Search Results - "NAKAMOTO, Yasunari"

Promising new strategies for hepatocellular carcinoma by Nakamoto, Yasunari

“…Hepatocellular carcinoma (HCC) is one of the most common causes of cancer death worldwide. It usually arises based on a background of chronic liver diseases,…”
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Emergence of immunotherapy as a novel way to treat hepatocellular carcinoma by Mukaida, Naofumi, Nakamoto, Yasunari

“…Tumor immunity proceeds through multiple processes, which consist of antigen presentation by antigen presenting cells (APCs) to educate effector cells and…”
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Autophagy and Tau Protein by Hamano, Tadanori, Enomoto, Soichi, Shirafuji, Norimichi, Ikawa, Masamichi, Yamamura, Osamu, Yen, Shu-Hui, Nakamoto, Yasunari

“…Neurofibrillary tangles, which consist of highly phosphorylated tau protein, and senile plaques (SPs) are pathological hallmarks of Alzheimer’s disease (AD)…”
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Increase in CD14+HLA-DR−/low myeloid-derived suppressor cells in hepatocellular carcinoma patients and its impact on prognosis by Arihara, Fumitaka, Mizukoshi, Eishiro, Kitahara, Masaaki, Takata, Yoshiko, Arai, Kuniaki, Yamashita, Tatsuya, Nakamoto, Yasunari, Kaneko, Shuichi

“…Myeloid-derived suppressor cells (MDSCs) are known as key immune regulators in various human malignancies, and it is reported that CD14 + HLA-DR −/low MDSCs…”
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Sofosbuvir plus velpatasvir treatment for hepatitis C virus in patients with decompensated cirrhosis: a Japanese real-world multicenter study by Tahata, Yuki, Hikita, Hayato, Mochida, Satoshi, Kawada, Norifumi, Enomoto, Nobuyuki, Ido, Akio, Yoshiji, Hitoshi, Miki, Daiki, Hiasa, Yoichi, Takikawa, Yasuhiro, Sakamori, Ryotaro, Kurosaki, Masayuki, Yatsuhashi, Hiroshi, Tateishi, Ryosuke, Ueno, Yoshiyuki, Itoh, Yoshito, Yamashita, Taro, Kanto, Tatsuya, Suda, Goki, Nakamoto, Yasunari, Kato, Naoya, Asahina, Yasuhiro, Matsuura, Kentaro, Terai, Shuji, Nakao, Kazuhiko, Shimizu, Masahito, Takami, Taro, Akuta, Norio, Yamada, Ryoko, Kodama, Takahiro, Tatsumi, Tomohide, Yamada, Tomomi, Takehara, Tetsuo

“…Background Real-world data on the efficacy and safety of sofosbuvir plus velpatasvir (SOF/VEL) treatment for patients with hepatitis C virus (HCV)-related…”
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Efficacy of immunotherapy targeting the neoantigen derived from epidermal growth factor receptor T790M/C797S mutation in non–small cell lung cancer by Akazawa, Yu, Saito, Yuki, Yoshikawa, Toshiaki, Saito, Keigo, Nosaka, Kazuto, Shimomura, Manami, Mizuno, Shoichi, Nakamoto, Yasunari, Nakatsura, Tetsuya

“…Lung cancer is the leading cause of cancer‐related deaths worldwide. Epidermal growth factor receptor‐tyrosine kinase inhibitors (EGFR‐TKI) often have good…”
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Liver-related events after direct-acting antiviral therapy in patients with hepatitis C virus-associated cirrhosis by Tahata, Yuki, Hikita, Hayato, Mochida, Satoshi, Enomoto, Nobuyuki, Kawada, Norifumi, Kurosaki, Masayuki, Ido, Akio, Miki, Daiki, Yoshiji, Hitoshi, Takikawa, Yasuhiro, Sakamori, Ryotaro, Hiasa, Yoichi, Nakao, Kazuhiko, Kato, Naoya, Ueno, Yoshiyuki, Yatsuhashi, Hiroshi, Itoh, Yoshito, Tateishi, Ryosuke, Suda, Goki, Takami, Taro, Nakamoto, Yasunari, Asahina, Yasuhiro, Matsuura, Kentaro, Yamashita, Taro, Kanto, Tatsuya, Akuta, Norio, Terai, Shuji, Shimizu, Masahito, Sobue, Satoshi, Miyaki, Tomokatsu, Moriuchi, Akihiro, Yamada, Ryoko, Kodama, Takahiro, Tatsumi, Tomohide, Yamada, Tomomi, Takehara, Tetsuo

“…Background Direct-acting antiviral (DAA) therapy enables a high rate of sustained virologic response (SVR) in patients with hepatitis C virus associated…”
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Discrete nature of EpCAM+ and CD90+ cancer stem cells in human hepatocellular carcinoma by Yamashita, Taro, Honda, Masao, Nakamoto, Yasunari, Baba, Masayo, Nio, Kouki, Hara, Yasumasa, Zeng, Sha Sha, Hayashi, Takehiro, Kondo, Mitsumasa, Takatori, Hajime, Yamashita, Tatsuya, Mizukoshi, Eishiro, Ikeda, Hiroko, Zen, Yoh, Takamura, Hiroyuki, Wang, Xin Wei, Kaneko, Shuichi

“…Recent evidence suggests that hepatocellular carcinoma (HCC) is organized by a subset of cells with stem cell features (cancer stem cells; CSCs). CSCs are…”
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PET Imaging for Oxidative Stress in Neurodegenerative Disorders Associated with Mitochondrial Dysfunction by Ikawa, Masamichi, Okazawa, Hidehiko, Nakamoto, Yasunari, Yoneda, Makoto

“…Oxidative stress based on mitochondrial dysfunction is assumed to be the principal molecular mechanism for the pathogenesis of many neurodegenerative…”
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Persistent Severe Cerebral Edema with Neutrophil Infiltration Following Listeria Meningitis by Ueno, Asako, Ikawa, Masamichi, Maeda, Kenichiro, Tai, Katsuhide, Ito, Tomomi, Shirafuji, Norimichi, Yamamura, Osamu, Nakamoto, Yasunari, Hamano, Tadanori

“…A 51-year-old man was admitted to the hospital with a diagnosis of Listeria monocytogenes meningitis. Diffuse cerebral edema appeared after improvement of…”
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Lung Macrophages: Multifunctional Regulator Cells for Metastatic Cells by Mukaida, Naofumi, Nosaka, Takuto, Nakamoto, Yasunari, Baba, Tomohisa

“…Metastasis is responsible for most of the cancer-associated deaths and proceeds through multiple steps. Several lines of evidence have established an…”
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Regulatory function of interferon‐inducible 44‐like for hepatitis B virus covalently closed circular DNA in primary human hepatocytes by Nosaka, Takuto, Naito, Tatsushi, Murata, Yosuke, Matsuda, Hidetaka, Ohtani, Masahiro, Hiramatsu, Katsushi, Nishizawa, Tsutomu, Okamoto, Hiroaki, Nakamoto, Yasunari

“…Aim Curing hepatitis B virus (HBV) infection requires elimination of covalently closed circular DNA (cccDNA). Interferon (IFN)‐γ has noncytolytic antiviral…”
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Serum Laminin γ2 Monomer as a Diagnostic and Predictive Biomarker for Hepatocellular Carcinoma by Yamashita, Taro, Koshikawa, Naohiko, Shimakami, Tetsuro, Terashima, Takeshi, Nakagawa, Masatoshi, Nio, Kouki, Horii, Rika, Iida, Noriho, Kawaguchi, Kazunori, Arai, Kuniaki, Sakai, Yoshio, Yamashita, Tatsuya, Mizukoshi, Eishiro, Honda, Masao, Kitao, Azusa, Kobayashi, Satoshi, Takahara, Shizuko, Imai, Yasuhito, Yoshimura, Kenichi, Murayama, Toshinori, Nakamoto, Yasunari, Yoshida, Eisaku, Yoshimura, Toru, Seiki, Motoharu, Kaneko, Shuichi

“…Backgrounds and Aims Structural dynamics of basement membrane components are still to be elucidated in the process of hepatocarcinogenesis. We evaluated the…”
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Cholesterol crystal embolism in multiple organs after transarterial chemoembolization for hepatocellular carcinoma: An autopsy case report by Yamashita, Junki, Nosaka, Takuto, Takahashi, Kazuto, Naito, Tatsushi, Ofuji, Kazuya, Matsuda, Hidetaka, Ohtani, Masahiro, Hiramatsu, Katsushi, Kobayashi, Motohiro, Nakamoto, Yasunari

“…Transcatheter arterial chemoembolization (TACE) for hepatocellular carcinoma (HCC) rarely causes cholesterol crystal embolism (CCE). In our case, the…”
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Homocysteine Increases Tau Phosphorylation, Truncation and Oligomerization by Shirafuji, Norimichi, Hamano, Tadanori, Yen, Shu-Hui, Kanaan, Nicholas M, Yoshida, Hirotaka, Hayashi, Kouji, Ikawa, Masamichi, Yamamura, Osamu, Kuriyama, Masaru, Nakamoto, Yasunari

“…Increased plasma homocysteinemia is considered a risk factor of dementia, including Alzheimer's disease (AD) and vascular dementia. However, the reason…”
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Gd‐EOB‐DTPA‐enhanced magnetic resonance imaging and alpha‐fetoprotein predict prognosis of early‐stage hepatocellular carcinoma by Yamashita, Taro, Kitao, Azusa, Matsui, Osamu, Hayashi, Takehiro, Nio, Kouki, Kondo, Mitsumasa, Ohno, Naoki, Miyati, Tosiaki, Okada, Hikari, Yamashita, Tatsuya, Mizukoshi, Eishiro, Honda, Masao, Nakanuma, Yasuni, Takamura, Hiroyuki, Ohta, Tetsuo, Nakamoto, Yasunari, Yamamoto, Masakazu, Takayama, Tadatoshi, Arii, Shigeki, Wang, XinWei, Kaneko, Shuichi

“…The survival of patients with hepatocellular carcinoma (HCC) is often individually different even after surgery for early‐stage tumors. Gadolinium ethoxybenzyl…”
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Hepatocellular carcinoma progression promoted by 5-lipoxygenase activity in CD163(+) tumor-associated macrophages by Nosaka, Takuto, Murata, Yosuke, Takahashi, Kazuto, Naito, Tatsushi, Ofuji, Kazuya, Matsuda, Hidetaka, Ohtani, Masahiro, Hiramatsu, Katsushi, Imamura, Yoshiaki, Goi, Takanori, Nakamoto, Yasunari

“…Arachidonic acid 5-lipoxygenase (5-LOX), an enzyme that synthesizes leukotrienes (LTs), is involved in cancer development including proliferation, invasion,…”
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Progressive Encephalomyelitis with Rigidity and Myoclonus (PERM)-like Symptoms Associated with Anti-ganglionic Acetylcholine Receptor Antibodies by Kitazaki, Yuki, Ikawa, Masamichi, Kishitani, Toru, Kamisawa, Tomoko, Nakane, Shunya, Nakamoto, Yasunari, Hamano, Tadanori

“…This report describes a 59-year-old woman who presented with progressive encephalomyelitis with rigidity and myoclonus (PERM)-like symptoms and severe…”
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Usefulness of serum microRNA as a predictive marker of recurrence and prognosis in biliary tract cancer after radical surgery by Akazawa, Yu, Mizuno, Shoichi, Fujinami, Norihiro, Suzuki, Toshihiro, Yoshioka, Yusuke, Ochiya, Takahiro, Nakamoto, Yasunari, Nakatsura, Tetsuya

“…Biliary tract cancer (BTC) is an aggressive type of malignant tumour. Even after radical resection, the risk of recurrence is still high, resulting in a poor…”
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Syk inhibitors reduce tau protein phosphorylation and oligomerization by Yamaguchi, Tomohisa, Hamano, Tadanori, Sada, Kiyonao, Asano, Rei, Kanaan, Nicholas M., Sasaki, Hirohito, Yen, Shu-Hui, Kitazaki, Yuki, Endo, Yoshinori, Enomoto, Soichi, Shirafuji, Norimichi, Ikawa, Masamichi, Yamamura, Osamu, Fujita, Youshi, Aoki, Koji, Naiki, Hironobu, Morishima, Maho, Saito, Yuko, Murayama, Shigeo, Nakamoto, Yasunari

“…Spleen tyrosine kinase (Syk), a non-receptor-type tyrosine kinase, has a wide range of physiological functions. A possible role of Syk in Alzheimer's disease…”
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