Search Results - "NEMENOFF, R. A"

Phosphorylation and activation of a high molecular weight form of phospholipase A2 by p42 microtubule-associated protein 2 kinase and protein kinase C by NEMENOFF, R. A, WINITZ, S, NAN-XIN QIAN, VAN PUTTEN, V, JOHNSON, G. L, HEASLEY, L. E

“…Phospholipase A2 (PLA2) is the enzyme regulating the release of arachidonic acid in most cell types. A high molecular mass, 85-kDa soluble form of PLA2 (cPLA2)…”
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Recombinant human erythropoietin dosing errors due to concentrated EPO by Spiegel, D M, Nemenoff, R A

“…Recombinant human erythropoietin (rHuEPO) is widely used to treat anemia. A dialysis provider enacted a policy utilizing 20,000 U/ml multi-dose vials for…”
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Purification of a high-molecular-mass form of phospholipase A2 from rat kidney activated at physiological calcium concentrations by Gronich, J H, Bonventre, J V, Nemenoff, R A

“…Rat kidney contains a soluble phospholipase A2 (PLA2), which is chromatographically identical with a previously identified hormonally regulated form of the…”
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Identification and characterization of a hormonally regulated form of phospholipase A2 in rat renal mesangial cells by Gronich, J H, Bonventre, J V, Nemenoff, R A

“…The activity of phospholipase A2 (PLA2), the regulatory enzyme in arachidonic acid release and prostaglandin synthesis, was measured in cell-free extracts of…”
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Purification of a Hepatic S6 Kinase from Cycloheximide-treated Rats by Price, D J, Nemenoff, R A, Avruch, J

“…Cycloheximide injection of rats results in the activation of a protein kinase that phosphorylates 40 S ribosomal protein S6. This Ca2+/cyclic…”
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Glutamate stably enhances the activity of two cytosolic forms of phospholipase A2 in brain cortical cultures by Kim, D K, Rordorf, G, Nemenoff, R A, Koroshetz, W J, Bonventre, J V

“…The mechanisms by which glutamatergic neurotransmitters modulate neuronal lipid metabolism are not well established. We have directly measured phospholipase A2…”
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AVP-induced activation of MAP kinase in vascular smooth muscle cells is mediated through protein kinase C by Kribben, A, Wieder, E D, Li, X, van Putten, V, Granot, Y, Schrier, R W, Nemenoff, R A

“…Arginine vasopressin (AVP) has been shown to stimulate tyrosine phosphorylation and activation of p42 mitogen-activated protein (MAP) kinase (p42MAPK) in…”
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Inhibition of MAP kinase by prostaglandin E2 and forskolin in rat renal mesangial cells by Li, X, Zarinetchi, F, Schrier, R W, Nemenoff, R A

“…Activation of the mitogen-activated protein (MAP) kinase pathway is believed to play a critical role in normal and pathophysiological proliferation of…”
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Epidermal growth factor enhances glomerular mesangial cell soluble phospholipase A2 activity by BONVENTRE, J. V, GRONICH, J. H, NEMENOFF, R. A

“…We have previously characterized a hormonally regulated soluble form of phospholipase A2 (PLA2) in the cultured renal mesangial cell which is similar and…”
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Vascular smooth muscle cells grown on Matrigel. A model of the contractile phenotype with decreased activation of mitogen-activated protein kinase by LI, X, PHOEBE TSAI, WIEDER, E. D, KRIBBEN, A, VAN PUTTEN, V, SCHRIER, R. W, NEMENOFF, R. A

“…Vascular smooth muscle cells have been shown to exist in two phenotypic states which have been designated proliferative and contractile. The properties of rat…”
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Effect of nitric oxide donors on renal tubular epithelial cell-matrix adhesion by Wangsiripaisan, Adisorn, Gengaro, Patricia E., Nemenoff, Raphael A., Ling, Hong, Edelstein, Charles L., Schrier, Robert W.

“…Effect of nitric oxide donors on renal tubular epithelial cell-matrix adhesion. Nitric oxide (NO) and its metabolite, peroxynitrite (ONOO-), are involved in…”
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Identification of the insulin receptor tyrosine residues undergoing insulin-stimulated phosphorylation in intact rat hepatoma cells by Tornqvist, H E, Gunsalus, J R, Nemenoff, R A, Frackelton, A R, Pierce, M W, Avruch, J

“…Tyr(P)-containing proteins were purified from extracts of insulin-treated rat hepatoma cells (H4-II-E-C3) by antiphosphotyrosine immunoaffinity chromatography…”
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The Role of Cysteine Proteases in Hypoxia-Induced Rat Renal Proximal Tubular Injury by Edelstein, Charles L., Wieder, Eric D., Yaqoob, Muhammad M., Gengaro, Patricia E., Burke, Thomas J., Nemenoff, Raphael A., Schrier, Robert W.

“…The role of the lysosomal proteases cathepsins B and L and the calcium-dependent cytosolic protease calpain in hypoxia-induced renal proximal tubular injury…”
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Nitric oxide kinetics during hypoxia in proximal tubules: Effects of acidosis and glycine by Yaqoob, Muhammad, Edelstein, Charles L., Wieder, Eric D., Alkhunaizi, Ahmed M., Gengaro, Patricia E., Nemenoff, Raphael A., Schrier, Robert W.

“…Nitric oxide kinetics during hypoxia in proximal tubules: effects of glycine and acidosis. In the present study, we directly monitored nitric oxide (NO) with…”
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Inhibitory actions of cyclic adenosine monophosphate and pertussis toxin define two distinct epidermal growth factor–regulated pathways leading to activation of mitogen‐activated protein kinase in rat hepatocytes by Gines, P, Li, X, Brown, S E, Nakamura, T, Guzelian, P S, Heasley, L E, Schrier, R W, Nemenoff, R A

“…Increased intracellular cyclic adenosine monophosphate (cAMP) levels have been shown in some reports to inhibit and in other studies to stimulate growth…”
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Subendothelial Cells From Normal Bovine Arteries Exhibit Autonomous Growth and Constitutively Activated Intracellular Signaling by Frid, Maria G, Aldashev, Almaz A, Nemenoff, Raphael A, Higashito, Ryuji, Westcott, Jay Y, Stenmark, Kurt R

“…The arterial media is comprised of heterogeneous smooth muscle cell (SMC) subpopulations with markedly different growth responses to pathophysiological…”
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Peroxisome Proliferator-Activated Receptor Gamma (PPARγ) Expression Is Decreased in Pulmonary Hypertension and Affects Endothelial Cell Growth by Ameshima, Shingo, Golpon, Heiko, Cool, Carlyne D, Chan, Daniel, Vandivier, R William, Gardai, Shyra J, Wick, Marilee, Nemenoff, Raphael A, Geraci, Mark W, Voelkel, Norbert F

“…ABSTRACT—PPARγ is a member of a family of nuclear receptors/ligand–dependent transcription factors, which bind to hormone response elements on target gene…”
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Peroxisome proliferator-activated receptor-γ (PPARγ) inhibits tumorigenesis by reversing the undifferentiated phenotype of metastatic non-small-cell lung cancer cells (NSCLC) by BREN-MATTISON, Yvette, VAN PUTTEN, Vicki, CHAN, Daniel, WINN, Robert, GERACI, Mark W, NEMENOFF, Raphael A

“…Pharmacological activators of peroxisome proliferator-activated receptor-gamma (PPAR(gamma)) have been shown to inhibit growth of lung tumors largely through…”
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Regulation of Smooth Muscle α-Actin Promoter by Vasopressin and Platelet-Derived Growth Factor in Rat Aortic Vascular Smooth Muscle Cells by Putten, Vicki Van, Li, Xiaomei, Maselli, Judith, Nemenoff, Raphael A

“…Vasoconstrictors such as arginine vasopressin (AVP) and angiotensin II (Ang II) have been shown to increase protein and mRNA levels of smooth muscle α-actin…”
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Subcellular characteristics of phospholipase A2 activity in the rat kidney. Enhanced cytosolic, mitochondrial, and microsomal phospholipase A2 enzymatic activity after renal ischemia and reperfusion by Nakamura, H, Nemenoff, R A, Gronich, J H, Bonventre, J V

“…Phospholipase A2 (PLA2) activities in cytosolic, mitochondrial, and microsomal fractions of rat kidneys were characterized under control conditions, after…”
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