Search Results - "NAKAMURA, Yohko"
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A multicentre clinical validation of AminoIndex Cancer Screening (AICS)
Published in Scientific reports (25-09-2019)“…AminoIndex Cancer Screening (AICS) is a novel cancer screening test based on plasma free amino acid (PFAA) levels. This system categorises subjects as rank A,…”
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Functional interplay between MYCN, NCYM, and OCT4 promotes aggressiveness of human neuroblastomas
Published in Cancer science (01-07-2015)“…Neuroblastoma is a pediatric solid tumor that originates from embryonic neural crest cells. The MYCN gene locus is frequently amplified in unfavorable…”
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Matters of data openness and KapWeb, a web tool of multi‐cancer survival analysis for cancer survivors
Published in Cancer science (01-05-2021)“…KapWeb is an interactive tool for the determination of cancer survival rates based on case outcomes compiled from more than half a million records from cancer…”
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4
Association between plasma levels of homocysteine, folate, and vitamin B12, and dietary folate intake and hypertension in a cross-sectional study
Published in Scientific reports (28-10-2020)“…There are few studies examining the association between homocysteine (Hcy) level and the risk of hypertension with consideration for folate and vitamin B 12 as…”
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5
Co-Inhibition of the DNA Damage Response and CHK1 Enhances Apoptosis of Neuroblastoma Cells
Published in International journal of molecular sciences (29-07-2019)“…Checkpoint kinase 1 (CHK1) is a central mediator of the DNA damage response (DDR) at the S and G2/M cell cycle checkpoints, and plays a crucial role in…”
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6
Association of perceived stress and coping strategies with the renal function in middle-aged and older Japanese men and women
Published in Scientific reports (07-01-2022)“…Elucidating the risk factors for chronic kidney disease is important for preventing end-stage renal disease and reducing mortality. However, little is known…”
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Genomewide Association Study of Leisure-Time Exercise Behavior in Japanese Adults
Published in Medicine and science in sports and exercise (01-12-2018)“…PURPOSEAlthough several genetic factors may play a role in leisure-time exercise behavior, there is currently no evidence of a significant genomewide…”
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Associations of breastfeeding history with metabolic syndrome and cardiovascular risk factors in community-dwelling parous women: The Japan Multi-Institutional Collaborative Cohort Study
Published in PloS one (19-01-2022)“…The aim of the present study was to investigate the associations between breastfeeding and the prevalence of metabolic syndrome in community-dwelling parous…”
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Programmed expression of pro-apoptotic BMCC1 during apoptosis, triggered by DNA damage in neuroblastoma cells
Published in BMC cancer (06-06-2019)“…The multi-functional BMCC1 (BCH motif-containing molecule at the carboxyl terminal region 1)/PRUNE2 plays a clear role in suppression of tumor activity. In the…”
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NCYM, a Cis-antisense gene of MYCN, encodes a de novo evolved protein that inhibits GSK3β resulting in the stabilization of MYCN in human neuroblastomas
Published in PLoS genetics (01-01-2014)“…The rearrangement of pre-existing genes has long been thought of as the major mode of new gene generation. Recently, de novo gene birth from non-genic DNA was…”
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Association of 25-hydroxyvitamin D with risk of overall and colorectal cancer among Japanese using a Mendelian randomization approach
Published in Scientific reports (10-02-2023)“…The association between vitamin D and total and colorectal cancer risk was inconsistent in observational studies. We conducted Mendelian randomization approach…”
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Effects of gene-lifestyle interactions on obesity based on a multi-locus risk score: A cross-sectional analysis
Published in PloS one (08-02-2023)“…The relationship between lifestyle and obesity is a major focus of research. Personalized nutrition, which utilizes evidence from nutrigenomics, such as…”
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Association between consumption of small fish and all-cause mortality among Japanese: the Japan Multi-Institutional Collaborative Cohort Study
Published in Public health nutrition (2024)“…Although small fish are an important source of micronutrients, the relationship between their intake and mortality remains unclear. This study aimed to clarify…”
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14
Genomic analysis-integrated whole-exome sequencing of neuroblastomas identifies genetic mutations in axon guidance pathway
Published in Oncotarget (22-08-2017)“…Neuroblastoma (NB) is a childhood solid malignant tumor originating from precursor cells of the peripheral nervous system. We have previously established a…”
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A genome-wide association study on confection consumption in a Japanese population: the Japan Multi-Institutional Collaborative Cohort Study
Published in British journal of nutrition (28-12-2021)“…Differences in individual eating habits may be influenced by genetic factors, in addition to cultural, social or environmental factors. Previous studies…”
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Elemental analysis by Metallobalance provides a complementary support layer over existing blood biochemistry panel-based cancer risk assessment
Published in PeerJ (San Francisco, CA) (04-10-2021)“…Despite the benefit of early cancer screening, Japan has one of the lowest cancer screening rates among developed countries, possibly due to there being a lack…”
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A genome-wide association study in Japanese identified one variant associated with a preference for a Japanese dietary pattern
Published in European journal of clinical nutrition (01-06-2021)“…Background/Objectives Individual eating habits may be influenced by genetic factors, in addition to environmental factors. Previous studies suggested that…”
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The interaction between ABCA1 polymorphism and physical activity on the HDL-cholesterol levels in a Japanese population
Published in Journal of lipid research (01-01-2020)“…Few studies have investigated the interactions between HDL-C-related SNPs identified by genome-wide association (GWA) study and physical activity (PA) on…”
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Association of Dietary Acid Load with the Prevalence of Metabolic Syndrome among Participants in Baseline Survey of the Japan Multi-Institutional Collaborative Cohort Study
Published in Nutrients (29-05-2020)“…The association between dietary acid load and metabolic syndrome (MetS) has not been fully investigated. A cross-sectional study was performed on 14,042 men…”
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NLRR1 Is a Potential Therapeutic Target in Neuroblastoma and MYCN-Driven Malignant Cancers
Published in Frontiers in oncology (25-06-2021)“…Receptor tyrosine kinases (RTKs) receive different modulation before transmitting proliferative signals. We previously identified neuronal leucine-rich repeat…”
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