Search Results - "NAKASHIMA, Emi"

Hypotaurine Is a Substrate of GABA Transporter Family Members GAT2/Slc6a13 and TAUT/Slc6a6 by Nishimura, Tomohiro, Higuchi, Kei, Yoshida, Yuko, Sugita-Fujisawa, Yuki, Kojima, Kazuaki, Sugimoto, Maiko, Santo, Marie, Tomi, Masatoshi, Nakashima, Emi

“…Hypotaurine is a precursor of taurine and a physiological antioxidant that circulates in adult and fetal plasma. The purpose of the present study was to…”
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Organic Anion Transporter 4-Mediated Transport of Olmesartan at Basal Plasma Membrane of Human Placental Barrier by Noguchi, Saki, Nishimura, Tomohiro, Fujibayashi, Ayasa, Maruyama, Tetsuo, Tomi, Masatoshi, Nakashima, Emi

“…Mechanisms regulating fetal transfer of olmesartan, an angiotensin-II receptor type 1 antagonist, are important as potential determinants of life-threatening…”
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Mother-to-fetus transfer of antiviral drugs and the involvement of transporters at the placental barrier by Tomi, Masatoshi, Nishimura, Tomohiro, Nakashima, Emi

“…Administration of antiviral drugs to pregnant women with influenza, human immunodeficiency virus (HIV), and herpes simplex virus (HSV) infections is widely…”
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Cellular Uptake of Levocetirizine by Organic Anion Transporter 4 by Noguchi, Saki, Nishimura, Tomohiro, Mukaida, Saya, Benet, Leslie Z, Nakashima, Emi, Tomi, Masatoshi

“…The pharmacokinetics of cetirizine, a nonsedating antihistamine, is profoundly affected by transporter-mediated membrane transport in the kidney. In this…”
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A pericyte‐derived angiopoietin‐1 multimeric complex induces occludin gene expression in brain capillary endothelial cells through Tie‐2 activation in vitro by Hori, Satoko, Ohtsuki, Sumio, Hosoya, Ken‐ichi, Nakashima, Emi, Terasaki, Tetsuya

“…Although tight‐junctions (TJs) at the blood–brain barrier (BBB) are important to prevent non‐specific entry of compounds into the CNS, molecular mechanisms…”
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Contribution of equilibrative nucleoside transporter (ENT) 2 to fluorouracil transport in rat placental trophoblast cells by Takagi, Akinori, Nishimura, Tomohiro, Akashi, Tomoya, Tomi, Masatoshi, Nakashima, Emi

“…Fluorouracil is used for treatment of breast cancer even in pregnant women, except during fetal organogenesis. The purpose of this study was to clarify the…”
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Layer II of placental syncytiotrophoblasts expresses MDR1 and BCRP at the apical membrane in rodents by Akashi, Tomoya, Nishimura, Tomohiro, Takaki, Yoshiya, Takahashi, Masaya, Shin, Bo-Chul, Tomi, Masatoshi, Nakashima, Emi

“…•In rodents, MDR1 and BCRP are expressed in syncytiotrophoblast layer II.•In layer II, MDR1 and BCRP are localized in the apical membrane.•Layer II plays a…”
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System A amino acid transporter SNAT2 shows subtype-specific affinity for betaine and hyperosmotic inducibility in placental trophoblasts by Nishimura, Tomohiro, Yagi, Risa, Usuda, Mariko, Oda, Kenji, Yamazaki, Mai, Suda, Sayaka, Takahashi, Yu, Okazaki, Fumiyasu, Sai, Yoshimichi, Higuchi, Kei, Maruyama, Tetsuo, Tomi, Masatoshi, Nakashima, Emi

“…Betaine uptake is induced by hypertonic stress in a placental trophoblast cell line, and involvement of amino acid transport system A was proposed. Here, we…”
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Mechanism of Nucleoside Uptake in Rat Placenta and Induction of Placental CNT2 in Experimental Diabetes by Nishimura, Tomohiro, Chishu, Takuya, Tomi, Masatoshi, Nakamura, Ryo, Sato, Kazuko, Kose, Noriko, Sai, Yoshimichi, Nakashima, Emi

“…The purpose of this study was to clarify the transport characteristics of nucleosides in rat placenta and the changes of functional expression of nucleoside…”
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Fetal growth retardation and lack of hypotaurine in ezrin knockout mice by Nishimura, Tomohiro, Higuchi, Kei, Sai, Yoshimichi, Sugita, Yuki, Yoshida, Yuko, Tomi, Masatoshi, Wada, Masami, Wakayama, Tomohiko, Tamura, Atsushi, Tsukita, Sachiko, Soga, Tomoyoshi, Nakashima, Emi

“…Ezrin is a membrane-associated cytoplasmic protein that serves to link cell-membrane proteins with the actin-based cytoskeleton, and also plays a role in…”
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Evaluation of rat in vivo fetal-to-maternal transfer clearances of various xenobiotics by umbilical perfusion by Nishimura, Tomohiro, Takanohashi, Tatsuya, Tomi, Masatoshi, Horikoshi, Miho, Higuchi, Kei, Sai, Yoshimichi, Nakashima, Emi

“…It is important to address the tissue permeability of drugs, particularly in tissues that have a blood-tissue barrier, in terms of both lipophilicity and the…”
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Contribution of Prostaglandin Transporter OATP2A1/SLCO2A1 to Placenta-to-Maternal Hormone Signaling and Labor Induction by Inagaki, Mai, Nishimura, Tomohiro, Nakanishi, Takeo, Shimada, Hiroaki, Noguchi, Saki, Akanuma, Shin-ichi, Tachikawa, Masanori, Hosoya, Ken-ichi, Tamai, Ikumi, Nakashima, Emi, Tomi, Masatoshi

“…We evaluated the contribution of organic anion transporting polypeptide 2A1 (OATP2A1/SLCO2A1), a high-affinity carrier for prostaglandins (PGs), to the…”
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New approaches to in vitro models of blood–brain barrier drug transport by Terasaki, Tetsuya, Ohtsuki, Sumio, Hori, Satoko, Takanaga, Hitomi, Nakashima, Emi, Hosoya, Ken-ichi

“…The pharmaceutical industry has been searching for an in vitro blood-brain barrier (BBB) model that preserves in vivo transporter functions in CNS drug…”
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Transporter-Mediated Specific Drug Therapy During Pregnancy by Nakashima, Emi

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Basic Fibroblast Growth Factor Is Essential to Maintain Endothelial Progenitor Cell Phenotype in TR-BME2 Cells by Sai, Yoshimichi, Nishimura, Tomohiro, Muta, Mariko, Iizasa, Hisashi, Miyata, Takashi, Nakashima, Emi

“…Endothelial progenitor cells (EPC) can differentiate into both endothelial cells and contractile smooth muscle cells (SMC). Previously we reported that TR-BME2…”
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Functional expression of rat ABCG2 on the luminal side of brain capillaries and its enhancement by astrocyte‐derived soluble factor(s) by Hori, Satoko, Ohtsuki, Sumio, Tachikawa, Masanori, Kimura, Norihisa, Kondo, Tetsu, Watanabe, Masahiko, Nakashima, Emi, Terasaki, Tetsuya

“…The purpose of the present study was to clarify the expression, transport properties and regulation of ATP‐binding cassette G2 (ABCG2) transporter at the rat…”
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Interaction of endothelial progenitor cells expressing cytosine deaminase in tumor tissues and 5‐fluorocytosine administration suppresses growth of 5‐fluorouracil‐sensitive liver cancer in mice by Torimura, Takuji, Ueno, Takato, Taniguchi, Eitaro, Masuda, Hiroshi, Iwamoto, Hideki, Nakamura, Toru, Inoue, Kinya, Hashimoto, Osamu, Abe, Mitsuhiko, Koga, Hironori, Barresi, Vincenza, Nakashima, Emi, Yano, Hirohisa, Sata, Michio

“…The drug delivery system to tumors is a critical factor in upregulating the effect of anticancer drugs and reducing adverse events. Recent studies indicated…”
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Molecular Cloning of a Gene Encoding a New Type of Metalloproteinase-disintegrin Family Protein with Thrombospondin Motifs as an Inflammation Associated Gene by Kuno, K, Kanada, N, Nakashima, E, Fujiki, F, Ichimura, F, Matsushima, K

“…A cellular disintegrin and metalloproteinase (ADAM) is a new family of genes with structural homology to the snake venom metalloproteinases and disintegrins…”
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6-Mercaptopurine transport by equilibrative nucleoside transporters in conditionally immortalized rat syncytiotrophoblast cell lines TR-TBTs by Lee, Na-young, Sai, Yoshimichi, Nakashima, Emi, Ohtsuki, Sumio, Kang, Young-sook

“…Recently, more women were provided with 6-mercaptopurine (6-MP) during pregnancy. Therefore, we attempted to clarify the transport mechanisms of 6-MP through…”
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Heterophilic Binding of the Adhesion Molecules Poliovirus Receptor and Immunoglobulin Superfamily 4A in the Interaction Between Mouse Spermatogenic and Sertoli Cells by Wakayama, Tomohiko, Sai, Yoshimichi, Ito, Akihiko, Kato, Yukio, Kurobo, Miho, Murakami, Yoshinori, Nakashima, Emi, Tsuji, Akira, Kitamura, Yukihiko, Iseki, Shoichi

“…The cell adhesion protein immunoglobulin superfamily 4A (IGSF4A) is expressed on the surfaces of spermatogenic cells in the mouse testis. During…”
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