Search Results - "NARDUCCI, M. G"
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The Tcl1 oncogene defines secondary hair germ cells differentiation at catagen–telogen transition and affects stem-cell marker CD34 expression
Published in Oncogene (12-03-2009)“…Overexpression of the TCL1 gene family plays a role in the onset of T-cell leukemias in mice and in humans. The Tcl1 gene is tightly regulated during early…”
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TCL1 transgenic mouse model as a tool for the study of therapeutic targets and microenvironment in human B-cell chronic lymphocytic leukemia
Published in Cell death & disease (01-01-2016)“…Chronic lymphocytic leukemia (CLL) is a B-cell malignancy with a mature phenotype. In spite of its relatively indolent nature, no radical cure is as yet…”
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MicroRNA profiling reveals that miR-21, miR486 and miR-214 are upregulated and involved in cell survival in Sézary syndrome
Published in Cell death & disease (01-04-2011)“…Sézary syndrome (SS) is an incurable leukemic variant of cutaneous T-cell lymphoma and its pathogenesis is still unknown. Diagnosis/prognosis may strongly…”
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Identification of the TCL1 Gene Involved in T-Cell Malignancies
Published in Proceedings of the National Academy of Sciences - PNAS (20-12-1994)“…The TCL1 locus on chromosome 14q32.1 is frequently involved in chromosomal translocations and inversions with one of the T-cell receptor loci in human T-cell…”
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Acquired Chromosome 11q Deletion Involving the Ataxia Teleangiectasia Locus in B-Cell Non-Hodgkin’s Lymphoma: Correlation With Clinicobiologic Features
Published in Journal of clinical oncology (01-07-2000)“…To study the clinicobiologic significance of acquired 11q deletions involving the ataxia teleangiectasia locus (ATM+/-) in B-cell non-Hodgkin's lymphomas…”
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Chromosome Walking on the TCL1 Locus Involved in T-Cell Neoplasia
Published in Proceedings of the National Academy of Sciences - PNAS (15-10-1993)“…The TCL1 locus on chromosome 14 band q32.1 is frequently involved in the chromosomal translocations and inversions with the T-cell receptor genes observed in…”
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TCL1 is overexpressed in patients affected by adult T-cell leukemias
Published in Cancer research (Chicago, Ill.) (15-12-1997)“…Among mature postthymic T-cell leukemias, adult T-cell leukemia (ATL) has characteristic clinicopathological entities. The association with the human T-cell…”
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TCL1 promotes blastomere proliferation through nuclear transfer, but not direct phosphorylation, of AKT PKB in early mouse embryos
Published in Cell death and differentiation (01-02-2008)Get full text
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Molecular prenatal diagnosis of ataxia telangiectasia heterozygosity by direct mutational assays
Published in Prenatal diagnosis (01-06-1999)“…Ataxia telangiectasia (AT) is a severe autosomal recessive disease, rare but not infrequent in Italy. Owing to the seriousness of the disease, prenatal…”
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TCL1 Oncogene Activation in Preleukemic T Cells From a Case of Ataxia-Telangiectasia
Published in Blood (15-09-1995)“…The TCL1 oncogene on human chromosome 14q32.1 is involved in chromosome translocations [t(14;14)(q11;q32.1) and t(7;14)(q35;q32.1)] and inversions…”
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Characterization and localization of the TCL-1 oncogene product
Published in Cancer research (Chicago, Ill.) (15-12-1994)“…The TCL-1 gene maps at chromosome 14q32.1 and is activated in T cell leukemias and lymphomas by either chromosome translocations or inversions that juxtapose…”
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The murine Tcl1 oncogene : embryonic and lymphoid cell expression
Published in Oncogene (21-08-1997)“…In human leukemias and lymphomas nonrandom chromosomal rearrangements cause changes in cell growth and/or survival in such a way as to promote malignancy. The…”
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TCL1 Participates in Early Embryonic Development and Is Overexpressed in Human Seminomas
Published in Proceedings of the National Academy of Sciences - PNAS (03-09-2002)“…Overexpression of the TCL1 oncogene has been shown to play a causative role in T cell leukemias of humans and mice. The characterization of Tcl1-deficient mice…”
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Regulation of TCL1 expression in B- and T-cell lymphomas and reactive lymphoid tissues
Published in Cancer research (Chicago, Ill.) (15-04-2000)“…Chromosomal rearrangements observed in T-cell prolymphocytic leukemia involve the translocation of one T-cell receptor gene to either chromosome 14q32 or Xq28,…”
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Deregulated Expression of TCL1 Causes T Cell Leukemia in Mice
Published in Proceedings of the National Academy of Sciences - PNAS (31-03-1998)“…The TCL1 oncogene on human chromosome 14q32.1 is involved in the development of T cell leukemia in humans. These leukemias are classified either as T…”
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Skewed Expression of Activation, Differentiation and Homing-Related Antigens in Circulating Cells from Patients with Cutaneous T Cell Lymphoma Associated with CD7– T Helper Lymphocytes Expansion
Published in Journal of investigative dermatology (01-10-1999)“…Mycosis fungoides and Sézary syndrome represent the most frequent forms of cutaneous T cell lymphoma. Both are characterized by skin infiltrating and/or…”
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Identification of the TCL1/MTCP1-like 1 (TML1) gene from the region next to the TCL1 locus
Published in Cancer research (Chicago, Ill.) (15-05-1999)“…The region on chromosome 14q32.1 is frequently involved in chromosomal translocations and inversions with one of the T-cell receptor loci in human T-cell…”
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The role of 9-O-acetylated ganglioside D3 (CD60) and {alpha}4{beta}1 (CD49d) expression in predicting the survival of patients with Sezary syndrome
Published in Haematologica (Roma) (01-11-2010)“…Sézary syndrome is a rare and very aggressive leukemic variant of cutaneous T-cell lymphoma characterized by extensive skin involvement and a malignant…”
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Skin homing of Sézary cells involves SDF-1-CXCR4 signaling and down-regulation of CD26/dipeptidylpeptidase IV
Published in Blood (01-02-2006)“…Sézary syndrome (SS) is a rare form of cutaneous T-cell lymphoma (CTCL) characterized by a distinct metastatic pattern mainly involving blood and skin…”
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Impaired T- and B-cell development in Tcl1-deficient mice
Published in Blood (01-02-2005)“…TCL1, the overexpression of which may result in T-cell leukemia, is normally expressed in early embryonic tissues, the ovary, and lymphoid lineage cells. Our…”
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