Search Results - "NATUK, Robert J"

Attenuation of Recombinant Vesicular Stomatitis Virus-Human Immunodeficiency Virus Type 1 Vaccine Vectors by Gene Translocations and G Gene Truncation Reduces Neurovirulence and Enhances Immunogenicity in Mice by COOPER, David, WRIGHT, Kevin J, NATUK, Robert J, HENDRY, R. Michael, UDEM, Stephen A, CLARKE, David K, CALDERON, Priscilla C, MIN GUO, NASAR, Farooq, JOHNSON, J. Erik, COLEMAN, John W, LEE, Margaret, KOTASH, Cheryl, YURGELONIS, Irene

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Development and validation of a standardized human complement serum bactericidal activity assay to measure functional antibody responses to Neisseria gonorrhoeae by Matthias, Kathryn A., Reveille, Alexandra, Dhara, Kumaresh, Lyle, Christopher S., Natuk, Robert J., Bonk, Brian, Bash, Margaret C.

“…The recent entry of multiple vaccines targeting Neisseria gonorrhoeae (Ng) into the clinical development pathway has highlighted the need to establish methods…”
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Recombinant Vesicular Stomatitis Virus Vectors Expressing Herpes Simplex Virus Type 2 gD Elicit Robust CD4+ Th1 Immune Responses and Are Protective in Mouse and Guinea Pig Models of Vaginal Challenge by NATUK, Robert J, COOPER, David, TUMMOLO, Donna, ABRAMOVITZ, Aaron S, GANGOLLI, Seema, KALYAN, Narender, CLARKE, David K, HENDRY, R. Michael, ELDRIDGE, John H, UDEM, Stephen A, KOWALSKI, Jacek, MIN GUO, CALDERON, Priscilla, WRIGHT, Kevin J, NASAR, Farooq, WITKO, Susan, PAWLYK, Diane, LEE, Margaret, DESTEFANO, Joanne

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Herpes Simplex Virus Type 2 UL24 Gene Is a Virulence Determinant in Murine and Guinea Pig Disease Models by BLAKENEY, Susan, KOWALSKI, Jacek, VISALLI, Robert J, TUMMOLO, Donna, DESTEFANO, Joanne, COOPER, David, MIN GUO, GANGOLLI, Seema, LONG, Deborah, ZAMB, Timothy, NATUK, Robert J

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Vaccination with a HSV-2 UL24 mutant induces a protective immune response in murine and guinea pig vaginal infection models by Visalli, Robert J, Natuk, Robert J, Kowalski, Jacek, Guo, Min, Blakeney, Susan, Gangolli, Seema, Cooper, David

“…Highlights • Attenuated HSV-2 is a viable approach for genital herpes vaccine development. • An UL24 mutant had reduced virulence in mouse and guinea pig…”
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In vivo biodistribution of a highly attenuated recombinant vesicular stomatitis virus expressing HIV-1 Gag following intramuscular, intranasal, or intravenous inoculation by Erik Johnson, J, Coleman, John W, Kalyan, Narender K, Calderon, Priscilla, Wright, Kevin J, Obregon, Jennifer, Ogin-Wilson, Eleanor, Natuk, Robert J, Clarke, David K, Udem, Stephen A, Cooper, David, Michael Hendry, R

“…Abstract Recombinant vesicular stomatitis viruses (rVSVs) are being developed as potential HIV-1 vaccine candidates. To characterize the in vivo replication…”
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Evaluation of neurovirulence and biodistribution of Venezuelan equine encephalitis replicon particles expressing herpes simplex virus type 2 glycoprotein D by Kowalski, Jacek, Adkins, Karissa, Gangolli, Seema, Ren, Jian, Arendt, Heather, DeStefano, Joanne, Obregon, Jennifer, Tummolo, Donna, Natuk, Robert J, Brown, Tom P, Parks, Christopher L, Udem, Stephen A, Long, Deborah

“…Abstract The safety of a propagation-defective Venezuelan equine encephalitis virus (VEEV) replicon particle vaccine was examined in mice. After intracranial…”
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Interleukin-12 redirects murine immune responses to soluble or aluminum phosphate adsorbed HSV-2 glycoprotein D towards Th1 and CD4 + CTL responses by Cooper, David, Pride, Michael W., Guo, Min, Cutler, Mark, Mester, Joseph C., Nasar, Farooq, She, Jian, Souza, Victor, York, Laura, Mishkin, Eric, Eldridge, John, Natuk, Robert J.

“…The type of immune response elicited against HSV-2 infection may be a factor in the frequency and severity of recurrent disease, with non-recurrent status…”
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Epitope mapping of full-length glycoprotein D from HSV-2 reveals a novel CD4 + CTL epitope located at the transmembrane-cytoplasmic junction by Cooper, David, Mester, Joseph C., Guo, Min, Nasar, Farooq, Souza, Victor, Dispoto, Sharon, Sidhu, Maninder, Hagen, Michael, Eldridge, John H., Natuk, Robert J., Pride, Michael W.

“…The glycoprotein D of HSV-2 (gD2) is currently a leading candidate vaccine target for genital herpes vaccines as both cellular and humoral responses can be…”
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Induction of Neutralizing Antibodies to T-Cell Line-Adapted and Primary Human Immunodeficiency Virus Type 1 Isolates with a Prime-Boost Vaccine Regimen in Chimpanzees by Zolla-Pazner, S, Lubeck, M, Xu, S, Burda, S, Natuk, R J, Sinangil, F, Steimer, K, Gallo, R C, Eichberg, J W, Matthews, T, Robert-Guroff, M

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Immunogenicity of recombinant adenovirus-human immunodeficiency virus vaccines in chimpanzees following intranasal administration by Lubeck, M D, Natuk, R J, Chengalvala, M, Chanda, P K, Murthy, K K, Murthy, S, Mizutani, S, Lee, S G, Wade, M S, Bhat, B M

“…Recombinant adenovirus (Ad)-human immunodeficiency virus (HIV) vaccines expressing HIVIIIB Env and Gag proteins were evaluated for immunogenicity in…”
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Adenovirus-Human Immunodeficiency Virus (HIV) Envelope Recombinant Vaccines Elicit High-Titered HIV-Neutralizing Antibodies in the Dog Model by Natuk, Robert J., Chanda, Pranab K., Lubeck, Michael D., Davis, Alan R., Wilhelm, James, Hjorth, Richard, Wade, Mark S., Bhat, Bheem M., Mizutani, Satoshi, Lee, Sally, Eichberg, Jorg, Gallo, Robert C., Hung, paul P., Robert-Guroff, Marjorie

“…Recombinant human adenoviruses (Ads) (types 4, 5, and 7) expressing the HIV-1 envelope membrane glycoprotein (gp160) were tested for immunogenicity in the dog…”
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Blastogenesis of large granular lymphocytes in nonlymphoid organs by McIntyre, K W, Natuk, R J, Biron, C A, Kase, K, Greenberger, J, Welsh, R M

“…High numbers of large granular lymphocytes (LGL) accumulate in the livers and peritoneal cavities of mice during the course of viral infection. Accumulation of…”
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Immunogenicity of co-administered recombinant VSV vectors expressing GM-CSF and HIV-1 Gag in mice (47.25) by Wright, Kevin James, Calderon, Priscilla C, Guo, Min, Natuk, Robert J, Nasar, Farooq, Johnson, J Erik, Witko, Susan, Clarke, David K, Hendry, R Michael, Parks, Christopher, Eldridge, John, Cooper, David

“…Abstract Highly attenuated recombinant vesicular stomatitis virus (rVSV) vectors expressing HIV-1 Gag have been shown to be immunogenic in preclinical animal…”
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Recombinant Vesicular Stomatitis Virus Vectors Expressing Herpes Simplex Virus Type 2 gD Elicit Robust CD4 super(+) Th1 Immune Responses and Are Protective in Mouse and Guinea Pig Models of Vaginal Challenge by Natuk, Robert J, Cooper, David, Guo, Min, Calderon, Priscilla, Wright, Kevin J, Nasar, Farooq, Witko, Susan, Pawlyk, Diane, Lee, Margaret, DeStefano, Joanne, Tummolo, Donna, Abramovitz, Aaron S, Gangolli, Seema, Kalyan, Narender, Clarke, David K, Hendry, RMichael, Eldridge, John H, Udem, Stephen A, Kowalski, Jacek

“…Recombinant vesicular stomatitis virus (rVSV) vectors offer an attractive approach for the induction of robust cellular and humoral immune responses directed…”
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Immunogenicity and Efficacy Testing in Chimpanzees of an Oral Hepatitis B Vaccine Based on Live Recombinant Adenovirus by Lubeck, Michael D., Davis, Alan R., Chengalvala, Murty, Natuk, Robert J., Morin, John E., Molnar-Kimber, Katherine, Mason, Bruce B., Bhat, Bheem M., Mizutani, Satoshi, Hung, Paul P., Purcell, Robert H.

“…As a major cause of acute and chronic liver disease as well as hepatocellular carcinoma, hepatitis B virus (HBV) continues to pose significant health problems…”
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Immunogenicity of recombinant human adenovirus-human immunodeficiency virus vaccines in chimpanzees by Natuk, R J, Lubeck, M D, Chanda, P K, Chengalvala, M, Wade, M S, Murthy, S C, Wilhelm, J, Vernon, S K, Dheer, S K, Mizutani, S

“…Recombinant human adenovirus (Ad) type 4-, 5-, and 7-vectored vaccines expressing either the HIV env or gag-protease genes were tested for immunogenicity in…”
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Adenovirus vectors for gene expression by Chengalvala, M V, Lubeck, M D, Selling, B J, Natuk, R J, Hsu, K H, Mason, B B, Chanda, P K, Bhat, R A, Bhat, B M, Mizutani, S

“…Adenoviruses possess a combination of features that make them highly suitable as vectors for expression of heterologous genes. Non-conditional and…”
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High level expression of the envelope glycoproteins of the human immunodeficiency virus type I in presence of rev gene using helper-independent adenovirus type 7 recombinants by Chanda, P K, Natuk, R J, Mason, B B, Bhat, B M, Greenberg, L, Dheer, S K, Molnar-Kimber, K L, Mizutani, S, Lubeck, M D, Davis, A R

“…The effect of rev (art/trs) gene on the level of HIV-1 envelope (env) expression using recombinant adenovirus was investigated. Recombinant adenoviruses…”
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Vaccinia virus proteins on the plasma membrane of infected cells. III. Infection of peritoneal macrophages by Natuk, R J, Holowczak, J A

“…Primary macrophage cultures were prepared from the peritoneal exudate cell population harvested from mice challenged intraperitoneally with saline,…”
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