Search Results - "NEAL, J. W"

Flaviviruses are neurotropic, but how do they invade the CNS? by Neal, J.W

“…Summary Flaviruses (FV) are RNA viruses carried by mosquitoes. Neurological signs including acute encephalitis, meningitis and acute flaccid paralysis develop…”
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Consequence of Aβ immunization on the vasculature of human Alzheimer's disease brain by Boche, D., Zotova, E., Weller, R. O., Love, S., Neal, J. W., Pickering, R. M., Wilkinson, D., Holmes, C., Nicoll, J. A. R.

“…A major feature of Alzheimer's disease is the accumulation of amyloid-β peptide (Aβ) in the brain both in the form of plaques in the cerebral cortex and in…”
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Microglial alterations in human Alzheimer's disease following Aβ42 immunization by Zotova, E., Holmes, C., Johnston, D., Neal, J. W., Nicoll, J. A. R., Boche, D.

“…E. Zotova, C. Holmes, D. Johnston, J. W. Neal, J. A. R. Nicoll and D. Boche (2011) Neuropathology and Applied Neurobiology37, 513–524 Microglial alterations in…”
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Evolving concepts of chronic traumatic encephalopathy as a neuropathological entity by Ling, H., Neal, J. W., Revesz, T.

“…Chronic traumatic encephalopathy (CTE) is a long‐term neurodegenerative consequence of repetitive head impacts which can only be definitively diagnosed in…”
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Effect of fishing effort on catch rate and catchability of largemouth bass in small impoundments by Wegener, M. G., Schramm, H. L., Neal, J. W., Gerard, P. D.

“…Largemouth bass Micropterus salmoides (Lacepède) catch rates decline with sustained fishing effort, even without harvest. It is unclear why declines in catch…”
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Encephalitis due to emerging viruses: CNS innate immunity and potential therapeutic targets by Denizot, M, Neal, J.W, Gasque, P

“…Summary The emerging viruses represent a group of pathogens that are intimately connected to a diverse range of animal vectors. The recent escalation of air…”
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The membrane attack pathway of complement drives pathology in passively induced experimental autoimmune myasthenia gravis in mice by Morgan, B. P., Chamberlain‐Banoub, J., Neal, J. W., Song, W., Mizuno, M., Harris, C. L.

“…Summary The human neuromuscular disease myasthenia gravis (MG) is characterized by the generation of autoantibodies reactive with nicotinic acetylcholine…”
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A phase II multicentre study of ziv-aflibercept in combination with cisplatin and pemetrexed in patients with previously untreated advanced/metastatic non-squamous non-small cell lung cancer by Chen, H, Modiano, M R, Neal, J W, Brahmer, J R, Rigas, J R, Jotte, R M, Leighl, N B, Riess, J W, Kuo, C J, Liu, L, Gao, B, DiCioccio, A T, Adjei, A A, Wakelee, H A

“…Background: This study evaluated the efficacy and safety of ziv-aflibercept in combination with cisplatin and pemetrexed in non-small cell lung cancer (NSCLC)…”
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Increased Complement Biosynthesis By Microglia and Complement Activation on Neurons in Huntington's Disease by Singhrao, S.K, Neal, J.W, Morgan, B.P, Gasque, P

“…In this study complement activation and biosynthesis have been analysed in the brains of Huntington's disease (HD) (n=9) and normal (n=3) individuals. In HD…”
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Aberrant Interactions of Transcriptional Repressor Proteins with the Huntington's Disease Gene Product, Huntingtin by Boutell, Jonathan M., Thomas, Philip, Neal, James W., Weston, Victoria J., Duce, James, Harper, Peter S., Lesley Jones, A.

“…We detected an interaction of the N-terminus of huntingtin (htt171) with the C-terminal region of the nuclear receptor co-repressor (N-CoR) using the yeast…”
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Complement membrane attack is required for endplate damage and clinical disease in passive experimental myasthenia gravis in Lewis rats by Chamberlain‐Banoub, J., Neal, J. W., Mizuno, M., Harris, C. L., Morgan, B. P.

“…Summary Myasthenia gravis (MG) is a debilitating and potentially fatal neuromuscular disease characterized by the generation of autoantibodies reactive with…”
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Magnetic resonance imaging of fixed post mortem brains reliably reflects subcortical vascular pathology of frontal, parietal and occipital white matter by McAleese, K. E., Firbank, M., Hunter, D., Sun, L., Hall, R., Neal, J. W., Mann, D. M. A., Esiri, M., Jellinger, K. A., O'Brien, J. T., Attems, J.

“…Aims Subcortical vascular pathology of the white and deep grey matter (WM and DGM) is associated with cognitive impairment. Routine neuropathological…”
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A phase I dose-escalation study of aflibercept administered in combination with pemetrexed and cisplatin in patients with advanced solid tumours by Diaz-Padilla, I, Siu, L L, San Pedro-Salcedo, M, Razak, A R A, Colevas, A D, Shepherd, F A, Leighl, N B, Neal, J W, Thibault, A, Liu, L, Lisano, J, Gao, B, Lawson, E B, Wakelee, H A

“…Background: To evaluate the safety, pharmacokinetics (PKs), and pharmacodynamics of aflibercept, and to identify the recommended phase II dose (RP2D) of…”
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The Regulation of the CNS Innate Immune Response Is Vital for the Restoration of Tissue Homeostasis (Repair) after Acute Brain Injury: A Brief Review by Griffiths, M. R., Neal, J. W., Gasque, P.

“…Neurons and glia respond to acute injury by participating in the CNS innate immune response. This involves the recognition and clearance of “not self ”…”
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The Membrane Attack Complex of Complement Causes Severe Demyelination Associated with Acute Axonal Injury by Mead, Richard J, Singhrao, Sim K, Neal, James W, Lassmann, H, Morgan, B. Paul

“…Complement is implicated in pathology in the human demyelinating disease multiple sclerosis and in animal models that mimic the demyelination seen in multiple…”
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Expression of the receptor for complement C5a (CD88) is up-regulated on reactive astrocytes, microglia, and endothelial cells in the inflamed human central nervous system by Gasque, P, Singhrao, SK, Neal, JW, Gotze, O, Morgan, BP

“…C5a receptor (C5aR, CD88) is a receptor originally described on neutrophils and monocyte-macrophages but recently found on hepatocytes, epithelial cells,…”
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The role of primary infection of Schwann cells in the aetiology of infective inflammatory neuropathies by Neal, J.W, Gasque, P

“…Summary Numerous different pathogens are responsible for infective peripheral neuropathies and this is generally the result of the indirect effects of pathogen…”
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Consequence of A[beta] immunization on the vasculature of human Alzheimer's disease brain by Boche, D, Zotova, E, Weller, R O, Love, S, Neal, J W, Pickering, R M, Wilkinson, D, Holmes, C, Nicoll, J A R

“…A major feature of Alzheimer's disease is the accumulation of amyloid-β peptide (Aβ) in the brain both in the form of plaques in the cerebral cortex and in…”
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A case of multiple cutaneous schwannomas; schwannomatosis or neurofibromatosis type 2? by Murray, A J, Hughes, T A T, Neal, J W, Howard, E, Evans, D G R, Harper, P S

“…A 54 year old man presented with numerous cutaneous schwannomas, cranial nerve lesions, and spinal cord lesions, but no evidence of vestibular nerve…”
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Blockade of the C5a receptor fails to protect against experimental autoimmune encephalomyelitis in rats by MORGAN, B. P., GRIFFITHS, M., KHANOM, H., TAYLOR, S. M., NEAL, J. W.

“…SUMMARY Complement activation contributes to inflammation and tissue damage in human demyelinating diseases and in rodent models of demyelination. Inhibitors…”
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