Search Results - "NAKANO, Manabu"

Antimicrobial properties of L-amino acid oxidase: biochemical features and biomedical applications by Kasai, Kosuke, Nakano, Manabu, Ohishi, Masami, Nakamura, Toshiya, Miura, Tomisato

“…Mucus layer that covers the body surface of various animal functions as a defense barrier against microbes, environmental xenobiotics, and predators. Previous…”
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KPNB1 Inhibitor Importazole Reduces Ionizing Radiation-Increased Cell Surface PD-L1 Expression by Modulating Expression and Nuclear Import of IRF1 by Yoshino, Hironori, Sato, Yoshiaki, Nakano, Manabu

“…Programmed death-ligand 1 (PD-L1) is an immune checkpoint molecule that negatively regulates anti-tumor immunity. Recent reports indicate that anti-cancer…”
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ΔNp63 Regulates Radioresistance in Human Head and Neck Squamous Carcinoma Cells by Sato, Kota, Yoshino, Hironori, Sato, Yoshiaki, Nakano, Manabu, Tsuruga, Eichi

“…Radiation therapy is commonly used to treat head and neck squamous cell carcinoma (HNSCC); however, recurrence results from the development of radioresistant…”
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Effects of Casein-Derived Peptide Met-Lys-Pro on Systolic and Diastolic Blood Pressure: A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study by Sato, Soichiro, Ochi, Daisuke, Nabeshima, Kazumi, Sakiyama, Ryo, Somoto, Yuki, Nakano, Manabu, Tanaka, Miyuki, Nakamura, Masahiko

“…Hypertension is defined as a systolic blood pressure (SBP) of over 140 mmHg or diastolic blood pressure (DBP) of over 90 mmHg. Hypertension is widely known to…”
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Effect of tablets containing lactoferrin and lactoperoxidase on gingival health in adults: A randomized, double‐blind, placebo‐controlled clinical trial by Nakano, Manabu, Yoshida, Akihiro, Wakabayashi, Hiroyuki, Tanaka, Miyuki, Yamauchi, Koji, Abe, Fumiaki, Masuda, Yuji

“…Objective To evaluate the effect of tablets containing lactoferrin (LF) and lactoperoxidase (LPO) on gingival health and oral health‐related quality of life in…”
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UDP/P2Y6 receptor signaling regulates IgE-dependent degranulation in human basophils by Nakano, Manabu, Ito, Koichi, Yuno, Takeo, Soma, Nobuyuki, Aburakawa, Syun, Kasai, Kosuke, Nakamura, Toshiya, Takami, Hideki

“…P2Y purinergic receptors (P2YR) are G protein-coupled receptors that are stimulated by extracellular nucleotides. They mediate cellular effects by regulating…”
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Relationship between oral and gut microbiota in elderly people by Iwauchi, Megumi, Horigome, Ayako, Ishikawa, Kentaro, Mikuni, Aya, Nakano, Manabu, Xiao, Jin‐zhong, Odamaki, Toshitaka, Hironaka, Shouji

“…Aim Recent studies have suggested that oral bacteria induce systemic inflammation through the alteration of gut microbiota. We examined the relationship…”
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Frequent cyclic variation of heart rate is associated with left ventricular diastolic dysfunction in patients without ischemia by Yaegashi, Takanori, Nakano, Manabu, Murata, Yoshiharu

“…Background Cyclic variation of heart rate (CVHR) associated with sleep‐disordered breathing reflects cardiac autonomic responses to apneic/hypoxic stress…”
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Effects of lactoferrin and lactoperoxidase‐containing food on the oral microbiota of older individuals by Nakano, Manabu, Wakabayashi, Hiroyuki, Sugahara, Hirosuke, Odamaki, Toshitaka, Yamauchi, Koji, Abe, Fumiaki, Xiao, Jin‐Zhong, Murakami, Kohji, Ishikawa, Kentaro, Hironaka, Shouji

“…ABSTRACT The oral microbiota influences health and disease states. Some gram‐negative anaerobic bacteria play important roles in tissue destruction associated…”
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Effects of lactoferrin and lactoperoxidase‐containing food on the oral hygiene status of older individuals: A randomized, double blinded, placebo‐controlled clinical trial by Morita, Yu, Ishikawa, Kentaro, Nakano, Manabu, Wakabayashi, Hiroyuki, Yamauchi, Koji, Abe, Fumiaki, Ooka, Takafumi, Hironaka, Shouji

“…Aim Lactoferrin and lactoperoxidase have antimicrobial effects against oral pathogens. This randomized, double‐blinded, placebo‐controlled parallel group study…”
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Phytoestrogenic activity of blackcurrant (Ribes nigrum) anthocyanins is mediated through estrogen receptor alpha by Nanashima, Naoki, Horie, Kayo, Tomisawa, Toshiko, Chiba, Mitsuru, Nakano, Manabu, Fujita, Toshifumi, Maeda, Hayato, Kitajima, Maiko, Takamagi, Shizuka, Uchiyama, Daishi, Watanabe, Jun, Nakamura, Toshiya, Kato, Yoji

“…SCOPE: Blackcurrants (Ribes nigrum L., Grossulariaceae) contain high amounts of anthocyanin polyphenols, which have antioxidant and anti‐carcinogenic health…”
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Rapid and simple identification of Beijing genotype strain of Mycobacterium tuberculosis using a loop-mediated isothermal amplification assay by Nagai, Yuhki, Iwade, Yoshito, Nakano, Manabu, Akachi, Shigehiro, Kobayashi, Takashi, Nishinaka, Takamichi

“…ABSTRACT Beijing genotype strains of Mycobacterium tuberculosis are geographically widespread and pose a notorious public health problem, these strains causing…”
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Inactivating effects of the lactoperoxidase system on bacterial lyases involved in oral malodour production by Nakano, Manabu, Shin, Kouichirou, Wakabayashi, Hiroyuki, Yamauchi, Koji, Abe, Fumiaki, Hironaka, Shouji

“…The main components of oral malodour have been identified as volatile sulfur compounds (VSCs), including hydrogen sulfide (H(2)S) and methyl mercaptan…”
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Anthocyanin-rich blackcurrant extract inhibits proliferation of the MCF10A healthy human breast epithelial cell line through induction of G0/G1 arrest and apoptosis by Nanashima, Naoki, Horie, Kayo, Chiba, Mitsuru, Nakano, Manabu, Maeda, Hayato, Nakamura, Toshiya

“…Blackcurrants (Ribes nigrum L., Grossulariaceae) possess a high content of anthocyanin polyphenols, which have been demonstrated to exhibit beneficial effects…”
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Recombinant production and evaluation of an antibacterial L-amino acid oxidase derived from flounder Platichthys stellatus by Kasai, Kosuke, Hashiguchi, Kenro, Takahashi, Hiroki, Kasai, Ayano, Takeda, Sadanori, Nakano, Manabu, Ishikawa, Takashi, Nakamura, Toshiya, Miura, Tomisato

“…Fish produce mucus substances as a defensive outer barrier against several bacterial infections. We have recently identified an antibacterial L-amino acid…”
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Synergistic anti-candida activities of lactoferrin and the lactoperoxidase system by Nakano, Manabu, Suzuki, Motofumi, Wakabayashi, Hiroyuki, Hayama, Kazumi, Yamauchi, Koji, Abe, Fumiaki, Abe, Shigeru

“…Candida albicans is a commensal fungus in human mucosal surfaces, including the oral cavity. Lactoferrin (LF) and the lactoperoxidase (LPO) system, which are…”
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Mitigative Effects of a Combination of Multiple Pharmaceutical Drugs on the Survival of Mice Exposed to Lethal Ionizing Radiation by Hirouchi, Tokuhisa, Ito, Koichi, Nakano, Manabu, Monzen, Satoru, Yoshino, Hironori, Chiba, Mitsuru, Hazawa, Masaharu, Nakano, Akira, Ishikawa, Junya, Yamaguchi, Masaru, Tanaka, Kimio, Kashiwakura, Ikuo

“…It is important to establish an easy-to-use therapeutic protocol for the emergency medical care of patients involved in radiation accidents to reduce the…”
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A randomized, double-blind, crossover, placebo-controlled clinical trial to assess effects of the single ingestion of a tablet containing lactoferrin, lactoperoxidase, and glucose oxidase on oral malodor by Nakano, Manabu, Shimizu, Eiju, Wakabayashi, Hiroyuki, Yamauchi, Koji, Abe, Fumiaki

“…The main components of oral malodor have been identified as volatile sulfur compounds (VSCs) including hydrogen sulfide (H2S) and methyl mercaptan (CH3SH)…”
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Altered firing pattern of single-unit muscle sympathetic nerve activity during handgrip exercise in chronic heart failure by Murai, Hisayoshi, Takamura, Masayuki, Maruyama, Michirou, Nakano, Manabu, Ikeda, Tatsunori, Kobayashi, Daisuke, Otowa, Kan‐ichi, Ootsuji, Hiroshi, Okajima, Masaki, Furusho, Hiroshi, Takata, Shigeo, Kaneko, Shuichi

“…Sympathetic activation in chronic heart failure (CHF) is greatly augmented at rest but the response to exercise remains controversial. We previously…”
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High resolution melting curve assay for rapid detection of drug-resistant Mycobacterium tuberculosis by Nagai, Yuhki, Iwade, Yoshito, Katayama, Masahiko, Yamaguchi, Tetsuo, Hayakawa, Eri, Nakano, Manabu, Sakai, Takashi, Mitarai, Satoshi, Nosaka, Tetsuya

“…Abstract We developed and evaluated a high resolution melting (HRM) curve assay by using real-time PCR for the detection of the most frequent mutations of…”
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