Search Results - "NEAME, Stephen J"

Microglial signalling pathway deficits associated with the patient derived R47H TREM2 variants linked to AD indicate inability to activate inflammasome by Cosker, Katharina, Mallach, Anna, Limaye, Janhavi, Piers, Thomas M., Staddon, James, Neame, Stephen J., Hardy, John, Pocock, Jennifer M.

“…The R47H variant of the microglial membrane receptor TREM2 is linked to increased risk of late onset Alzheimer’s disease. Human induced pluripotent stem cell…”
Get full text

Dominant-Negative c-Jun Promotes Neuronal Survival by Reducing BIM Expression and Inhibiting Mitochondrial Cytochrome c Release by Whitfield, Jonathan, Neame, Stephen J, Paquet, Luc, Bernard, Ora, Ham, Jonathan

“…Sympathetic neurons require nerve growth factor for survival and die by apoptosis in its absence. Key steps in the death pathway include c-Jun activation,…”
Get full text

c-Jun and the transcriptional control of neuronal apoptosis by Ham, Jonathan, Eilers, Andreas, Whitfield, Jonathan, Neame, Stephen J, Shah, Bina

“…There has been considerable interest in the molecular mechanisms of apoptosis in mammalian neurons because this form of neuronal cell death is important for…”
Get full text

Blocking Cytochrome c Activity within Intact Neurons Inhibits Apoptosis by Neame, Stephen J., Rubin, Lee L., Philpott, Karen L.

“…Cytochrome c has been shown to play a role in cell-free models of apoptosis. During NGF withdrawal-induced apoptosis of intact rat superior cervical ganglion…”
Get full text

Selection and structural characterization of anti-TREM2 scFvs that reduce levels of shed ectodomain by Szykowska, Aleksandra, Chen, Yu, Smith, Thomas B., Preger, Charlotta, Yang, Jingjing, Qian, Dongming, Mukhopadhyay, Shubhashish M., Wigren, Edvard, Neame, Stephen J., Gräslund, Susanne, Persson, Helena, Atkinson, Peter J., Di Daniel, Elena, Mead, Emma, Wang, John, Davis, John B., Burgess-Brown, Nicola A., Bullock, Alex N.

“…Mutations in TREM2, a receptor expressed by microglia in the brain, are associated with an increased risk of neurodegeneration, including Alzheimer's disease…”
Get full text

The neuroprotective action of JNK3 inhibitors based on the 6,7-dihydro-5H-pyrrolo[1,2-a]imidazole scaffold by GRACZYK, Piotr P, KHAN, Afzal, SMALES, Caroline, WHITFIELD, Jonathan, NEAME, Stephen J, SHAH, Bina, WILTON, Daniel, MORGAN, Louise, PATEL, Toshal, CHUNG, Raymond, DESMOND, Howard, STADDON, James M, BHATIA, Gurpreet S, SATO, Nobuaki, INOUE, Atsushi, PALMER, Vanessa, MEDLAND, Darren, NUMATA, Hirotoshi, OINUMA, Hitoshi, CATCHICK, Jacqueline, DUNNE, Angela, ELLIS, Moira

“…Imidazole-based structures of p38 inhibitors served as a starting point for the design of JNK3 inhibitors. Construction of a…”
Get full text

Methods for culturing primary sympathetic neurons and for determining neuronal viability by Whitfield, Jonathan, Neame, Stephen J, Ham, Jonathan

“…Developing nerve growth factor (NGF)-dependent sympathetic neurons are one of the best-studied in vitro models of neuronal apoptosis and have been used to…”
Get more information

Immunocytochemical techniques for studying apoptosis in primary sympathetic neurons by Neame, Stephen J, Whitfield, Jonathan, Ham, Jonathan

“…Developing sympathetic neurons, which depend on nerve growth factor for survival, are one of the best studied in vitro models of neuronal apoptosis and have…”
Get more information

Development of a pentylenetetrazole-induced seizure model to evaluate kinase inhibitor efficacy in the central nervous system by Morgan, Louise, Neame, Stephen J., Child, Hannah, Chung, Raymond, Shah, Bina, Barden, Laura, Staddon, James M., Patel, Toshal R.

“…c-Jun N-terminal kinases (JNKs) are implicated in cell death in neurodegenerative disorders. Therefore, JNK inhibitors could act as neuroprotective agents. To…”
Get full text

The Cytoplasmic Tail of CD44 Is Required for Basolateral Localization in Epithelial MDCK Cells but Does Not Mediate Association with the Detergent-Insoluble Cytoskeleton of Fibroblasts by Neame, Stephen J., Isacke, Clare M.

“…A number of recent reports on the trafficking of receptor proteins in MDCK epithelial cells have provided evidence that delivery to the basolateral domain…”
Get full text

CD44 exhibits a cell type dependent interaction with triton X-100 insoluble, lipid rich, plasma membrane domains by Neame, S J, Uff, C R, Sheikh, H, Wheatley, S C, Isacke, C M

“…CD44 is an abundant, widely expressed transmembrane glycoprotein which can act as a receptor for the extracellular matrix glycosaminoglycan, hyaluronan…”
Get full text

The neuroprotective action of JNK3 inhibitors based on the 6,7-dihydro-5 H-pyrrolo[1,2- a]imidazole scaffold by Graczyk, Piotr P., Khan, Afzal, Bhatia, Gurpreet S., Palmer, Vanessa, Medland, Darren, Numata, Hirotoshi, Oinuma, Hitoshi, Catchick, Jacqueline, Dunne, Angela, Ellis, Moira, Smales, Caroline, Whitfield, Jonathan, Neame, Stephen J., Shah, Bina, Wilton, Daniel, Morgan, Louise, Patel, Toshal, Chung, Raymond, Desmond, Howard, Staddon, James M., Sato, Nobuaki, Inoue, Atsushi

“…The synthesis and neuroprotective properties of three representative enantiomeric pairs ( S)- 2 and ( R)- 2 are reported. Imidazole-based structures of p38…”
Get full text

Phosphorylation of CD44 in vivo requires both Ser323 and Ser325, but does not regulate membrane localization or cytoskeletal interaction in epithelial cells by Neame, S.J., Isacke, C.M.

“…CD44 has been implicated to play an important role in a diverse range of physiological processes, which involve cell‐matrix recognition, cell‐cell adhesion and…”
Get full text

c-Jun and Bax: regulators of programmed cell death in developing neurons by Eilers, A, Whitfield, J, Vekrellis, K, Neame, S J, Shah, B, Ham, J

Get more information

Hyaluronan binding by CD44 is regulated by a phosphorylation-independent mechanism by Uff, C R, Neame, S J, Isacke, C M

“…CD44 is an adhesion receptor for which the major characterized ligand is the extracellular matrix glycosaminoglycan, hyaluronan. This interaction underlies…”
Get more information

A comparison of the effect of several factors on the plasminogen activator activity of cloned lines from an ethylnitrosourea-induced glioma and from normal tissue by Neame, S J, Roscoe, J P

“…Cells from gliomas induced by N-ethyl-N-nitrosourea have a high basal level of plasminogen activator activity compared with cells from normal tissue…”
Get more information