Search Results - "NASH, Michael A"

High-throughput screening, next generation sequencing and machine learning: advanced methods in enzyme engineering by Vanella, Rosario, Kovacevic, Gordana, Doffini, Vanni, Fernández de Santaella, Jaime, Nash, Michael A

“…Enzyme engineering is an important biotechnological process capable of generating tailored biocatalysts for applications in industrial chemical conversion and…”
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Direct Comparison of Lysine versus Site‐Specific Protein Surface Immobilization in Single‐Molecule Mechanical Assays by Liu, Haipei, Liu, Zhaowei, Sá Santos, Mariana, Nash, Michael A.

“…Single‐molecule force spectroscopy (SMFS) is powerful for studying folding states and mechanical properties of proteins, however, it requires protein…”
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Magnetic Separation of Elastin-like Polypeptide Receptors for Enrichment of Cellular and Molecular Targets by Ta, Duy Tien, Vanella, Rosario, Nash, Michael A

“…Protein-conjugated magnetic nanoparticles (mNPs) are promising tools for a variety of biomedical applications, from immunoassays and biosensors to theranostics…”
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Scalable Online Learning in Physical Chemistry by Nash, Michael A

“…The SARS-CoV-2/COVID-19 pandemic has disrupted higher education across the globe. As of early November 2020, Europe now finds itself in the middle of a second…”
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Influence of Fluorination on Single-Molecule Unfolding and Rupture Pathways of a Mechanostable Protein Adhesion Complex by Yang, Byeongseon, Liu, Haipei, Liu, Zhaowei, Doenen, Regina, Nash, Michael A

“…We investigated the influence of fluorination on unfolding and unbinding reaction pathways of a mechanostable protein complex comprising the tandem dyad…”
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High force catch bond mechanism of bacterial adhesion in the human gut by Liu, Zhaowei, Liu, Haipei, Vera, Andrés M., Bernardi, Rafael C., Tinnefeld, Philip, Nash, Michael A.

“…Bacterial colonization of the human intestine requires firm adhesion of bacteria to insoluble substrates under hydrodynamic flow. Here we report the molecular…”
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Understanding activity-stability tradeoffs in biocatalysts by enzyme proximity sequencing by Vanella, Rosario, Küng, Christoph, Schoepfer, Alexandre A., Doffini, Vanni, Ren, Jin, Nash, Michael A.

“…Understanding the complex relationships between enzyme sequence, folding stability and catalytic activity is crucial for applications in industry and…”
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Single-molecule and Single-cell Approaches in Molecular Bioengineering by Nash, Michael A.

“…Protein sequences inhabit a discrete set in macromolecular space with incredible capacity to treat human disease. Despite our ability to program and manipulate…”
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Engineering an artificial catch bond using mechanical anisotropy by Liu, Zhaowei, Liu, Haipei, Vera, Andrés M., Yang, Byeongseon, Tinnefeld, Philip, Nash, Michael A.

“…Catch bonds are a rare class of protein-protein interactions where the bond lifetime increases under an external pulling force. Here, we report how…”
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Broad spectrum pesticide application alters natural enemy communities and may facilitate secondary pest outbreaks by Hill, Matthew P, Macfadyen, Sarina, Nash, Michael A

“…Pesticide application is the dominant control method for arthropod pests in broad-acre arable systems. In Australia, organophosphate pesticides are often…”
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Next Generation Methods for Single-Molecule Force Spectroscopy on Polyproteins and Receptor-Ligand Complexes by Yang, Byeongseon, Liu, Zhaowei, Liu, Haipei, Nash, Michael A.

“…Single-molecule force spectroscopy with the atomic force microscope provides molecular level insights into protein function, allowing researchers to…”
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Mechanisms of Nanonewton Mechanostability in a Protein Complex Revealed by Molecular Dynamics Simulations and Single-Molecule Force Spectroscopy by Bernardi, Rafael C, Durner, Ellis, Schoeler, Constantin, Malinowska, Klara H, Carvalho, Bruna G, Bayer, Edward A, Luthey-Schulten, Zaida, Gaub, Hermann E, Nash, Michael A

“…Can molecular dynamics simulations predict the mechanical behavior of protein complexes? Can simulations decipher the role of protein domains of unknown…”
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Multiplexed Enrichment and Detection of Malarial Biomarkers Using a Stimuli-Responsive Iron Oxide and Gold Nanoparticle Reagent System by Nash, Michael A, Waitumbi, John N, Hoffman, Allan S, Yager, Paul, Stayton, Patrick S

“…There is a need for simple yet robust biomarker and antigen purification and enrichment strategies that are compatible with current rapid diagnostic…”
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Mapping Mechanical Force Propagation through Biomolecular Complexes by Schoeler, Constantin, Bernardi, Rafael C, Malinowska, Klara H, Durner, Ellis, Ott, Wolfgang, Bayer, Edward A, Schulten, Klaus, Nash, Michael A, Gaub, Hermann E

“…Here we employ single-molecule force spectroscopy with an atomic force microscope (AFM) and steered molecular dynamics (SMD) simulations to reveal force…”
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Single-molecule dissection of the high-affinity cohesin–dockerin complex by Stahl, Stefan W, Nash, Michael A, Fried, Daniel B, Slutzki, Michal, Barak, Yoav, Bayer, Edward A, Gaub, Hermann E

“…Cellulose-degrading enzyme systems are of significant interest from both a scientific and technological perspective due to the diversity of cellulase families,…”
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Scale-dependent thermal tolerance variation in Australian mountain grasshoppers by Slatyer, Rachel A., Nash, Michael A., Hoffmann, Ary A.

“…Physiological variation among and within species is thought to play a key role in determining distribution patterns across environmental gradients. We tested…”
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Ultrastable cellulosome-adhesion complex tightens under load by Schoeler, Constantin, Malinowska, Klara H., Bernardi, Rafael C., Milles, Lukas F., Jobst, Markus A., Durner, Ellis, Ott, Wolfgang, Fried, Daniel B., Bayer, Edward A., Schulten, Klaus, Gaub, Hermann E., Nash, Michael A.

“…Challenging environments have guided nature in the development of ultrastable protein complexes. Specialized bacteria produce discrete multi-component protein…”
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Nanoscale Engineering of Designer Cellulosomes by Gunnoo, Melissabye, Cazade, Pierre-André, Galera-Prat, Albert, Nash, Michael A., Czjzek, Mirjam, Cieplak, Marek, Alvarez, Beatriz, Aguilar, Marina, Karpol, Alon, Gaub, Hermann, Carrión-Vázquez, Mariano, Bayer, Edward A., Thompson, Damien

“…Biocatalysts showcase the upper limit obtainable for high‐speed molecular processing and transformation. Efforts to engineer functionality in synthetic…”
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Automated Formation of Lipid-Bilayer Membranes in a Microfluidic Device by Malmstadt, Noah, Nash, Michael A, Purnell, Robert F, Schmidt, Jacob J

“…Although membrane channel proteins are important to drug discovery and hold great promise as engineered nanopore sensing elements, their widespread application…”
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High-Performance, Superparamagnetic, Nanoparticle-Based Heavy Metal Sorbents for Removal of Contaminants from Natural Waters by Warner, Cynthia L., Addleman, R. Shane, Cinson, Anthony D., Droubay, Timothy C., Engelhard, Mark H., Nash, Michael A., Yantasee, Wassana, Warner, Marvin G.

“…We describe the synthesis and characterization of high‐performance, superparamagnetic, iron oxide nanoparticle‐based, heavy metal sorbents, which demonstrate…”
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