Search Results - "NEUBERT, Reinhard H. H"

Potentials of new nanocarriers for dermal and transdermal drug delivery by Neubert, Reinhard H.H.

“…A colloidal carrier system with an oily colloidal phase (O/W microemulsion) is shown on the right hand side which is used to improve dermal and transdermal…”
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Investigation of a CER[NP]- and [AP]-Based Stratum Corneum Modeling Membrane System: Using Specifically Deuterated CER Together with a Neutron Diffraction Approach by Schmitt, Thomas, Lange, Stefan, Dobner, Bodo, Sonnenberger, Stefan, Hauß, Thomas, Neubert, Reinhard H. H

“…Neutron diffraction was used as a tool to investigate the lamellar as well as molecular nanostructure of ceramide-[NP]/ceramide-[AP]/cholesterol/lignoceric…”
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Two- and Three-Dimensional Physical–Chemical Characterization of CER[AP]: A Study of Stereochemistry and Chain Symmetry by Strati, Fabio, Oliveira, Joana S. L, Opalka, Lukas, Mukhina, Tetiana, Dobner, Bodo, Neubert, Reinhard H. H, Brezesinski, Gerald

“…The stratum corneum represents the first skin barrier against chemical and physical damage. These unique properties are based on its peculiar lipid composition…”
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Microemulsions--modern colloidal carrier for dermal and transdermal drug delivery by Heuschkel, Sandra, Goebel, Alexandra, Neubert, Reinhard H H

“…Microemulsions are modern colloidal drug carrier systems. They form spontaneously combining appropriate amounts of a lipophilic and a hydrophilic ingredient,…”
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Production of Rare Phyto-Ceramides from Abundant Food Plant Residues by Reisberg, Mathias, Arnold, Norbert, Porzel, Andrea, Neubert, Reinhard H. H, Dräger, Birgit

“…Ceramides (Cers) are major components of the outermost layer of the skin, the stratum corneum, and play a crucial role in permeability barrier functions…”
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Preparation of a New Oligolamellar Stratum Corneum Lipid Model by Mueller, Josefin, Schroeter, Annett, Steitz, Roland, Trapp, Marcus, Neubert, Reinhard H. H

“…In this study, we present a preparation method for a new stratum corneum (SC) model system, which is closer to natural SC than the commonly used multilayer…”
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Free amino acid contents of selected Ethiopian plant and fungi species: a search for alternative natural free amino acid sources for cosmeceutical applications by Kahsay, Birhanu Nigusse, Ziegler, Jörg, Imming, Peter, Gebre-Mariam, Tsige, Neubert, Reinhard H. H., Moeller, Lucie

“…Free amino acids (FAAs), the major constituents of the natural moisturizing factor (NMF), are very important for maintaining the moisture balance of human skin…”
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Lecithin-Based Microemulsions for Targeted Delivery of Ceramide AP into the Stratum Corneum: Formulation, Characterizations, and In Vitro Release and Penetration Studies by Sahle, Fitsum F., Metz, Hendrik, Wohlrab, Johannes, Neubert, Reinhard H. H.

“…ABSTRACT Purpose To improve the solubility and penetration of Ceramide AP (CER [AP]) into the stratum corneum that potentially restores the barrier function of…”
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Preparation, characterization and in vivo evaluation of amorphous atorvastatin calcium nanoparticles using supercritical antisolvent (SAS) process by Kim, Min-Soo, Jin, Shun-Ji, Kim, Jeong-Soo, Park, Hee Jun, Song, Ha-Seung, Neubert, Reinhard H.H., Hwang, Sung-Joo

“…In this work, amorphous atorvastatin calcium nanoparticles were successfully prepared using the supercritical antisolvent (SAS) process. The effect of process…”
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Development and validation of LC/APCI-MS method for the quantification of oat ceramides in skin permeation studies by Tessema, Efrem N., Gebre-Mariam, Tsige, Frolov, Andrej, Wohlrab, Johannes, Neubert, Reinhard H. H.

“…Ceramides (CERs) are the backbone of the intercellular lipid lamellae of the stratum corneum (SC), the outer layer of the skin. Skin diseases such as atopic…”
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Does human leukocyte elastase degrade intact skin elastin? by Schmelzer, Christian E. H., Jung, Michael C., Wohlrab, Johannes, Neubert, Reinhard H. H., Heinz, Andrea

“…This study aimed to investigate the susceptibility of intact fibrillar human elastin to human leukocyte elastase and cathepsin G. Elastin is a vital protein of…”
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Dermal targeting of tacrolimus using colloidal carrier systems by Goebel, Alexandra S.B., Neubert, Reinhard H.H., Wohlrab, Johannes

“…In the therapy of chronic inflammatory skin diseases, the epicutaneous application of anti-inflammatory drugs in combination with maintenance therapy leads to…”
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Drug Release from ß-Cyclodextrin Complexes and Drug Transfer into Model Membranes Studied by Affinity Capillary Electrophoresis by Darwish, Kinda A., Mrestani, Yahya, Rüttinger, Hans-Hermann, Neubert, Reinhard H. H.

“…Purpose Is to characterize the drug release from the ß-cyclodextrin (ß-CD) cavity and the drug transfer into model membranes by affinity capillary…”
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Polyglycerol fatty acid ester surfactant–based microemulsions for targeted delivery of ceramide AP into the stratum corneum: Formulation, characterisation, in vitro release and penetration investigation by Sahle, Fitsum F., Metz, Hendrik, Wohlrab, Johannes, Neubert, Reinhard H.H.

“…The different nanostructures of CER [AP] MEs as characterised by EPR and other conventional techniques as well as their in vitro release and penetration…”
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Influence of a Novel Dimeric Ceramide Molecule on the Nanostructure and Thermotropic Phase Behavior of a Stratum Corneum Model Mixture by Stahlberg, Sören, Eichner, Adina, Sonnenberger, Stefan, Kováčik, Andrej, Lange, Stefan, Schmitt, Thomas, Demé, Bruno, Hauß, Thomas, Dobner, Bodo, Neubert, Reinhard H. H, Huster, Daniel

“…The stratum corneum (SC) is the outermost layer of the skin and is composed of a multilayered assembly of mostly ceramids (Cer), free fatty acids, cholesterol…”
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Normal phase liquid chromatography coupled to quadrupole time of flight atmospheric pressure chemical ionization mass spectrometry for separation, detection and mass spectrometric profiling of neutral sphingolipids and cholesterol by Farwanah, Hany, Wirtz, Jennifer, Kolter, Thomas, Raith, Klaus, Neubert, Reinhard H.H., Sandhoff, Konrad

“…Many lipidomic approaches focus on investigating aspects of sphingolipid metabolism. Special emphasis is put on neutral sphingolipids and cholesterol and their…”
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Skin Ceramide Alterations in First-Episode Schizophrenia Indicate Abnormal Sphingolipid Metabolism by SMESNY, Stefan, SCHMELZER, Christian E. H, SAUER, Heinrich, NEUBERT, Reinhard H. H, FLUHR, Joachim W, HINDER, Anke, KÖHLER, Alexandra, SCHNEIDER, Christiane, RUDZOK, Maria, SCHMIDT, Ulrike, MILLEIT, Berko, MILLEIT, Christine, NENADIC, Igor

“…There is considerable evidence for specific pathology of lipid metabolism in schizophrenia, affecting polyunsaturated fatty acids and in particular…”
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Controlled penetration of ceramides into and across the stratum corneum using various types of microemulsions and formulation associated toxicity studies by Sahle, Fitsum F., Wohlrab, Johannes, Neubert, Reinhard H.H.

“…Several skin diseases such as psoriasis and atopic dermatitis are associated with the depletion or disturbance of stratum corneum (SC) lipids such as ceramides…”
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Optimization of ion‐pair formation between glycopyrronium bromide and different ion‐pair agents using ACE by Darwish, Kinda A, Mrestani, Yahya, Neubert, Reinhard H. H

“…Glycopyrronium bromide (GLB) is an anticholinergic drug. Its highly polar quaternary ammonium group could limit the skin permeation of the topical hydrophilic…”
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Characterization of honeybee venom by MALDI-TOF and nanoESI-QqTOF mass spectrometry by Matysiak, Jan, Schmelzer, Christian E.H., Neubert, Reinhard H.H., Kokot, Zenon J.

“…The aim of the study was to comprehensively characterize different honeybee venom samples applying two complementary mass spectrometry methods. 41 honeybee…”
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