Search Results - "NANDAKUMAR, Ramya"

Sensing of HSV-1 by the cGAS–STING pathway in microglia orchestrates antiviral defence in the CNS by Reinert, Line S., Lopušná, Katarína, Winther, Henriette, Sun, Chenglong, Thomsen, Martin K., Nandakumar, Ramya, Mogensen, Trine H., Meyer, Morten, Vægter, Christian, Nyengaard, Jens R., Fitzgerald, Katherine A., Paludan, Søren R.

“…Herpes simplex encephalitis (HSE) is the most common form of acute viral encephalitis in industrialized countries. Type I interferon (IFN) is important for…”
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Lack of immunological DNA sensing in hepatocytes facilitates hepatitis B virus infection by Thomsen, Martin K., Nandakumar, Ramya, Stadler, Daniela, Malo, Antje, Valls, Roser Marin, Wang, Fan, Reinert, Line S., Dagnæs‐Hansen, Frederik, Hollensen, Anne Kruse, Mikkelsen, Jacob Giehm, Protzer, Ulrike, Paludan, Søren R.

“…Hepatitis B virus (HBV) is a major human pathogen, and about one third of the global population will be exposed to the virus in their lifetime. HBV infects…”
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STEEP mediates STING ER exit and activation of signaling by Zhang, Bao-cun, Nandakumar, Ramya, Reinert, Line S., Huang, Jinrong, Laustsen, Anders, Gao, Zong-liang, Sun, Cheng-long, Jensen, Søren Beck, Troldborg, Anne, Assil, Sonia, Berthelsen, Martin F., Scavenius, Carsten, Zhang, Yan, Windross, Samuel J., Olagnier, David, Prabakaran, Thaneas, Bodda, Chiranjeevi, Narita, Ryo, Cai, Yujia, Zhang, Cong-gang, Stenmark, Harald, Doucet, Christine M., Noda, Takeshi, Guo, Zheng, Goldbach-Mansky, Raphaela, Hartmann, Rune, Chen, Zhijian J., Enghild, Jan J., Bak, Rasmus O., Thomsen, Martin K., Paludan, Søren R.

“…STING is essential for control of infections and for tumor immunosurveillance, but it can also drive pathological inflammation. STING resides on the…”
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Intracellular bacteria engage a STING–TBK1–MVB12b pathway to enable paracrine cGAS–STING signalling by Nandakumar, Ramya, Tschismarov, Roland, Meissner, Felix, Prabakaran, Thaneas, Krissanaprasit, Abhichart, Farahani, Ensieh, Zhang, Bao-cun, Assil, Sonia, Martin, Amandine, Bertrams, Wilhelm, Holm, Christian K., Ablasser, Andrea, Klause, Tanja, Thomsen, Martin K., Schmeck, Bernd, Howard, Kenneth A., Henry, Thomas, Gothelf, Kurt V., Decker, Thomas, Paludan, Søren R.

“…The innate immune system is crucial for eventual control of infections, but may also contribute to pathology. Listeria monocytogenes is an intracellular…”
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A STING antagonist modulating the interaction with STIM1 blocks ER-to-Golgi trafficking and inhibits lupus pathology by Prabakaran, Thaneas, Troldborg, Anne, Kumpunya, Sarinya, Alee, Isara, Marinković, Emilija, Windross, Samuel J., Nandakumar, Ramya, Narita, Ryo, Zhang, Bao-cun, Carstensen, Mikkel, Vejvisithsakul, Pichpisith, Marqvorsen, Mikkel H.S., Iversen, Marie B., Holm, Christian K., Østergaard, Lars J., Pedersen, Finn Skou, Pisitkun, Trairak, Behrendt, Rayk, Pisitkun, Prapaporn, Paludan, Søren R.

“…Nucleic acids are potent stimulators of type I interferon (IFN-I) and antiviral defense, but may also promote pathological inflammation. A range of diseases…”
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Author Correction: STEEP mediates STING ER exit and activation of signaling by Zhang, Bao-cun, Nandakumar, Ramya, Reinert, Line S., Huang, Jinrong, Laustsen, Anders, Gao, Zong-liang, Sun, Cheng-long, Jensen, Søren Beck, Troldborg, Anne, Assil, Sonia, Berthelsen, Martin F., Scavenius, Carsten, Zhang, Yan, Windross, Samuel J., Olagnier, David, Prabakaran, Thaneas, Bodda, Chiranjeevi, Narita, Ryo, Cai, Yujia, Zhang, Cong-gang, Stenmark, Harald, Doucet, Christine M., Noda, Takeshi, Guo, Zheng, Goldbach-Mansky, Raphaela, Hartmann, Rune, Chen, Zhijian J., Enghild, Jan J., Bak, Rasmus O., Thomsen, Martin K., Paludan, Søren R.

“…An amendment to this paper has been published and can be accessed via a link at the top of the paper…”
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IRF-1 Expression Is Essential for Natural Killer Cells to Suppress Metastasis by KSIENZYK, Antje, NEUMANN, Berit, NANDAKUMAR, Ramya, FINSTERBUSCH, Katja, GRASHOFF, Martina, ZAWATZKY, Rainer, BERNHARDT, Gunter, HAUSER, Hansjörg, KRÖGER, Andrea

“…IFN-γ promotes tumoral immune surveillance, but its involvement in controlling metastases is less clear. Using a mouse model of pulmonary metastases, we show…”
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Utility of saliva and hair follicles in donor selection for hematopoietic stem cell transplantation and chimerism monitoring by Kaur, Gurvinder, Kumar, Neeraj, Nandakumar, Ramya, Rapthap, Chowphi C., Sharma, Gaurav, Neolia, Shekhar, Kumra, Heena, Mahalwar, Prateek, Garg, Abhinav, Kumar, Sunil, Kaur, Jasmeet, Hakim, Mrinali, Kumar, Lalit, Mehra, Narinder K.

“…Selection of an HLA identical donor is a critical pre-requisite for successful hematopoietic stem cell transplantation (HSCT). Most transplant centers utilize…”
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Catching the adaptor— WDFY 1, a new player in the TLR – TRIF pathway by Nandakumar, Ramya, Paludan, Søren R

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T. gondii inveSTING in a latent future by Nandakumar, Ramya, Paludan, Søren R.

“…Toxoplasma gondii is an obligate protozoan parasite that naturally infects all mammals, where it alters the host environment to establish chronic infection…”
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Catching the adaptor-WDFY1, a new player in the TLR-TRIF pathway by Nandakumar, Ramya, Paludan, Søren R

“…The innate immune system detects microbes and abnormal self through pattern recognition receptors (PRRs), which detect molecules that are either specific for…”
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An innate antiviral pathway acting before interferons at epithelial surfaces by Iversen, Marie B, Reinert, Line S, Thomsen, Martin K, Bagdonaite, Ieva, Nandakumar, Ramya, Cheshenko, Natalia, Prabakaran, Thaneas, Vakhrushev, Sergey Y, Krzyzowska, Malgosha, Kratholm, Sine K, Ruiz-Perez, Fernando, Petersen, Steen V, Goriely, Stanislas, Bibby, Bo Martin, Eriksson, Kristina, Ruland, Jürgen, Thomsen, Allan R, Herold, Betsy C, Wandall, Hans H, Frische, Sebastian, Holm, Christian K, Paludan, Søren R

“…Mucosal surfaces often represent the first point of entry for pathogens. Paludan and colleagues demonstrate that disruption of the mucus itself can initiate a…”
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Hepatitis C Virus Replication in Mouse Cells Is Restricted by IFN-Dependent and -Independent Mechanisms by Nandakumar, Ramya, Finsterbusch, Katja, Lipps, Christoph, Neumann, Berit, Grashoff, Martina, Nair, Sharmila, Hochnadel, Inga, Lienenklaus, Stefan, Wappler, Ilka, Steinmann, Eike, Hauser, Hansjörg, Pietschmann, Thomas, Kröger, Andrea

“…Background & Aims Current treatment strategies for hepatitis C virus (HCV) infection include pegylated interferon (IFN)-alfa and ribavirin. Approximately 50%…”
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PS2-078 Interferon Regulatory Factor-1 promotes NK cell-mediated suppression of lung metastasis through DNAM1/CD155 interaction by Ksienzyk, A., Neumann, Berit, Finsterbusch, Katja, RamyaNandakumar, Grashoff, Martina, Zawatzky, Rainer, Bernhardt, Günter, Hauser, Hansjörg, Kröger, Andrea

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