing evidence…”
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To transfer mitochondria or not to transfer mitochondria: ADP does the trick by Novak, Jaromir, Neuzil, Jiri

“…Horizontal mitochondrial transfer (HMT) has emerged as a novel phenomenon in cell biology, but it is unclear how this process of intercellular movement of…”
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Exosome-derived microRNAs in cancer metabolism: possible implications in cancer diagnostics and therapy by Tomasetti, Marco, Lee, Wan, Santarelli, Lory, Neuzil, Jiri

“…Malignant progression is greatly affected by dynamic cross-talk between stromal and cancer cells. Exosomes are secreted nanovesicles that have key roles in…”
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Mitochondrial Complex II: At the Crossroads by Bezawork-Geleta, Ayenachew, Rohlena, Jakub, Dong, Lanfeng, Pacak, Karel, Neuzil, Jiri

“…Mitochondrial complex II (CII), also called succinate dehydrogenase (SDH), is a central purveyor of the reprogramming of metabolic and respiratory adaptation…”
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Targeting mitochondria as an anticancer strategy by Dong, Lanfeng, Neuzil, Jiri

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Mitochondrial complex II and reactive oxygen species in disease and therapy by Hadrava Vanova, Katerina, Kraus, Michal, Neuzil, Jiri, Rohlena, Jakub

“…Increasing evidence points to the respiratory Complex II (CII) as a source and modulator of reactive oxygen species (ROS). Both functional loss of CII as well…”
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Mitochondria-adaptor TRAK1 promotes kinesin-1 driven transport in crowded environments by Henrichs, Verena, Grycova, Lenka, Barinka, Cyril, Nahacka, Zuzana, Neuzil, Jiri, Diez, Stefan, Rohlena, Jakub, Braun, Marcus, Lansky, Zdenek

“…Intracellular trafficking of organelles, driven by kinesin-1 stepping along microtubules, underpins essential cellular processes. In absence of other proteins…”
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Oxidative stress and Rho GTPases in the biogenesis of tunnelling nanotubes: implications in disease and therapy by Raghavan, Abinaya, Rao, Pooja, Neuzil, Jiri, Pountney, Dean L., Nath, Sangeeta

“…Tunnelling nanotubes (TNTs) are an emerging route of long-range intercellular communication that mediate cell-to-cell exchange of cargo and organelles and…”
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Targeting Mitochondrial Iron Metabolism Suppresses Tumor Growth and Metastasis by Inducing Mitochondrial Dysfunction and Mitophagy by Sandoval-Acuña, Cristian, Torrealba, Natalia, Tomkova, Veronika, Jadhav, Sukanya B, Blazkova, Kristyna, Merta, Ladislav, Lettlova, Sandra, Adamcová, Miroslava K, Rosel, Daniel, Brábek, Jan, Neuzil, Jiri, Stursa, Jan, Werner, Lukas, Truksa, Jaroslav

“…Deferoxamine (DFO) represents a widely used iron chelator for the treatment of iron overload. Here we describe the use of mitochondrially targeted deferoxamine…”
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Exosomal miR-126 as a circulating biomarker in non-small-cell lung cancer regulating cancer progression by Grimolizzi, Franco, Monaco, Federica, Leoni, Francesca, Bracci, Massimo, Staffolani, Sara, Bersaglieri, Cristiana, Gaetani, Simona, Valentino, Matteo, Amati, Monica, Rubini, Corrado, Saccucci, Franca, Neuzil, Jiri, Tomasetti, Marco, Santarelli, Lory

“…Lung cancer is one of the leading causes of cancer-related deaths. It is diagnosed mostly at the locally advanced or metastatic stage. Recently, micro RNAs…”
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Mitochondrial Genome Acquisition Restores Respiratory Function and Tumorigenic Potential of Cancer Cells without Mitochondrial DNA by Tan, An S., Baty, James W., Dong, Lan-Feng, Bezawork-Geleta, Ayenachew, Endaya, Berwini, Goodwin, Jacob, Bajzikova, Martina, Kovarova, Jaromira, Peterka, Martin, Yan, Bing, Pesdar, Elham Alizadeh, Sobol, Margarita, Filimonenko, Anatolyj, Stuart, Shani, Vondrusova, Magdalena, Kluckova, Katarina, Sachaphibulkij, Karishma, Rohlena, Jakub, Hozak, Pavel, Truksa, Jaroslav, Eccles, David, Haupt, Larisa M., Griffiths, Lyn R., Neuzil, Jiri, Berridge, Michael V.

“…We report that tumor cells without mitochondrial DNA (mtDNA) show delayed tumor growth, and that tumor formation is associated with acquisition of mtDNA from…”
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MicroRNA in Metabolic Re-Programming and Their Role in Tumorigenesis by Tomasetti, Marco, Amati, Monica, Santarelli, Lory, Neuzil, Jiri

“…The process of metabolic re-programing is linked to the activation of oncogenes and/or suppression of tumour suppressor genes, which are regulated by microRNAs…”
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Epigenetic Regulation of miRNA Expression in Malignant Mesothelioma: miRNAs as Biomarkers of Early Diagnosis and Therapy by Tomasetti, Marco, Gaetani, Simona, Monaco, Federica, Neuzil, Jiri, Santarelli, Lory

“…Asbestos exposure leads to epigenetic and epigenomic modifications that, in association with ROS-induced DNA damage, contribute to cancer onset. Few miRNAs…”
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Replication and ribosomal stress induced by targeting pyrimidine synthesis and cellular checkpoints suppress p53-deficient tumors by Hubackova, Sona, Davidova, Eliska, Boukalova, Stepana, Kovarova, Jaromira, Bajzikova, Martina, Coelho, Ana, Terp, Mikkel G., Ditzel, Henrik J., Rohlena, Jakub, Neuzil, Jiri

“…p53-mutated tumors often exhibit increased resistance to standard chemotherapy and enhanced metastatic potential. Here we demonstrate that inhibition of…”
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Classification of mitocans, anti-cancer drugs acting on mitochondria by Neuzil, Jiri, Dong, Lan-Feng, Rohlena, Jakub, Truksa, Jaroslav, Ralph, Stephen J

“…Mitochondria have emerged as an intriguing target for anti-cancer drugs, inherent to vast majority if not all types of tumours. Drugs that target mitochondria…”
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Intracellular and Intercellular Mitochondrial Dynamics in Parkinson’s Disease by Valdinocci, Dario, Simões, Rui F., Kovarova, Jaromira, Cunha-Oliveira, Teresa, Neuzil, Jiri, Pountney, Dean L.

“…The appearance of alpha-synuclein-positive inclusion bodies (Lewy bodies) and the loss of catecholaminergic neurons are the primary pathological hallmarks of…”
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The role of Her2 and other oncogenes of the PI3K/AKT pathway in mitochondria by Rohlenova, Katerina, Neuzil, Jiri, Rohlena, Jakub

“…Altered metabolism and resistance to cell death are typical hallmarks of cancer phenotype. Mitochondria are organelles central to cellular metabolism as well…”
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The causes of cancer revisited: “Mitochondrial malignancy” and ROS-induced oncogenic transformation – Why mitochondria are targets for cancer therapy by Ralph, Stephen J., Rodríguez-Enríquez, Sara, Neuzil, Jiri, Saavedra, Emma, Moreno-Sánchez, Rafael

“…The role of oncoproteins and tumor suppressor proteins in promoting the malignant transformation of mammalian cells by affecting properties such as…”
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Mitochondrially targeted tamoxifen alleviates markers of obesity and type 2 diabetes mellitus in mice by Vacurova, Eliska, Trnovska, Jaroslava, Svoboda, Petr, Skop, Vojtech, Novosadova, Vendula, Reguera, David Pajuelo, Petrezselyová, Silvia, Piavaux, Benoit, Endaya, Berwini, Spoutil, Frantisek, Zudova, Dagmar, Stursa, Jan, Melcova, Magdalena, Bielcikova, Zuzana, Werner, Lukas, Prochazka, Jan, Sedlacek, Radislav, Huttl, Martina, Hubackova, Sona Stemberkova, Haluzik, Martin, Neuzil, Jiri

“…Type 2 diabetes mellitus represents a major health problem with increasing prevalence worldwide. Limited efficacy of current therapies has prompted a search…”
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Characterization of regeneration initiating cells during Xenopus laevis tail regeneration by Sindelka, Radek, Naraine, Ravindra, Abaffy, Pavel, Zucha, Daniel, Kraus, Daniel, Netusil, Jiri, Smetana, Jr, Karel, Lacina, Lukas, Endaya, Berwini Beduya, Neuzil, Jiri, Psenicka, Martin, Kubista, Mikael

“…Embryos are regeneration and wound healing masters. They rapidly close wounds and scarlessly remodel and regenerate injured tissue. Regeneration has been…”
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