Search Results - "NEGISHI, Masahiko"

Phenobarbital Meets Phosphorylation of Nuclear Receptors by Negishi, Masahiko

“…Phenobarbital was the first therapeutic drug to be characterized for its induction of hepatic drug metabolism. Essentially at the same time, cytochrome P450,…”
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Phosphorylated nuclear receptors as drug-targets by Negishi, Masahiko

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Nuclear receptor phosphorylation in xenobiotic signal transduction by Negishi, Masahiko, Kobayashi, Kaoru, Sakuma, Tsutomu, Sueyoshi, Tatsuya

“…Nuclear pregnane X receptor (PXR, NR1I2) and constitutive active/androstane receptor (CAR, NR1I3) are nuclear receptors characterized in 1998 by their…”
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Statin-activated nuclear receptor PXR promotes SGK2 dephosphorylation by scaffolding PP2C to induce hepatic gluconeogenesis by Gotoh, Saki, Negishi, Masahiko

“…Statin therapy is known to increase blood glucose levels in humans. Statins utilize pregnane X receptor (PXR) and serum/glucocorticoid regulated kinase 2…”
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Phenobarbital indirectly activates the constitutive active androstane receptor (CAR) by inhibition of epidermal growth factor receptor signaling by Mutoh, Shingo, Sobhany, Mack, Moore, Rick, Perera, Lalith, Pedersen, Lee, Sueyoshi, Tatsuya, Negishi, Masahiko

“…Phenobarbital is a central nervous system depressant that also indirectly activates nuclear receptor constitutive active androstane receptor (CAR), which…”
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CAR and PXR: The xenobiotic-sensing receptors by Timsit, Yoav E., Negishi, Masahiko

“…The xenobiotic receptors CAR and PXR constitute two important members of the NR1I nuclear receptor family. They function as sensors of toxic byproducts derived…”
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Regulation of gene expression by CAR: an update by Kobayashi, Kaoru, Hashimoto, Mari, Honkakoski, Paavo, Negishi, Masahiko

“…The constitutive androstane receptor (CAR), a member of the nuclear receptor superfamily, is a well-known xenosensor that regulates hepatic drug metabolism and…”
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Phosphorylation of nuclear receptors: Novelty and therapeutic implications by Shindo, Sawako, Kakizaki, Satoru, Sakaki, Toshiyuki, Kawasaki, Yuki, Sakuma, Tsutomu, Negishi, Masahiko, Shizu, Ryota

“…Nuclear receptors (NR) collectively regulate several biological functions in various organs. While NRs can be characterized by activation of the transcription…”
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Glucose elicits serine/threonine kinase VRK1 to phosphorylate nuclear pregnane X receptor as a novel hepatic gluconeogenic signal by Gotoh, Saki, Miyauchi, Yuu, Moore, Rick, Negishi, Masahiko

“…Low glucose stimulated phosphorylation of pregnane X receptor (PXR) at Ser350 in correlation with an increased gluconeogenesis in human hepatoma-derived HepG2…”
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Serum- and glucocorticoid-regulated kinase 2 determines drug-activated pregnane X receptor to induce gluconeogenesis in human liver cells by Gotoh, Saki, Negishi, Masahiko

“…Drug activation of the human nuclear pregnane X receptor (PXR) induced gluconeogenic genes and increased glucose production. In this study, we have determined…”
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Ligand induced dissociation of the AR homodimer precedes AR monomer translocation to the nucleus by Shizu, Ryota, Yokobori, Kosuke, Perera, Lalith, Pedersen, Lee, Negishi, Masahiko

“…The androgen receptor (AR) regulates male sexual development. We have now investigated AR homodimerization, hormone-dependent monomerization and nuclear…”
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Nuclear Pregnane X Receptor Cross-talk with FoxA2 to Mediate Drug-induced Regulation of Lipid Metabolism in Fasting Mouse Liver by Nakamura, Kouichi, Moore, Rick, Negishi, Masahiko, Sueyoshi, Tatsuya

“…Upon drug activation, the nuclear pregnane X receptor (PXR) regulates not only hepatic drug but also energy metabolism. Using Pxr–/– mice, we have now…”
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Nuclear Receptor CAR Suppresses GADD45B-p38 MAPK Signaling to Promote Phenobarbital-induced Proliferation in Mouse Liver by Hori, Takeshi, Saito, Kosuke, Moore, Rick, Flake, Gordon P, Negishi, Masahiko

“…Phenobarbital, a nongenotoxic hepatocarcinogen, induces hepatic proliferation and promotes development of hepatocellular carcinoma (HCC) in rodents. Nuclear…”
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Phosphorylated Nuclear Receptor CAR Forms a Homodimer To Repress Its Constitutive Activity for Ligand Activation by Shizu, Ryota, Osabe, Makoto, Perera, Lalith, Moore, Rick, Sueyoshi, Tatsuya, Negishi, Masahiko

“…The nuclear receptor CAR (NR1I3) regulates hepatic drug and energy metabolism as well as cell fate. Its activation can be a critical factor in drug-induced…”
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CAR requires Gadd45β to promote phenobarbital-induced mouse liver tumors in early stage by Hori, Takeshi, Yokobori, Kosuke, Moore, Rick, Negishi, Masahiko, Sueyoshi, Tatsuya

“…Phenobarbital (PB) is an archetypal substance used as a mouse hepatocellular carcinoma (HCC) promotor in established experimental protocols. Our previous…”
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Nuclear receptor CAR-ERα signaling regulates the estrogen sulfotransferase gene in the liver by Yi, MyeongJin, Fashe, Muluneh, Arakawa, Shingo, Moore, Rick, Sueyoshi, Tatsuya, Negishi, Masahiko

“…Estrogen sulfotransferase (SULT1E1) inactivates estrogen and regulates its metabolic homeostats. Whereas SULT1E1 is expressed low in the liver of adult mice,…”
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The Roles of Nuclear Receptors CAR and PXR in Hepatic Energy Metabolism by Konno, Yoshihiro, Negishi, Masahiko, Kodama, Susumu

“…Nuclear receptors constitutive active/androstane receptor (CAR) and pregnane X receptor (PXR) were originally characterized as transcription factors regulating…”
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A phosphorylation-deficient mutant of retinoid X receptor α at Thr 167 alters fasting response and energy metabolism in mice by Sueyoshi, Tatsuya, Sakuma, Tsutomu, Shindo, Sawako, Fashe, Muluneh, Kanayama, Tomohiko, Ray, Manas, Moore, Rick, Negishi, Masahiko

“…Retinoid X receptor α (RXRα) has a conserved phosphorylation motif at threonine 162 (humans) and threonine 167 (mice) within the DNA-binding domain. Here we…”
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Coordinated regulation of nuclear receptor CAR by CCRP/DNAJC7, HSP70 and the ubiquitin-proteasome system by Timsit, Yoav E, Negishi, Masahiko

“…The constitutive active/androstane receptor (CAR) plays an important role as a coordinate transcription factor in the regulation of various hepatic metabolic…”
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Serine 216 phosphorylation of estrogen receptor α in neutrophils: migration and infiltration into the mouse uterus by Shindo, Sawako, Moore, Rick, Flake, Gordon, Negishi, Masahiko

“…Whereas estrogen receptors are present in immune cells, it is not known if they are phosphorylated to regulate immune cell functions. Here we determined the…”
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