Search Results - "NAOE, T"

Acetylation-dependent regulation of MDM2 E3 ligase activity dictates its oncogenic function by Nihira, Naoe T, Ogura, Kohei, Shimizu, Kouhei, North, Brian J, Zhang, Jinfang, Gao, Daming, Inuzuka, Hiroyuki, Wei, Wenyi

“…Abnormal activation of the oncogenic E3 ubiquitin ligase murine double minute 2 (MDM2) is frequently observed in human cancers. By ubiquitinating the tumor…”
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High-dose methotrexate therapy significantly improved survival of adult acute lymphoblastic leukemia: a phase III study by JALSG by Sakura, T, Hayakawa, F, Sugiura, I, Murayama, T, Imai, K, Usui, N, Fujisawa, S, Yamauchi, T, Yujiri, T, Kakihana, K, Ito, Y, Kanamori, H, Ueda, Y, Miyata, Y, Kurokawa, M, Asou, N, Ohnishi, K, Ohtake, S, Kobayashi, Y, Matsuo, K, Kiyoi, H, Miyazaki, Y, Naoe, T

“…High-dose methotrexate (Hd-MTX) therapy has recently been applied to the treatment of adult acute lymphoblastic leukemia (ALL) based on pediatric protocols;…”
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Role of anti-oncomirs miR-143 and -145 in human colorectal tumors by Akao, Y, Nakagawa, Y, Hirata, I, Iio, A, Itoh, T, Kojima, K, Nakashima, R, Kitade, Y, Naoe, T

“…We examined the expression levels of microRNAs (miRNAs (miRs)) in colorectal tumors (63 cancer specimens and 65 adenoma specimens) and paired non-tumorous…”
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Diminished DYRK2 sensitizes hormone receptor-positive breast cancer to everolimus by the escape from degrading mTOR by Mimoto, Rei, Nihira, Naoe T, Hirooka, Shinichi, Takeyama, Hiroshi, Yoshida, Kiyotsugu

“…Abstract Mammalian target of rapamycin (mTOR) inhibitor, everolimus, provides benefit for metastatic hormone receptor positive breast cancer after failure of…”
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Comprehensive analysis of genetic alterations and their prognostic impacts in adult acute myeloid leukemia patients by Kihara, R, Nagata, Y, Kiyoi, H, Kato, T, Yamamoto, E, Suzuki, K, Chen, F, Asou, N, Ohtake, S, Miyawaki, S, Miyazaki, Y, Sakura, T, Ozawa, Y, Usui, N, Kanamori, H, Kiguchi, T, Imai, K, Uike, N, Kimura, F, Kitamura, K, Nakaseko, C, Onizuka, M, Takeshita, A, Ishida, F, Suzushima, H, Kato, Y, Miwa, H, Shiraishi, Y, Chiba, K, Tanaka, H, Miyano, S, Ogawa, S, Naoe, T

“…To clarify the cooperative roles of recurrently identified mutations and to establish a more precise risk classification system in acute myeloid leukemia…”
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Prognostic significance of FLT3 internal tandem duplication and tyrosine kinase domain mutations for acute myeloid leukemia: a meta-analysis by YANADA, M, MATSUO, K, SUZUKI, T, KIYOI, H, NAOE, T

“…Two distinct forms of fms-like tyrosine kinase (FLT3) gene aberrations, internal tandem duplication (ITD) and tyrosine kinase domain (TKD) mutations, have been…”
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A novel STAT inhibitor, OPB-31121, has a significant antitumor effect on leukemia with STAT-addictive oncokinases by Hayakawa, F, Sugimoto, K, Harada, Y, Hashimoto, N, Ohi, N, Kurahashi, S, Naoe, T

“…Signal transduction and activator of transcription (STAT) proteins are extracellular ligand-responsive transcription factors that mediate cell proliferation,…”
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Array-based genomic resequencing of human leukemia by Yamashita, Y, Yuan, J, Suetake, I, Suzuki, H, Ishikawa, Y, Choi, Y L, Ueno, T, Soda, M, Hamada, T, Haruta, H, Takada, S, Miyazaki, Y, Kiyoi, H, Ito, E, Naoe, T, Tomonaga, M, Toyota, M, Tajima, S, Iwama, A, Mano, H

“…To identify oncogenes in leukemias, we performed large-scale resequencing of the leukemia genome using DNA sequence arrays that determine ∼9 Mbp of sequence…”
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Pre-transplant imatinib-based therapy improves the outcome of allogeneic hematopoietic stem cell transplantation for BCR–ABL-positive acute lymphoblastic leukemia by Mizuta, S, Matsuo, K, Yagasaki, F, Yujiri, T, Hatta, Y, Kimura, Y, Ueda, Y, Kanamori, H, Usui, N, Akiyama, H, Miyazaki, Y, Ohtake, S, Atsuta, Y, Sakamaki, H, Kawa, K, Morishima, Y, Ohnishi, K, Naoe, T, Ohno, R

“…A high complete remission (CR) rate has been reported in newly diagnosed Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ALL) following…”
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JAK3 mutations occur in acute megakaryoblastic leukemia both in Down syndrome children and non-Down syndrome adults by Kiyoi, H, Yamaji, S, Kojima, S, Naoe, T

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Frequent somatic mutations in epigenetic regulators in newly diagnosed chronic myeloid leukemia by Togasaki, E, Takeda, J, Yoshida, K, Shiozawa, Y, Takeuchi, M, Oshima, M, Saraya, A, Iwama, A, Yokote, K, Sakaida, E, Hirase, C, Takeshita, A, Imai, K, Okumura, H, Morishita, Y, Usui, N, Takahashi, N, Fujisawa, S, Shiraishi, Y, Chiba, K, Tanaka, H, Kiyoi, H, Ohnishi, K, Ohtake, S, Asou, N, Kobayashi, Y, Miyazaki, Y, Miyano, S, Ogawa, S, Matsumura, I, Nakaseko, C, Naoe, T

“…Although tyrosine kinase inhibitors (TKIs) have significantly improved the prognosis of chronic myeloid leukemia (CML), the ability of TKIs to eradicate CML…”
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Leukemic evolution of donor-derived cells harboring IDH2 and DNMT3A mutations after allogeneic stem cell transplantation by Yasuda, T, Ueno, T, Fukumura, K, Yamato, A, Ando, M, Yamaguchi, H, Soda, M, Kawazu, M, Sai, E, Yamashita, Y, Murata, M, Kiyoi, H, Naoe, T, Mano, H

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Somatic PHF6 mutations in 1760 cases with various myeloid neoplasms by Mori, T, Nagata, Y, Makishima, H, Sanada, M, Shiozawa, Y, Kon, A, Yoshizato, T, Sato-Otsubo, A, Kataoka, K, Shiraishi, Y, Chiba, K, Tanaka, H, Ishiyama, K, Miyawaki, S, Mori, H, Nakamaki, T, Kihara, R, Kiyoi, H, Koeffler, H P, Shih, L-Y, Miyano, S, Naoe, T, Haferlach, C, Kern, W, Haferlach, T, Ogawa, S, Yoshida, K

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Development and analysis of patient-derived xenograft mouse models in intravascular large B-cell lymphoma by Shimada, K, Shimada, S, Sugimoto, K, Nakatochi, M, Suguro, M, Hirakawa, A, Hocking, T D, Takeuchi, I, Tokunaga, T, Takagi, Y, Sakamoto, A, Aoki, T, Naoe, T, Nakamura, S, Hayakawa, F, Seto, M, Tomita, A, Kiyoi, H

“…Intravascular large B-cell lymphoma (IVLBCL) is a distinct disease entity with the peculiar characteristic that tumor cells proliferate within vessels. Despite…”
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Homing, proliferation and survival sites of human leukemia cells in vivo in immunodeficient mice by NINOMIYA, M, ABE, A, NAOE, T, KATSUMI, A, XU, J, ITO, M, ARAI, F, SUDA, T, ITO, M, KIYOI, H, KINOSHITA, T

“…The cellular components of the hematopoietic stem cell niche have been gradually identified. However, the niche for malignant hematopoiesis remains to be…”
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Mast cells promote the growth of Hodgkin's lymphoma cell tumor by modifying the tumor microenvironment that can be perturbed by bortezomib by Mizuno, H, Nakayama, T, Miyata, Y, Saito, S, Nishiwaki, S, Nakao, N, Takeshita, K, Naoe, T

“…Hodgkin's lymphoma is frequently associated with mast cell infiltration that correlates directly with disease severity, but the mechanisms underlying this…”
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Normal and oncogenic FLT3 by Naoe, T, Kiyoi, H

“…FLT3, a member of the class III receptor tyrosine kinases (RTKs), is preferentially expressed on the cell surface of hematopoietic progenitors, and the ligand…”
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Small gas bubble experiment for mitigation of cavitation damage and pressure waves in short-pulse mercury spallation targets by Riemer, B.W., Wendel, M.W., Felde, D.K., Sangrey, R.L., Abdou, A., West, D.L., Shea, T.J., Hasegawa, S., Kogawa, H., Naoe, T., Farny, C.H., Kaminsky, A.L.

“…Populations of small helium gas bubbles were introduced into a flowing mercury experiment test loop to evaluate mitigation of beam-pulse induced cavitation…”
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Integration of humoral and cellular HLA-specific immune responses in cord blood allograft rejection by Hanajiri, R, Murata, M, Sugimoto, K, Murase, M, Sakemura, R, Goto, T, Watanabe, K, Imahashi, N, Terakura, S, Ohashi, H, Akatsuka, Y, Kurahashi, S, Miyamura, K, Kiyoi, H, Nishida, T, Naoe, T

“…In allo-stem cell transplantation (SCT), it is unclear whether donor-specific anti-HLA Abs (DSAs) can actually mediate graft rejection or if they are simply…”
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Activating mutation of D835 within the activation loop of FLT3 in human hematologic malignancies by Yamamoto, Yukiya, Kiyoi, Hitoshi, Nakano, Yasuyuki, Suzuki, Ritsuro, Kodera, Yoshihisa, Miyawaki, Shuichi, Asou, Norio, Kuriyama, Kazutaka, Yagasaki, Fumiharu, Shimazaki, Chihiro, Akiyama, Hideki, Saito, Kenji, Nishimura, Miki, Motoji, Toshiko, Shinagawa, Katsuji, Takeshita, Akihiro, Saito, Hidehiko, Ueda, Ryuzo, Ohno, Ryuzo, Naoe, Tomoki

“…Mutations of receptor tyrosine kinases are implicated in the constitutive activation and development of human malignancy. An internal tandem duplication (ITD)…”
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