Search Results - "NEUREITER, Daniel"

Epigenetics and pancreatic cancer:Pathophysiology and novel treatment aspects by Neureiter, Daniel

“…An improvement in pancreatic cancer treatment represents an urgent medical goal.Late diagnosis and high intrinsic resistance to conventional chemotherapy has…”
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The efficacy of ferroptosis-inducing compounds IKE and RSL3 correlates with the expression of ferroptotic pathway regulators CD71 and SLC7A11 in biliary tract cancer cells by Bekric, Dino, Kiesslich, Tobias, Ocker, Matthias, Winklmayr, Martina, Ritter, Markus, Dobias, Heidemarie, Beyreis, Marlena, Neureiter, Daniel, Mayr, Christian

“…Biliary tract cancer (BTC) is a lethal disease with a bad overall survivability, partly arising from inadequate therapeutic alternatives, detection at a…”
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The Crosstalk of miRNA and Oxidative Stress in the Liver: From Physiology to Pathology and Clinical Implications by Klieser, Eckhard, Mayr, Christian, Kiesslich, Tobias, Wissniowski, Till, Fazio, Pietro Di, Neureiter, Daniel, Ocker, Matthias

“…The liver is the central metabolic organ of mammals. In humans, most diseases of the liver are primarily caused by an unhealthy lifestyle-high fat diet, drug…”
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Inhibition of Neuroblastoma Tumor Growth by Ketogenic Diet and/or Calorie Restriction in a CD1-Nu Mouse Model by Morscher, Raphael Johannes, Aminzadeh-Gohari, Sepideh, Feichtinger, René Gunther, Mayr, Johannes Adalbert, Lang, Roland, Neureiter, Daniel, Sperl, Wolfgang, Kofler, Barbara

“…Neuroblastoma is a malignant pediatric cancer derived from neural crest cells. It is characterized by a generalized reduction of mitochondrial oxidative…”
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Targeting class I histone deacetylases by the novel small molecule inhibitor 4SC‐202 blocks oncogenic hedgehog‐GLI signaling and overcomes smoothened inhibitor resistance by Gruber, Wolfgang, Peer, Elisabeth, Elmer, Dominik P., Sternberg, Christina, Tesanovic, Suzana, del Burgo, Pedro, Coni, Sonia, Canettieri, Gianluca, Neureiter, Daniel, Bartz, René, Kohlhof, Hella, Vitt, Daniel, Aberger, Fritz

“…Aberrant activation of Hedgehog (HH)/GLI signaling is causally involved in numerous human malignancies, including basal cell carcinoma (BCC) and…”
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Ouabain at nanomolar concentrations is cytotoxic for biliary tract cancer cells by Mayr, Christian, Kiesslich, Tobias, Bekric, Dino, Beyreis, Marlena, Kittl, Michael, Ablinger, Celina, Neureiter, Elen, Pichler, Martin, Prinz, Felix, Ritter, Markus, Neureiter, Daniel, Jakab, Martin, Dobias, Heidemarie

“…Biliary tract cancer is a deadly disease with limited therapeutic options. Ouabain is a well-known inhibitor of the pumping function of Na+/K+-ATPase, though…”
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Patient Selection Approaches in FGFR Inhibitor Trials—Many Paths to the Same End? by Ellinghaus, Peter, Neureiter, Daniel, Nogai, Hendrik, Stintzing, Sebastian, Ocker, Matthias

“…Inhibitors of fibroblast growth factor receptor (FGFR) signaling have been investigated in various human cancer diseases. Recently, the first compounds…”
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Additive antitumour response to the rabbit VX2 hepatoma by combined radio frequency ablation and toll like receptor 9 stimulation by Behm, Barbara, Di Fazio, Pietro, Michl, Patrick, Neureiter, Daniel, Kemmerling, Ralf, Hahn, Eckhart Georg, Strobel, Deike, Gress, Thomas, Schuppan, Detlef, Wissniowski, Thaddaeus Till

“…Radiofrequency ablation (RFA), a palliative therapeutic option for solid hepatic tumours, stimulates localised and systemic antitumour cytotoxic T cells. We…”
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HtrA-Dependent E-Cadherin Shedding Impairs the Epithelial Barrier Function in Primary Gastric Epithelial Cells and Gastric Organoids by Canadas-Ortega, Marina, Mühlbacher, Iris, Posselt, Gernot, Diechler, Sebastian, Ferner, Christian Daniel, Boccellato, Francesco, Koch, Oliver Owen, Neureiter, Daniel, Weitzendorfer, Michael, Emmanuel, Klaus, Wessler, Silja

“…Impaired E-cadherin (Cdh1) functions are closely associated with cellular dedifferentiation, infiltrative tumor growth and metastasis, particularly in gastric…”
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Pharmacological Inhibition of Class IIA HDACs by LMK-235 in Pancreatic Neuroendocrine Tumor Cells by Wanek, Julia, Gaisberger, Martin, Beyreis, Marlena, Mayr, Christian, Helm, Katharina, Primavesi, Florian, Jäger, Tarkan, Di Fazio, Pietro, Jakab, Martin, Wagner, Andrej, Neureiter, Daniel, Kiesslich, Tobias

“…Histone deacetylases (HDACs) play a key role in epigenetic mechanisms in health and disease and their dysfunction is implied in several cancer entities…”
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A modified scoring of the NCCN‐IPI is more accurate in the elderly and is improved by albumin and β2‐microglobulin by Melchardt, Thomas, Troppan, Katharina, Weiss, Lukas, Hufnagl, Clemens, Neureiter, Daniel, Tränkenschuh, Wolfgang, Hopfinger, Georg, Magnes, Teresa, Deutsch, Alexander, Neumeister, Peter, Hackl, Hubert, Greil, Richard, Pichler, Martin, Egle, Alexander

“…Summary The International Prognostic Index (IPI) has been used for decades in diffuse large B‐cell lymphoma (DLBCL). A retrospective cancer registry analysis…”
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CD44 engagement enhances acute myeloid leukemia cell adhesion to the bone marrow microenvironment by increasing VLA-4 avidity by Gutjahr, Julia C, Bayer, Elisabeth, Yu, Xiaobing, Laufer, Julia M, Höpner, Jan P, Tesanovic, Suzana, Härzschel, Andrea, Auer, Georg, Rieß, Tanja, Salmhofer, Astrid, Szenes, Eva, Haslauer, Theresa, Durand-Onayli, Valerie, Ramspacher, Andrea, Pennisi, Sandra P, Artinger, Marc, Zaborsky, Nadja, Chigaev, Alexandre, Aberger, Fritz, Neureiter, Daniel, Pleyer, Lisa, Legler, Daniel F, Orian-Rousseau, Veronique, Greil, Richard, Hartmann, Tanja N

“…Adhesive properties of leukemia cells shape the degree of organ infiltration and the extent of leukocytosis. CD44 and the integrin VLA-4, a CD49d/CD29…”
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A POLE Splice Site Deletion Detected in a Patient with Biclonal CLL and Prostate Cancer: A Case Report by Steiner, Markus, Gassner, Franz J., Parigger, Thomas, Neureiter, Daniel, Egle, Alexander, Geisberger, Roland, Greil, Richard, Zaborsky, Nadja

“…Chronic lymphocytic leukemia (CLL) is considered a clonal B cell malignancy. Sporadically, CLL cases with multiple productive heavy and light-chain…”
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NLRP3 promotes allergic responses to birch pollen extract in a model of intranasal sensitization by Bauer, Renate, Dang, Hieu-Hoa, Neureiter, Daniel, Unger, Michael Stefan, Neuper, Theresa, Jensen, Melanie, Taliento, Alice Emma, Strandt, Helen, Gratz, Iris, Weiss, Richard, Sales, Angelika, Horejs-Hoeck, Jutta

“…Allergic sensitization is an essential step in the development of allergic airway inflammation to birch pollen (BP); however, this process remains to be fully…”
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Comprehensive immunohistochemical analysis of histone deacetylases in pancreatic neuroendocrine tumors: HDAC5 as a predictor of poor clinical outcome by Klieser, Eckhard, MD, Urbas, Romana, MD PhD, Stättner, Stefan, MD, Primavesi, Florian, MD, Jäger, Tarkan, MD, Dinnewitzer, Adam, MD, Mayr, Christian, PhD, Kiesslich, Tobias, PhD, Holzmann, Klaus, MSc PhD, Di Fazio, Pietro, PhD, Neureiter, Daniel, MD,MA, Swierczynski, Stefan, MSc

“…Epigenetic factors contribute to carcinogenesis, tumor promotion and chemoresistance. Histone deacetylases (HDACs) are epigenetic regulators that primarily…”
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Epigenetic control of epithelial-mesenchymal-transition in human cancer by KIESSLICH, TOBIAS, PICHLER, MARTIN, NEUREITER, DANIEL

“…Development and tissue homeostasis as well as carcinogenesis share the evolutionary conserved process of epithelial-mesenchymal transition (EMT). EMT enables…”
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Downregulation of HMGA2 by the pan-deacetylase inhibitor panobinostat is dependent on hsa-let-7b expression in liver cancer cell lines by Di Fazio, Pietro, Montalbano, Roberta, Neureiter, Daniel, Alinger, Beate, Schmidt, Ansgar, Merkel, Anna Lena, Quint, Karl, Ocker, Matthias

“…Inhibitors of protein deacetylases represent a novel therapeutic option for cancer diseases due to their effects on transcriptional regulation by interfering…”
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Two Cases of Pancytopenia with Coombs-Negative Hemolytic Anemia after Chimeric Antigen Receptor T-Cell Therapy by Kiem, Dominik, Leisch, Michael, Neureiter, Daniel, Haslauer, Theresa, Egle, Alexander, Melchardt, Thomas, Topp, Max S., Greil, Richard

“…Background: Chimeric antigen receptor (CAR) T-cells are changing the therapeutic landscape of hematologic malignancies. Severe side effects include cytokine…”
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Biliary tract cancer stem cells - translational options and challenges by Mayr, Christian, Ocker, Matthias, Ritter, Markus, Pichler, Martin, Neureiter, Daniel, Kiesslich, Tobias

“…Management of biliary tract cancer remains challenging. Tumors show high recurrence rates and therapeutic resistance, leading to dismal prognosis and short…”
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Epidermal activation of Hedgehog signaling establishes an immunosuppressive microenvironment in basal cell carcinoma by modulating skin immunity by Grund‐Gröschke, Sandra, Ortner, Daniela, Szenes‐Nagy, Antal B., Zaborsky, Nadja, Weiss, Richard, Neureiter, Daniel, Wipplinger, Martin, Risch, Angela, Hammerl, Peter, Greil, Richard, Sibilia, Maria, Gratz, Iris K., Stoitzner, Patrizia, Aberger, Fritz

“…Activation of hedgehog/glioma‐associated oncogene homolog (HH/GLI) signaling induces basal cell carcinoma (BCC) and establishes an immunosuppressive tumor…”
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