Search Results - "NENQUIN, Myriam"

Activators of PKA and Epac Distinctly Influence Insulin Secretion and Cytosolic Ca2+ in Female Mouse Islets Stimulated by Glucose and Tolbutamide by Henquin, Jean-Claude, Nenquin, Myriam

“…Amplification of insulin secretion by cAMP is mediated by protein kinase A (PKA) and exchange protein directly activated by cAMP (Epac). Using selective…”
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Dynamics and Regulation of Insulin Secretion in Pancreatic Islets from Normal Young Children by Henquin, Jean-Claude, Nenquin, Myriam

“…Insulin secretion has only exceptionally been investigated in pancreatic islets from healthy young children. It remains unclear whether those islets behave…”
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Nutrient Control of Insulin Secretion in Isolated Normal Human Islets by HENQUIN, Jean-Claude, DUFRANE, Denis, NENQUIN, Myriam

“…Nutrient Control of Insulin Secretion in Isolated Normal Human Islets Jean-Claude Henquin 1 , Denis Dufrane 1 2 and Myriam Nenquin 1 1 Endocrinology and…”
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Immaturity of insulin secretion by pancreatic islets isolated from one human neonate by Henquin, Jean‐Claude, Nenquin, Myriam

“…Human β‐cells are functionally mature by the age of 1 year. The timeline and mechanisms of this maturation are unknown owing to the exceptional availability of…”
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Human Insulinomas Show Distinct Patterns of Insulin Secretion In Vitro by Henquin, Jean-Claude, Nenquin, Myriam, Guiot, Yves, Rahier, Jacques, Sempoux, Christine

“…Insulinomas are β-cell tumors that cause hypoglycemia through inappropriate secretion of insulin. Characterization of the in vitro dynamics of insulin…”
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Glucose Controls Cytosolic Ca2+ and Insulin Secretion in Mouse Islets Lacking Adenosine Triphosphate-Sensitive K+ Channels Owing to a Knockout of the Pore-Forming Subunit Kir6.2 by Ravier, Magalie A, Nenquin, Myriam, Miki, Takashi, Seino, Susumu, Henquin, Jean-Claude

“…Glucose-induced insulin secretion is classically attributed to the cooperation of an ATP-sensitive potassium (KATP) channel-dependent Ca2+ influx with a…”
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Overnight Culture Unmasks Glucose-induced Insulin Secretion in Mouse Islets Lacking ATP-sensitive K+ Channels by Improving the Triggering Ca2+ Signal by Szollosi, Andras, Nenquin, Myriam, Henquin, Jean-Claude

“…A current model ascribes glucose-induced insulin secretion to the interaction of a triggering pathway (KATP channel-dependent Ca2+ influx and rise in cytosolic…”
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Signals and Pools Underlying Biphasic Insulin Secretion by HENQUIN, Jean-Claude, ISHIYAMA, Nobuyoshi, NENQUIN, Myriam, RAVIER, Magalie A, JONAS, Jean-Christophe

“…Signals and Pools Underlying Biphasic Insulin Secretion Jean-Claude Henquin , Nobuyoshi Ishiyama , Myriam Nenquin , Magalie A. Ravier and Jean-Christophe Jonas…”
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Insulin secretion in islets from mice with a double knockout for the dense core vesicle proteins islet antigen-2 (IA-2) and IA-2β by Henquin, Jean-Claude, Nenquin, Myriam, Szollosi, Andras, Kubosaki, Atsutaka, Louis Notkins, Abner

“…Islet antigen-2 (IA-2 or ICA 512) and IA-2β (or phogrin) are major autoantigens in type 1 diabetes. They are located in dense core secretory vesicles including…”
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The Elevation of Glutamate Content and the Amplification of Insulin Secretion in Glucose-stimulated Pancreatic Islets Are Not Causally Related by Bertrand, Gyslaine, Ishiyama, Nobuyoshi, Nenquin, Myriam, Ravier, Magalie A., Henquin, Jean-Claude

“…Glucose increases insulin secretion by raising cytoplasmic Ca2+([Ca2+]i) in β-cells (triggering pathway) and augmenting the efficacy of Ca2+ on exocytosis…”
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SERCA3 Ablation Does Not Impair Insulin Secretion but Suggests Distinct Roles of Different Sarcoendoplasmic Reticulum Ca2+ Pumps for Ca2+ Homeostasis in Pancreatic β-cells by ARREDOUANI, Abdelilah, GUIOT, Yves, WUYTACK, Frank, HENQUIN, Jean-Claude, GILON, Patrick, JONAS, Jean-Christophe, LIU, Lynne H, NENQUIN, Myriam, PERTUSA, José A, RAHIER, Jacques, ROLLAND, Jean-Francois, SHULL, Gary E, STEVENS, Martine

“…SERCA3 Ablation Does Not Impair Insulin Secretion but Suggests Distinct Roles of Different Sarcoendoplasmic Reticulum Ca 2+ Pumps for Ca 2+ Homeostasis in…”
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In Vivo and In Vitro Glucose-Induced Biphasic Insulin Secretion in the Mouse by Henquin, Jean-Claude, Nenquin, Myriam, Stiernet, Patrick, Ahren, Bo

“…In Vivo and In Vitro Glucose-Induced Biphasic Insulin Secretion in the Mouse Pattern and Role of Cytoplasmic Ca 2+ and Amplification Signals in β-Cells…”
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Dynamics of glucose-induced insulin secretion in normal human islets by Henquin, Jean-Claude, Dufrane, Denis, Kerr-Conte, Julie, Nenquin, Myriam

“…The biphasic pattern of glucose-induced insulin secretion is altered in type 2 diabetes. Impairment of the first phase is an early sign of β-cell dysfunction,…”
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The Oscillatory Behavior of Pancreatic Islets from Mice with Mitochondrial Glycerol-3-phosphate Dehydrogenase Knockout by Ravier, Magalie A., Eto, Kazuhiro, Jonkers, Françoise C., Nenquin, Myriam, Kadowaki, Takashi, Henquin, Jean-Claude

“…Glucose stimulation of pancreatic β cells induces oscillations of the membrane potential, cytosolic Ca2+ ([Ca2+]i), and insulin secretion. Each of these events…”
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Relative contribution of Ca2+‐dependent and Ca2+‐independent mechanisms to the regulation of insulin secretion by glucose by Sato, Yoshihiko, Nenquin, Myriam, Henquin, Jean-Claude

“…Although insulin secretion is usually regarded as a Ca2+‐dependent mechanism, recent studies have suggested the existence of a Ca2+‐independent pathway of…”
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Congenital Hyperinsulinism Caused by Hexokinase I Expression or Glucokinase-Activating Mutation in a Subset of β-Cells by HENQUIN, Jean-Claude, SEMPOUX, Christine, MARCHANDISE, Joelle, GODECHARLES, Sebastien, GUIOT, Yves, NENQUIN, Myriam, RAHIER, Jacques

“…Congenital hyperinsulinism causes persistent hypoglycemia in neonates and infants. Most often, uncontrolled insulin secretion (IS) results from a lack of…”
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Pharmacological approach to understanding the control of insulin secretion in human islets by Henquin, Jean‐Claude, Dufrane, Denis, Gmyr, Valery, Kerr‐Conte, Julie, Nenquin, Myriam

“…Aims To understand better the control of insulin secretion by human β cells and to identify similarities to and differences from rodent models. Methods Dynamic…”
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Metabolic amplifying pathway increases both phases of insulin secretion independently of beta-cell actin microfilaments by Mourad, Nizar I, Nenquin, Myriam, Henquin, Jean-Claude

“…Two pathways control glucose-induced insulin secretion (IS) by beta-cells. The triggering pathway involves ATP-sensitive potassium (K(ATP)) channel-dependent…”
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In vivo and in vitro glucose-induced biphasic insulin secretion in the mouse : Pattern and role of cytoplasmic Ca2+ and amplification signals in β-cells by HENQUIN, Jean-Claude, NENQUIN, Myriam, STIERNET, Patrick, AHREN, Bo

“…The mechanisms underlying biphasic insulin secretion have not been completely elucidated. We compared the pattern of plasma insulin changes during…”
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cAMP-Mediated and Metabolic Amplification of Insulin Secretion Are Distinct Pathways Sharing Independence of β-Cell Microfilaments by Mourad, Nizar I, Nenquin, Myriam, Henquin, Jean-Claude

“…Insulin secretion is triggered by an increase in the cytosolic calcium concentration ([Ca2+]c) in β-cells. Ca2+-induced exocytosis of insulin granules can be…”
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