Search Results - "NAKAZATO, Atsuro"

Metabotropic glutamate 2/3 receptor antagonists improve behavioral and prefrontal dopaminergic alterations in the chronic corticosterone-induced depression model in mice by Ago, Yukio, Yano, Koji, Araki, Ryota, Hiramatsu, Naoki, Kita, Yuki, Kawasaki, Toshiyuki, Onoe, Hirotaka, Chaki, Shigeyuki, Nakazato, Atsuro, Hashimoto, Hitoshi, Baba, Akemichi, Takuma, Kazuhiro, Matsuda, Toshio

“…Metabotropic glutamate 2/3 (mGlu2/3) receptor antagonists have an antidepressant-like effect, but the exact mechanism still remains unclear. This study…”
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The Selective Metabotropic Glutamate 2/3 Receptor Agonist MGS0028 Reverses Isolation Rearing–Induced Abnormal Behaviors in Mice by Ago, Yukio, Araki, Ryota, Yano, Koji, Kawasaki, Toshiyuki, Chaki, Shigeyuki, Nakazato, Atsuro, Onoe, Hirotaka, Hashimoto, Hitoshi, Baba, Akemichi, Takuma, Kazuhiro, Matsuda, Toshio

“…Isolation-induced abnormal behaviors are useful animal models for assessing potential anti-psychotic drugs. This study examined the effect of MGS0028, a…”
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Design, synthesis and structure-affinity relationships of aryloxyanilide derivatives as novel peripheral benzodiazepine receptor ligands by OKUBO, Taketoshi, YOSHIKAWA, Ryoko, CHAKI, Shigeyuki, OKUYAMA, Shigeru, NAKAZATO, Atsuro

“…Since the peripheral benzodiazepine receptor (PBR) has been primarily found as a high-affinity binding site for diazepam in rat kidney, numerous studies of it…”
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Increased binding of cortical and hippocampal group II metabotropic glutamate receptors in isolation-reared mice by Kawasaki, Toshiyuki, Ago, Yukio, Yano, Koji, Araki, Ryota, Washida, Yusuke, Onoe, Hirotaka, Chaki, Shigeyuki, Nakazato, Atsuro, Hashimoto, Hitoshi, Baba, Akemichi, Takuma, Kazuhiro, Matsuda, Toshio

“…Post-weaning social isolation in rodents induces behavioral alterations, including hyperlocomotion, depression- and anxiety-like behaviors, aggression, and…”
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Anxiolytic- and antidepressant-like profile of a new CRF1 receptor antagonist, R278995/CRA0450 by CHAKI, Shigeyuki, NAKAZATO, Atsuro, KENNIS, Ludo, NAKAMURA, Masato, MACKIE, Claire, SUGIURA, Masayuki, VINKEN, Petra, ASHTON, David, LANGLOIS, Xavier, STECKLER, Thomas

“…1-[8-(2,4-dichlorophenyl)-2-methylquinolin-4-yl]-1,2,3,6-tetrahydropyridine-4-carboxamide benzenesulfonate (R278995/CRA0450) is a newly synthesized…”
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Activation of metabotropic glutamate 2/3 receptors attenuates methamphetamine-induced hyperlocomotion and increase in prefrontal serotonergic neurotransmission by Ago, Yukio, Araki, Ryota, Yano, Koji, Hiramatsu, Naoki, Kawasaki, Toshiyuki, Chaki, Shigeyuki, Nakazato, Atsuro, Onoe, Hirotaka, Hashimoto, Hitoshi, Baba, Akemichi, Takuma, Kazuhiro, Matsuda, Toshio

“…Rationale Metabotropic glutamate (mGlu) 2/3 receptor agonists inhibit amphetamine- and phencyclidine-induced hyperlocomotion. The mechanism for the…”
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The selective metabotropic glutamate 2/3 receptor agonist MGS0028 reverses psychomotor abnormalities and recognition memory deficits in mice lacking the pituitary adenylate cyclase-activating polypeptide by Ago, Yukio, Hiramatsu, Naoki, Ishihama, Toshihiro, Hazama, Keisuke, Hayata-Takano, Atsuko, Shibasaki, Yasuhiro, Shintani, Norihito, Hashimoto, Hitoshi, Kawasaki, Toshiyuki, Onoe, Hirotaka, Chaki, Shigeyuki, Nakazato, Atsuro, Baba, Akemichi, Takuma, Kazuhiro, Matsuda, Toshio

“…Previous studies suggest that metabotropic glutamate 2/3 receptors are involved in psychiatric disorders. In this study, we examined the effects of the…”
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Anxiolytic-like and antidepressant-like activities of MCL0129 (1-[(S)-2-(4-fluorophenyl)-2-(4-isopropylpiperadin-1-yl)ethyl]-4-[4-(2-methoxynaphthalen-1-yl)butyl]piperazine), a novel and potent nonpeptide antagonist of the melanocortin-4 receptor by Chaki, Shigeyuki, Hirota, Shiho, Funakoshi, Takeo, Suzuki, Yoshiko, Suetake, Sayoko, Okubo, Taketoshi, Ishii, Takaaki, Nakazato, Atsuro, Okuyama, Shigeru

“…We investigated the effects of a novel melanocortin-4 (MC4) receptor…”
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Neuropharmacological profiles of antagonists of group II metabotropic glutamate receptors by Kawashima, Naoya, Karasawa, Jun-ichi, Shimazaki, Toshiharu, Chaki, Shigeyuki, Okuyama, Shigeru, Yasuhara, Akito, Nakazato, Atsuro

“…Glutamatergic abnormalities play roles in several psychiatric disorders. Glutamate acts at two classes of receptors, ionotropic and metabotropic glutamate…”
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Receptor binding, behavioral, and electrophysiological profiles of nonpeptide corticotropin-releasing factor subtype 1 receptor antagonists CRA1000 and CRA1001 by Okuyama, S, Chaki, S, Kawashima, N, Suzuki, Y, Ogawa, S, Nakazato, A, Kumagai, T, Okubo, T, Tomisawa, K

“…Receptor binding, behavioral, and electrophysiological profiles of 2-[N-(2-methylthio-4-isopropylphenyl)-N-ethylamino]-4-[4-(3-flu orophe…”
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Synthesis, in Vitro Pharmacology, Structure−Activity Relationships, and Pharmacokinetics of 3-Alkoxy-2-amino-6-fluorobicyclo[3.1.0]hexane-2,6-dicarboxylic Acid Derivatives as Potent and Selective Group II Metabotropic Glutamate Receptor Antagonists by Nakazato, Atsuro, Sakagami, Kazunari, Yasuhara, Akito, Ohta, Hiroshi, Yoshikawa, Ryoko, Itoh, Manabu, Nakamura, Masato, Chaki, Shigeyuki

“…Novel group II metabotropic glutamate receptor (mGluR) antagonists, 3-alkoxy-2-amino-6-fluorobicyclo[3.1.0]hexane-2,6-dicarboxylic acid derivatives 11 and 12,…”
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Synthesis, SARs, and Pharmacological Characterization of 2-Amino-3 or 6-fluorobicyclo[3.1.0]hexane-2,6-dicarboxylic Acid Derivatives as Potent, Selective, and Orally Active Group II Metabotropic Glutamate Receptor Agonists by Nakazato, Atsuro, Kumagai, Toshihito, Sakagami, Kazunari, Yoshikawa, Ryoko, Suzuki, Yoshiko, Chaki, Shigeyuki, Ito, Hisanaka, Taguchi, Takeo, Nakanishi, Shigetada, Okuyama, Shigeru

“…(+)-2-Aminobicyclo[3.1.0]hexane-2,6-dicarboxylic acid (4, LY354740), a highly selective and orally active group II metabotropic glutamate receptor (mGluR)…”
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Design, synthesis, and structure–activity relationships of novel tetracyclic compounds as peripheral benzodiazepine receptor ligands by Okubo, Taketoshi, Yoshikawa, Ryoko, Chaki, Shigeyuki, Okuyama, Shigeru, Nakazato, Atsuro

“…Graphic The peripheral benzodiazepine receptor (PBR) is pharmacologically distinct from the central benzodiazepine receptor (CBR) and has been identified in a…”
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Structure–activity relationships of novel piperazines as antagonists for the melanocortin-4 receptor by Nozawa, Dai, Okubo, Taketoshi, Ishii, Takaaki, Kakinuma, Hiroyuki, Chaki, Shigeyuki, Okuyama, Shigeru, Nakazato, Atsuro

“…During the investigation of antagonists for the MC4 receptor, we found that 10ab having a naphthyl group showed almost the same binding affinity for the MC4…”
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Identification of Arginine Analogues as Antagonists and Agonists for the Melanocortin-4 Receptor by Nozawa, Dai, Okubo, Taketoshi, Chaki, Shigeyuki, Okuyama, Shigeru, Nakazato, Atsuro

“…In the present study, conducted to explore potent and small molecular melanocortin-4 (MC4) receptor ligands, we found that tripeptide 3a, containing a…”
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Synthesis, in vitro pharmacology, and pharmacokinetic profiles of 2-[1-amino-1-carboxy-2-(9 H-xanthen-9-yl)-ethyl]-1-fluorocyclopropanecarboxylic acid and its 6-heptyl ester, a potent mGluR2 antagonist by Sakagami, Kazunari, Yasuhara, Akito, Chaki, Shigeyuki, Yoshikawa, Ryoko, Kawakita, Yasunori, Saito, Akio, Taguchi, Takeo, Nakazato, Atsuro

“…In this paper, we describe the synthesis of (+)-(1 R ∗,2 R ∗)-2-[(1 S ∗)-1-amino-1-carboxy-2-(9 H-xanthen-9-yl)-ethyl]-1-fluorocyclopropanecarboxylic acid…”
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Binding characteristics of [formula omitted]DAA1106, a novel and selective ligand for peripheral benzodiazepine receptors by Chaki, Shigeyuki, Funakoshi, Takeo, Yoshikawa, Ryoko, Okuyama, Shigeru, Okubo, Taketoshi, Nakazato, Atsuro, Nagamine, Masashi, Tomisawa, Kazuyuki

“…Here, we investigated the binding characteristics of [ 3 H ] N-(2,5-dimethoxybenzyl)- N-(5-fluoro-2-phenoxyphenyl)acetamide ([ 3 H ]DAA1106), a potent and…”
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Synthesis of Diphenylmethyl Analogues and Their Affinity for the Melanocortin-4 Receptor and the Serotonin Transporter by Nozawa, Dai, Okubo, Taketoshi, Ishii, Takaaki, Chaki, Shigeyuki, Okuyama, Shigeru, Nakazato, Atsuro

“…While examining antagonists of the melanocortin-4 receptor (MC4 receptor), we found that compound 12b, containing a diphenylmethyl moiety, had a relatively…”
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Neuropharmacological profile of peripheral benzodiazepine receptor agonists, DAA1097 and DAA1106 by Okuyama, Shigeru, Chaki, Shigeyuki, Yoshikawa, Ryoko, Ogawa, Shin-ichi, Suzuki, Yoshiko, Okubo, Taketoshi, Nakazato, Atsuro, Nagamine, Masasi, Tomisawa, Kazuyuki

“…Receptor binding and behavioral profiles of N-(4-chloro-2-phenoxyphenyl)-N-(2-isopropoxybenzyl)acetamide (DAA1097) and…”
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Scalable Synthesis of (+)-2-Amino-3-fluorobicyclo[3.1.0]hexane-2,6-dicarboxylic Acid as a Potent and Selective Group II Metabotropic Glutamate Receptor Agonist by Sakagami, Kazunari, Kumagai, Toshihito, Taguchi, Takeo, Nakazato, Atsuro

“…We successfully synthesized the potent and selective group II mGluR agonist (+)-1 (MGS0008) via a process incorporating the key step of efficient fluorination…”
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