Search Results - "NEESSE, Albrecht"

Stromal biology and therapy in pancreatic cancer: a changing paradigm by Neesse, Albrecht, Algül, Hana, Tuveson, David A, Gress, Thomas M

“…Pancreatic ductal adenocarcinoma (PDA) exhibits one of the poorest prognosis of all solid tumours and poses an unsolved problem in cancer medicine. Despite the…”
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Microenvironmental Determinants of Pancreatic Cancer by Hessmann, Elisabeth, Buchholz, Sören M, Demir, Ihsan Ekin, Singh, Shiv K, Gress, Thomas M, Ellenrieder, Volker, Neesse, Albrecht

“…Pancreatic ductal adenocarcinoma (PDAC) belongs to the most lethal solid tumors in humans. A histological hallmark feature of PDAC is the pronounced tumor…”
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A tangled tale of molecular subtypes in pancreatic cancer by Singh, Shiv, Hasselluhn, Marie Christin, Neesse, Albrecht

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The Pancreas Cancer Microenvironment by FEIG, Christine, GOPINATHAN, Aarthi, NEESSE, Albrecht, CHAN, Derek S, COOK, Natalie, TUVESON, David A

“…Pancreatic ductal adenocarcinoma (PDA) is a common and lethal malignancy resulting in more than 250,000 deaths per year worldwide. Despite extensive efforts,…”
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Suppression of HSF1 activity by wildtype p53 creates a driving force for p53 loss-of-heterozygosity by Isermann, Tamara, Şener, Özge Çiçek, Stender, Adrian, Klemke, Luisa, Winkler, Nadine, Neesse, Albrecht, Li, Jinyu, Wegwitz, Florian, Moll, Ute M., Schulz-Heddergott, Ramona

“…The vast majority of human tumors with p53 mutations undergo loss of the remaining wildtype p53 allele (loss-of-heterozygosity, p53LOH). p53LOH has watershed…”
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The Microbiome in PDAC-Vantage Point for Future Therapies? by Pfisterer, Nina, Lingens, Catharina, Heuer, Cathleen, Dang, Linh, Neesse, Albrecht, Ammer-Herrmenau, Christoph

“…Microorganisms have been increasingly implicated in the pathogenesis of malignant diseases, potentially affecting different hallmarks of cancer. Despite the…”
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nab-Paclitaxel potentiates gemcitabine activity by reducing cytidine deaminase levels in a mouse model of pancreatic cancer by Frese, Kristopher K, Neesse, Albrecht, Cook, Natalie, Bapiro, Tashinga E, Lolkema, Martijn P, Jodrell, Duncan I, Tuveson, David A

“…Nanoparticle albumin-bound (nab)-paclitaxel, an albumin-stabilized paclitaxel formulation, demonstrates clinical activity when administered in combination with…”
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CTGF antagonism with mAb FG-3019 enhances chemotherapy response without increasing drug delivery in murine ductal pancreas cancer by Neesse, Albrecht, Frese, Kristopher K., Bapiro, Tashinga E., Nakagawa, Tomoaki, Sternlicht, Mark D., Seeley, Todd W., Pilarsky, Christian, Jodrell, Duncan I., Spong, Suzanne M., Tuveson, David A.

“…Pancreatic ductal adenocarcinoma (PDA) is characterized by abundant desmoplasia and poor tissue perfusion. These features are proposed to limit the access of…”
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Diagnostic accuracy of B-Mode ultrasound and Hepatorenal Index for graduation of hepatic steatosis in patients with chronic liver disease by Petzold, Golo, Lasser, Julian, Rühl, Janina, Bremer, Sebastian C B, Knoop, Richard F, Ellenrieder, Volker, Kunsch, Steffen, Neesse, Albrecht

“…The aim of our study was to evaluate the diagnostic accuracy of B-Mode ultrasound and Hepatorenal Index (HRI) by high-end devices for the detection and…”
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Expression of gemcitabine metabolizing enzymes and stromal components reveal complexities of preclinical pancreatic cancer models for therapeutic testing by Knoll, Lisa, Hamm, Jacob, Stroebel, Philipp, Jovan, Todorovic, Goetze, Robert, Singh, Shiv, Hessmann, Elisabeth, Ellenrieder, Volker, Ammer-Herrmenau, Christoph, Neesse, Albrecht

“…Pancreatic ductal adenocarcinoma (PDAC) poorly responds to antineoplastic agents. Discrepancies between preclinical success and clinical failure of compounds…”
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Gut microbiota predicts severity and reveals novel metabolic signatures in acute pancreatitis by Ammer-Herrmenau, Christoph, Antweiler, Kai L, Asendorf, Thomas, Beyer, Georg, Buchholz, Soeren M, Cameron, Silke, Capurso, Gabriele, Damm, Marko, Dang, Linh, Frost, Fabian, Gomes, Antonio, Hamm, Jacob, Henker, Robert, Hoffmeister, Albrecht, Meinhardt, Christian, Nawacki, Lukasz, Nunes, Vitor, Panyko, Arpad, Pardo, Cesareo, Phillip, Veit, Pukitis, Aldis, Rasch, Sebastian, Riekstina, Diana, Rinja, Ecaterina, Ruiz-Rebollo, María Lourdes, Sirtl, Simon, Weingarten, Mark, Sandru, Vasile, Woitalla, Julia, Ellenrieder, Volker, Neesse, Albrecht

“…Early disease prediction is challenging in acute pancreatitis (AP). Here, we prospectively investigate whether the microbiome predicts severity of AP…”
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Endoscopic submucosal dissection with an additional working channel (ESD+): a novel technique to improve procedure time and safety of ESD by Knoop, Richard F., Wedi, Edris, Petzold, Golo, Bremer, Sebastian C. B., Amanzada, Ahmad, Ellenrieder, Volker, Neesse, Albrecht, Kunsch, Steffen

“…Background and aims A new external additional working channel (AWC) was recently introduced by which endoscopic submucosal dissection (ESD) can be converted to…”
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USP22 Suppresses SPARC Expression in Acute Colitis and Inflammation-Associated Colorectal Cancer by Kosinsky, Robyn Laura, Saul, Dominik, Ammer-Herrmenau, Christoph, Faubion, William A, Neesse, Albrecht, Johnsen, Steven A

“…As a member of the 11-gene "death-from-cancer" gene expression signature, ubiquitin-specific protease 22 (USP22) has been considered an oncogene in various…”
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The ETS-Transcription Factor ETV1 Regulates Stromal Expansion and Metastasis in Pancreatic Cancer by Heeg, Steffen, Das, Koushik K, Reichert, Maximilian, Bakir, Basil, Takano, Shigetsugu, Caspers, Julia, Aiello, Nicole M, Wu, Katherine, Neesse, Albrecht, Maitra, Anirban, Iacobuzio-Donahue, Christine A, Hicks, Philip, Rustgi, Anil K

“…Abstract Background & aims The ETS-transcription factor ETV1 is involved in the epithelial–mesenchymal transition (EMT) during pancreatic development and is…”
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Claudin-4 SPECT Imaging Allows Detection of Aplastic Lesions in a Mouse Model of Breast Cancer by Mosley, Michael, Knight, James, Neesse, Albrecht, Michl, Patrick, Iezzi, Manuela, Kersemans, Veerle, Cornelissen, Bart

“…The expression of claudin-4, a protein involved in tight junction complexes, is widely dysregulated in epithelial malignancies. Claudin-4 is overexpressed in…”
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Pathological gallbladder wall thickening is associated with advanced chronic liver disease and independent of serum albumin by Bremer, Sebastian C. B., Knoop, Richard F., Porsche, Melissa, Amanzada, Ahmad, Ellenrieder, Volker, Neesse, Albrecht, Kunsch, Steffen, Petzold, Golo

“…Purpose Increased gallbladder wall thickness (GBWT) is a common finding. Reported causes include advanced chronic liver disease (ACLD), ascites and…”
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Systematic Retesting for Helicobacter pylori: The Potential Overestimation of Suppressive Conditions by Knoop, Richard F., Gaertner, Pauline C., Petzold, Golo, Amanzada, Ahmad, Ellenrieder, Volker, Neesse, Albrecht, Bremer, Sebastian C. B., Kunsch, Steffen

“…Background and Aims. In contrast to guideline recommendations, endoscopic testing for Helicobacter pylori is frequently performed under Helicobacter pylori…”
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Impact of intensified chemotherapy in metastatic pancreatic ductal adenocarcinoma (PDAC) in clinical routine in Europe by Javed, Muhammad Ahsan, Beyer, Georg, Le, Nha, Vinci, Alessio, Wong, Helen, Palmer, Daniel, Morgan, Robert D., Lamarca, Angela, Hubner, Richard A., Valle, Juan W., Alam, Salma, Chowdhury, Sumsur, Ma, Yuk Ting, Archibugi, Livia, Capurso, Gabriele, Maisonneuve, Patrick, Neesse, Albrecht, Sund, Malin, Schober, Marvin, Krug, Sebastian

“…Pancreatic ductal adenocarcinoma (PDAC) is associated with poor prognosis. Gemcitabine is the standard chemotherapy for patients with metastatic pancreatic…”
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TP53-Status-Dependent Oncogenic EZH2 Activity in Pancreatic Cancer by Versemann, Lennart, Patil, Shilpa, Steuber, Benjamin, Zhang, Zhe, Kopp, Waltraut, Krawczyk, Hannah Elisa, Kaulfuß, Silke, Wollnik, Bernd, Ströbel, Philipp, Neesse, Albrecht, Singh, Shiv K., Ellenrieder, Volker, Hessmann, Elisabeth

“…Pancreatic Ductal Adenocarcinoma (PDAC) represents a lethal malignancy with a consistently poor outcome. Besides mutations in PDAC driver genes, the aggressive…”
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Gall bladder wall thickening as non-invasive screening parameter for esophageal varices - a comparative endoscopic - sonographic study by Tsaknakis, Birgit, Masri, Rawan, Amanzada, Ahmad, Petzold, Golo, Ellenrieder, Volker, Neesse, Albrecht, Kunsch, Steffen

“…The mortality due to hemorrhage of esophageal varices (EV) is still high. The predominant cause for EV is liver cirrhosis, which has a high prevalence in…”
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