Search Results - "NATHANSON, David"

Neoadjuvant PD-1 blockade induces T cell and cDC1 activation but fails to overcome the immunosuppressive tumor associated macrophages in recurrent glioblastoma by Lee, Alexander H., Sun, Lu, Mochizuki, Aaron Y., Reynoso, Jeremy G., Orpilla, Joey, Chow, Frances, Kienzler, Jenny C., Everson, Richard G., Nathanson, David A., Bensinger, Steven J., Liau, Linda M., Cloughesy, Timothy, Hugo, Willy, Prins, Robert M.

“…Primary brain tumors, such as glioblastoma (GBM), are remarkably resistant to immunotherapy, even though pre-clinical models suggest effectiveness. To…”
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Biosafety and Biohazards: Understanding Biosafety Levels and Meeting Safety Requirements of a Biobank by Ta, Lisa, Gosa, Laura, Nathanson, David A

“…When it comes to biobanking and working with different types of laboratory specimens, it is important to understand potential biohazards to ensure safety of…”
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Extrachromosomal oncogene amplification drives tumour evolution and genetic heterogeneity by Turner, Kristen M., Deshpande, Viraj, Beyter, Doruk, Koga, Tomoyuki, Rusert, Jessica, Lee, Catherine, Li, Bin, Arden, Karen, Ren, Bing, Nathanson, David A., Kornblum, Harley I., Taylor, Michael D., Kaushal, Sharmeela, Cavenee, Webster K., Wechsler-Reya, Robert, Furnari, Frank B., Vandenberg, Scott R., Rao, P. Nagesh, Wahl, Geoffrey M., Bafna, Vineet, Mischel, Paul S.

“…Circular extrachromosomal DNA is found in nearly half of human cancers of a wide variety of histologic types, increasing the copy number of driver oncogenes…”
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Clinicopathological Evaluation of the Potential Anatomic Pathways of Systemic Metastasis from Primary Breast Cancer Suggests an Orderly Spread Through the Regional Lymph Nodes by David Nathanson, S., Leonard-Murali, Shravan, Burmeister, Charlotte, Susick, Laura, Baker, Patricia

“…Background Two conflicting hypotheses as to how breast cancer (BC) accesses the systemic circulation dominated the 20th century and affected surgical…”
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2-Hydroxyglutarate Inhibits ATP Synthase and mTOR Signaling by Fu, Xudong, Chin, Randall M., Vergnes, Laurent, Hwang, Heejun, Deng, Gang, Xing, Yanpeng, Pai, Melody Y., Li, Sichen, Ta, Lisa, Fazlollahi, Farbod, Chen, Chuo, Prins, Robert M., Teitell, Michael A., Nathanson, David A., Lai, Albert, Faull, Kym F., Jiang, Meisheng, Clarke, Steven G., Cloughesy, Timothy F., Graeber, Thomas G., Braas, Daniel, Christofk, Heather R., Jung, Michael E., Reue, Karen, Huang, Jing

“…We discovered recently that the central metabolite α-ketoglutarate (α-KG) extends the lifespan of C. elegans through inhibition of ATP synthase and TOR…”
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Targeted Therapy Resistance Mediated by Dynamic Regulation of Extrachromosomal Mutant EGFR DNA by Nathanson, David A., Gini, Beatrice, Mottahedeh, Jack, Visnyei, Koppany, Koga, Tomoyuki, Gomez, German, Estin, Ascia, Hwang, Kiwook, Wang, Jun, Masui, Kenta, Paucar, Andres, Yang, Huijun, Ohashi, Minori, Zhu, Shaojun, Wykosky, Jill, Reed, Rachel, Nelson, Stanley F., Cloughesy, Timothy F., James, C. David, Rao, P. Nagesh, Kornblum, Harley I., Heath, James R., Cavenee, Webster K., Furnari, Frank B., Mischel, Paul S.

“…Intratumoral heterogeneity contributes to cancer drug resistance, but the underlying mechanisms are not understood. Single-cell analyses of patient-derived…”
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Metabolic Vulnerabilities in Brain Cancer by Morrow, Danielle, Minami, Jenna, Nathanson, David A.

“…Glioblastomas (GBMs) exhibit altered metabolism to support a variety of bioenergetic and biosynthetic demands for tumor growth, invasion, and drug resistance…”
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Processing of Primary Patient Tumors and Subsequent Generation of Primary Cell Lines by Gosa, Laura, Ta, Lisa, Nathanson, David A

“…Patient tumor tissue processing is an important step in the generation of clinically relevant specimens for in vitro and in vivo studies. Proper disassociation…”
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CDKN2A deletion remodels lipid metabolism to prime glioblastoma for ferroptosis by Minami, Jenna K., Morrow, Danielle, Bayley, Nicholas A., Fernandez, Elizabeth G., Salinas, Jennifer J., Tse, Christopher, Zhu, Henan, Su, Baolong, Plawat, Rhea, Jones, Anthony, Sammarco, Alessandro, Liau, Linda M., Graeber, Thomas G., Williams, Kevin J., Cloughesy, Timothy F., Dixon, Scott J., Bensinger, Steven J., Nathanson, David A.

“…Malignant tumors exhibit heterogeneous metabolic reprogramming, hindering the identification of translatable vulnerabilities for metabolism-targeted therapy…”
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Bioengineered scaffolds for 3D culture demonstrate extracellular matrix-mediated mechanisms of chemotherapy resistance in glioblastoma by Xiao, Weikun, Wang, Shanshan, Zhang, Rongyu, Sohrabi, Alireza, Yu, Qi, Liu, Sihan, Ehsanipour, Arshia, Liang, Jesse, Bierman, Rebecca D., Nathanson, David A., Seidlits, Stephanie K.

“…Originating in the brain, glioblastoma (GBM) is a highly lethal and virtually incurable cancer, in large part because it readily develops resistance to…”
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Mechanisms of breast cancer metastasis by Nathanson, S. David, Detmar, Michael, Padera, Timothy P., Yates, Lucy R., Welch, Danny R., Beadnell, Thomas C., Scheid, Adam D., Wrenn, Emma D., Cheung, Kevin

“…Invasive breast cancer tends to metastasize to lymph nodes and systemic sites. The management of metastasis has evolved by focusing on controlling the growth…”
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Ferroptosis inhibition by lysosome-dependent catabolism of extracellular protein by Armenta, David A, Laqtom, Nouf N, Alchemy, Grace, Dong, Wentao, Morrow, Danielle, Poltorack, Carson D, Nathanson, David A, Abu-Remalieh, Monther, Dixon, Scott J

“…Cancer cells need a steady supply of nutrients to evade cell death and proliferate. Depriving cancer cells of the amino acid cystine can trigger the…”
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18F-Labeled brain-penetrant EGFR tyrosine kinase inhibitors for PET imaging of glioblastoma by Narayanam, Maruthi Kumar, Tsang, Jonathan E, Xu, Shili, Nathanson, David A, Murphy, Jennifer M

“…Significant evidence suggests that the failure of clinically tested epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (e.g. erlotinib,…”
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The transcription factor Fli1 restricts the formation of memory precursor NK cells during viral infection by Riggan, Luke, Ma, Feiyang, Li, Joey H., Fernandez, Elizabeth, Nathanson, David A., Pellegrini, Matteo, O’Sullivan, Timothy E.

“…Natural killer (NK) cells are innate lymphocytes that possess traits of adaptive immunity, such as memory formation. However, the molecular mechanisms by which…”
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Brain-Mimetic 3D Culture Platforms Allow Investigation of Cooperative Effects of Extracellular Matrix Features on Therapeutic Resistance in Glioblastoma by Xiao, Weikun, Zhang, Rongyu, Sohrabi, Alireza, Ehsanipour, Arshia, Sun, Songping, Liang, Jesse, Walthers, Christopher M, Ta, Lisa, Nathanson, David A, Seidlits, Stephanie K

“…Glioblastoma (GBM) tumors exhibit potentially actionable genetic alterations against which targeted therapies have been effective in treatment of other…”
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F-Labeled brain-penetrant EGFR tyrosine kinase inhibitors for PET imaging of glioblastoma by Narayanam, Maruthi Kumar, Tsang, Jonathan E, Xu, Shili, Nathanson, David A, Murphy, Jennifer M

“…Significant evidence suggests that the failure of clinically tested epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors ( e.g. erlotinib,…”
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18 F-Labeled brain-penetrant EGFR tyrosine kinase inhibitors for PET imaging of glioblastoma by Narayanam, Maruthi Kumar, Tsang, Jonathan E, Xu, Shili, Nathanson, David A, Murphy, Jennifer M

“…Significant evidence suggests that the failure of clinically tested epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors ( erlotinib, lapatinib,…”
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Chemical Methods for the Simultaneous Quantitation of Metabolites and Proteins from Single Cells by Xue, Min, Wei, Wei, Su, Yapeng, Kim, Jungwoo, Shin, Young Shik, Mai, Wilson X, Nathanson, David A, Heath, James R

“…We describe chemical approaches for integrated metabolic and proteomic assays from single cells. Quantitative assays for intracellular metabolites, including…”
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African Ancestry-Associated Gene Expression Profiles in Triple-Negative Breast Cancer Underlie Altered Tumor Biology and Clinical Outcome in Women of African Descent by Martini, Rachel, Delpe, Princesca, Chu, Timothy R, Arora, Kanika, Lord, Brittany, Verma, Akanksha, Bedi, Deepa, Karanam, Balasubramanyam, Elhussin, Isra, Chen, Yalei, Gebregzabher, Endale, Oppong, Joseph K, Adjei, Ernest K, Jibril Suleiman, Aisha, Awuah, Baffour, Muleta, Mahteme Bekele, Abebe, Engida, Kyei, Ishmael, Aitpillah, Frances S, Adinku, Michael O, Ankomah, Kwasi, Osei-Bonsu, Ernest Baawuah, Chitale, Dhananjay A, Bensenhaver, Jessica M, Nathanson, David S, Jackson, LaToya, Petersen, Lindsay F, Proctor, Erica, Stonaker, Brian, Gyan, Kofi K, Gibbs, Lee D, Monojlovic, Zarko, Kittles, Rick A, White, Jason, Yates, Clayton C, Manne, Upender, Gardner, Kevin, Mongan, Nigel, Cheng, Esther, Ginter, Paula, Hoda, Syed, Elemento, Olivier, Robine, Nicolas, Sboner, Andrea, Carpten, John D, Newman, Lisa, Davis, Melissa B

“…Women of sub-Saharan African descent have disproportionately higher incidence of triple-negative breast cancer (TNBC) and TNBC-specific mortality across all…”
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EGFR, the Lazarus target for precision oncology in glioblastoma by Lin, Benjamin, Ziebro, Julia, Smithberger, Erin, Skinner, Kasey R, Zhao, Eva, Cloughesy, Timothy F, Binder, Zev A, O'Rourke, Donald M, Nathanson, David A, Furnari, Frank B, Miller, C Ryan

“…The Lazarus effect is a rare condition that happens when someone seemingly dead shows signs of life. The epidermal growth factor receptor (EGFR) represents a…”
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