Search Results - "NELSESTUEN, G. L"

Correlation of a T45S variant of apolipoprotein C1 with elevated BMI in persons of American Indian and Mexican ancestries by KASTHURI, R. S, MCMILLAN, K. R, FLOOD-URDANGARIN, C, HARVEY, S. B, WILSON-GRADY, J. T, NELSESTUEN, G. L

“…Obesity and diabetes are serious health problems for Americans and especially for those with American Indian or Mexican ancestry. A preliminary survey by…”
Get full text

Predicting decline of kidney function in lupus nephritis using urine biomarkers by Abulaban, K M, Song, H, Zhang, X, Kimmel, P L, Kusek, J W, Nelson, R G, Feldman, H I, Vasan, R S, Ying, J, Mauer, M, Nelsestuen, G L, Bennett, M, Brunner, H I, Rovin, B H

“…Objective To evaluate candidate biomarkers to predict future renal function decline (RFD) in children and adults with lupus nephritis (LN). Methods At the time…”
Get full text

Potential biomarkers of an exaggerated response to endotoxemia by Kasthuri, R. S., Wroblewski, M., Jilma, B., Key, N. S., Nelsestuen, G. L.

“…Abstract Serial plasma protein analysis was used to study the acute plasma proteome response to endotoxemia (presence of toxic bacterial products called…”
Get full text

Reduced Outer Membrane Permeability of Escherichia coli O157:H7:  Suggested Role of Modified Outer Membrane Porins and Theoretical Function in Resistance to Antimicrobial Agents by Martinez, Michael B, Flickinger, Michael, Higgins, LeeAnn, Krick, Thomas, Nelsestuen, Gary L

“…Outer membrane permeability of Escherichia coli O157:H7 was determined by an in vivo kinetic model with the periplasmic enzyme alkaline phosphatase [Martinez…”
Get full text

Vitamin K-dependent proteins by Nelsestuen, Gary L., Shah, Amit M., Harvey, Stephen B.

“…Vitamin K is required for the synthesis of γ-carboxyglutamate (Gla) during postribosomal protein modification. Substrates include blood clotting proteins, vone…”
Get full text

Independent association of serum amyloid P component, protein S, and complement C4b with complement C4b-binding protein and subsequent association of the complex with membranes by Schwalbe, R A, Dahlbäck, B, Nelsestuen, G L

“…C4b-binding protein (C4BP) is a large complex assembly of eight subunits that functions as an inhibitor of the complement cascade. A portion of the C4BP in…”
Get full text

Protein Structural Requirements and Properties of Membrane Binding by γ-Carboxyglutamic Acid-containing Plasma Proteins and Peptides by Schwalbe, R.A., Ryan, J, Stern, D.M., Kisiel, W, Dahlbäck, B, Nelsestuen, G.L.

“…The membrane-binding characteristics of a number of modified vitamin K-dependent proteins and peptides showed a general pattern of structural requirements. The…”
Get full text

Extensive segregation of acidic phospholipids in membranes induced by protein kinase C and related proteins by Bazzi, Mohammad D, Nelsestuen, Gary L

“…Protein kinase C and two other proteins with molecular masses of 64 and 32 kDa, purified from bovine brain, constitute a type of protein that binds a large…”
Get full text

Importance of phosphatidylethanolamine for association of protein kinase C and other cytoplasmic proteins with membranes by Bazzi, Mohammad D, Youakim, M. Angelique, Nelsestuen, Gary L

“…Biological membranes exhibit an asymmetric distribution of phospholipids. Phosphatidylserine (PS) is an acidic phospholipid that is found almost entirely on…”
Get full text

Pentraxin family of proteins interact specifically with phosphorylcholine and/or phosphorylethanolamine by Schwalbe, Ruth A, Dahlbaeck, Bjoern, Coe, John E, Nelsestuen, Gary L

“…Pentraxins are a family of serum proteins characterized by five identical subunits that are noncovalently linked. The two major types of pentraxins are…”
Get full text

Protein kinase C interaction with calcium: a phospholipid-dependent process by Bazzi, Mohammad D, Nelsestuen, Gary L

“…The calcium-binding properties of calcium- and phospholipid-dependent protein kinase C (PKC) were investigated by equilibrium dialysis in the presence and the…”
Get full text

Role of substrate in imparting calcium and phospholipid requirements to protein kinase C activation by Bazzi, Mohammad D, Nelsestuen, Gary L

“…The role of substrate in influencing the cofactor requirements of the phospholipid- and Ca2+-dependent protein kinase C (PKC) was investigated by using several…”
Get full text

Autophosphorylation of protein kinase C may require a high order of protein-phospholipid aggregates by BAZZI, M. D, NELSESTUEN, G. L

“…The activation of protein kinase C (PKC) usually displays cofactor requirements that include phosphatidylserine (PS), diacylglycerol, and calcium. A…”
Get full text

Enhancing the Activity of Protein C by Mutagenesis To Improve the Membrane-Binding Site:  Studies Related to Proline-10 by Shen, Lei, Shah, Amit M, Dahlbäck, Björn, Nelsestuen, Gary L

“…Bovine and human protein C show high homology in the amino acids of their GLA domains (amino-terminal 44 residues), despite the about 10-fold higher membrane…”
Get full text

Role of gamma-carboxyglutamic acid. An unusual protein transition required for the calcium-dependent binding of prothrombin to phospholipid by Nelsestuen, G L

“…A first order calcium-dependent transition can be monitored by a decrease in the intrinsic fluorescence of the isolated "pro" (Fragment1) region of…”
Get full text

Properties of membrane-inserted protein kinase C by Bazzi, Mohammad D, Nelsestuen, Gary L

“…Protein kinase C (PKC) interacted with phospholipid vesicles in a calcium-dependent manner and produced two forms of membrane-associated PKC: a reversibly…”
Get full text

Highly sequential binding of protein kinase C and related proteins to membranes by Bazzi, Mohammad D, Nelsestuen, Gary L

“…Protein kinase C belongs to a class of proteins that displays simultaneous interaction with calcium and phospholipids. Other members of this class include two…”
Get full text

Observations on the binding of lanthanides and calcium to vitamin D-dependent chick intestinal calcium-binding protein. Implications regarding calcium-binding protein function by Gross, M D, Nelsestuen, G L, Kumar, R

“…The binding of calcium and terbium to purified chick vitamin D-dependent intestinal calcium-binding protein was studied by terbium fluorescence, circular…”
Get full text

Association of protein kinase C with phospholipid vesicles by Bazzi, Mohammad D, Nelsestuen, Gary L

“…The Ca2+- and phospholipid-dependent protein kinase, protein kinase C (PKC), was purified from bovine brain by a modified procedure that provided sufficient…”
Get full text

Differences in the effects of phorbol esters and diacylglycerols on protein kinase C by Bazzi, Mohammad D, Nelsestuen, Gary L

“…The binding of protein kinase C (PKC) to membranes and appearance of kinase activity are separable events. Binding is a two-step process consisting of a…”
Get full text