Search Results - "NECKERS, L"

Update on Hsp90 inhibitors in clinical trial by Kim, Y S, Alarcon, S V, Lee, S, Lee, M-J, Giaccone, G, Neckers, L, Trepel, J B

“…Twenty-five years ago the first small molecule inhibitors of Hsp90 were identified. In the intervening years there has been dramatic progress in basic…”
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Chaperoning oncogenes: Hsp90 as a target of geldanamycin by Neckers, L

“…Heat shock protein 90 (Hsp90) is a molecular chaperone required for the stability and function of a number of conditionally activated and/or expressed…”
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The mitochondrial type IB topoisomerase drives mitochondrial translation and carcinogenesis by Baechler, S. A., Factor, V. M., Dalla Rosa, I., Ravji, A., Becker, D., Khiati, S., Miller Jenkins, L. M., Lang, M., Sourbier, C., Michaels, S. A., Neckers, L. M., Zhang, H. L., Spinazzola, A., Huang, S. N., Marquardt, J. U., Pommier, Y.

“…Mitochondrial topoisomerase IB (TOP1MT) is a nuclear-encoded topoisomerase, exclusively localized to mitochondria, which resolves topological stress generated…”
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A small molecule cell-impermeant Hsp90 antagonist inhibits tumor cell motility and invasion by Tsutsumi, S, Scroggins, B, Koga, F, Lee, M-J, Trepel, J, Felts, S, Carreras, C, Neckers, L

“…Heat shock protein 90 (Hsp90) is a molecular chaperone that maintains function of numerous intracellular signaling nodes utilized by cancer cells for…”
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Novel mutations in FH and expansion of the spectrum of phenotypes expressed in families with hereditary leiomyomatosis and renal cell cancer by Wei, M-H, Toure, O, Glenn, G M, Pithukpakorn, M, Neckers, L, Stolle, C, Choyke, P, Grubb, R, Middelton, L, Turner, M L, Walther, M M, Merino, M J, Zbar, B, Linehan, W M, Toro, J R

“…Background: Hereditary leiomyomatosis and renal cell cancer (HLRCC; OMIM 605839) is the predisposition to develop smooth muscle tumours of the skin and uterus…”
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Stabilization of wild-type p53 by hypoxia-inducible factor 1α by Neckers, Leonard M, An, Won G, Kanekal, Meera, Simon, M. Celeste, Maltepe, Emin, Blagosklonny, Mikhail V

“…Although hypoxia (lack of oxygen in body tissues) is perhaps the most physiological inducer of the wild-type p53 gene, the mechanism of this induction is…”
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HIF and fumarate hydratase in renal cancer by SUDARSHAN, S, LINEHAN, W. M, NECKERS, L

“…Hereditary leiomyomatosis and renal cell cancer is a recently described hereditary cancer syndrome in which affected individuals are predisposed to the…”
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The benzoquinone ansamycin 17-allylamino-17-demethoxygeldanamycin binds to HSP90 and shares important biologic activities with geldanamycin by SCHULTE, T. W, NECKERS, L. M

“…Benzoquinone ansamycins are antibiotics with anticancer potential. First described as tyrosine kinase inhibitors, they are now frequently used to target HSP90…”
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The Hsp90 inhibitor geldanamycin selectively sensitizes Bcr-Abl-expressing leukemia cells to cytotoxic chemotherapy by BLAGOSKLONNY, M. V, FOJO, T, BHALLA, K. N, KIM, J-S, TREPEL, J. B, FIGG, W. D, RIVERA, Y, NECKERS, L. M

“…The Bcr-Abl fusion protein drives leukemogenesis and can render leukemia cells resistant to conventional chemotherapy. Geldanamycin (GA), a drug which…”
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Sensitivity of epidermal growth factor receptor and ErbB2 exon 20 insertion mutants to Hsp90 inhibition by XU, W, SOGA, S, BEEBE, K, LEE, M. J, KIM, Y. S, TREPEL, J, NECKERS, L

“…The mature epidermal growth factor receptor (EGFR) neither associates with nor requires the molecular chaperone heat-shock protein 90 (Hsp90). Mutations in…”
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Tumor-intrinsic and tumor-extrinsic factors impacting hsp90- targeted therapy by Alarcon, S V, Mollapour, M, Lee, M-J, Tsutsumi, S, Lee, S, Kim, Y S, Prince, T, Apolo, A B, Giaccone, G, Xu, W, Neckers, L M, Trepel, J B

“…In 1994 the first heat shock protein 90 (Hsp90) inhibitor was identified and Hsp90 was reported to be a target for anticancer therapeutics. In the past 18…”
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Taxol-induced apoptosis and phosphorylation of Bcl-2 protein involves c-Raf-1 and represents a novel c-Raf-1 signal transduction pathway by BLAGOSKLONNY, M. V, SCHULTE, T, PHUONGMAI NGUYEN, TREPEL, J, NECKERS, L. M

“…c-Raf-1 (Raf-1) is a central component of signal transduction pathways stimulated by various growth factors, protein kinase C, and other protein kinases. Raf-1…”
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Hsp90 Regulates a von Hippel Lindau-independent Hypoxia-inducible Factor-1α-degradative Pathway by Isaacs, Jennifer S., Jung, Yun-Jin, Mimnaugh, Edward G., Martinez, Alfredo, Cuttitta, Frank, Neckers, Leonard M.

“…HIF-1α is a normally labile proangiogenic transcription factor that is stabilized and activated in hypoxia. Although the von Hippel Lindau (VHL) gene product,…”
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KF25706, a novel oxime derivative of radicicol, exhibits in vivo antitumor activity via selective depletion of Hsp90 binding signaling molecules by SOGA, S, NECKERS, L. M, AKINAGA, S, SCHULTE, T. W, SHIOTSU, Y, AKASAKA, K, NARUMI, H, AGATSUMA, T, IKUINA, Y, MURAKATA, C, TAMAOKI, T

“…Radicicol, a macrocyclic antifungal antibiotic, has been shown to bind to the heat shock protein 90 (Hsp90) chaperone, interfering with its function. Hsp90…”
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Mutant Conformation of p53 Translated in vitro or in vivo Requires Functional HSP90 by Blagosklonny, Mikhail V., Toretsky, Jeffrey, Bohen, Sean, Neckers, Len

“…The p53 mutant, 143ala, was translated in vitro in either rabbit reticulocyte lysate (RRL) or wheat germ extract (WGE). In RRL, p53-143ala protein of both…”
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FLT3 regulates β-catenin tyrosine phosphorylation, nuclear localization, and transcriptional activity in acute myeloid leukemia cells by KAJIGUCHI, T, CHUNG, E. J, LEE, S, STINE, A, KIYOI, H, NAOE, T, LEVIS, M. J, NECKERS, L, TREPEL, J. B

“…Deregulated accumulation of nuclear beta-catenin enhances transcription of beta-catenin target genes and promotes malignant transformation. Recently, acute…”
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The Heat Shock Protein 90 Antagonist Novobiocin Interacts with a Previously Unrecognized ATP-binding Domain in the Carboxyl Terminus of the Chaperone by Marcu, Monica G., Chadli, Ahmed, Bouhouche, Ilham, Catelli, Maria, Neckers, Leonard M.

“…Heat shock protein 90 (Hsp90), one of the most abundant chaperones in eukaryotes, participates in folding and stabilization of signal-transducing molecules…”
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Characterization of Oligonucleotide Transport into Living Cells by Loke, S. L., Stein, C. A., Zhang, X. H., Mori, K., Nakanishi, M., Subasinghe, C., Cohen, J. S., Neckers, L. M.

“…Addition of antisense oligonucleotides to cell cultures has been used to specifically inhibit gene expression. We have investigated the mechanism by which…”
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Stability, Clearance, and Disposition of Intraventricularly Administered Oligodeoxynucleotides: Implications for Therapeutic Application within the Central Nervous System by Whitesell, Luke, Geselowitz, Daniel, Chavany, Christine, Fahmy, Brigid, Walbridge, Stuart

“…We report experiments in the rat demonstrating the feasibility of intraventricular administration of oligodeoxynucleotides (ODNs) as a regional treatment…”
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Destabilization of Raf-1 by geldanamycin leads to disruption of the Raf-1-MEK-mitogen-activated protein kinase signalling pathway by Schulte, Theodor W., Blagosklonny, Mikhail V., Romanova, Larissa, Mushinski, J. Frederic, Monia, Brett P., Johnston, Joseph F., Nguyen, Phuongmai, Trepel, Jane, Neckers, Leonard M.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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