Search Results - "NAYLOR, C. E"

Clostridium perfringensα-toxin interaction with red cells and model membranes by Jewell, S A, Titball, R W, Huyet, J, Naylor, C E, Basak, A K, Gologan, P, Winlove, C P, Petrov, P G

“…The effects of Clostridium perfringensα-toxin on host cells have previously been studied extensively but the biophysical processes associated with toxicity are…”
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Crystal Structure of R120G Disease Mutant of Human αB-Crystallin Domain Dimer Shows Closure of a Groove by Clark, A.R., Naylor, C.E., Bagnéris, C., Keep, N.H., Slingsby, C.

“…Small heat shock proteins form large cytosolic assemblies from an “α-crystallin domain” (ACD) flanked by sequence extensions. Mutation of a conserved arginine…”
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Glucose 6-phosphate dehydrogenase mutations causing enzyme deficiency in a model of the tertiary structure of the human enzyme by NAYLOR, C. E, ROWLAND, P, BASAK, A. K, GOVER, S, MASON, P. J, BAUTISTA, J. M, VULLIAMY, T. J, LUZZATTO, L, ADAMS, M. J

“…Human glucose 6-phosphate dehydrogenase (G6PD) has a particularly large number of variants resulting from point mutations; some 60 mutations have been…”
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An Examination of the Role of Asp-177 in the His-Asp Catalytic Dyad of Leuconostoc mesenteroides Glucose 6-Phosphate Dehydrogenase:  X-ray Structure and pH Dependence of Kinetic Parameters of the D177N Mutant Enzyme by Cosgrove, Michael S, Gover, Sheila, Naylor, Claire E, Vandeputte-Rutten, Lucy, Adams, Margaret J, Levy, H. Richard

“…The role of Asp-177 in the His-Asp catalytic dyad of glucose 6-phosphate dehydrogenase from Leuconostoc mesenteroides has been investigated by a structural and…”
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NADP+ and NAD+ binding to the dual coenzyme specific enzyme Leuconostoc mesenteroides glucose 6-phosphate dehydrogenase: different interdomain hinge angles are seen in different binary and ternary complexes by Naylor, Claire E., Gover, Sheila, Basak, Ajit K., Cosgrove, Michael S., Levy, H. Richard, Adams, Margaret J.

“…The reduced coenzymes NADH and NADPH only differ by one phosphate, but in the cell NADH provides reducing power for catabolism while NADPH is utilized in…”
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Modified constraint-induced movement therapy for young children with hemiplegic cerebral palsy: a pilot study by Naylor, CE, Bower, E

“…The objective of the study was to evaluate the effectiveness of modified constraint-induced movement therapy in young children with hemiplegia. It was a…”
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Opening of the active site of Clostridium perfringens α-toxin may be triggered by membrane binding by Titball, R.W., Naylor, C.E., Miller, J., Moss, D.S., Basak, A.K.

“…On the basis of amino acid sequence homologies with other phospholipases C, the α-toxin of Clostridium perfringens was predicted to be a two-domain protein…”
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Neuropsychological profile of adult dyslexics by Felton, R H, Naylor, C E, Wood, F B

“…One hundred and fifteen adults with well-documented childhood reading status underwent a series of neuropsychological tests including tests of memory,…”
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A destructive nasal lesion and glomerulonephritis by Wilson, F.P., Nasr, S.H., Markowitz, G.S., Naylor, E.C., Sterman, P.L., D'Agati, V.D.

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Comparison of a nontoxic variant of Clostridium perfringensα-toxin with the toxic wild-type strain by Vachieri, S. G., Clark, G. C., Alape-Girón, A., Flores-Díaz, M., Justin, N., Naylor, C. E., Titball, R. W., Basak, A. K.

“…The α‐toxin produced by Clostridium perfringens is one of the best‐studied examples of a toxic phospholipase C. In this study, a nontoxic mutant protein from…”
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Structure of the key toxin in gas gangrene by Naylor, C E, Eaton, J T, Howells, A, Justin, N, Moss, D S, Titball, R W, Basak, A K

“…Clostridium perfringens alpha-toxin is the key virulence determinant in gas gangrene and has also been implicated in the pathogenesis of sudden death syndrome…”
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The Clostridium perfringensα-toxin by Titball, Richard W, Naylor, Claire E, Basak, Ajit K

“…The gene encoding the α-(cpa) is present in all strains of Clostridium perfringens , and the purified α-toxin has been shown to be a zinc-containing…”
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Crystal Structures of α-Crystallin Domain Dimers of αB-Crystallin and Hsp20 by Bagnéris, C., Bateman, O.A., Naylor, C.E., Cronin, N., Boelens, W.C., Keep, N.H., Slingsby, C.

“…Small heat shock proteins (sHsps) are a family of large and dynamic oligomers highly expressed in long-lived cells of muscle, lens and brain. Several family…”
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Effects of Subcutaneous Expansion on the Mechanical Properties of Porcine Skin by Belkoff, Stephen M., Naylor, Ellen C., Walshaw, Richard, Lanigan, Edward, Colony, Lee, Haut, Roger C.

“…The purpose of this study was to determine the effects of conventional and intraoperative tissue expansion on the biomechanical properties of skin. Two 200-cc…”
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Phosphate/calcium alterations in the first stages of Alzheimer's disease: implications for etiology and pathogenesis by Landfield, P W, Applegate, M D, Schmitzer-Osborne, S E, Naylor, C E

“…The present study tested aspects of a novel etiological/pathogenetic hypothesis of Alzheimer's disease (AD), which proposes that alterations in endocrine…”
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A destructive nasal lesion and glomerulonephritis by Wilson, F P, Nasr, S H, Markowitz, G S, Naylor, E C, Sterman, P L, D'Agati, V D

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Characterisation of the calcium-binding C-terminal domain of Clostridium perfringens alpha-toxin by Naylor, C E, Jepson, M, Crane, D T, Titball, R W, Miller, J, Basak, A K, Bolgiano, B

“…Alpha-toxin is the key determinant in gas-gangrene. The toxin, a phospholipase C, cleaves phosphatidylcholine in eukaryotic cell membranes. Calcium ions have…”
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Crystallographic study of coenzyme, coenzyme analogue and substrate binding in 6-phosphogluconate dehydrogenase: implications for NADP specificity and the enzyme mechanism by Adams, M J, Ellis, G H, Gover, S, Naylor, C E, Phillips, C

“…The nicotinamide adenine dinucleotide phosphate (NADP)-dependent oxidative decarboxylase, 6-phosphogluconate dehydrogenase, is a major source of reduced…”
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Solution of the structure of tetrameric human glucose 6-phosphate dehydrogenase by molecular replacement by Au, Shannon W. N., Naylor, Claire E., Gover, Sheila, Vandeputte-Rutten, Lucy, Scopes, Deborah A., Mason, Philip J., Luzzatto, Lucio, Lam, Veronica M. S., Adams, Margaret J.

“…Recombinant human glucose 6‐phosphate dehydrogenase (G6PD) has been crystallized and its structure solved by molecular replacement. Crystals of the natural…”
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Regional cerebral blood flow correlates of language processes in reading disability by Flowers, D L, Wood, F B, Naylor, C E

“…This series of studies tests the hypothesis of abnormal left hemisphere activation in reading-disabled subjects during language task performance. First, a left…”
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