Search Results - "NAZIROGLU, Mustafa"

Editorial: Involvements of TRP Channels, Oxidative Stress and Apoptosis in Neurodegenerative Diseases by Braidy, Nady, Smani, Tarik, Naziroglu, Mustafa

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Selenium and high dose vitamin E administration protects cisplatin-induced oxidative damage to renal, liver and lens tissues in rats by Nazıroǧlu, Mustafa, Karaoğlu, Aziz, Aksoy, Asude Orhan

“…Cisplatin is one of the most active cytotoxic agents in the treatment of cancer but its clinical use is associated with nephrotoxicity. Several studies suggest…”
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Melatonin potentiates chemotherapy-induced cytotoxicity and apoptosis in rat pancreatic tumor cells by Uguz, Abdulhadi C., Cig, Bilal, Espino, Javier, Bejarano, Ignacio, Naziroglu, Mustafa, Rodríguez, Ana B., Pariente, José A.

“…:  Melatonin has antitumor activity via several mechanisms including its antiproliferative and proapoptotic effects in addition to its potent antioxidant…”
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A novel antagonist of TRPM2 and TRPV4 channels: Carvacrol by Nazıroğlu, Mustafa

“…The overload cytosolic free Ca 2+ (cCa 2+ ) influx-mediated excessive generation of oxidative stress in the pathophysiological conditions induces neuronal and…”
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Resveratrol attenuates hypoxia-induced neuronal cell death, inflammation and mitochondrial oxidative stress by modulation of TRPM2 channel by Akyuva, Yener, Nazıroğlu, Mustafa

“…Hypoxia (HYPX) induced-overload Ca 2+ entry results in increase of mitochondrial oxidative stress, inflammation and apoptosis in several neurons. Ca 2+…”
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Glutathione Depletion and Parkinsonian Neurotoxin MPP+-Induced TRPM2 Channel Activation Play Central Roles in Oxidative Cytotoxicity and Inflammation in Microglia by Yıldızhan, Kenan, Nazıroğlu, Mustafa

“…Parkinson’s disease (PD) is one of most common neurodegenerative diseases. Environmental stressors such as oxidative stress (OS), calcium ion influx,…”
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Molecular role of catalase on oxidative stress-induced Ca(2+) signaling and TRP cation channel activation in nervous system by Nazıroğlu, Mustafa

“…Catalase catalyzes the reduction of H(2)O(2) to water and it can also remove organic hydroperoxides. Nervous system in body is especially sensitive to free…”
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TRPM2 Cation Channels, Oxidative Stress and Neurological Diseases: Where Are We Now? by Nazirolu, Mustafa

“…The Na+ and Ca 2+ -permeable melastatin related transient receptor potential 2 (TRPM2) channels can be gated either by ADP-ribose (ADPR) in concert with Ca 2+…”
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Editorial: Involvements of TRP Channels and Oxidative Stress in Pain by Carrasco, Cristina, Naziroglu, Mustafa, Pecze, Laszlo, Pariente, José A

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New molecular mechanisms on the activation of TRPM2 channels by oxidative stress and ADP-ribose by Naziroglu, Mustafa

“…The Na(+) and Ca(2+)-permeable melastatin related transient receptor potential (TRPM2) cation channels can be gated either by ADP-ribose (ADPR) in concert with…”
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NMDA Receptor Activation Stimulates Hypoxia-Induced TRPM2 Channel Activation, Mitochondrial Oxidative Stress, and Apoptosis in Neuronal Cell Line: Modular Role of Memantine by Yıldızhan, Kenan, Nazıroğlu, Mustafa

“…The possible mechanisms of hypoxia-induced NMDA receptor and TRPM2 channel activation on the mitochondrial oxidative stress, apoptosis, and cytokine in the…”
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TRPV1 Channel: A Potential Drug Target for Treating Epilepsy by Mustafa Nazıroglu

“…Epilepsy has 2-3% incidence worldwide. However, present antiepileptic drugs provide only partial control of seizures. Calcium ion accumulation in hippocampal…”
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Honey bee venom melittin increases the oxidant activity of cisplatin and kills human glioblastoma cells by stimulating the TRPM2 channel by Ertilav, Kemal, Nazıroğlu, Mustafa

“…Melittin (MLT) treatment is believed to enhance tumor cell death, apoptotic, and oxidative cytotoxic effects of cisplatin (CSP) via the modulation of Ca2+…”
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The effect of platelet rich plasma on angiogenesis in ischemic flaps in VEGFR2-luc mice by Sönmez, Tolga Taha, Vinogradov, Alexandra, Zor, Fatih, Kweider, Nisreen, Lippross, Sebastian, Liehn, Elisa Anamaria, Naziroglu, Mustafa, Hölzle, Frank, Wruck, Christoph, Pufe, Thomas, Tohidnezhad, Mersedeh

“…Abstract To improve skin flap healing, one promising strategy in reconstructive surgery might be to optimize platelet rich plasma (PRP) bioactivity and the…”
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Assessing the effects of the neonicotinoid insecticide imidacloprid in the cholinergic synapses of the stellate cells of the mouse cochlear nucleus using whole-cell patch-clamp recording by Bal, Ramazan, Erdogan, Suat, Theophilidis, George, Baydas, Giyasettin, Naziroglu, Mustafa

“…Imidacloprid (IMI) is widely used systemic insecticide that acts as an agonist on nicotinic acetylcholine receptors (nAChRs). IMI has been reported to be more…”
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Selenium and Resveratrol Attenuated Diabetes Mellitus-Mediated Oxidative Retinopathy and Apoptosis via the Modulation of TRPM2 Activity in Mice by Daldal, Hatice, Nazıroğlu, Mustafa

“…Diabetes mellitus induces optic nerve injury via the excessive generation of mitochondria reactive free oxygen radical (mitROS). TRPM2 channel is activated by…”
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Role of Selenium on Calcium Signaling and Oxidative Stress-induced Molecular Pathways in Epilepsy by Nazirolu, Mustafa

“…Epilepsy is one of the oldest neurological conditions known to humankind. It is known that oxidative stress and generation of reactive oxygen species are a…”
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Molecular role of catalase on oxidative stress-induced Ca2+ signaling and TRP cation channel activation in nervous system by Naz ro lu, Mustafa

“…Background: Catalase catalyzes the reduction of H2O2 to water and it can also remove organic hydroperoxides. Nervous system in body is especially sensitive to…”
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Selenium and Neurological Diseases: Focus on Peripheral Pain and TRP Channels by Mustafa Nazıroğlu, Ahmi Öz, Kenan Yıldızhan

“…Pain is a complex physiological process that includes many components. Growing evidence supports the idea that oxidative stress and Ca2+ signaling pathways…”
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Protective role of selenium on MPP+ and homocysteine-induced TRPM2 channel activation in SH-SY5Y cells by Yıldızhan, Kenan, Nazıroğlu, Mustafa

“…Homocysteine is an intermediate product of biochemical reactions occurring in living organisms. It is known that drugs that increase dopamine synthesis used in…”
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