Search Results - "NEMETHOVA, Miroslava"

Brain to blood efflux as a mechanism underlying the neuroprotection mediated by rapid remote preconditioning in brain ischemia by Jachova, Jana, Gottlieb, Miroslav, Nemethova, Miroslava, Bona, Martin, Bonova, Petra

“…Glutamate represents the main excitatory neurotransmitter in the mammalian brain; however, its excessive elevation in the extracellular space is cytotoxic and…”
Get full text

Modifications of gene expression detected in peripheral blood after brain ischemia treated with remote postconditioning by Furman, Marek, Nemethova, Miroslava, Macakova, Lubica, Sihotsky, Vladimir, Kopolovets, Ivan, Berek, Peter, Virag, Michal, Mucha, Rastislav

“…Background A stroke is an acute damage to a certain area of a nerve tissue of the brain. In developed countries, it ranks second among the most often causes of…”
Get full text

Identification of Proteins Responsible for the Neuroprotective Effect of the Secretome Derived from Blood Cells of Remote Ischaemic Conditioned Rats by Bonova, Petra, Koncekova, Jana, Nemethova, Miroslava, Petrova, Klaudia, Bona, Martin, Gottlieb, Miroslav

“…We have recently shown that the blood cell-derived secretome of remote ischaemic (RIC)-conditioned individuals provides an external source of neuroprotection…”
Get full text

Delayed post-conditioning reduces post-ischemic glutamate level and improves protein synthesis in brain by Bonova, Petra, Burda, Jozef, Danielisova, Viera, Nemethova, Miroslava, Gottlieb, Miroslav

“…► Ischemia elevates blood and brain glutamate and tissue protein synthesis. ► Post-conditioning activates mechanisms to eliminate glutamate from brain and…”
Get full text

Effectiveness of remote ischaemic conditioning is not affected by hyper-inflammation in a rat model of stroke by Končeková, Jana, Kotorová, Klaudia, Némethová, Miroslava, Bona, Martin, Bonová, Petra

“…The inflammation and coagulopathy during coronavirus disease (COVID-19) impairs the efficiency of the current stroke treatments. Remote ischaemic conditioning…”
Get full text

Clinical usage of ischemic tolerance-where are its limits? by Burda, Rastislav, Křemen, Róbert, Némethová, Miroslava, Burda, Jozef

“…Ischemic tolerance is a robust internal defense mechanism of all living organisms. The effectiveness of this mechanism has been repeatedly demonstrated in…”
Get full text

Remote ischemic postconditioning as well as blood plasma from double-conditioned donor ameliorate reperfusion syndrome in skeletal muscle by Burda, Rastislav, Morochovič, Radoslav, Némethová, Miroslava, Burda, Jozef

“…The aim of this study was to verify the possibility of preparation and effectiveness of the use of blood plasma containing an effector of ischemic tolerance…”
Get more information

Quantitative analysis of selected genetic markers of induced brain stroke ischemic tolerance detected in human blood by Furman, Marek, Sihotsky, Vladimir, Virag, Michal, Kopolovets, Ivan, Nemethova, Miroslava, Mucha, Rastislav

“…[Display omitted] •ADM, GADD45G, IL6, TM4SF1 and CDKN1A in blood is affected by ischemic brain stroke.•Carotid endarterectomy may activate ischemic stroke…”
Get full text

Rapid remote conditioning mediates modulation of blood cell paracrine activity and leads to the production of a secretome with neuroprotective features by Bonova, Petra, Jachova, Jana, Nemethova, Miroslava, Macakova, Lubica, Bona, Martin, Gottlieb, Miroslav

“…The indirect use of the protective potential of stem cells in the form of cell secretomes has become an attractive strategy in regenerative medicine. In the…”
Get full text

Delayed postconditionig initiates additive mechanism necessary for survival of selectively vulnerable neurons after transient ischemia in rat brain by Burda, Jozef, Danielisová, Viera, Némethová, Miroslava, Gottlieb, Miroslav, Matiasová, Milina, Domoráková, Iveta, Mechírová, Eva, Feriková, Marianna, Salinas, Matilde, Burda, Rastislav

“…1. The aim of this study was to validate the role of postconditioning, used 2 days after lethal ischemia, for protection of selectively vulnerable brain…”
Get full text

Neuroprotection mediated by remote preconditioning is associated with a decrease in systemic oxidative stress and changes in brain and blood glutamate concentration by Jachova, Jana, Gottlieb, Miroslav, Nemethova, Miroslava, Macakova, Lubica, Bona, Martin, Bonova, Petra

“…It has been shown that ischemia of remote organs can generate resistance to ischemic conditions within sensitive brain tissues. However, only limited…”
Get full text

Accelerated capacity of glutamate uptake via blood elements as a possible tool of rapid remote conditioning mediated tissue protection by Bonova, Petra, Jachova, Jana, Nemethova, Miroslava, Bona, Martin, Kollarova, Patricia, Gottlieb, Miroslav

“…Recently, the function of blood cells in remote ischemic conditioning (RIC) mediated neuroprotection was undoubtedly confirmed. In the present paper, we have…”
Get full text

Effects of Bradykinin Postconditioning on Endogenous Antioxidant Enzyme Activity After Transient Forebrain Ischemia in Rat by Danielisová, Viera, Gottlieb, Miroslav, Némethová, Miroslava, Burda, Jozef

“…Bradykinin is considered an important mediator of the inflammatory response in both the peripheral and the central nervous system and it has attracted recent…”
Get full text

The changes in endogenous antioxidant enzyme activity after postconditioning by Danielisová, Viera, Némethová, Miroslava, Gottlieb, Miroslav, Burda, Jozef

“…1. The aim of this work was to study potential mechanisms participating in postischemic protection of selectively vulnerable CA1 neurons in the hippocampus…”
Get full text

Bradykinin Postconditioning Protects Pyramidal CA1 Neurons Against Delayed Neuronal Death in Rat Hippocampus by Danielisová, Viera, Gottlieb, Miroslav, Némethová, Miroslava, Kravčuková, Petra, Domoráková, Iveta, Mechírová, Eva, Burda, Jozef

“…Aims The present study was undertaken to evaluate possible neuroprotective effect of bradykinin against delayed neuronal death in hippocampal CA1 neurons if…”
Get full text

THE EFFECT OF NORMOVOLEMIC HEMODILUTION ON C-FOS PROTEIN IMMUNOREACTIVITY IN THE POSTISCHEMIC RAT BRAIN CORTEX by Miroslava, Némethová, Burda, Jozef, Danielisová, Viera, Maršala, Jozef

“…The hemodilution effect was evaluated in the parietal, temporal, and basal regions of postischemic rat brain neocortex by the immunohistochemical detection of…”
Get full text

Bradykinin postconditioning ameliorates focal cerebral ischemia in the rat by Danielisova, Viera, Gottlieb, Miroslav, Bonova, Petra, Nemethova, Miroslava, Burda, Jozef

“…•We tested possible delay of postconditioning after MCAO.•Regional distribution of SOD changes after ischemia was followed.•We confirmed that bradykinin is…”
Get full text

Development of a pattern in biochemical parameters in the core and penumbra during infarct evolution after transient MCAO in rats by Bonova, Petra, Burda, Jozef, Danielisova, Viera, Nemethova, Miroslava, Gottlieb, Miroslav

“…► Core and penumbra differ in biochemical parameters. ► Parameters clearly reflect spreading of tissue damage after MCAO. ► Patterns seem to be clearly…”
Get full text

Changes of endogenous antioxidant enzymes during ischemic tolerance acquisition by Danielisová, Viera, Némethová, Miroslava, Gottlieb, Miroslav, Burda, Jozef

“…The purpose of this study was to investigate the role of superoxide dismutase (SOD) and catalase (CAT) in brain ischemic tolerance induced by ischemic…”
Get full text

Blood cells serve as a source of factor-inducing rapid ischemic tolerance in brain by Bonova, Petra, Nemethova, Miroslava, Matiasova, Milina, Bona, Martin, Gottlieb, Miroslav

“…Ischemic tolerance (IT) has gained attention as an attractive strategy for improving stroke outcome. Recently, it was shown that signal responsible for rapid…”
Get full text