Search Results - "NATHAN, H C"

Cure of murine Trypanosoma brucei rhodesiense infections with an S-adenosylmethionine decarboxylase inhibitor by BACCHI, C. J, NATHAN, H. C, YARLETT, N, GOLDBERG, B, MCCANN, P. P, BITONTI, A. J, SJOERDSMA, A

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Combination chemotherapy of drug-resistant Trypanosoma brucei rhodesiense infections in mice using DL-alpha-difluoromethylornithine and standard trypanocides by BACCHI, C. J, NATHAN, H. C, YARLETT, N, GOLDBERG, B, MCCANN, P. P, SJOERDSMA, A, SARIC, M, CLARKSON, A. B

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Differential susceptibility to DL-alpha-difluoromethylornithine in clinical isolates of Trypanosoma brucei rhodesiense by BACCHI, C. J, NATHAN, H. C, LIVINGSTON, T, VALLADARES, G, SARIC, M, SAYER, P. D, NJOGU, A. R, CLARKSON, A. B

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Polyamine Metabolism: A Potential Therapeutic Target in Trypanosomes by Bacchi, C. J., Nathan, H. C., Hutner, S. H., McCann, P. P., Sjoerdsma, A.

“…α-Difluoromethylornithine (RMI 71, 782), a specific irreversible inhibitor of the first step in polyamine biosynthesis, that is, the formation of putrescine…”
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5'-Alkyl-substituted analogs of 5'-methylthioadenosine as trypanocides by BACCHI, C. J, SUFRIN, J. R, NATHAN, H. C, SPIESS, A. J, HANNAN, T, GAROFALO, J, ALECIA, K, KATZ, L, YARLETT, N

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Synergism between 9-deazainosine and DL-alpha-difluoromethylornithine in treatment of experimental African trypanosomiasis by BACCHI, C. J, BERENS, R. L, NATHAN, H. C, KLEIN, R. S, ELEGBE, I. A, RAO, K. V. B, MCCANN, P. P, MARR, J. J

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New drug combination for experimental late-stage African trypanosomiasis: DL-alpha-difluoromethylornithine (DFMO) with suramin by Clarkson, Jr, A B, Bienen, E J, Bacchi, C J, McCann, P P, Nathan, H C, Hutner, S H, Sjoerdsma, A

“…Using a previously described mouse model of late-stage African trypanosomiasis (i.e., involvement of the central nervous system), we demonstrate that a…”
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Effects of the ornithine decarboxylase inhibitors DL-alpha-difluoromethylornithine and alpha-monofluoromethyldehydroornithine methyl ester alone and in combination with suramin against Trypanosoma brucei brucei central nervous system models by Bacchi, C J, Nathan, H C, Clarkson, Jr, A B, Bienen, E J, Bitonti, A J, McCann, P P, Sjoerdsma, A

“…Two ornithine decarboxylase inhibitors, DL-alpha-difluoromethylornithine (eflornithine; DFMO) and a-monofluoromethyldehydroornithine methyl ester (delta MFMO X…”
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Polyamines in trypanosomatids by Bacchi, C J, Lipschik, G Y, Nathan, H C

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Efficacy of combinations of difluoromethylornithine and bleomycin in a mouse model of central nervous system African trypanosomiasis by Clarkson, A.B., jr, Bacchi, C.J, Mellow, G.H, Nathan, H.C, McCann, P.P

“…Trypanosoma brucei brucei in mice as model of central nervous system African trypanosomiasis, responses to berenil, to mel-B, and to difluoromethylornithine…”
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Antitumor phthalanilides active in acute and chronic Trypanosoma brucei brucei murine infections by Nathan, H C, Bacchi, C J, Nichol, C A, Duch, D S, Mullaney, E A, Hutner, S H

“…A series of phthalanilides and related compounds were tested on a short-term, fulminating, mouse infection of Trypanosoma brucei brucei (EATRO 110 isolate)…”
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Polyamines antagonize both the antileukemic activity and the reverse transcriptase stimulatory activity of 4,4'-diacetyldiphenylurea bis(guanylhydrazone) (DDUG) by Marcus, S L, Nathan, H C, Hutner, S H, Bacchi, C J

“…(Diacetyldiphenylurea)bis(guanylhydrazone) (DDUG) functions as a cationic trypanocide antagonized in vivo by exogenous concomitant addition of the biologically…”
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Differential sensitivity of Trypanosoma brucei rhodesiense isolates to in vitro lysis by arsenicals by Yarlett, N, Goldberg, B, Nathan, H C, Garofalo, J, Bacchi, C J

“…Clinical isolates of Trypanosoma brucei rhodesiense, which were resistant to arsenical drugs in murine infections, were examined for resistance in vitro. A…”
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Detection of agents which interfere with the immune response by NATHAN, H C, BIEBER, S, ELION, G B, HITCHINGS, G H

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Film adaptations: The dynamics of intertextual analysis by Zee, Nathan C. H

“…This dissertation begins with a brief history of adaptation studies followed by a discussion on the issue of fidelity. After examining several of the major…”
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Suppression of the immune response by drugs in combination by BIEBER, S, ELION, G B, HITCHINGS, G H, HOOPER, D C, NATHAN, H C

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Further studies on difluoromethylornithine in African trypanosomes by McCann, P P, Bacchi, C J, Clarkson, Jr, A B, Seed, J R, Nathan, H C, Amole, B O, Hutner, S H, Sjoerdsma, A

“…DL-alpha-Difluoromethylornithine (DFMO), a specific enzyme-activated irreversible inhibitor of ornithine decarboxylase (ODC) was previously shown to cure mice…”
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Synthesis, structure, and antiparasitic activity of sulfamoyl derivatives of ribavirin by Kini, Ganesh D, Henry, Elizabeth M, Robins, Roland K, Larson, Steven B, Marr, J. Joseph, Berens, Randolph L, Bacchi, Cyrus J, Nathan, Henry C, Keithly, Jan S

“…The triazole nucleoside derivatives 1-(5'-O-sulfamoyl-beta-D-ribofuranosyl) [1,2,4]triazole-3-carboxamide (2), 1-(5'-O-sulfamoyl-beta-D-ribofuranosyl)…”
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Antagonism by polyamines of the curative effects of alpha-difluoromethylornithine in Trypanosoma brucei brucei infections by Nathan, H C, Bacchi, C J, Hutner, S H, Rescigno, D, McCann, P P, Sjoerdsma, A

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Novel combination chemotherapy of experimental trypanosomiasis by using bleomycin and DL-alpha-difluoromethylornithine; reversal by polyamines by Bacchi, C J, Nathan, H C, Hutner, S H, McCann, P P, Sjoerdsma, A

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