Search Results - "NAKASHIMA, Mihoko N."

Proteomic analysis and ATP assay reveal a positive effect of artificial cerebral spinal fluid perfusion following microdialysis sampling on repair of probe-induced brain damage by Ohyama, Kaname, Ikeshita, Yuka, Fuchigami, Yuki, Kawakami, Shigeru, Nakashima, Mihoko N., Nakashima, Mikiro

“…•We report how the proteome profile changes due to the acute trauma caused by microdialysis.•The present study is the first to comprehensively investigate the…”
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Computational study of the competitive binding of valproic acid glucuronide and carbapenem antibiotics to acylpeptide hydrolase by Ishikawa, Takeshi, Otaki, Hiroki, Mizuta, Satoshi, Kuriyama, Masami, Onomura, Osamu, Higuchi, Norihide, Nakashima, Mihoko N., Nakashima, Mikiro, Ohyama, Kaname

“…The efficacy of the antiepileptic drug VPA is decreased by co-administered carbapenems (CBPMs). The mechanism of CBPM selective inhibition of acylpeptide…”
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Population Pharmacokinetic Investigation for Optimization of Amiodarone Therapy in Japanese Patients by ARAKI, Ryosuke, YUKAWA, Eiji, NAKASHIMA, Mihoko N, FUKUCHI, Hiromitsu, SASAKI, Hitoshi, YANO, Katsusuke, NAKASHIMA, Mikiro

“…Optimal use of amiodarone (AMD) requires information regarding the drug's pharmacokinetics and the influence of various factors on the drug's disposition. This…”
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Immune complexome analysis of serum samples from non-small-cell lung cancer patients identifies predictive biomarkers for nivolumab therapy by Aizawa, Rika, Nakamura, Yoichi, Ikeda, Takaya, Aibara, Nozomi, Kutsuna, Yuki J., Kurosaki, Tomoaki, Aki, Keisei, Junya, Hashizume, Nakagawa, Hiroo, Sato, Kayoko, Kodama, Yukinobu, Nakashima, Mihoko N., Nakashima, Mikiro, Mukae, Hiroshi, Ohyama, Kaname

“…•We compared immune complex antigens between responders and non-responders for nivolumab therapy.•Combination of immune complex antigens may predict the…”
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Case-controlled Study on Risk Factors for the Development of Constipation in Hospitalized Patients by UEKI, Tetsuya, NAGAI, Keiko, OOE, Nobuharu, NAKASHIMA, Mihoko N., NISHIDA, Koyo, NAKAMURA, Junzo, NAKASHIMA, Mikiro

“…Constipation is a common problem in hospitalized patients; however, the relative risks of its development with various factors have not been clarified. To…”
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Decrease in serotonin concentration in raphe magnus nucleus and attenuation of morphine analgesia in two mice models of neuropathic pain by Sounvoravong, Sourisak, Nakashima, Mihoko N, Wada, Mitsuhiro, Nakashima, Kenichiro

“…The alleviation of neuropathic pain cannot be satisfactorily achieved by treatment with opioids. There is much evidence to indicate that the active site of…”
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Investigation of protective effects of sodium hyaluronate eyedrop against corneal epithelial disorders using an electrophysiological method by Araki, Ryosuke, Nakashima, Mikiro, Teshima, Mugen, Owaki, Yuichi, Nakashima, Mihoko N, Uematsu, Masafumi, Kitaoka, Takashi, Nakamura, Tadahiro, Kitahara, Takashi, Sasaki, Hitoshi

“…The purpose of this study was to investigate the protective effects of sodium hyaluronate eyedrop against corneal epithelial disorders caused by…”
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Determination of paclitaxel in human and rat blood samples after administration of low dose paclitaxel by HPLC-UV detection by Yonemoto, Haruo, Ogino, Seiko, Nakashima, Mihoko N., Wada, Mitsuhiro, Nakashima, Kenichiro

“…A simple and sensitive HPLC‐UV method was developed for the determination of paclitaxel (TXL) in human and rat blood samples. 4‐Hydroxybenzoic acid n‐hexyl…”
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Cross-sectional Study on Relationship between Constipation and Medication in Consideration of Sleep Disorder by UEKI, Tetsuya, NAGAI, Keiko, MIZUKAMI, Yasuko, TAKAHASHI, Akihiro, OOE, Nobuharu, NAKASHIMA, Mihoko N., NISHIDA, Koyo, NAKAMURA, Junzo, NAKASHIMA, Mikiro

“…Constipation can be caused by adverse drug reactions as a result of many drugs and might be induced by sleep disorders; however, the relative risk of its…”
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Possible Role of Nitric Oxide in Anxiety Following Transient Cerebral Ischemia in Mice by Nakashima, Mihoko N., Ajiki, Ken-ichi, Nakashima, Kenichiro, Takahashi, Masakatsu

“…The possible role of nitric oxide (NO) in anxiety following transient cerebral ischemia by a 10-min bilateral carotid occlusion was examined in mice. Two days…”
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Determination of Gemcitabine in Plasma of Bladder Cancer Patients by Hydrophilic Interaction Chromatography with Ultraviolet Detection by Wang, Meng, Hiraki, Ryoichi, Nakamura, Norihiro, Hayama, Tadashi, Yasuda, Takuji, Miyata, Yasuyoshi, Sakai, Hideki, Nakashima, Mihoko N, Nakashima, Mikiro, Ohyama, Kaname

“…Gemcitabine is a deoxycytidine analog that has been used for a broad spectrum of tumor, such as nonsmall-cell lung cancer, bladder cancer and pancreatic…”
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Hair analysis for fenfluramine and norfenfluramine as biomarkers for N-nitrosofenfluramine ingestion by Kaddoumi, Amal, Wada, Mitsuhiro, Nakashima, Mihoko N., Nakashima, Kenichiro

“…In this paper, a high performance liquid chromatographic method with fluorescence detection (HPLC-FL) for the determination of fenfluramine (Fen) and…”
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Liquid chromatography studies on the pharmacokinetics of phentermine and fenfluramine in brain and blood microdialysates after intraperitoneal administration to rats by Kaddoumi, Amal, Nakashima, Mihoko N, Maki, Toshihide, Matsumura, Yoshihiro, Nakamura, Junzo, Nakashima, Kenichiro

“…A highly sensitive and simple HPLC method with fluorescence detection for the determination of phentermine (Phen), fenfluramine (Fen) and norfenfluramine…”
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Disability of Development of Tolerance to Morphine and U-50,488H, a Selective κ-Opioid Receptor Agonist, in Neuropathic Pain Model Mice by Sounvoravong, Sourisak, Takahashi, Masakatsu, Nakashima, Mihoko N., Nakashima, Kennichiro

“…We examined the analgesic and anti-allodynic effects of morphine and U-50,488H…”
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Pharmacokinetic interactions between phenylpropanolamine, caffeine and chlorpheniramine in rats by Kaddoumi, Amal, Nakashima, Mihoko N, Wada, Mitsuhiro, Nakashima, Kenichiro

“…As the mechanism involved in the serious adverse effects associated with phenylpropanolamine (PPA) has not yet been clarified, and as PPA in usual cases is not…”
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High-performance liquid chromatographic method for the disposition of mazindol and its metabolite 2-(2-aminoethyl)-3-( p-chlorophenyl)-3-hydroxyphthalimidine in mouse brain and plasma by Nakashima, Kenichiro, Kaddoumi, Amal, Mori, Miwako, Nakashima, Mihoko N, Wada, Mitsuhiro, Aboul-Enein, Hassan Y

“…A high-performance liquid chromatographic method was developed for the analysis of the appetite suppressant mazindol and its metabolite 2-(2-aminoethyl)-3-(…”
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Determination of donepezil hydrochloride in human and rat plasma, blood and brain microdialysates by HPLC with a short C30 column by NAKASHIMA, Kenichiro, ITOH, Keiko, KONO, Michio, NAKASHIMA, Mihoko N, WADA, Mitsuhiro

“…A simple and sensitive HPLC method with fluorescence (FL) detection for determination of donepezil (DP) in plasma and microdialysate samples was developed. A…”
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Simultaneous determination of arylpropionic acidic non-steroidal anti-inflammatory drugs in pharmaceutical formulations and human plasma by HPLC with UV detection by Sun, Yen, Takaba, Kumiko, Kido, Hideaki, Nakashima, Mihoko N, Nakashima, Kenichiro

“…A simple and sensitive high-performance liquid chromatography-UV detection method was developed for the simultaneous determination of non-steroidal…”
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Local Distribution into Brain Tumor and Pharmacokinetics of 4-Pyridoxate Diammine Hydroxy Platinum, a Novel Cisplatin Derivative, after Intracarotid Administration in Rats with 9L Malignant Glioma : Simultaneous Brain Microdialysis Study by TOKUNAGA, Yoshiharu, NAKASHIMA, Mikiro, SASAKI, Hitoshi, TOMIYAMA, Naoki, NAKASHIMA, Mihoko N., ICHIKAWA, Masataka, KAMINOGO, Makio, SHIBATA, Shobu

“…Local distribution into brain tumor and the pharmacokinetics of 4-pyridoxate diammine hydroxy platinum (PyPt), a novel cisplatin derivative, were examined…”
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Sensitive determination of MDMA and its metabolite MDA in rat blood and brain microdialysates by HPLC with fluorescence detection by Tomita, Mamoru, Nakashima, Mihoko N., Wada, Mitsuhiro, Nakashima, Kenichiro

“…Simultaneous determination of 3,4‐methylenedioxymethamphetamine (MDMA) and 3,4‐methylenedioxyamphetamine (MDA) in rat blood and brain microdialysates by…”
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