Search Results - "NARDONE, Nancy A"

Novel pancreatic endocrine maturation pathways identified by genomic profiling and causal reasoning by Gutteridge, Alex, Rukstalis, J Michael, Ziemek, Daniel, Tié, Mark, Ji, Lin, Ramos-Zayas, Rebeca, Nardone, Nancy A, Norquay, Lisa D, Brenner, Martin B, Tang, Kim, McNeish, John D, Rowntree, Rebecca K

“…We have used a previously unavailable model of pancreatic development, derived in vitro from human embryonic stem cells, to capture a time-course of gene,…”
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Discovery of potent and orally bioavailable heterocycle-based β3-adrenergic receptor agonists, potential therapeutics for the treatment of obesity by LAFONTAINE, Jennifer A, DAY, Robert F, DASILVA-JARDINE, Paul, DIBRINO, Joe, HADCOCK, John R, HARGROVE, Diane M, LINHARES, Michael, MARTIN, Kelly A, MAURER, Tristan S, NARDONE, Nancy A, TESS, David A

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GLUT4 Overexpression in db/db Mice Dose-Dependently Ameliorates Diabetes But Is Not a Lifelong Cure by BROZINICK, Joseph T, MCCOID, Scott C, REYNOLDS, Thomas H, NARDONE, Nancy A, HARGROVE, Diane M, STEVENSON, Ralph W, CUSHMAN, Samuel W, GIBBS, E. Michael

“…GLUT4 Overexpression in db/db Mice Dose-Dependently Ameliorates Diabetes But Is Not a Lifelong Cure Joseph T. Brozinick, Jr. 1 , Scott C. McCoid 2 , Thomas H…”
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Discovery of N-benzyl-2-[(4S)-4-(1H-indol-3-ylmethyl)-5-oxo-1-phenyl-4,5-dihydro-6H-[1,2,4]triazolo[4,3-a][1,5]benzodiazepin-6-yl]-N-isopropylacetamide, an orally active, gut-selective CCK1 receptor agonist for the potential treatment of obesity by Elliott, Richard L., Cameron, Kimberly O., Chin, Janice E., Bartlett, Jeremy A., Beretta, Elena E., Chen, Yue, Jardine, Paul Da Silva, Dubins, Jeffrey S., Gillaspy, Melissa L., Hargrove, Diane M., Kalgutkar, Amit S., LaFlamme, Janet A., Lame, Mary E., Martin, Kelly A., Maurer, Tristan S., Nardone, Nancy A., Oliver, Robert M., Scott, Dennis O., Sun, Dexue, Swick, Andrew G., Trebino, Catherine E., Zhang, Yingxin

“…We report the design, synthesis, and SAR of triazolobenzodiazepinone CCK1 receptor agonists. Compound 4a is a potent, selective CCK1 receptor agonist which…”
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Potent and selective, sulfamide-based human β3-adrenergic receptor agonists by DOW, Robert L, PAIGHT, Ernest S, SCHNEIDER, Steven R, HADCOCK, John R, HARGROVE, Diane M, MARTIN, Kelly A, MAURER, Tristan S, NARDONE, Nancy A, TESS, David A, DASILVA-JARDINE, Paul

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Limited structure-activity relationships for carboxy and aminoterminal substitutions of peptide YY 25-36 by Singleton, David H, Boyd, James G, Nardone, Nancy A, Robinson, Brett S, Pan, Lydia C, Hadcock, John R, Wenzel, A Zane

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Distribution of β3-adrenoceptor mRNA in human tissues by BERKOWITZ, D. E, NARDONE, N. A, SMILEY, R. M, PRICE, D. T, KREUTTER, D. K, FREMEAU, R. T, SCHWINN, D. A

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Discovery of N-benzyl-2-[(4S)-4-(1H-indol-3-ylmethyl)-5-oxo-1-phenyl -4,5-dihydro-6H-[1,2,4]triazolo[4,3-a][1,5]benzodiazepin-6- y l]-N-isopropylacetamide, an orally active, gut-selective CCK1 receptor agonist for the potential treatment of obesity by Elliott, Richard L, Cameron, Kimberly O, Chin, Janice E, Bartlett, Jeremy A, Beretta, Elena E, Chen, Yue, Jardine, Paul da Silva, Dubins, Jeffrey S, Gillaspy, Melissa L, Hargrove, Diane M, Kalgutkar, Amit S, LaFlamme, Janet A, Lame, Mary E, Martin, Kelly A, Maurer, Tristan S, Nardone, Nancy A, Oliver, Robert M, Scott, Dennis O, Sun, Dexue, Swick, Andrew G, Trebino, Catherine E, Zhang, Yingxin

“…We describe the design, synthesis, and structure-activity relationships of triazolobenzodiazepinone CCK1 receptor agonists. Analogs in this series demonstrate…”
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Discovery of potent and orally bioavailable heterocycle-based beta3-adrenergic receptor agonists, potential therapeutics for the treatment of obesity by Lafontaine, Jennifer A, Day, Robert F, Dibrino, Joe, Hadcock, John R, Hargrove, Diane M, Linhares, Michael, Martin, Kelly A, Maurer, Tristan S, Nardone, Nancy A, Tess, David A, Dasilva-Jardine, Paul

“…A novel series of heterocycle-based analogs were prepared and evaluated for their in vitro and in vivo biological activity as human beta(3)-adrenergic receptor…”
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Discovery of potent and orally bioavailable heterocycle-based β 3-adrenergic receptor agonists, potential therapeutics for the treatment of obesity by Lafontaine, Jennifer A., Day, Robert F., Dibrino, Joe, Hadcock, John R., Hargrove, Diane M., Linhares, Michael, Martin, Kelly A., Maurer, Tristan S., Nardone, Nancy A., Tess, David A., DaSilva-Jardine, Paul

“…A novel series of heterocycle-based analogs were prepared and evaluated for their in vitro and in vivo biological activity as human β 3-adrenergic receptor…”
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Potent and selective, sulfamide-based human beta 3-adrenergic receptor agonists by Dow, Robert L, Paight, Ernest S, Schneider, Steven R, Hadcock, John R, Hargrove, Diane M, Martin, Kelly A, Maurer, Tristan S, Nardone, Nancy A, Tess, David A, DaSilva-Jardine, Paul

“…A series of sulfamide-based analogs related to L-796568 were prepared and evaluated for their biological activity at the human beta(3)-adrenergic receptor…”
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Potent and selective, sulfamide-based human β 3-adrenergic receptor agonists by Dow, Robert L., Paight, Ernest S., Schneider, Steven R., Hadcock, John R., Hargrove, Diane M., Martin, Kelly A., Maurer, Tristan S., Nardone, Nancy A., Tess, David A., DaSilva-Jardine, Paul

“…A series of sulfamide-based analogs related to L-796568 were prepared and evaluated for their biological activity at the human β 3-adrenergic receptor (AR)…”
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Enhanced peripheral glucose utilization in transgenic mice expressing the human GLUT4 gene by Treadway, J L, Hargrove, D M, Nardone, N A, McPherson, R K, Russo, J F, Milici, A J, Stukenbrok, H A, Gibbs, E M, Stevenson, R W, Pessin, J E

“…Human GLUT4 protein expression in muscle and adipose tissues of transgenic mice decreases plasma insulin and glucose levels and improves glucose tolerance…”
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Modulation of Insulin Secretion and Glycemia by Selective Inhibition of Cyclic AMP Phosphodiesterase III by Parker, Janice C., Vanvolkenburg, Maria A., Nardone, Nancy A., Hargrove, Diane M., Andrews, Kim M.

“…The effects of selective inhibition of cyclic AMP phosphodiesterase type III on insulin and glucose levels during an oral glucose challenge were evaluated in…”
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Glucose-dependent action of glucagon-like peptide-1(7-37) in vivo during short- or long-term administration by Hargrove, Diane M., Nardone, Nancy A., Persson, Lorna M., Parker, Janice C., Stevenson, Ralph W.

“…In vitro, truncated glucagon-like peptides [GLP-1(7-36)-amide and GLP-1(7-37)] increase insulin secretion in a glucose-dependent manner, and desensitization to…”
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Comparison of the glucose dependency of glucagon-like peptide-1(7–37) and glyburide in vitro and in vivo by Hargrove, Diane M., Nardone, Nancy A., Persson, Lorna M., Andrews, Kim M., Shepherd, Kandace L., Stevenson, Ralph W., Parker, Janice C.

“…The purpose of the present study was to compare the glucose dependency of the insulin secretagogue activity of the sulfonylurea, glyburide, versus that of…”
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