Search Results - "NAKAYAMA, TAKAHIRO"

Inactivation of seeding activity of amyloid β‐protein aggregates in vitro by Nakano, Hiroto, Hamaguchi, Tsuyoshi, Ikeda, Tokuhei, Watanabe‐Nakayama, Takahiro, Ono, Kenjiro, Yamada, Masahito

“…Our study demonstrates that autoclaving (AC) decreases beta (β)‐sheet‐rich structures in amyloid β‐protein (Aβ) aggregates, which inactivate Aβ seeding…”
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High molecular weight amyloid β1‐42 oligomers induce neurotoxicity via plasma membrane damage by Yasumoto, Taro, Takamura, Yusaku, Tsuji, Mayumi, Watanabe‐Nakayama, Takahiro, Imamura, Keiko, Inoue, Haruhisa, Nakamura, Shiro, Inoue, Tomio, Kimura, Atsushi, Yano, Satoshi, Nishijo, Hisao, Kiuchi, Yuji, Teplow, David B., Ono, Kenjiro

“…ABSTRACT Amyloid β‐protein (Aβ) molecules tend to aggregate and subsequently form low MW (LMW) oligomers, high MW (HMW) aggregates such as protofibrils, and…”
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Single-molecule observation of self-propagating amyloid fibrils by Watanabe-Nakayama, Takahiro, Ono, Kenjiro

“…Abstract The assembly of misfolded proteins into amyloid fibrils is associated with amyloidosis, including neurodegenerative diseases such as Alzheimer’s,…”
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Chromatin accessibility analysis suggested vascular induction of the biliary epithelium via the Notch signaling pathway in the human liver by Yoshihara, Masaharu, Nakayama, Takahiro, Takahashi, Satoru

“…The biliary epithelial cells (cholangiocytes) in the liver originate from undifferentiated liver parenchymal cells (hepatoblasts) that are located adjacent to…”
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A cationic polymethacrylate-copolymer acts as an agonist for β-amyloid and an antagonist for amylin fibrillation by Sahoo, Bikash R, Genjo, Takuya, Nakayama, Takahiro W, Stoddard, Andrea K, Ando, Toshio, Yasuhara, Kazuma, Fierke, Carol A, Ramamoorthy, Ayyalusamy

“…In humans, β-amyloid and islet amyloid polypeptide (IAPP, also known as amylin) aggregations are linked to Alzheimer's disease and type-2 diabetes,…”
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GSTP1 expression predicts poor pathological complete response to neoadjuvant chemotherapy in ER‐negative breast cancer by Miyake, Tomohiro, Nakayama, Takahiro, Naoi, Yasuto, Yamamoto, Noriaki, Otani, Yoko, Kim, Seung J., Shimazu, Kenzo, Shimomura, Atsushi, Maruyama, Naomi, Tamaki, Yasuhiro, Noguchi, Shinzaburo

“…The purpose of the present study was to investigate the association of glutathione S‐transferase P1 (GSTP1) expression with resistance to neoadjuvant…”
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Conformational Tuning of Amylin by Charged Styrene-Maleic-Acid Copolymers by Sahoo, Bikash R., Souders, Christopher L., Watanabe-Nakayama, Takahiro, Deng, Zhou, Linton, Hunter, Suladze, Saba, Ivanova, Magdalena I., Reif, Bernd, Ando, Toshio, Martyniuk, Christopher J., Ramamoorthy, Ayyalusamy

“…[Display omitted] •The generation of morphologically and pathologically distinct amylin species is reported.•Cationic SMAQA polymer drives the formation of…”
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Cerebral Microhemorrhages Secondary to a Hypervirulent Klebsiella Pneumoniae Infection by Sasaki, Takuya, Imai, Yurika, Nakayama, Takahiro, Imafuku, Ichiro

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The PBAP remodeling complex is required for histone H3.3 replacement at chromatin boundaries and for boundary functions by Nakayama, Takahiro, Shimojima, Tsukasa, Hirose, Susumu

“…Establishment and maintenance of epigenetic memories are essential for development. Replacement of canonical histone H3 by its variant H3.3 has been implicated…”
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Inflammatory Myopathy Associated with Anti-mitochondrial Antibody-negative Primary Biliary Cholangitis Diagnosed by a Liver Biopsy by Kainaga, Mitsuhiro, Sasaki, Takuya, Kitamura, Mizuki, Nakayama, Takahiro, Masuda, Keita, Kakuta, Yukio, Nishino, Ichizo, Imafuku, Ichiro

“…Anti-mitochondrial antibody (AMA)-associated myopathies represent a homogeneous disease entity with severe arrhythmia and slowly progressive proximal muscle…”
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Risk Factors for Ipsilateral Breast Tumor Recurrence in Triple-Negative or HER2-Positive Breast Cancer Patients Who Achieve a Pathologic Complete Response After Neoadjuvant Chemotherapy by Ishitobi, Makoto, Matsuda, Naoko, Tazo, Mizuho, Nakayama, Sayuka, Tokui, Ryu, Ogawa, Tomoko, Yoshida, Atsushi, Kojima, Yasuyuki, Kuwayama, Takashi, Nakayama, Takahiro, Yamauchi, Hideko, Nakamura, Seigo, Tsugawa, Koichiro, Hayashi, Naoki

“…Background Attention has been focused on attempts to eliminate breast surgery for breast cancer patients who achieve a pathologic complete response after…”
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Complete genomic sequence of Pseudomonas lactis bacteriophage HU1 isolated from raw cow’s milk by Tanaka, Chikage, Nakayama, Takahiro, Toba, Takahiro, Kashiwagi, Akiko

“…The lytic cold-active phage HU1, a member of the family Podoviridae , infects Pseudomonas lactis and was first isolated from raw cow’s milk. In this study, we…”
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Design and Fabrication Technology of Low Profile Tactile Sensor with Digital Interface for Whole Body Robot Skin by Makihata, Mitsutoshi, Muroyama, Masanori, Tanaka, Shuji, Nakayama, Takahiro, Nonomura, Yutaka, Esashi, Masayoshi

“…Covering a whole surface of a robot with tiny sensors which can measure local pressure and transmit the data through a network is an ideal solution to give an…”
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Notch1 signaling is limited in healthy mature kidneys in vivo by Sugiura, Ryosuke, Nakayama, Takahiro, Nishino, Teppei, Sambe, Naoto, Radtke, Freddy, Yoshihara, Masaharu, Takahashi, Satoru

“…A Delta-Notch signaling component, Notch1, is involved in the normal development and multiple disorders of the kidney. Although the increase in Notch1…”
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3-Axis Fully-Integrated Capacitive Tactile Sensor with Flip-Bonded CMOS on LTCC Interposer by Asano, Sho, Muroyama, Masanori, Nakayama, Takahiro, Hata, Yoshiyuki, Nonomura, Yutaka, Tanaka, Shuji

“…This paper reports a 3-axis fully integrated differential capacitive tactile sensor surface-mountable on a bus line. The sensor integrates a flip-bonded…”
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Acquisition and processing of high-speed atomic force microscopy videos for single amyloid aggregate observation by Watanabe-Nakayama, Takahiro, Ono, Kenjiro

“…•HS-AFM is able to visualize structural dynamics of individual amyloid aggregates.•Image processing is needed to remove HS-AFM stage drift to analyze the…”
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Identifying potential regulators of JAGGED1 expression in portal mesenchymal cells by Nishino, Teppei, Yoshihara, Masaharu, Nakayama, Takahiro, Tsuchiya, Takaho, Tahara, Saeko, Ozaki, Haruka, Takahashi, Satoru

“…Portal mesenchymal cells induce the epithelial differentiation of the bile ducts in the developing liver via one of the Delta-Notch signaling components,…”
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Muscle development in healthy children evaluated by bioelectrical impedance analysis by Uchiyama, Tomoka, Nakayama, Takahiro, Kuru, Satoshi

“…Abstract Objectives This study aimed to use bioelectrical impedance analysis (BIA) to generate a new muscle density index (MDI), the MDI_BIA, to evaluate…”
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Activator of KAT3 histone acetyltransferase family ameliorates a neurodevelopmental disorder phenotype in the syntaxin 1A ablated mouse model by Nakayama, Takahiro, Singh, Akash K., Fukutomi, Toshiyuki, Uchida, Noriyuki, Terao, Yasuo, Hamada, Hiroki, Muraoka, Takahiro, Muthusamy, Eswaramoorthy, Kundu, Tapas K., Akagawa, Kimio

“…Syntaxin-1A (stx1a) repression causes a neurodevelopmental disorder phenotype, low latent inhibition (LI) behavior, by disrupting 5-hydroxytryptaminergic…”
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Millisecond dynamic of SARS‐CoV‐2 spike and its interaction with ACE2 receptor and small extracellular vesicles by Lim, Keesiang, Nishide, Goro, Yoshida, Takeshi, Watanabe‐Nakayama, Takahiro, Kobayashi, Akiko, Hazawa, Masaharu, Hanayama, Rikinari, Ando, Toshio, Wong, Richard W.

“…SARS‐CoV‐2 spike protein (S) binds to human angiotensin‐converting enzyme 2 (hACE2), allowing virus to dock on cell membrane follow by viral entry. Here, we…”
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